{ "uniprot_canonical_ac": "O70423-1", "uniprot_ac": "O70423", "uniprot_id": "AOC3_MOUSE", "mass": { "chemical_mass": 84534.0, "monoisotopic_mass": 84534.0 }, "refseq": { "ac": "NP_033805", "name": "membrane primary amine oxidase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" }, "gene_names": [ { "name": "Aoc3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O70423", "id": "O70423" }, { "name": "Aoc3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805", "id": "NP_033805" }, { "name": "SSAO; VAP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805", "id": "NP_033805" }, { "name": "Vap1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O70423", "id": "O70423" } ], "protein_names": [ { "name": "Membrane primary amine oxidase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O70423" }, { "name": "1.4.3.21", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70423" }, { "name": "Copper amine oxidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70423" }, { "name": "SSAO", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70423" }, { "name": "Semicarbazide-sensitive amine oxidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70423" }, { "name": "VAP-1; copper amine oxidase; vascular adhesion protein 1; semicarbazide-sensitive amine oxidase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805", "id": "NP_033805" }, { "name": "VAP-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70423" }, { "name": "Vascular adhesion protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O70423" }, { "name": "membrane primary amine oxidase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805", "id": "NP_033805" } ], "function": [ { "annotation": "Amine oxidase copper-containing 3 aggravates cardiac remodelling by generating hydrogen peroxide after myocardial infarction.", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" }, { "database": "PubMed", "id": "36825552", "url": "https://glygen.org/publication/PubMed/36825552" } ] }, { "annotation": "Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423#function" } ] }, { "annotation": "Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" }, { "database": "PubMed", "id": "32410850", "url": "https://glygen.org/publication/PubMed/32410850" } ] }, { "annotation": "Enzyme is in involved in deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" }, { "database": "PubMed", "id": "12242458", "url": "https://glygen.org/publication/PubMed/12242458" } ] }, { "annotation": "Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" }, { "database": "PubMed", "id": "32712883", "url": "https://glygen.org/publication/PubMed/32712883" } ] }, { "annotation": "The blockade of VAP-1 could be a promising medical modality to combat the acute and chronic variants.", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" }, { "database": "PubMed", "id": "29490166", "url": "https://glygen.org/publication/PubMed/29490166" } ] }, { "annotation": "The increased enzyme activity observed in diabetes is not a result of increased SSAO gene transcription. 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"resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "type I diabetes mellitus", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type 1 diabetes mellitus", "description": "A chronic condition characterized by minimal or absent production of insulin by the pancreas." }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "IDDM", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "diabetes mellitis type 1", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "diabetes mellitis type I", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "immune mediated diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "juvenile diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type 1 diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type I diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type I diabetes mellitus", "description": "" }, { "id": "MIM:222100", "resource": "MIM", "url": "https://www.omim.org/entry/222100", "name": "Type 1 diabetes mellitus", "description": "Type 1 diabetes mellitus" } ], "evidence": [ { "id": "9744", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [ { "evidence": [ { "id": "rs27057387", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs27057387" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 659, "end_pos": 659, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NFT->DFT).", "chr_id": "11", "chr_pos": "101227263", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N659", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Aoc3", "url": "https://www.uniprot.org/uniprot/O70423", "locus": { "chromosome": "11", "start_pos": 101232764, "end_pos": 101221431, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000019326", "url": "https://www.ensembl.org/id/ENSMUSG00000019326" } ] } } ], "crossref": [ { "id": "ENSMUSG00000019326", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000019326", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "CHEMBL4727", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4727", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "11754", "url": "https://www.ncbi.nlm.nih.gov/gene/11754", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0001602", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0001602", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0003182", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003182", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0003183", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003183", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "O70423", "url": "https://www.ebi.ac.uk/intact/interactors/id:O70423*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:11754", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:11754", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1306797", "url": "http://www.informatics.jax.org/marker/MGI:1306797", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "CMFEIDK", "url": "https://omabrowser.org/oma/group/CMFEIDK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5490352at2759", "url": "http://www.orthodb.org/?query=5490352at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10638", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10638", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10638:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10638:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01179", "url": "http://pfam.xfam.org/family/PF01179", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02727", "url": "http://pfam.xfam.org/family/PF02727", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02728", "url": "http://pfam.xfam.org/family/PF02728", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O70423", "url": "http://purl.obolibrary.org/obo/PR_O70423", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-211945", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211945", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16153", "url": "https://www.rhea-db.org/rhea/16153", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A2A4I8", "url": "https://www.uniprot.org/uniprot/A2A4I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2A4I8-1", "url": "https://www.uniprot.org/uniprot/A2A4I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O70423-1", "url": "https://www.uniprot.org/uniprot/O70423-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O70423-2", "url": "https://www.uniprot.org/uniprot/O70423-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGGLSQPLHCPSVLPSVQPRTHPSQSQPFADLSPEELTAVMSFLTKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLDREYQDIEEMIFHRELPQASGLLHHCCFYKHQGQNLLTMTTAPRGLQSGDRATWFGLYYNLSGAGFYPHPIGLELLIDHKALDPALWTIQKVFYQGRYYESLTQLEDQFEAGLVNVVLVPNNGTGGSWSLKSSVPPGPAPPLQFHPQGPRFSVQGSQVSSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYVDGSFGIGKYSTPLIRGVDCPYLATYVDWHFLLESQAPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVGTVLVVRSVSTLLNYDYIWDMVFHPNGAIEVKFHATGYISSAFFFGAGEKFGNRVGAHTLGTVHTHSAHFKVDLDVAGLKNWAWAEDMAFVPTIVPWQPEYQMQRLQVTRKLLETEEEAAFPLGGATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIFNQNDPWTPTVNFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTAGNSVGFFLRPYNFFDEDPSFHSADSIYFREGQDATACEVNPLACLSQTATCAPEIPAFSHGGFAYRDN", "length": 765, "header": "sp|O70423-1|AOC3_MOUSE Isoform 1 of Membrane primary amine oxidase OS=Mus musculus OX=10090 GN=Aoc3 PE=1 SV=3 CANONICAL=O70423-1" }, "isoforms": [ { "isoform_ac": "A2A4I8-1", "url": "", "sequence": { "sequence": "VLPSVQPRTHPSQSQPFADLSPEELTAVMSFLTKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLDREYQDIEEMIFHRELPQASGLLHHCCFYKHQGQNLLTMTTAPRGLQSGDRATWFGLYYNLSGAGFYPHPIGLELLIDHKALDPALWTIQKVFYQGRYYESLTQLEDQFEAGLVNVVLVPNNGTGLKNWAWAEDMAFVPTIVPWQPEYQMQRLQVTRKLLETEEEAAFPLGGATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIFNQNDPWTPTVNFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTAGNSVGFFLRPYNFFDEDPSFHSADSIYFREGQDATACELDLMEEFSQGRLLSL", "length": 470, "header": "tr|A2A4I8-1|A2A4I8_MOUSE Computationally mapped isoform of Amine oxidase OS=Mus musculus OX=10090 GN=Aoc3 PE=1 SV=1 CANONICAL=O70423-1" }, "locus": { "chromosome": "11", "start_pos": 101232585, "end_pos": 101221895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000017316.7", "url": "https://www.ensembl.org/id/ENSMUST00000017316.7" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000017316.7", "url": "https://www.ensembl.org/id/ENSMUSP00000017316.7" } ] } }, { "isoform_ac": "O70423-1", "url": "", "sequence": { "sequence": "MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGGLSQPLHCPSVLPSVQPRTHPSQSQPFADLSPEELTAVMSFLTKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLDREYQDIEEMIFHRELPQASGLLHHCCFYKHQGQNLLTMTTAPRGLQSGDRATWFGLYYNLSGAGFYPHPIGLELLIDHKALDPALWTIQKVFYQGRYYESLTQLEDQFEAGLVNVVLVPNNGTGGSWSLKSSVPPGPAPPLQFHPQGPRFSVQGSQVSSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYVDGSFGIGKYSTPLIRGVDCPYLATYVDWHFLLESQAPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVGTVLVVRSVSTLLNYDYIWDMVFHPNGAIEVKFHATGYISSAFFFGAGEKFGNRVGAHTLGTVHTHSAHFKVDLDVAGLKNWAWAEDMAFVPTIVPWQPEYQMQRLQVTRKLLETEEEAAFPLGGATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIFNQNDPWTPTVNFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTAGNSVGFFLRPYNFFDEDPSFHSADSIYFREGQDATACEVNPLACLSQTATCAPEIPAFSHGGFAYRDN", "length": 765, "header": "sp|O70423-1|AOC3_MOUSE Isoform 1 of Membrane primary amine oxidase OS=Mus musculus OX=10090 GN=Aoc3 PE=1 SV=3 CANONICAL=O70423-1" }, "locus": { "chromosome": "11", "start_pos": 101228489, "end_pos": 101221766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000103105", "url": "https://www.ensembl.org/id/ENSMUST00000103105" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000099394", "url": "https://www.ensembl.org/id/ENSMUSP00000099394" } ] } }, { "isoform_ac": "O70423-2", "url": "", "sequence": { "sequence": "MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGGLSQPLHCPSVLPSVQPRTHPSQSQPFADLSPEELTAVMSFLTKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLDREYQDIEEMIFHRELPQASGLLHHCCFYKHQGQNLLTMTTAPRGLQSGDRATWFGLYYNLSGAGFYPHPIGLELLIDHKALDPALWTIQKVFYQGRYYESLTQLEDQFEAGLVNVVLVPNNGTGGSWSLKSSVPPGPAPPLQFHPQGPRFSVQGSQVSSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYVDGSFGIGKYSTPLIRGVDCPYLATYVDWHFLLESQAPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVGTVLVVRSVSTLLNYDYIWDMVFHPNGAIEVKFHATGYISSAFFFGAGEKFGNRVGAHTLGTVHTHSAHFKVDLDVAGLKNWAWAEDMAFVPTIVPWQPEYQMQRLQVTRKLLETEEEAAFPLGGATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGR", "length": 629, "header": "sp|O70423-2|AOC3_MOUSE Isoform 2 of Membrane primary amine oxidase OS=Mus musculus OX=10090 GN=Aoc3 PE=1 SV=3 CANONICAL=O70423-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 137, "start_aa": "Asn", "end_pos": 137, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn137", "evidence": [ { "id": "O70423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70423#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "predicted", "site_seq": "T", "relation": "attached", "comment": "O-linked (GalNAc...) threonine O-GalNAcylation", "start_pos": 212, "start_aa": "Thr", "end_pos": 212, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr212", "evidence": [ { "id": "O70423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70423#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 232, "start_aa": "Asn", "end_pos": 232, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn232", "evidence": [ { "id": "O70423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70423#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 294, "start_aa": "Asn", "end_pos": 294, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn294", "evidence": [ { "id": "O70423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70423#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "Complex", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) (complex) asparagine Complex", "start_pos": 592, "start_aa": "Asn", "end_pos": 592, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn592", "evidence": [ { "id": "O70423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70423#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 659, "start_aa": "Asn", "end_pos": 659, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn659", "evidence": [ { "id": "O70423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70423#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 666, "start_aa": "Asn", "end_pos": 666, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn666", "evidence": [ { "id": "O70423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70423#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Molecular cloning of a major mRNA species in murine 3T3 adipocyte lineage. differentiation-dependent expression, regulation, and identification as semicarbazide-sensitive amine oxidase.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Moldes M., Pairault J., Feve B.", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "reference": [ { "type": "PubMed", "id": "10092636", "url": "https://glygen.org/publication/PubMed/10092636" } ] }, { "title": "Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.", "journal": "Diabetologia", "date": "2002", "authors": "Yu PH, Wang M, Deng YL, Fan H, Shira-Bock L", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" } ], "reference": [ { "type": "PubMed", "id": "12242458", "url": "https://glygen.org/publication/PubMed/12242458" } ] }, { "title": "Semicarbazide-sensitive amine oxidase (SSAO) gene expression in alloxan-induced diabetes in mice.", "journal": "Molecular medicine (Cambridge, Mass.)", "date": "2002", "authors": "Nordquist JE, Gokturk C, Oreland L", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" } ], "reference": [ { "type": "PubMed", "id": "12606817", "url": "https://glygen.org/publication/PubMed/12606817" } ] }, { "title": "Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2018", "authors": "Mukai S, Ogawa Y, Kawakami Y, Mashima Y, Tsubota K", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" } ], "reference": [ { "type": "PubMed", "id": "29490166", "url": "https://glygen.org/publication/PubMed/29490166" } ] }, { "title": "Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes.", "journal": "PLoS biology", "date": "2018", "authors": "Yang H, Ralle M, Wolfgang MJ, Dhawan N, Burkhead JL, Rodriguez S, Kaplan JH, Wong GW, Haughey N, Lutsenko S", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" } ], "reference": [ { "type": "PubMed", "id": "30199530", "url": "https://glygen.org/publication/PubMed/30199530" } ] }, { "title": "Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1.", "journal": "Mediators of inflammation", "date": "2020", "authors": "Kubota R, Reid MJ, Lieu KL, Orme M, Diamond C, Tulberg N, Henry SH", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" } ], "reference": [ { "type": "PubMed", "id": "32410850", "url": "https://glygen.org/publication/PubMed/32410850" } ] }, { "title": "Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.", "journal": "Journal of physiology and biochemistry", "date": "2021", "authors": "Jargaud V, Bour S, Terce F, Collet X, Valet P, Bouloumie A, Guillemot JC, Mauriege P, Jalkanen S, Stolen C, Salmi M, Smith DJ, Carpene C", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" } ], "reference": [ { "type": "PubMed", "id": "32712883", "url": "https://glygen.org/publication/PubMed/32712883" } ] }, { "title": "Amine oxidase copper-containing 3 aggravates cardiac remodelling by generating hydrogen peroxide after myocardial infarction.", "journal": "The Journal of pathology", "date": "2023-02-24", "authors": "Zhong Chongbin, Que Dongdong, Yu Wenjie, Chen Deshu, Wang Yuxi, Zhang Xuwei, Rui Bowen, Yang Yashu, Hong Qingqing, Huang Guanlin, Yang Li, Yan Jing, Yang Pingzhen", "evidence": [ { "database": "RefSeq", "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805" } ], "reference": [ { "type": "PubMed", "id": "36825552", "url": "https://glygen.org/publication/PubMed/36825552" } ] }, { "title": "Isolation, structural characterization, and chromosomal mapping of the mouse vascular adhesion protein-1 gene and promoter.", "journal": "J. Immunol.", "date": "1998", "authors": "Palotie A., Bono P., Jalkanen S., Salmi M., Smith D.J., Horelli-Kuitunen N., Leppanen I.", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "reference": [ { "type": "PubMed", "id": "9743358", "url": "https://glygen.org/publication/PubMed/9743358" } ] } ], "pathway": [ { "id": "mmu:11754", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:11754", "resource": "KEGG Pathway" }, { "id": "R-MMU-211945", "name": "Phase I - Functionalization of compounds", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211945", "resource": "Reactome", "description": "Phase I - Functionalization of compounds" } ], "orthologs": [ { "uniprot_canonical_ac": "O08590-1", "protein_name": "Membrane primary amine oxidase", "gene_name": "Aoc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK", "length": 763 }, "evidence": [ { "id": "45239647", "url": "http://www.informatics.jax.org/homology/45239647", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q16853-1", "protein_name": "Membrane primary amine oxidase", "gene_name": "AOC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQAPKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN", "length": 763 }, "evidence": [ { "id": "45239647", "url": "http://www.informatics.jax.org/homology/45239647", "database": "MGI" }, { "id": "O70423", "url": "https://omabrowser.org/oma/group/O70423/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "regulation of blood pressure", "id": "GO:0008217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008217", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "eating behavior", "id": "GO:0042755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042755", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "leukocyte migration involved in inflammatory response", "id": "GO:0002523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002523", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "positive regulation of acute inflammatory response", "id": "GO:0002675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002675", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "response to antibiotic", "id": "GO:0046677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046677", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "amine metabolic process", "id": "GO:0009308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009308", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "negative regulation of primary amine oxidase activity", "id": "GO:1902283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902283", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "response to immobilization stress", "id": "GO:0035902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035902", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "positive regulation of glucose transmembrane transport", "id": "GO:0010828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010828", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "positive regulation of leukocyte migration", "id": "GO:0002687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002687", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "primary amine oxidase activity", "id": "GO:0008131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008131", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "quinone binding", "id": "GO:0048038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048038", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "tryptamine:oxygen oxidoreductase (deaminating) activity", "id": "GO:0052593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052593", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "aminoacetone:oxygen oxidoreductase(deaminating) activity", "id": "GO:0052594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052594", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" }, { "name": "phenethylamine:oxygen oxidoreductase (deaminating) activity", "id": "GO:0052596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052596", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 592, "end_pos": 594, "annotation": "n_glycosylation_sequon" }, { "start_pos": 659, "end_pos": 661, "annotation": "n_glycosylation_sequon" }, { "start_pos": 666, "end_pos": 668, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.", "evidence": [ { "database": "UniProtKB", "id": "O70423", "url": "https://www.uniprot.org/uniprot/O70423" }, { "database": "PubMed", "id": "P12807", "url": "https://glygen.org/publication/PubMed/P12807" }, { "database": "UniProtKB", "id": "A2A4I8", "url": "https://www.uniprot.org/uniprot/A2A4I8" }, { "database": "PubMed", "id": "RU000672", "url": "https://glygen.org/publication/PubMed/RU000672" } ] } ], "interactions": [], "reactions": [ { "id": "16153", "name": "", "equation": "an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08590-1", "P19643-1", "P21396-1", "Q16853-1", "O75106-1", "P27338-1", "P21397-1", "Q812C9-1", "O70423-1", "Q64133-1", "Q8BW75-1" ], "evidence": [ { "id": "16153", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16153" } ] }, { "id": "R-MMU-5696183", "name": "AOC3 deaminates BZAM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [ "R-ALL-5696148" ], "output_participant_list": [ "R-ALL-5696154" ], "enzyme_list": [ "O70423-1" ], "evidence": [ { "id": "R-MMU-5696183", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5696183" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5696148", "participant_name": "BZAM [extracellular region]", "crossref": [ { "id": "225238", "database": "ChEBI", "url": "" }, { "id": "000006096244", "database": "ZINC", "url": "" }, { "id": "000006096244", "database": "ZINC", "url": "" }, { "id": "225238", "database": "ChEBI", "url": "" }, { "id": "000006096244", "database": "ZINC", "url": "" }, { "id": "225238", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5696154", "participant_name": "BZAL [extracellular region]", "crossref": [ { "id": "17169", "database": "ChEBI", "url": 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