{ "uniprot_canonical_ac": "O70608-1", "uniprot_ac": "O70608", "uniprot_id": "SYCP2_RAT", "mass": { "chemical_mass": 172593.0, "monoisotopic_mass": 172593.0 }, "refseq": { "ac": "NP_570091", "name": "synaptonemal complex protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570091" }, "gene_names": [ { "name": "Sycp2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O70608", "id": "O70608" }, { "name": "Scp2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O70608", "id": "O70608" }, { "name": "Sycp2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570091", "id": "NP_570091" } ], "protein_names": [ { "name": "Synaptonemal complex protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O70608" }, { "name": "SCP-2; rnSCP2; synaptonemal complex lateral element protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570091", "id": "NP_570091" }, { "name": "SCP-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70608" }, { "name": "Synaptonemal complex lateral element protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70608" }, { "name": "rnSCP2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70608" }, { "name": "synaptonemal complex protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570091", "id": "NP_570091" } ], "function": [ { "annotation": "Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase (PubMed:9592139, PubMed:9933407). Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608#function" }, { "database": "PubMed", "id": "9933407", "url": "https://glygen.org/publication/PubMed/9933407" }, { "database": "UniProtKB", "id": "Q9CUU3", "url": "https://www.uniprot.org/uniprot/Q9CUU3#function" }, { "database": "PubMed", "id": "9592139", "url": "https://glygen.org/publication/PubMed/9592139" } ] } ], "disease": [ { "disease_id": "DOID:0070188", "recommended_name": { "id": "DOID:0070188", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070188", "name": "spermatogenic failure 1", "description": "A spermatogenic failure that is characterized by autosomal recessive inheritance of spermatogenic failure resulting from meiotic defects." }, "synonyms": [ { "id": "DOID:0070188", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070188", "name": "SPGF1", "description": "" }, { "id": "DOID:0070188", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070188", "name": "oligochiasmatic infertility", "description": "" }, { "id": "DOID:0070188", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070188", "name": "oligosynaptic infertility", "description": "" }, { "id": "MONDO:0009776", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009776", "name": "spermatogenic failure 1", "description": "" }, { "id": "MONDO:0009776", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009776", "name": "SPGF1", "description": "" }, { "id": "MONDO:0009776", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009776", "name": "spermatogenic failure 1", "description": "" }, { "id": "MONDO:0009776", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009776", "name": "Oligochiasmatic infertility", "description": "" }, { "id": "MONDO:0009776", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009776", "name": "Oligosynaptic infertility", "description": "" }, { "id": "MIM:258150", "resource": "MIM", "url": "https://www.omim.org/entry/258150", "name": "Spermatogenic failure 1", "description": "Spermatogenic failure 1" } ], "evidence": [ { "id": "0070188", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070188" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "common_name": "Rat" } ], "gene": [ { "name": "Sycp2", "url": "https://www.uniprot.org/uniprot/O70608", "locus": { "chromosome": "3", "start_pos": 165436331, "end_pos": 165498789, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000061690", "url": "https://www.ensembl.org/id/ENSRNOG00000061690" } ] } } ], "crossref": [ { "id": "ENSRNOG00000061690", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000061690", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "83820", "url": "https://www.ncbi.nlm.nih.gov/gene/83820", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:83820", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:83820", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SDWHIES", "url": "https://omabrowser.org/oma/group/SDWHIES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5407023at2759", "url": "http://www.orthodb.org/?query=5407023at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15607", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15607", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15607:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15607:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF18581", "url": "http://pfam.xfam.org/family/PF18581", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18584", "url": "http://pfam.xfam.org/family/PF18584", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O70608", "url": "http://purl.obolibrary.org/obo/PR_O70608", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_570091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570091", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "69429", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=69429", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8L2R2I5", "url": "https://www.uniprot.org/uniprot/A0A8L2R2I5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R2I5-1", "url": "https://www.uniprot.org/uniprot/A0A8L2R2I5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2RBT5", "url": "https://www.uniprot.org/uniprot/A0A8L2RBT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2RBT5-1", "url": "https://www.uniprot.org/uniprot/A0A8L2RBT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O70608-1", "url": "https://www.uniprot.org/uniprot/O70608-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVRPDPQQLEKCIDDALRKNDFKPLVTLLQIDICEDVKIKCSKQFLRKLDDLICRELHKKDIQTISNILISIGRCSKNIFILGQTGLQTMIKQGLVQKMVSWFENSKEIILSQRQSKDEAVMNMIEDLFDLLMVVYDVNDEGKNQVLESFIPHICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILCNQEILTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKKIKDCEFETDCRIFLNLVNGMLGDRRRVFTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDDDDHQWEAVTVPEEKVDMYNIEVRESKKLLTLTLKNIVKISKKEGKELLLYFDAALEITNVTKKLFGGNKYKEFTRKQDISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSNLQKKLTNPLEPDNSSSQRDRKNSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSRAPLQAIHSAEKAVSKTSESGVDYAVSLKSRQSDGRNRGNNRANHNKTATVQNKGHEHHESPDQTFNEIEETLSDAYAVEKVDKPVLPGVLDISKNKAHSRWACWTPVTTIKLCNNQRSCALPGDTFTQDTGVNKKCTKQKSVSDDDSEETQRVKYSKDVIKCNKSEEAEVCERNIQEQNHPKYSQKKNTANAKKNDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSMRSHTKSRKELMSEVTSCELDEIPVRENSKGKRFTGTAESLINLINKRYNSSDDMISTRKLKEPRDGSGFSKKPELQFNKVQRKSYRKLKTVVNVTSECPLNDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSIKLVDVRNRDERDLSLKTKDERILSHERKTLFSDTETECGWDDSKTDISWLRKPKSKRLMDYSRNKNTKKCKSIKSRSSTEKGQPRSTVVLSKNIAKNDYEVIVDGRTRLPRRATKTKKNYKDLSTSGSESESEKEISYLFKDKLPTKEETVHSSAQTKKLPKKQQKVFNTEALKGQPSEEQKNSSTLRNGREDSLYLSSASVSGSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAASPEFLNRSNRVVGHGKSPRISETSAVCVRKSCSPASGLPFSPRHTTKNNSVMNIKNTNSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPDSCENHVQSKREENHAASPFSLSSEKIEKIWFDMPNDNTHVSGPSQRGSKRRMYLEEDELSNPSEAEVQEAEEREHLVSKKLCQREHFDQHTSETSLSTPEFSVPKDWQQELQGAGMFYDNINSDYKRKTDTQHKIMDDFTTKTLKLTQQHLLAMACQARGHRDENIDKFQVTLLDELEKVEKDSQTLRDLEKEFVDIEEKIVHKMRAFHQSERERFRALKTSLDKSLLVYNSVYEENVLTSEMCLMKANMKMLQDKLLKEMHEEELLNIRRGLESLFKDHEGNNA", "length": 1505, "header": "sp|O70608-1|SYCP2_RAT Isoform 1 of Synaptonemal complex protein 2 OS=Rattus norvegicus OX=10116 GN=Sycp2 PE=1 SV=1 CANONICAL=O70608-1" }, "isoforms": [ { "isoform_ac": "A0A8L2R2I5-1", "url": "", "sequence": { "sequence": "MPVRPDPQQLEKCIDDALRKNDFKPLVTLLQIDICEDVKIKCSKQFLRKLDDLICRELHKKDIQTISNILISIGRCSKNIFILGQTGLQTMIKQGLNSNELLYVFIFYMVSWFENSKEIILSQRQSKDEAVMNMIEDLFDLLMVVYDVNDEGKNQVLESFIPHICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILCNQEILTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKKIKDCEFETVSSIKIMSLVKIFGVLFNFKTLFSFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDDDDHQWEAVTVPEEKVDMYNIEVRESKKLLTLTLKNIVKISKKEGKELLLYFDAALEITNVTKKLFGGNKYKEFTRKQDISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSNLQKKLTNPLEPDNSSSQRDRKNSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSRAPLQAIHSAEKAVSKTSESGVDYAVSLKSRQSDGRNRGNNRANHNKTATVQNKGHEHHESPDQTFNEIEETLSDAYAVEKVDKPVLPGVLDISKNKAHSRWACWTPVTTIKLCNNQRSCALPGDTFTQDTGVNKKCTKQKSVSDDDSEETQRVKYSKDVIKCNKSEEAEVCERNIQEQNHPKYSQKKNTANAKKNDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSMRSHTKSRKELMSEVTSCELDEIPVRENSKGKRFTGTAESLINLINKRYNSSDDMISTRKLKEPRDGSGFSKKPELQFNKVQRKSYRKLKTVVNVTSECPLNDVYNFSLNGADEPVIKLGVSWKSTDVVLSSSVVTLKVDVRNRDERDLSLKTKDERILSHERKTLFSDTETECGWDDSKTDISWLRKPKSKRLMDYSRNKNTKKCKSIKSRSSTEKGQPRSTVVLSKNIAKNDYEVIVDGRTRLPRRATKTKKNYKDLSTSGSESESEKEISYLFKDKLPTKEETVHSSAQTKKLPKKQQKVFNTEALKGQPSEEQKNSSTLRNGREDSLYLSSASVSGSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAASPEFLNRSNRVVGHGKSPRISETSAVCVRKSCSPASGLPFSPRHTTKNNSVMNIKNTNSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPDSCENHVQSKREENHAASPFSLSSEKIEKIWFDMPNDNTHVSGPSQRGSKRRMYLEEDELSNPSEAEVQEAEEREHLVSKKLCQREHFDQHTSETSLSTPEFSVPKDWQQELQGAGMFYDNINSDYKRKTDTQHKIMDDFTTKTLKLTQQHLLAMACQARGHRDENIDKFQVTLLDELEKVEKDSQTLRDLEKEFVDIEEKIVHKMRAFHQSERERFRALKTSLDKSLLVYNSVYEENVLTSEMCLMKANMKMLQDKLLKEMHEEELLNIRRGLESLFKDHEGNNA", "length": 1510, "header": "tr|A0A8L2R2I5-1|SYCP2_RAT Computationally mapped isoform of Synaptonemal complex protein 2 OS=Rattus norvegicus OX=10116 GN=Sycp2 PE=1 SV=1 CANONICAL=O70608-1" }, "locus": { "chromosome": "3", "start_pos": 165496135, "end_pos": 165436415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000078047.2", "url": "https://www.ensembl.org/id/ENSRNOT00000078047.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070540.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070540.2" } ] } }, { "isoform_ac": "A0A8L2RBT5-1", "url": "", "sequence": { "sequence": "MVSWFENSKEIILSQRQSKDEAVMNMIEDLFDLLMVVYDVNDEGKNQVLESFIPHICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILCNQEILTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKKIKDCEFETDCRIFLNLVNGMLGDRRRVFTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDDDDHQWEAVTVPEEKVDMYNIEVRESKKLLTLTLKNIVKISKKEGKELLLYFDAALEITNVTKKLFGGNKYKEFTRKQDISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSNLQKKLTNPLEPDNSSSQRDRKNSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSRAPLQAIHSAEKAVSKTSESGVDYAVSLKSRQSDGRNRGNNRANHNKTATVQNKGHEHHESPDQTFNEIEETLSDAYAVEKVDKPVLPGVLDISKNKAHSRWACWTPVTTIKLCNNQRSCALPGDTFTQDTGVNKKCTKQKSVSDDDSEETQRVKYSKDVIKCNKSEEAEVCERNIQEQNHPKYSQKKNTANAKKNDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSMRSHTKSRKELMSEVTSCELDEIPVRENSKGKRFTGTAESLINLINKRYNSSDDMISTRKLKEPRDGSGFSKKPELQFNKVQRKSYRKLKTVVNVTSECPLNDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSIKLVDVRNRDERDLSLKTKDERILSHERKTLFSDTETECGWDDSKTDISWLRKPKSKRLMDYSRNKNTKKCKSIKSRSSTEKGQPRSTVVLSKNIAKNDYEVIVDGRTRLPRRATKTKKNYKDLSTSGSESESEKEISYLFKDKLPTKEETVHSSAQTKKLPKKQQKVFNTEALKGQPSEEQKNSSTLRNGREDSLYLSSASVSGSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAASPEFLNRSNRVVGHGKSPRISETSAVCVRKSCSPASGLPFSPRHTTKNNSVMNIKNTNSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPDSCENHVQSKREENHAASPFSLSSEKIEKIWFDMPNDNTHVSGPSQRGSKRRMYLEEDELSNPSEAEVQEAEEREHLVSKKLCQREHFDQHTSETSLSTPEFSVPKDWQQELQGAGMFYDNINSDYKRKTDTQHKIMDDFTTKTLKLTQQHLLAMACQARGHRDENIDKFQVTLLDELEKVEKDSQTLRDLEKEFVDIEEKIVHKMRAFHQSERERFRALKTSLDKSLLVYNSVYEENVLTSEMCLMKANMKMLQDKLLKEMHEEELLNIRRGLESLFKDHEGNNA", "length": 1406, "header": "tr|A0A8L2RBT5-1|SYCP2_RAT Computationally mapped isoform of Synaptonemal complex protein 2 OS=Rattus norvegicus OX=10116 GN=Sycp2 PE=1 SV=1 CANONICAL=O70608-1" }, "locus": { "chromosome": "3", "start_pos": 165493445, "end_pos": 165436415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000079019.2", "url": "https://www.ensembl.org/id/ENSRNOT00000079019.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075596.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075596.2" } ] } }, { "isoform_ac": "O70608-1", "url": "", "sequence": { "sequence": "MPVRPDPQQLEKCIDDALRKNDFKPLVTLLQIDICEDVKIKCSKQFLRKLDDLICRELHKKDIQTISNILISIGRCSKNIFILGQTGLQTMIKQGLVQKMVSWFENSKEIILSQRQSKDEAVMNMIEDLFDLLMVVYDVNDEGKNQVLESFIPHICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILCNQEILTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKKIKDCEFETDCRIFLNLVNGMLGDRRRVFTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDDDDHQWEAVTVPEEKVDMYNIEVRESKKLLTLTLKNIVKISKKEGKELLLYFDAALEITNVTKKLFGGNKYKEFTRKQDISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSNLQKKLTNPLEPDNSSSQRDRKNSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSRAPLQAIHSAEKAVSKTSESGVDYAVSLKSRQSDGRNRGNNRANHNKTATVQNKGHEHHESPDQTFNEIEETLSDAYAVEKVDKPVLPGVLDISKNKAHSRWACWTPVTTIKLCNNQRSCALPGDTFTQDTGVNKKCTKQKSVSDDDSEETQRVKYSKDVIKCNKSEEAEVCERNIQEQNHPKYSQKKNTANAKKNDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSMRSHTKSRKELMSEVTSCELDEIPVRENSKGKRFTGTAESLINLINKRYNSSDDMISTRKLKEPRDGSGFSKKPELQFNKVQRKSYRKLKTVVNVTSECPLNDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSIKLVDVRNRDERDLSLKTKDERILSHERKTLFSDTETECGWDDSKTDISWLRKPKSKRLMDYSRNKNTKKCKSIKSRSSTEKGQPRSTVVLSKNIAKNDYEVIVDGRTRLPRRATKTKKNYKDLSTSGSESESEKEISYLFKDKLPTKEETVHSSAQTKKLPKKQQKVFNTEALKGQPSEEQKNSSTLRNGREDSLYLSSASVSGSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAASPEFLNRSNRVVGHGKSPRISETSAVCVRKSCSPASGLPFSPRHTTKNNSVMNIKNTNSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPDSCENHVQSKREENHAASPFSLSSEKIEKIWFDMPNDNTHVSGPSQRGSKRRMYLEEDELSNPSEAEVQEAEEREHLVSKKLCQREHFDQHTSETSLSTPEFSVPKDWQQELQGAGMFYDNINSDYKRKTDTQHKIMDDFTTKTLKLTQQHLLAMACQARGHRDENIDKFQVTLLDELEKVEKDSQTLRDLEKEFVDIEEKIVHKMRAFHQSERERFRALKTSLDKSLLVYNSVYEENVLTSEMCLMKANMKMLQDKLLKEMHEEELLNIRRGLESLFKDHEGNNA", "length": 1505, "header": "sp|O70608-1|SYCP2_RAT Isoform 1 of Synaptonemal complex protein 2 OS=Rattus norvegicus OX=10116 GN=Sycp2 PE=1 SV=1 CANONICAL=O70608-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1121, "end_pos": 1121, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser1121" }, { "start_pos": 1123, "end_pos": 1123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1123" }, { "start_pos": 1130, "end_pos": 1130, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1130" }, { "start_pos": 1146, "end_pos": 1146, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser1146" }, { "start_pos": 1150, "end_pos": 1150, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser1150" }, { "start_pos": 1162, "end_pos": 1162, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1162" }, { "start_pos": 1165, "end_pos": 1165, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser1165" }, { "start_pos": 1170, "end_pos": 1170, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1170" }, { "start_pos": 1174, "end_pos": 1174, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Thr1174" }, { "start_pos": 1188, "end_pos": 1188, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser1188" }, { "start_pos": 1218, "end_pos": 1218, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1218" }, { "start_pos": 1221, "end_pos": 1221, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1221" }, { "start_pos": 1237, "end_pos": 1237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1237" }, { "start_pos": 1280, "end_pos": 1280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1280" }, { "start_pos": 1283, "end_pos": 1283, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser1283" }, { "start_pos": 1318, "end_pos": 1318, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Thr1318" }, { "start_pos": 457, "end_pos": 457, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser457" }, { "start_pos": 465, "end_pos": 465, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser465" }, { "start_pos": 471, "end_pos": 471, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Thr471" }, { "start_pos": 494, "end_pos": 494, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser494" }, { "start_pos": 503, "end_pos": 503, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Thr503" }, { "start_pos": 507, "end_pos": 507, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser507" }, { "start_pos": 516, "end_pos": 516, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser516" }, { "start_pos": 525, "end_pos": 525, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser525" }, { "start_pos": 534, "end_pos": 534, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser534" }, { "start_pos": 613, "end_pos": 613, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Thr613" }, { "start_pos": 638, "end_pos": 638, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Thr638" }, { "start_pos": 651, "end_pos": 651, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser651" }, { "start_pos": 655, "end_pos": 655, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "site_lbl": "Ser655" }, { "start_pos": 746, "end_pos": 746, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser746" }, { "start_pos": 920, "end_pos": 920, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Ser920" }, { "start_pos": 922, "end_pos": 922, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "site_lbl": "Thr922" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Association of mammalian SMC1 and SMC3 proteins with meiotic chromosomes and synaptonemal complexes.", "journal": "J. Cell Sci.", "date": "2000", "authors": "Gross B., Jessberger R., Heyting C., Eijpe M.", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "reference": [ { "type": "PubMed", "id": "10652260", "url": "https://glygen.org/publication/PubMed/10652260" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "iPTMnet", "id": "O70608", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70608" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat.", "journal": "Nucleic Acids Res.", "date": "1998", "authors": "Offenberg H.H., Heyting C., Meuwissen R.L.J., Kester H.A., Dietrich A.J.J., Schalk J.A.C., van Aalderen M.", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "reference": [ { "type": "PubMed", "id": "9592139", "url": "https://glygen.org/publication/PubMed/9592139" } ] }, { "title": "Localization of SCP2 and SCP3 protein molecules within synaptonemal complexes of the rat.", "journal": "Chromosoma", "date": "1998", "authors": "Schalk JA, Dietrich AJ, Vink AC, Offenberg HH, van Aalderen M, Heyting C", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "reference": [ { "type": "PubMed", "id": "9933407", "url": "https://glygen.org/publication/PubMed/9933407" } ] } ], "pathway": [ { "id": "rno:83820", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:83820", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9BX26-1", "protein_name": "Synaptonemal complex protein 2", "gene_name": "SYCP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHNVSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRICSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFIAKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPEEKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPESQISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQMTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDNICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQQQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQKKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNLNGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLIDYSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIHSRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSSLESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESPHINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADHHIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNIRHKMLSYFTTQSWKTAQQHLRTMNHQSQDSRIKKLDKFQFIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSAYQKSEQQRLHLLKTSLAKSVFCNTDSEETVFTSEMCLMKEDMKVLQDRLLKDMLEEELLNVRRELMSVFMSHERNANV", "length": 1530 }, "evidence": [ { "id": "45234835", "url": "http://www.informatics.jax.org/homology/45234835", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CUU3-1", "protein_name": "Synaptonemal complex protein 2", "gene_name": "Sycp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPVRPDLQQLEKCIDDALRKNDFKPLLALLQIDICEDVKIKCSKQFLRKLDDLICRELNKKDIQTVSSILISIGRCSKNIFILGQAGLQTMIKQGLVQKMVSWFENSKEIILNQQQSKDEAVMNMIEDLFDLLMVIYDISDEGKNQVLESFIPQICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILSNQEMLTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKEIKDCEFETDCRIFLNLVNGILGDKRRVYTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDEEDHQWEAVTVPEEKVQMYNIEVRESKKLLTLTLKNIVKISKKEGKELLFYFDESLEITNVTKKVFGGNKYKEFTRKQGISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSDIQKKLVNPLELGNSSSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSREPLQAINSVEKAVSKTSESGMDYAASPKSRQSDGRKRWNNRANHNKTTAVIQNKQYEDNESPDQNFNEIEDTLSNVSSAVGKVDKPVLPGVLDISKNTTHSRWACWTPVTTIKLCNNQRSRALPGDTCTQDTGVNKKCTKQKSVSDDDSEETQKGKYSKDVIKCNKSDEAEFCERNIQEQNHPKYSQKKNTANAKKSDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSKRNHTKSRKELMSELTSCELEEIPVRENSKGKRFTGASESLINQISRRYNPSDSMMSTRKLKEPQDGSGFSKKPDLQFNKVQRKSYRKLKATVVNVTSECPLDDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSLKLVKNHDEHDPFLKTKDKRMLSYEKKTLLSDTETECGCDDSKTDISWLKEPKTKRLMDYSRNKNTTKYKSRKSRSSMEKGQPRPTMVLNKNSMKNDYEVVVDGRTRLPRRATKTKKNYKDLSTSESESESEKECSYLFKDKLPTKEETIHSRAQTKKLPEKQQKVFNSEALKGQPSEEQKNSSRLREGREDSLCLSSASVSRSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAPSPEFLNGNNSVVGRGQSPRISETSAMCVRKSYSPASGPPFSPRHTPTKNNSVVNMKKANSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPESCDNHMQNKREGNHAASPLSLSSEKIEKMWFDMPSENTHVSGPSQRGSKRRMYLEDDELSNSNEAEVEEAEEREHLLSKKRCQWENSDQHTFKTSLSTPDFSVPKDWQQELQGAGMFYDNISSDYKRKTDSQHKIMDDFTTKTLKLTQQHLMAMTSQAQGRRDENVEKFQVTLLDELEKVEKDSQTLRDLEKELVDIEEKLVQKMRAYHRCERERFRVLKTSLDKSFLVYNSVYEESVFTSEMCLMKANMKMLQDKLLKEMHEEEVLNIRRGLQSLFKAHEGNDA", "length": 1500 }, "evidence": [ { "id": "45234835", "url": "http://www.informatics.jax.org/homology/45234835", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "animal organ morphogenesis", "id": "GO:0009887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009887", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "female meiotic nuclear division", "id": "GO:0007143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007143", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "male meiotic nuclear division", "id": "GO:0007140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "male genitalia morphogenesis", "id": "GO:0048808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048808", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "ectopic germ cell programmed cell death", "id": "GO:0035234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035234", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "negative regulation of reproductive process", "id": "GO:2000242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000242", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "negative regulation of developmental process", "id": "GO:0051093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051093", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "lateral element", "id": "GO:0000800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000800", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "synaptonemal complex", "id": "GO:0000795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000795", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1071, "end_pos": 1073, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1135, "end_pos": 1137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1177, "end_pos": 1179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1207, "end_pos": 1209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" }, { "start_pos": 671, "end_pos": 673, "annotation": "n_glycosylation_sequon" }, { "start_pos": 719, "end_pos": 721, "annotation": "n_glycosylation_sequon" }, { "start_pos": 739, "end_pos": 741, "annotation": "n_glycosylation_sequon" }, { "start_pos": 801, "end_pos": 803, "annotation": "n_glycosylation_sequon" }, { "start_pos": 845, "end_pos": 847, "annotation": "n_glycosylation_sequon" }, { "start_pos": 857, "end_pos": 859, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated.", "evidence": [ { "database": "UniProtKB", "id": "O70608", "url": "https://www.uniprot.org/uniprot/O70608" }, { "database": "PubMed", "id": "Q9CUU3", "url": "https://glygen.org/publication/PubMed/Q9CUU3" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 32 }, { "field": "total_sites", "count": 32 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }