{ "uniprot_canonical_ac": "O75822-1", "uniprot_ac": "O75822", "uniprot_id": "EIF3J_HUMAN", "mass": { "chemical_mass": 29062.0, "monoisotopic_mass": 29062.0 }, "refseq": { "ac": "NP_001271264", "name": "eukaryotic translation initiation factor 3 subunit J isoform 2", "summary": "This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271264" }, "gene_names": [ { "name": "EIF3J", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75822", "id": "O75822" }, { "name": "EIF3J", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271264", "id": "NP_001271264" }, { "name": "EIF3S1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75822", "id": "O75822" }, { "name": "PRO0391", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75822", "id": "O75822" }, { "name": "eIF3-alpha; eIF3-p35; EIF3S1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271264", "id": "NP_001271264" } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 3 subunit J", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75822" }, { "name": "Eukaryotic translation initiation factor 3 subunit 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75822" }, { "name": "eIF-3-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75822" }, { "name": "eIF3 p35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75822" }, { "name": "eIF3j", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75822" }, { "name": "eukaryotic translation initiation factor 3 subunit J isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271264", "id": "NP_001271264" }, { "name": "eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271264", "id": "NP_001271264" } ], "function": [ { "annotation": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822#function" }, { "database": "PubMed", "id": "27462815", "url": "https://glygen.org/publication/PubMed/27462815" }, { "database": "PubMed", "id": "25849773", "url": "https://glygen.org/publication/PubMed/25849773" } ] }, { "annotation": "EIF3a sustains non-small cell lung cancer stem cell-like properties by promoting YY1-mediated transcriptional activation of beta-catenin.", "evidence": [ { "database": "RefSeq", "id": "NP_001271264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271264" }, { "database": "PubMed", "id": "37211173", "url": "https://glygen.org/publication/PubMed/37211173" } ] }, { "annotation": "EIF3j facilitates loading of release factors into the ribosome.", "evidence": [ { "database": "RefSeq", "id": "NP_001271264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271264" }, { "database": "PubMed", "id": "34591963", "url": "https://glygen.org/publication/PubMed/34591963" } ] }, { "annotation": "This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_001271264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271264" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "88.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "93.56", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "92.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "83.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "95.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "95.83", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "80.9", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "92.92", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "91.98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "82.92", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "94.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "93.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000104131", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000104131" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O75822", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75822" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", 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"sequence": "MAAAAAAAGDSDSWDADAFSVEDPVRKVGGGGTAGGDRWEGEDEDEDVKDNWDDDDDEKKEEAEVKPEVKISEKKKIAEKIKEKERQQKKRQEEIKKRLEEPEEPKVLTPEEQLADKLRLKKLQEESDLELAKETFGVNNAVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM", "length": 258, "header": "sp|O75822-1|EIF3J_HUMAN Isoform 1 of Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2 CANONICAL=O75822-1" }, "locus": { "chromosome": "15", "start_pos": 44561146, "end_pos": 44537195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000261868.10", "url": "https://www.ensembl.org/id/ENST00000261868.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000261868.5", "url": "https://www.ensembl.org/id/ENSP00000261868.5" } ] } }, { "isoform_ac": "O75822-2", "url": "", "sequence": { "sequence": "MAAAAAAAGDSDSWDADAFSVEDPVRKVGGGGTAGGDRWEGEDEDEDVKDNWDDDDDEKKEEAEVKPEVKISEKKKIAEKIKEKERQQKKRQEEIKKRLEEPEEPKVLTPEEQLADKLRLKKLQEESDLELAKETFVEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM", "length": 204, "header": "sp|O75822-2|EIF3J_HUMAN Isoform 2 of Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2 CANONICAL=O75822-1" }, "locus": { "chromosome": "15", "start_pos": 44561146, "end_pos": 44537195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000535391.5", "url": "https://www.ensembl.org/id/ENST00000535391.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000440221.1", "url": "https://www.ensembl.org/id/ENSP00000440221.1" } ] } }, { "isoform_ac": "O75822-3", "url": "", "sequence": { "sequence": "MAAAAAAAGDSDSWDADAFSVEDPVRKVGGGGTAGGDRWEGEDEDEDVKLEEPEEPKVLTPEEQLADKLRLKKLQEESDLELAKETFGVNNAVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM", "length": 209, "header": "sp|O75822-3|EIF3J_HUMAN Isoform 3 of Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2 CANONICAL=O75822-1" }, "locus": { "chromosome": "15", "start_pos": 44561146, "end_pos": 44537195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000424492.7", "url": "https://www.ensembl.org/id/ENST00000424492.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000414548.3", "url": "https://www.ensembl.org/id/ENSP00000414548.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O75822", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75822" }, { "id": "20305658", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/20305658" }, { "id": "21740066", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21740066" } ] } ], "phosphorylation": [ { "start_pos": 109, "end_pos": 109, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "PubMed", "id": "17924679", "url": "https://glygen.org/publication/PubMed/17924679" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "17322308", "url": "https://glygen.org/publication/PubMed/17322308" }, { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" }, { "database": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" }, { "database": "phospho.ELM", "id": "O75822", "url": "http://phospho.elm.eu.org/byAccession/O75822.html" } ], "site_lbl": "Thr109" }, { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "17322308", "url": "https://glygen.org/publication/PubMed/17322308" }, { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" }, { "database": "phospho.ELM", "id": "O75822", "url": "http://phospho.elm.eu.org/byAccession/O75822.html" } ], "site_lbl": "Ser11" }, { "start_pos": 127, "end_pos": 127, "kinase_uniprot_canonical_ac": "P68400-1", "kinase_gene_name": "CSNK2A1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" }, { "database": "PubMed", "id": "25887626", "url": "https://glygen.org/publication/PubMed/25887626" } ], "site_lbl": "Ser127" }, { "start_pos": 127, "end_pos": 127, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "phospho.ELM", "id": "O75822", "url": "http://phospho.elm.eu.org/byAccession/O75822.html" }, { "database": "PubMed", "id": "25887626", "url": "https://glygen.org/publication/PubMed/25887626" } ], "site_lbl": "Ser127" }, { "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "17322308", "url": "https://glygen.org/publication/PubMed/17322308" }, { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "phospho.ELM", "id": "O75822", "url": "http://phospho.elm.eu.org/byAccession/O75822.html" } ], "site_lbl": "Ser13" }, { "start_pos": 20, "end_pos": 20, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "PubMed", "id": "17322308", "url": "https://glygen.org/publication/PubMed/17322308" }, { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" } ], "site_lbl": "Ser20" }, { "start_pos": 254, "end_pos": 254, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" } ], "site_lbl": "Tyr254" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Iost I, Dreyfus M, Linder P", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "10364207", "url": "https://glygen.org/publication/PubMed/10364207" } ] }, { "title": "The joining of ribosomal subunits in eukaryotes requires eIF5B.", "journal": "Nature", "date": "2000", "authors": "Pestova TV, Lomakin IB, Lee JH, Choi SK, Dever TE, Hellen CU", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "10659855", "url": "https://glygen.org/publication/PubMed/10659855" } ] }, { "title": "Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.", "journal": "The Journal of biological chemistry", "date": "1975", "authors": "Merrick WC, Kemper WM, Anderson WF", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "1095581", "url": "https://glygen.org/publication/PubMed/1095581" } ] }, { "title": "A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.", "journal": "Genes & development", "date": "2000", "authors": "Asano K, Clayton J, Shalev A, Hinnebusch AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "11018020", "url": "https://glygen.org/publication/PubMed/11018020" } ] }, { "title": "Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.", "journal": "The Journal of biological chemistry", "date": "1975", "authors": "Safer B, Adams SL, Anderson WF, Merrick WC", "evidence": [ { "database": "Reactome", "id": "R-HSA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72695" } ], "reference": [ { "type": "PubMed", "id": "1104615", "url": "https://glygen.org/publication/PubMed/1104615" } ] }, { "title": "Mammalian translation initiation factor eIF1 functions with eIF1A and eIF3 in the formation of a stable 40 S preinitiation complex.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Majumdar R, Bandyopadhyay A, Maitra U", "evidence": [ { "database": "Reactome", "id": "R-HSA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72689" } ], "reference": [ { "type": "PubMed", "id": "12493757", "url": "https://glygen.org/publication/PubMed/12493757" } ] }, { "title": "Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Sampath P, Mazumder B, Seshadri V, Fox PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827" } ], "reference": [ { "type": "PubMed", "id": "12588972", "url": "https://glygen.org/publication/PubMed/12588972" } ] }, { "title": "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3.", "journal": "Eur. J. Biochem.", "date": "2003", "authors": "Hershey J.W.B., Block K.L., Fraser C.S., Mayeur G.L., Peiretti F.", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" } ], "reference": [ { "type": "PubMed", "id": "14519125", "url": "https://glygen.org/publication/PubMed/14519125" } ] }, { "title": "Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.", "journal": "Cell", "date": "2003", "authors": "Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827" } ], "reference": [ { "type": "PubMed", "id": "14567916", "url": "https://glygen.org/publication/PubMed/14567916" } ] }, { "title": "The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" } ], "reference": [ { "type": "PubMed", "id": "14688252", "url": "https://glygen.org/publication/PubMed/14688252" } ] }, { "title": "Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.", "journal": "RNA", "date": "2005", "authors": "Kolupaeva VG, Unbehaun A, Lomakin IB, Hellen CU, Pestova TV", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" } ], "reference": [ { "type": "PubMed", "id": "15703437", "url": "https://glygen.org/publication/PubMed/15703437" } ] }, { "title": "Structural roles for human translation factor eIF3 in initiation of protein synthesis.", "journal": "Science", "date": "2005", "authors": "Doudna J.A., Nogales E., Fraser C.S., Hall R.J., Siridechadilok B.", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" } ], "reference": [ { "type": "PubMed", "id": "16322461", "url": "https://glygen.org/publication/PubMed/16322461" } ] }, { "title": "Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.", "journal": "J. Biol. Chem.", "date": "2006", "authors": "Rhoads R.E., Hershey J.W.B., Bradley C.A., Cvek U., Duzan R.D., Korneeva N.L., LeFebvre A.K., Trutschl M.", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" } ], "reference": [ { "type": "PubMed", "id": "16766523", "url": "https://glygen.org/publication/PubMed/16766523" } ] }, { "title": "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.", "journal": "Nature biotechnology", "date": "2006", "authors": "Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" } ], "reference": [ { "type": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "iPTMnet", "id": "O75822-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822-1" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit.", "journal": "J. Biol. Chem.", "date": "2007", "authors": "ElAntak L., Locker N., Lukavsky P.J., Tzakos A.G.", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" } ], "reference": [ { "type": "PubMed", "id": "17190833", "url": "https://glygen.org/publication/PubMed/17190833" } ] }, { "title": "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Sugiyama N, Masuda T, Shinoda K, Nakamura A, Tomita M, Ishihama Y", "evidence": [ { "database": "iPTMnet", "id": "O75822-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822-1" } ], "reference": [ { "type": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" } ] }, { "title": "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna JA, Robinson CV, Leary JA", "evidence": [ { "database": "UniProtKB", "id": "O75822", "url": "https://www.uniprot.org/uniprot/O75822" }, { "database": "iPTMnet", "id": "O75822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75822" } ], "reference": [ { "type": "PubMed", "id": "17322308", "url": "https://glygen.org/publication/PubMed/17322308" } ] }, { "title": "eIF3j is located in the decoding center of the human 40S ribosomal subunit.", "journal": "Mol. 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