{
    "uniprot_canonical_ac": "O70377-1",
    "uniprot_ac": "O70377",
    "uniprot_id": "SNP23_RAT",
    "mass": {
        "chemical_mass": 23235.0,
        "monoisotopic_mass": 23235.0
    },
    "refseq": {
        "ac": "NP_073180",
        "name": "synaptosomal-associated protein 23",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
    },
    "gene_names": [
        {
            "name": "Snap23",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/O70377",
            "id": "O70377"
        },
        {
            "name": "Snap23",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180",
            "id": "NP_073180"
        }
    ],
    "protein_names": [
        {
            "name": "Synaptosomal-associated protein 23",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "O70377"
        },
        {
            "name": "SNAP-23; vesicle-membrane fusion protein SNAP-23; synaptosomal-associated protein, 23 kD",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180",
            "id": "NP_073180"
        },
        {
            "name": "SNAP-23",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O70377"
        },
        {
            "name": "Vesicle-membrane fusion protein SNAP-23",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O70377"
        },
        {
            "name": "synaptosomal-associated protein 23",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180",
            "id": "NP_073180"
        }
    ],
    "function": [
        {
            "annotation": "Blocking dephosphorylation at serine 120 residue in SNAP-23 leads to massive inhibition in exocytosis from mast cells.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                },
                {
                    "database": "PubMed",
                    "id": "29485121",
                    "url": "https://glygen.org/publication/PubMed/29485121"
                }
            ]
        },
        {
            "annotation": "Electrostatic anchoring precedes stable membrane attachment of SNAP25 and SNAP23 to the plasma membrane. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                },
                {
                    "database": "PubMed",
                    "id": "28240595",
                    "url": "https://glygen.org/publication/PubMed/28240595"
                }
            ]
        },
        {
            "annotation": "Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377#function"
                }
            ]
        },
        {
            "annotation": "PKCepsilon controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                },
                {
                    "database": "PubMed",
                    "id": "34147527",
                    "url": "https://glygen.org/publication/PubMed/34147527"
                }
            ]
        },
        {
            "annotation": "Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                },
                {
                    "database": "PubMed",
                    "id": "33213278",
                    "url": "https://glygen.org/publication/PubMed/33213278"
                }
            ]
        },
        {
            "annotation": "SNAP-23 is expressed in alveolar type II cells of the lung; evidence supports its functional role in exocytosis of lung surfactant by alveolar type II cells.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                },
                {
                    "database": "PubMed",
                    "id": "15035620",
                    "url": "https://glygen.org/publication/PubMed/15035620"
                }
            ]
        },
        {
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            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                },
                {
                    "database": "PubMed",
                    "id": "37057886",
                    "url": "https://glygen.org/publication/PubMed/37057886"
                }
            ]
        }
    ],
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    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
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                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
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            "common_name": "Rat"
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    ],
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    ],
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            "id": "ENSRNOG00000050552",
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        },
        {
            "id": "cd15884",
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        },
        {
            "id": "cd15895",
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            "url": "https://www.ebi.ac.uk/intact/interactors/id:O70377*",
            "database": "IntAct",
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            ]
        },
        {
            "id": "IPR000727",
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            ]
        },
        {
            "id": "IPR000928",
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        },
        {
            "id": "rno:64630",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64630",
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            ]
        },
        {
            "id": "NYAVHKA",
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            "database": "OMA",
            "categories": [
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            ]
        },
        {
            "id": "388796at2759",
            "url": "http://www.orthodb.org/?query=388796at2759",
            "database": "OrthoDB",
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            ]
        },
        {
            "id": "PTHR19305",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19305",
            "database": "PANTHER",
            "categories": [
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            ]
        },
        {
            "id": "PTHR19305:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19305:SF4",
            "database": "PANTHER",
            "categories": [
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        },
        {
            "id": "PF00835",
            "url": "http://pfam.xfam.org/family/PF00835",
            "database": "Pfam",
            "categories": [
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            ]
        },
        {
            "id": "PR_O70377",
            "url": "http://purl.obolibrary.org/obo/PR_O70377",
            "database": "PRO",
            "categories": [
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            ]
        },
        {
            "id": "R-RNO-1236974",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1236974",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-199992",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-199992",
            "database": "Reactome",
            "categories": [
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            ]
        },
        {
            "id": "R-RNO-6798695",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695",
            "database": "Reactome",
            "categories": [
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        },
        {
            "id": "R-RNO-8980692",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8980692",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013026",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013026",
            "database": "Reactome",
            "categories": [
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        },
        {
            "id": "R-RNO-9013149",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013406",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013406",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9013423",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013423",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9035034",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9035034",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
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            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "620221",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620221",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "M0R4V3",
            "url": "https://www.uniprot.org/uniprot/M0R4V3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0R4V3-1",
            "url": "https://www.uniprot.org/uniprot/M0R4V3-1",
            "database": "UniProtKB",
            "categories": [
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            ]
        },
        {
            "id": "O70377",
            "url": "https://www.uniprot.org/uniprot/O70377",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O70377-1",
            "url": "https://www.uniprot.org/uniprot/O70377-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MDDLSPEEIQLRAHQVTDESLESTRRILGLAIESQDAGIKTITMLDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCVCPCNRTKNFESGKNYKATWGDGGDSSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS",
        "length": 210,
        "header": "sp|O70377-1|SNP23_RAT Isoform 1 of Synaptosomal-associated protein 23  OS=Rattus norvegicus OX=10116 GN=Snap23 PE=1 SV=1 CANONICAL=O70377-1"
    },
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        {
            "isoform_ac": "M0R4V3-1",
            "url": "",
            "sequence": {
                "sequence": "MDDLSPEEIQLRAHQVTDESLESTRRILGLAIESQDAGIKTITMLDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCVCPCNRFSVGGCFFETRTKNFESGKNYKATWGDGGDSSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS",
                "length": 221,
                "header": "tr|M0R4V3-1|M0R4V3_RAT Computationally mapped isoform of Synaptosomal-associated protein  OS=Rattus norvegicus OX=10116 GN=Snap23 PE=1 SV=3 CANONICAL=O70377-1"
            },
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                        "id": "ENSRNOT00000074392.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000074392.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000064401.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000064401.3"
                    }
                ]
            }
        },
        {
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                "sequence": "MDDLSPEEIQLRAHQVTDESLESTRRILGLAIESQDAGIKTITMLDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCVCPCNRTKNFESGKNYKATWGDGGDSSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS",
                "length": 210,
                "header": "sp|O70377-1|SNP23_RAT Isoform 1 of Synaptosomal-associated protein 23  OS=Rattus norvegicus OX=10116 GN=Snap23 PE=1 SV=1 CANONICAL=O70377-1"
            },
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                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000096953",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000096953"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000091304",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000091304"
                    }
                ]
            }
        }
    ],
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        {
            "start_pos": 102,
            "end_pos": 102,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "O70377",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70377"
                },
                {
                    "database": "PubMed",
                    "id": "28784843",
                    "url": "https://glygen.org/publication/PubMed/28784843"
                }
            ],
            "site_lbl": "Thr102"
        },
        {
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            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
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                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
                }
            ],
            "site_lbl": "Ser110"
        },
        {
            "start_pos": 120,
            "end_pos": 120,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
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                    "database": "iPTMnet",
                    "id": "O70377",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70377"
                },
                {
                    "database": "PubMed",
                    "id": "15611044",
                    "url": "https://glygen.org/publication/PubMed/15611044"
                },
                {
                    "database": "PubMed",
                    "id": "28784843",
                    "url": "https://glygen.org/publication/PubMed/28784843"
                },
                {
                    "database": "PubMed",
                    "id": "33213278",
                    "url": "https://glygen.org/publication/PubMed/33213278"
                }
            ],
            "site_lbl": "Ser120"
        },
        {
            "start_pos": 160,
            "end_pos": 160,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
                }
            ],
            "site_lbl": "Ser160"
        },
        {
            "start_pos": 20,
            "end_pos": 20,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
                }
            ],
            "site_lbl": "Ser20"
        },
        {
            "start_pos": 23,
            "end_pos": 23,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
                }
            ],
            "site_lbl": "Ser23"
        },
        {
            "start_pos": 34,
            "end_pos": 34,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
                }
            ],
            "site_lbl": "Ser34"
        },
        {
            "start_pos": 5,
            "end_pos": 5,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
                }
            ],
            "site_lbl": "Ser5"
        },
        {
            "start_pos": 95,
            "end_pos": 95,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "O70377",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70377"
                },
                {
                    "database": "PubMed",
                    "id": "15611044",
                    "url": "https://glygen.org/publication/PubMed/15611044"
                },
                {
                    "database": "PubMed",
                    "id": "28784843",
                    "url": "https://glygen.org/publication/PubMed/28784843"
                },
                {
                    "database": "PubMed",
                    "id": "33213278",
                    "url": "https://glygen.org/publication/PubMed/33213278"
                }
            ],
            "site_lbl": "Ser95"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "SNAP-23 participates in SNARE complex assembly in rat adipose cells.",
            "journal": "Biochem. J.",
            "date": "1999",
            "authors": "St-Denis JF, Cabaniols JP, Cushman SW, Roche PA",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10051443",
                    "url": "https://glygen.org/publication/PubMed/10051443"
                }
            ]
        },
        {
            "title": "Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis.",
            "journal": "J. Biol. Chem.",
            "date": "2004",
            "authors": "Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O70377",
                    "url": "https://www.uniprot.org/uniprot/O70377"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14993220",
                    "url": "https://glygen.org/publication/PubMed/14993220"
                }
            ]
        },
        {
            "title": "Syntaxin 2 and SNAP-23 are required for regulated surfactant secretion.",
            "journal": "Biochemistry",
            "date": "2004",
            "authors": "Abonyo BO, Gou D, Wang P, Narasaraju T, Wang Z, Liu L",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15035620",
                    "url": "https://glygen.org/publication/PubMed/15035620"
                }
            ]
        },
        {
            "title": "Phosphorylation of SNAP-23 regulates exocytosis from mast cells.",
            "journal": "The Journal of biological chemistry",
            "date": "2005",
            "authors": "Hepp R, Puri N, Hohenstein AC, Crawford GL, Whiteheart SW, Roche PA",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "O70377",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70377"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15611044",
                    "url": "https://glygen.org/publication/PubMed/15611044"
                }
            ]
        },
        {
            "title": "Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane.",
            "journal": "eLife",
            "date": "2017",
            "authors": "Weber P, Batoulis H, Rink KM, Dahlhoff S, Pinkwart K, Sollner TH, Lang T",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28240595",
                    "url": "https://glygen.org/publication/PubMed/28240595"
                }
            ]
        },
        {
            "title": "Phosphorylation of SNAP-23 regulates its dynamic membrane association during mast cell exocytosis.",
            "journal": "Biology open",
            "date": "2017",
            "authors": "Naskar P, Puri N",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "O70377",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O70377"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28784843",
                    "url": "https://glygen.org/publication/PubMed/28784843"
                }
            ]
        },
        {
            "title": "Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23 leads to massive inhibition in exocytosis from mast cells.",
            "journal": "Journal of biosciences",
            "date": "2018",
            "authors": "Naskar P, Naqvi N, Puri N",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29485121",
                    "url": "https://glygen.org/publication/PubMed/29485121"
                }
            ]
        },
        {
            "title": "Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.",
            "journal": "Autophagy",
            "date": "2021",
            "authors": "Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, Roche PA, Cattral MS, Gaisano HY",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_073180",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180"
                },
                {
                    "database": "iPTMnet",
                    "id": "O70377",
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                    "type": "PubMed",
                    "id": "33213278",
                    "url": "https://glygen.org/publication/PubMed/33213278"
                }
            ]
        },
        {
            "title": "PKCepsilon controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode.",
            "journal": "International journal of biological macromolecules",
            "date": "2021",
            "authors": "Serrano-Lopez EM, Lopez-Martinez D, Gomez-Fernandez JC, Egea-Jimenez AL, Corbalan-Garcia S",
            "evidence": [
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                    "id": "34147527",
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        },
        {
            "title": "SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A.",
            "journal": "Bioscience reports",
            "date": "2023-04-14",
            "authors": "Chen Jun, Wang Ziyan, Wang Tuanlao, Cheng Ji Dong, Zhuang Ruijuan, Wang Wei",
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                {
                    "type": "PubMed",
                    "id": "37057886",
                    "url": "https://glygen.org/publication/PubMed/37057886"
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        {
            "id": "rno:64630",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64630",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1236974",
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            "resource": "Reactome",
            "description": "ER-Phagosome pathway"
        },
        {
            "id": "R-RNO-199992",
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        },
        {
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            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695",
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        },
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            "id": "R-RNO-8980692",
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            "id": "R-RNO-9013026",
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            "description": "RHOB GTPase cycle"
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            "id": "R-RNO-9013149",
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            "id": "R-RNO-9013406",
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        },
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            "id": "R-RNO-9013423",
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            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013423",
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        {
            "id": "R-RNO-9035034",
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            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9035034",
            "resource": "Reactome",
            "description": "RHOF GTPase cycle"
        }
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        {
            "uniprot_canonical_ac": "O00161-1",
            "protein_name": "Synaptosomal-associated protein 23",
            "gene_name": "SNAP23",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS",
                "length": 211
            },
            "evidence": [
                {
                    "id": "45238928",
                    "url": "http://www.informatics.jax.org/homology/45238928",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O09044-1",
            "protein_name": "Synaptosomal-associated protein 23",
            "gene_name": "Snap23",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MDNLSPEEVQLRAHQVTDESLESTRRILGLAIESQDAGIKTITMLDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCICPCNRTKNFESGKNYKATWGDGGDNSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS",
                "length": 210
            },
            "evidence": [
                {
                    "id": "45238928",
                    "url": "http://www.informatics.jax.org/homology/45238928",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 17,
                "go_terms": [
                    {
                        "name": "synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex",
                        "id": "GO:0070032",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070032",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glutamatergic synapse",
                        "id": "GO:0098978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GABA-ergic synapse",
                        "id": "GO:0098982",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrion",
                        "id": "GO:0005739",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "adherens junction",
                        "id": "GO:0005912",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "terminal bouton",
                        "id": "GO:0043195",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043195",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic vesicle membrane",
                        "id": "GO:0030659",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic vesicle",
                        "id": "GO:0031410",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "postsynapse",
                        "id": "GO:0098794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "specific granule",
                        "id": "GO:0042581",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042581",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "azurophil granule",
                        "id": "GO:0042582",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042582",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "SNARE complex",
                        "id": "GO:0031201",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuron projection",
                        "id": "GO:0043005",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "presynapse",
                        "id": "GO:0098793",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "syntaxin binding",
                        "id": "GO:0019905",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "SNAP receptor activity",
                        "id": "GO:0005484",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005484",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "syntaxin-1 binding",
                        "id": "GO:0017075",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017075",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "vesicle-mediated transport",
                        "id": "GO:0016192",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane fusion",
                        "id": "GO:0061025",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061025",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "exocytosis",
                        "id": "GO:0006887",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle fusion to presynaptic active zone membrane",
                        "id": "GO:0031629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "exocytic insertion of neurotransmitter receptor to postsynaptic membrane",
                        "id": "GO:0098967",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098967",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histamine secretion by mast cell",
                        "id": "GO:0002553",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002553",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle priming",
                        "id": "GO:0016082",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016082",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "vesicle-mediated transport in synapse",
                        "id": "GO:0099003",
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                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of exocytosis",
                        "id": "GO:0017157",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017157",
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                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein-containing complex assembly",
                        "id": "GO:0065003",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O70377",
                                "url": "https://www.uniprot.org/uniprot/O70377"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
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            "start_pos": 154,
            "end_pos": 156,
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            "start_pos": 88,
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    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
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        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
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