{ "uniprot_canonical_ac": "O70475-1", "uniprot_ac": "O70475", "uniprot_id": "UGDH_MOUSE", "mass": { "chemical_mass": 54832.0, "monoisotopic_mass": 54832.0 }, "refseq": { "ac": "NP_033492", "name": "UDP-glucose 6-dehydrogenase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492" }, "gene_names": [ { "name": "Ugdh", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O70475", "id": "O70475" }, { "name": "Udpgdh", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492", "id": "NP_033492" }, { "name": "Ugdh", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492", "id": "NP_033492" } ], "protein_names": [ { "name": "UDP-glucose 6-dehydrogenase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O70475" }, { "name": "1.1.1.22", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70475" }, { "name": "UDP-Glc dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70475" }, { "name": "UDP-GlcDH; UDP-Glc dehydrogenase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492", "id": "NP_033492" }, { "name": "UDP-GlcDH", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70475" }, { "name": "UDP-glucose 6-dehydrogenase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492", "id": "NP_033492" }, { "name": "UDPGDH", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70475" } ], "function": [ { "annotation": "Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:9737970). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (PubMed:14505572). Required for proper brain and neuronal development (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475#function" }, { "database": "UniProtKB", "id": "O60701", "url": "https://www.uniprot.org/uniprot/O60701#function" }, { "database": "PubMed", "id": "9737970", "url": "https://glygen.org/publication/PubMed/9737970" }, { "database": "PubMed", "id": "14505572", "url": "https://glygen.org/publication/PubMed/14505572" } ] }, { "annotation": "Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.", "evidence": [ { "database": "RefSeq", "id": "NP_033492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492" }, { "database": "PubMed", "id": "24859727", "url": "https://glygen.org/publication/PubMed/24859727" } ] }, { "annotation": "UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_033492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492" }, { "database": "PubMed", "id": "37169760", "url": "https://glygen.org/publication/PubMed/37169760" } ] } ], "disease": [ { "disease_id": "DOID:0112219", "recommended_name": { "id": "DOID:0112219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112219", "name": "developmental and epileptic encephalopathy 84", "description": "A developmental and epileptic encephalopathy characterized by onset in the first months or years of life of refractory seizures, severely impaired global development, impaired intellectual development, absent speech, and inability to walk that has_material_basis_in homozygous or compound heterozygous mutation in the UGDH gene on chromosome 4p14." }, "synonyms": [ { "id": "DOID:0112219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112219", "name": "Jamuar syndrome", "description": "" }, { "id": "DOID:0112219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112219", "name": "DEE84", "description": "" }, { "id": "DOID:0112219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112219", "name": "early infantile epileptic encephalopathy 84", "description": "" }, { "id": "MONDO:0032918", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032918", "name": "developmental and epileptic encephalopathy, 84", "description": "" }, { "id": "MONDO:0032918", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032918", "name": "DEE84", "description": "" }, { "id": "MONDO:0032918", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032918", "name": "EIEE84", "description": "" }, { "id": "MONDO:0032918", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032918", "name": "EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 84", "description": "" }, { "id": "MONDO:0032918", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032918", "name": "developmental and epileptic encephalopathy 84", "description": "" }, { "id": "MONDO:0032918", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032918", "name": "epileptic encephalopathy, early infantile, 84", "description": "" }, { "id": "MONDO:0032918", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032918", "name": "Jamuar Syndrome", "description": "" }, { "id": "MIM:618792", "resource": "MIM", "url": "https://www.omim.org/entry/618792", "name": "Developmental and epileptic encephalopathy 84", "description": "Developmental and epileptic encephalopathy 84" } ], "evidence": [ { "id": "0112219", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112219" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 302, "end_pos": 302, "sequence_org": "Q", "sequence_mut": "QFQ", "comment": "In lzme; causes arrest of embryonic development during gastrulation due to chondroitin sulfate and heparan sulfate deficiency, impaired FGF signaling and impaired migration of mesoderm and endoderm.", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" }, { "database": "PubMed", "id": "14505572", "url": "https://glygen.org/publication/PubMed/14505572" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ugdh", "url": "https://www.uniprot.org/uniprot/O70475", "locus": { "chromosome": "5", "start_pos": 65570564, "end_pos": 65593292, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000029201", "url": "https://www.ensembl.org/id/ENSMUSG00000029201" } ] } } ], "crossref": [ { "id": "ENSMUSG00000029201", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029201", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "1.1.1.22", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.22&UniProtAcc=O70475", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "22235", "url": "https://www.ncbi.nlm.nih.gov/gene/22235", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O70475", "url": "https://www.ebi.ac.uk/intact/interactors/id:O70475*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036220", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036220", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:22235", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22235", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1306785", "url": "http://www.informatics.jax.org/marker/MGI:1306785", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "O70475", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O70475", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "CECLNLP", "url": "https://omabrowser.org/oma/group/CECLNLP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "167209at2759", "url": "http://www.orthodb.org/?query=167209at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11374", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11374", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11374:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11374:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00984", "url": "http://pfam.xfam.org/family/PF00984", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03720", "url": "http://pfam.xfam.org/family/PF03720", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03721", "url": "http://pfam.xfam.org/family/PF03721", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O70475", "url": "http://purl.obolibrary.org/obo/PR_O70475", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-173599", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-173599", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_033492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "23596", "url": "https://www.rhea-db.org/rhea/23596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "D3YXP9", "url": "https://www.uniprot.org/uniprot/D3YXP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YXP9-1", "url": "https://www.uniprot.org/uniprot/D3YXP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O70475-1", "url": "https://www.uniprot.org/uniprot/O70475-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNEARINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIREADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQKAVRALCAVYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSADDQVSRLVTISKDPYEACDGAHALVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHSELQTIGFQIETIGKKVSSKRIPYTPGEIPKFSLQDPPNKKPKV", "length": 493, "header": "sp|O70475-1|UGDH_MOUSE Isoform 1 of UDP-glucose 6-dehydrogenase OS=Mus musculus OX=10090 GN=Ugdh PE=1 SV=1 CANONICAL=O70475-1" }, "isoforms": [ { "isoform_ac": "D3YXP9-1", "url": "", "sequence": { "sequence": "MVEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNEARINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIREADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQV", "length": 156, "header": "tr|D3YXP9-1|UGDH_MOUSE Computationally mapped isoform of UDP-glucose 6-dehydrogenase OS=Mus musculus OX=10090 GN=Ugdh PE=1 SV=8 CANONICAL=O70475-1" }, "locus": { "chromosome": "5", "start_pos": 65584920, "end_pos": 65580699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000131263.3", "url": "https://www.ensembl.org/id/ENSMUST00000131263.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118999.2", "url": "https://www.ensembl.org/id/ENSMUSP00000118999.2" } ] } }, { "isoform_ac": "O70475-1", "url": "", "sequence": { "sequence": "MVEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNEARINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIREADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQKAVRALCAVYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSADDQVSRLVTISKDPYEACDGAHALVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHSELQTIGFQIETIGKKVSSKRIPYTPGEIPKFSLQDPPNKKPKV", "length": 493, "header": "sp|O70475-1|UGDH_MOUSE Isoform 1 of UDP-glucose 6-dehydrogenase OS=Mus musculus OX=10090 GN=Ugdh PE=1 SV=1 CANONICAL=O70475-1" }, "locus": { "chromosome": "5", "start_pos": 65584920, "end_pos": 65571302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000031103", "url": "https://www.ensembl.org/id/ENSMUST00000031103" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000031103", "url": "https://www.ensembl.org/id/ENSMUSP00000031103" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O70475", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O70475" }, { "id": "34887587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34887587" } ] } ], "phosphorylation": [ { "start_pos": 473, "end_pos": 473, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O70475", "url": "http://phospho.elm.eu.org/byAccession/O70475.html" }, { "database": "iPTMnet", "id": "O70475", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70475" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Tyr473" }, { "start_pos": 474, "end_pos": 474, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" }, { "database": "PubMed", "id": "19131326", "url": "https://glygen.org/publication/PubMed/19131326" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "phospho.ELM", "id": "O70475", "url": "http://phospho.elm.eu.org/byAccession/O70475.html" }, { "database": "iPTMnet", "id": "O70475", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70475" } ], "site_lbl": "Thr474" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation.", "journal": "Cell", "date": "2003", "authors": "Garcia-Garcia MJ, Anderson KV", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "reference": [ { "type": "PubMed", "id": "14505572", "url": "https://glygen.org/publication/PubMed/14505572" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" }, { "database": "iPTMnet", "id": "O70475", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70475" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.", "journal": "J. Proteome Res.", "date": "2008", "authors": "Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "reference": [ { "type": "PubMed", "id": "18630941", "url": "https://glygen.org/publication/PubMed/18630941" } ] }, { "title": "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" }, { "database": "iPTMnet", "id": "O70475", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70475" } ], "reference": [ { "type": "PubMed", "id": "19131326", "url": "https://glygen.org/publication/PubMed/19131326" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" }, { "database": "iPTMnet", "id": "O70475", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70475" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "journal": "Mol. Cell", "date": "2013", "authors": "Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y", "evidence": [ { "database": "UniProtKB", "id": "D3YXP9", "url": "https://www.uniprot.org/uniprot/D3YXP9" }, { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "reference": [ { "type": "PubMed", "id": "23806337", "url": "https://glygen.org/publication/PubMed/23806337" } ] }, { "title": "Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.", "journal": "Journal of proteomics", "date": "2014", "authors": "Walsh J, Jenkins RE, Wong M, Olayanju A, Powell H, Copple I, O'Neill PM, Goldring CE, Kitteringham NR, Park BK", "evidence": [ { "database": "RefSeq", "id": "NP_033492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492" } ], "reference": [ { "type": "PubMed", "id": "24859727", "url": "https://glygen.org/publication/PubMed/24859727" } ] }, { "title": "Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.", "journal": "Nature chemical biology", "date": "2022", "authors": "Shu XE, Mao Y, Jia L, Qian SB", "evidence": [ { "database": "O-GlcNAc Database", "id": "O70475", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O70475" } ], "reference": [ { "type": "PubMed", "id": "34887587", "url": "https://glygen.org/publication/PubMed/34887587" } ] }, { "title": "UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis.", "journal": "Nature communications", "date": "2023-05-11", "authors": "Zhang Tao, Zhang Na, Xing Jing, Zhang Shuhua, Chen Yulu, Xu Daichao, Gu Jinyang", "evidence": [ { "database": "RefSeq", "id": "NP_033492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492" } ], "reference": [ { "type": "PubMed", "id": "37169760", "url": "https://glygen.org/publication/PubMed/37169760" } ] }, { "title": "Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Seldin M.F., Smith T.J., Spicer A.P., Kaback L.A.", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "reference": [ { "type": "PubMed", "id": "9737970", "url": "https://glygen.org/publication/PubMed/9737970" } ] } ], "pathway": [ { "id": "mmu:22235", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22235", "resource": "KEGG Pathway" }, { "id": "R-MMU-173599", "name": "Formation of the active cofactor, UDP-glucuronate", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-173599", "resource": "Reactome", "description": "Formation of the active cofactor, UDP-glucuronate" } ], "orthologs": [ { "uniprot_canonical_ac": "O02373-1", "protein_name": "UDP-glucose 6-dehydrogenase", "gene_name": "sgl", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKVCCIGAGYVGGPTCAVMALKCPDIVITLVDKSSERIAQWNSDKLPIYEPGLDEVVKKCRNVNLFFSTDIETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVRAAESIMHILRANQKPGIHYDILSNPEFLAEGTAINDLLNADRVLIGGEETPEGHQAVEKLSWIYEHWIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRRFSQKIIESLFNTVSDKRIAILGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATHALVICTEWDEFVDLDFKRIYQSMMKPAYIFDGRKILDHERLQQIGFHVQTIGKKYQRTGLLRSWGIVPQL", "length": 476 }, "evidence": [ { "id": "O70475", "url": "https://omabrowser.org/oma/group/O70475/", "database": "OMA" } ], "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O60701-1", "protein_name": "UDP-glucose 6-dehydrogenase", "gene_name": "UGDH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDPPNKKPKV", "length": 494 }, "evidence": [ { "id": "45224190", "url": "http://www.informatics.jax.org/homology/45224190", "database": "MGI" }, { "id": "O70475", "url": "https://omabrowser.org/oma/group/O70475/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "O70199-1", "protein_name": "UDP-glucose 6-dehydrogenase", "gene_name": "Ugdh", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVEIKKICCIGAGYVGGPTCSVIARMCPEIRVTVVDVNEARINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIREADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCESTGADVEEVATAIGMDQRIGNKFLKASVGFGGGCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSADDQVSRLVTISKDPYEACDGAHALVICTEWDMFKELDYERIHKRMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYTPGEIPKFSLQDPPNKKPKV", "length": 493 }, "evidence": [ { "id": "45224190", "url": "http://www.informatics.jax.org/homology/45224190", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "UDP-glucose 6-dehydrogenase activity", "id": "GO:0003979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003979", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "gastrulation with mouth forming second", "id": "GO:0001702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001702", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "glycosaminoglycan biosynthetic process", "id": "GO:0006024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006024", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "heparan sulfate proteoglycan biosynthetic process", "id": "GO:0015012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015012", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "UDP-glucuronate biosynthetic process", "id": "GO:0006065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006065", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "chondroitin sulfate biosynthetic process", "id": "GO:0030206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030206", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" }, { "name": "protein hexamerization", "id": "GO:0034214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034214", "evidence": [ { "database": "UniProtKB", "id": "O70475", "url": "https://www.uniprot.org/uniprot/O70475" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23596", "name": "", "equation": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70199-1", "O60701-1", "O70475-1", "O02373-1" ], "evidence": [ { "id": "23596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23596" } ] }, { "id": "R-MMU-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29410" ], "output_participant_list": [], "enzyme_list": [ "O70475-1" ], "evidence": [ { "id": "R-MMU-173597", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-173597" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29410", "participant_name": "UDP-D-glucose(2-) [cytosol]", "crossref": [ { "id": "C00029", "database": "COMPOUND", "url": "" }, { "id": "58367", "database": "ChEBI", "url": "" }, { "id": "000008215472", "database": "ZINC", "url": "" }, { "id": "C00001514", "database": "KNApSAcK", "url": "" }, { "id": "000008551096", "database": "ZINC", "url": "" }, { "id": "44229134", "database": "PubChem Compound", "url": "" }, { "id": "C00029", "database": "KEGG Gene", "url": "" }, { "id": "133-89-1", "database": "CAS", "url": "" }, { "id": "UDP-GLUCOSE", "database": "AraCyc", "url": "" }, { "id": "44229134", "database": "PubChem Compound", "url": "" }, { "id": "58367", "database": "ChEBI", "url": "" }, { "id": "133-89-1", "database": "CAS", "url": "" }, { "id": "C00001514", "database": "KNApSAcK", "url": "" }, { "id": "UDP-GLUCOSE", "database": "AraCyc", "url": "" }, { "id": "000008215472", "database": "ZINC", "url": "" }, { "id": "C00029", "database": "KEGG Gene", "url": "" }, { "id": "C00029", "database": "COMPOUND", "url": "" }, { "id": "000008551096", "database": "ZINC", "url": "" }, { "id": "C00029", "database": "COMPOUND", "url": "" }, { "id": "58367", "database": "ChEBI", "url": "" }, { "id": "000008215472", "database": "ZINC", "url": "" }, { "id": "C00001514", "database": "KNApSAcK", "url": "" }, { "id": "000008551096", "database": "ZINC", "url": "" }, { "id": "44229134", "database": "PubChem Compound", "url": "" }, { "id": "C00029", "database": "KEGG Gene", "url": "" }, { "id": "133-89-1", "database": "CAS", "url": "" }, { "id": "UDP-GLUCOSE", "database": "AraCyc", "url": "" }, { "id": "58367", "database": "ChEBI", "url": "" }, { "id": "44229134", "database": "PubChem Compound", "url": "" }, { "id": "133-89-1", "database": "CAS", "url": "" }, { "id": "C00001514", "database": "KNApSAcK", "url": "" }, { "id": "UDP-GLUCOSE", "database": "AraCyc", "url": "" }, { "id": "000008215472", "database": "ZINC", "url": "" }, { "id": "C00029", "database": "KEGG Gene", "url": "" }, { "id": "C00029", "database": "COMPOUND", "url": "" }, { "id": "000008551096", "database": "ZINC", "url": "" }, { "id": "C00029", "database": "COMPOUND", "url": "" }, { "id": "58367", "database": "ChEBI", "url": "" }, { "id": "000008215472", "database": "ZINC", "url": "" }, { "id": "C00001514", "database": "KNApSAcK", "url": "" }, { "id": "000008551096", "database": "ZINC", "url": "" }, { "id": "44229134", "database": "PubChem Compound", "url": "" }, { "id": "C00029", "database": "KEGG Gene", "url": "" }, { "id": "133-89-1", "database": "CAS", "url": "" }, { "id": "UDP-GLUCOSE", "database": "AraCyc", "url": "" }, { "id": "C00029", "database": "COMPOUND", "url": "" }, { "id": "000008551096", "database": "ZINC", "url": "" }, { "id": "C00029", "database": "KEGG Gene", "url": "" }, { "id": "000008215472", "database": "ZINC", "url": "" }, { "id": "UDP-GLUCOSE", "database": "AraCyc", "url": "" }, { "id": "C00001514", "database": "KNApSAcK", "url": "" }, { "id": "133-89-1", "database": "CAS", "url": "" }, { "id": "58367", "database": "ChEBI", "url": "" }, { "id": "44229134", "database": "PubChem Compound", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O02373", "gene_name": "sgl", "activity": [ { "ec_number": "1.1.1.22", "activity": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.", "evidence": [ { "id": "O02373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O02373" } ] }, { "ec_number": "1.1.1.22", "activity": "", "evidence": [ { "id": "O02373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O02373" } ] } ] }, { "uniprot_ac": "O60701", "gene_name": "UGDH", "activity": [ { "ec_number": "1.1.1.22", "activity": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.", "evidence": [ { "id": "O60701", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60701" } ] }, { "ec_number": "1.1.1.22", "activity": "", "evidence": [ { "id": "O60701", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60701" } ] } ] }, { "uniprot_ac": "O70199", "gene_name": "Ugdh", "activity": [ { "ec_number": "1.1.1.22", "activity": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.", "evidence": [ { "id": "O70199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70199" } ] }, { "ec_number": "1.1.1.22", "activity": "", "evidence": [ { "id": "O70199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70199" } ] } ] }, { "uniprot_ac": "O70475", "gene_name": "Ugdh", "activity": [ { "ec_number": "1.1.1.22", "activity": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.", "evidence": [ { "id": "O70475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70475" } ] }, { "ec_number": "1.1.1.22", "activity": "", "evidence": [ { "id": "O70475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70475" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }