{ "uniprot_canonical_ac": "O60315-1", "uniprot_ac": "O60315", "uniprot_id": "ZEB2_HUMAN", "mass": { "chemical_mass": 136447.0, "monoisotopic_mass": 136447.0 }, "refseq": { "ac": "NP_001165124", "name": "zinc finger E-box-binding homeobox 2 isoform 2", "summary": "The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" }, "gene_names": [ { "name": "ZEB2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60315", "id": "O60315" }, { "name": "HRIHFB2411", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60315", "id": "O60315" }, { "name": "HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124", "id": "NP_001165124" }, { "name": "KIAA0569", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60315", "id": "O60315" }, { "name": "SIP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60315", "id": "O60315" }, { "name": "ZEB2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124", "id": "NP_001165124" }, { "name": "ZFHX1B", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60315", "id": "O60315" }, { "name": "ZFX1B", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60315", "id": "O60315" } ], "protein_names": [ { "name": "Zinc finger E-box-binding homeobox 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60315" }, { "name": "SMADIP1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60315" }, { "name": "Smad-interacting protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60315" }, { "name": "Zinc finger homeobox protein 1b", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60315" }, { "name": "zinc finger E-box-binding homeobox 2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124", "id": "NP_001165124" }, { "name": "zinc finger homeobox 1b; Smad-interacting protein 1; SMAD interacting protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124", "id": "NP_001165124" } ], "function": [ { "annotation": "Association of Polymorphisms in ZFHX1B and PAX6 With Anisometropia in Chinese Children: The Hong Kong Children Eye Genetics Study.", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" }, { "database": "PubMed", "id": "37266952", "url": "https://glygen.org/publication/PubMed/37266952" } ] }, { "annotation": "Conditional expression of SIP1 in E-cadherin-positive cells abrogates E-cadherin-mediated intercellular adhesion and induces invasion. SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors.", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" }, { "database": "PubMed", "id": "11430829", "url": "https://glygen.org/publication/PubMed/11430829" } ] }, { "annotation": "Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" }, { "database": "PubMed", "id": "37575267", "url": "https://glygen.org/publication/PubMed/37575267" } ] }, { "annotation": "MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC.", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" }, { "database": "PubMed", "id": "37566546", "url": "https://glygen.org/publication/PubMed/37566546" } ] }, { "annotation": "MiR-454-3p promotes apoptosis and autophagy of AML cells by targeting ZEB2 and regulating AKT/mTOR pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" }, { "database": "PubMed", "id": "37313984", "url": "https://glygen.org/publication/PubMed/37313984" } ] }, { "annotation": "The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" } ] }, { "annotation": "Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212).", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315#function" }, { "database": "PubMed", "id": "16061479", "url": "https://glygen.org/publication/PubMed/16061479" }, { "database": "PubMed", "id": "20516212", "url": "https://glygen.org/publication/PubMed/20516212" } ] } ], "disease": [ { "disease_id": "DOID:0060485", "recommended_name": { "id": "DOID:0060485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060485", "name": "Mowat-Wilson syndrome", "description": "A syndrome characterized by distinctive facial features, intellectual disability, delayed development, Hirschsprung disease and has_material_basis_in de novo heterozygous mutation in the ZEB2 gene on chromosome 2q22." }, "synonyms": [ { "id": "DOID:0060485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060485", "name": "Hirschsprung disease mental retardation syndrome", "description": "" }, { "id": "DOID:0060485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060485", "name": "microcephaly, mental retardation, and distinct facial featrues, with or without Hirschprung disease", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "Mowat-Wilson syndrome", "description": "Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome characterized by a distinct facial phenotype, intellectual disability, epilepsy, Hirschsprung disease (HSCR) and variable congenital malformations." }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "Hirschsprung disease intellectual disability syndrome", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "Hirschsprung disease mental retardation syndrome", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "Hirschsprung disease-intellectual disability syndrome", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "Mowat-Wilson syndrome", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "microcephaly, intellectual disability, and distinct facial featrues, with or without Hirschprung disease", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "microcephaly, mental retardation, and distinct facial featrues, with or without Hirschprung disease", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "Hirschsprung disease-mental retardation syndrome", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "MOWS", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "intellectual disability, microcephaly, and distinct facial features with or without Hirschsprung disease", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "mental retardation, microcephaly, and distinct facial features with or without Hirschsprung disease", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "microcephaly, intellectual disability, and distinct Facial features, with or without Hirschsprung disease", "description": "" }, { "id": "MONDO:0009341", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009341", "name": "microcephaly, mental retardation, and distinct Facial features, with or without Hirschsprung disease", "description": "" }, { "id": "MIM:235730", "resource": "MIM", "url": "https://www.omim.org/entry/235730", "name": "Mowat-Wilson syndrome", "description": "Mowat-Wilson syndrome" } ], "evidence": [ { "id": "235730", "database": "MIM", "url": "https://www.omim.org/entry/235730" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "73.11", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "74.04", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "81.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "67.7", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "93.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "92.55", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "52.19", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "88.51", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "83.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "70.52", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "88.56", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "82.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "89.15", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "O60315", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60315" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "common_name": "Human" } ], "gene": [ { "name": "ZEB2", "url": "https://www.uniprot.org/uniprot/O60315", "locus": { "chromosome": "2", "start_pos": 144364364, "end_pos": 144521057, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000169554", "url": "https://www.ensembl.org/id/ENSG00000169554" } ] } } ], "crossref": [ { "id": "ENSG00000169554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169554", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ZEB2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZEB2", "database": "GeneCards", "categories": [ "Organism-specific", "Gene Annotation" ] }, { "id": "9839", "url": "https://www.ncbi.nlm.nih.gov/gene/9839", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "14881", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=14881", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O60315", "url": "https://www.ebi.ac.uk/intact/interactors/id:O60315*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:9839", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9839", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "235730", "url": "http://www.omim.org/entry/235730", "database": "MIM", "categories": [ "Other" ] }, { "id": "605802", "url": "http://www.omim.org/entry/605802", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O60315", "url": "https://www.nextprot.org/entry/NX_O60315", "database": "neXtProt", "categories": [ "Organism-specific", "Protein" ] }, { "id": "QENMFTP", "url": "https://omabrowser.org/oma/group/QENMFTP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4266655at2759", "url": "http://www.orthodb.org/?query=4266655at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24391", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24391", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24391:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24391:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2DA7", "url": "https://www.rcsb.org/structure/2DA7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00096", "url": "http://pfam.xfam.org/family/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05605", "url": "http://pfam.xfam.org/family/PF05605", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12874", "url": "http://pfam.xfam.org/family/PF12874", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O60315", "url": "https://pharos.nih.gov/targets/O60315", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O60315", "url": "http://purl.obolibrary.org/obo/PR_O60315", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9823739", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9823739", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9832991", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9832991", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0D9SF71", "url": "https://www.uniprot.org/uniprot/A0A0D9SF71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0D9SF71-1", "url": "https://www.uniprot.org/uniprot/A0A0D9SF71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0D9SF74", "url": "https://www.uniprot.org/uniprot/A0A0D9SF74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0D9SF74-1", "url": "https://www.uniprot.org/uniprot/A0A0D9SF74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0D9SG93", "url": "https://www.uniprot.org/uniprot/A0A0D9SG93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0D9SG93-1", "url": "https://www.uniprot.org/uniprot/A0A0D9SG93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0D9SGG5", "url": "https://www.uniprot.org/uniprot/A0A0D9SGG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0D9SGG5-1", "url": "https://www.uniprot.org/uniprot/A0A0D9SGG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GTH3", "url": "https://www.uniprot.org/uniprot/A0A1B0GTH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GTH3-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GTH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GUM8", "url": "https://www.uniprot.org/uniprot/A0A1B0GUM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GUM8-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GUM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GV02", "url": "https://www.uniprot.org/uniprot/A0A1B0GV02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GV02-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GV02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GVV8", "url": "https://www.uniprot.org/uniprot/A0A1B0GVV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GVV8-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GVV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GW50", "url": "https://www.uniprot.org/uniprot/A0A1B0GW50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GW50-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GW50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GWA7", "url": "https://www.uniprot.org/uniprot/A0A1B0GWA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GWA7-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GWA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PS25", "url": "https://www.uniprot.org/uniprot/A0A1W2PS25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PS25-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PS25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1X7SC99", "url": "https://www.uniprot.org/uniprot/A0A1X7SC99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1X7SC99-1", "url": "https://www.uniprot.org/uniprot/A0A1X7SC99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YDQ8", "url": "https://www.uniprot.org/uniprot/A0A2R8YDQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YDQ8-1", "url": "https://www.uniprot.org/uniprot/A0A2R8YDQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A6Q8PH34", "url": "https://www.uniprot.org/uniprot/A0A6Q8PH34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A6Q8PH34-1", "url": "https://www.uniprot.org/uniprot/A0A6Q8PH34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KV18", "url": "https://www.uniprot.org/uniprot/A0A8I5KV18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KV18-1", "url": "https://www.uniprot.org/uniprot/A0A8I5KV18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0JP08", "url": "https://www.uniprot.org/uniprot/A0JP08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0JP08-1", "url": "https://www.uniprot.org/uniprot/A0JP08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JU62", "url": "https://www.uniprot.org/uniprot/C9JU62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JU62-1", "url": "https://www.uniprot.org/uniprot/C9JU62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JUQ1", "url": "https://www.uniprot.org/uniprot/C9JUQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JUQ1-1", "url": "https://www.uniprot.org/uniprot/C9JUQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7ESP8", "url": "https://www.uniprot.org/uniprot/E7ESP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7ESP8-1", "url": "https://www.uniprot.org/uniprot/E7ESP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EUW9", "url": "https://www.uniprot.org/uniprot/E7EUW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EUW9-1", "url": "https://www.uniprot.org/uniprot/E7EUW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EVG9", "url": "https://www.uniprot.org/uniprot/E7EVG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EVG9-1", "url": "https://www.uniprot.org/uniprot/E7EVG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C0G0", "url": "https://www.uniprot.org/uniprot/H7C0G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C0G0-1", "url": "https://www.uniprot.org/uniprot/H7C0G0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60315-1", "url": "https://www.uniprot.org/uniprot/O60315-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60315-2", "url": "https://www.uniprot.org/uniprot/O60315-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "U3KPV5", "url": "https://www.uniprot.org/uniprot/U3KPV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "U3KPV5-1", "url": "https://www.uniprot.org/uniprot/U3KPV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "U3KPX6", "url": "https://www.uniprot.org/uniprot/U3KPX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "U3KPX6-1", "url": "https://www.uniprot.org/uniprot/U3KPX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "U3KQ33", "url": "https://www.uniprot.org/uniprot/U3KQ33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "U3KQ33-1", "url": "https://www.uniprot.org/uniprot/U3KQ33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "U3KQ51", "url": "https://www.uniprot.org/uniprot/U3KQ51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "U3KQ51-1", "url": "https://www.uniprot.org/uniprot/U3KQ51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM", "length": 1214, "header": "sp|O60315-1|ZEB2_HUMAN Isoform 1 of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "isoforms": [ { "isoform_ac": "A0A0D9SF71-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNAKTNHLNREINSTSVQH", "length": 41, "header": "tr|A0A0D9SF71-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144464293, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000484313.3", "url": "https://www.ensembl.org/id/ENST00000484313.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000486341.1", "url": "https://www.ensembl.org/id/ENSP00000486341.1" } ] } }, { "isoform_ac": "A0A0D9SF74-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETD", "length": 39, "header": "tr|A0A0D9SF74-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144429983, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000630572.2", "url": "https://www.ensembl.org/id/ENST00000630572.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000486346.1", "url": "https://www.ensembl.org/id/ENSP00000486346.1" } ] } }, { "isoform_ac": "A0A0D9SG93-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNGSSRLSEKAWTTCLSQH", "length": 41, "header": "tr|A0A0D9SG93-1|A0A0D9SG93_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=4 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144497715, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000434448.5", "url": "https://www.ensembl.org/id/ENST00000434448.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000487261.1", "url": "https://www.ensembl.org/id/ENSP00000487261.1" } ] } }, { "isoform_ac": "A0A0D9SGG5-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCT", "length": 141, "header": "tr|A0A0D9SGG5-1|A0A0D9SGG5_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=4 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144405005, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000465308.5", "url": "https://www.ensembl.org/id/ENST00000465308.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000487476.1", "url": "https://www.ensembl.org/id/ENSP00000487476.1" } ] } }, { "isoform_ac": "A0A1B0GTH3-1", "url": "", "sequence": { "sequence": "XTFQKSSSLLRHKYEHTDSYD", "length": 21, "header": "tr|A0A1B0GTH3-1|A0A1B0GTH3_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=4 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144396461, "end_pos": 144390589, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000637873.1", "url": "https://www.ensembl.org/id/ENST00000637873.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489701.1", "url": "https://www.ensembl.org/id/ENSP00000489701.1" } ] } }, { "isoform_ac": "A0A1B0GUM8-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPESSLFLCLACLV", "length": 122, "header": "tr|A0A1B0GUM8-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144424919, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000636732.2", "url": "https://www.ensembl.org/id/ENST00000636732.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000490175.1", "url": "https://www.ensembl.org/id/ENSP00000490175.1" } ] } }, { "isoform_ac": "A0A1B0GV02-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSDSSLGRQLQLLSNQGNVTVILIIILGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM", "length": 1239, "header": "tr|A0A1B0GV02-1|A0A1B0GV02_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144389454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000636471.1", "url": "https://www.ensembl.org/id/ENST00000636471.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000490317.1", "url": "https://www.ensembl.org/id/ENSP00000490317.1" } ] } }, { "isoform_ac": "A0A1B0GVV8-1", "url": "", "sequence": { "sequence": "MKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM", "length": 1102, "header": "tr|A0A1B0GVV8-1|A0A1B0GVV8_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144424862, "end_pos": 144389454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000637045.1", "url": "https://www.ensembl.org/id/ENST00000637045.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000490141.1", "url": "https://www.ensembl.org/id/ENSP00000490141.1" } ] } }, { "isoform_ac": "A0A1B0GW50-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRALPLRGTLTRRRGRVCRGMARARRSTRKKARMATGSWADRMATRSSRRKRKKVKIKVWIRIPKRYEMKKRLEITPWTIVRRMGKWKPNQTTRKTIWKMACNKLLHFKLPIFFSSSIVTCLKTLLC", "length": 1202, "header": "tr|A0A1B0GW50-1|A0A1B0GW50_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144389378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000636026.2", "url": "https://www.ensembl.org/id/ENST00000636026.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000490776.1", "url": "https://www.ensembl.org/id/ENSP00000490776.1" } ] } }, { "isoform_ac": "A0A1B0GWA7-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVSTWSGGARYPG", "length": 36, "header": "tr|A0A1B0GWA7-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144516519, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000636445.1", "url": "https://www.ensembl.org/id/ENST00000636445.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000490851.1", "url": "https://www.ensembl.org/id/ENSP00000490851.1" } ] } }, { "isoform_ac": "A0A1W2PS25-1", "url": "", "sequence": { "sequence": "MSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTVYDSHASREEELSAWFWSGT", "length": 70, "header": "tr|A0A1W2PS25-1|A0A1W2PS25_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144396562, "end_pos": 144365568, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000639389.1", "url": "https://www.ensembl.org/id/ENST00000639389.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492572.1", "url": "https://www.ensembl.org/id/ENSP00000492572.1" } ] } }, { "isoform_ac": "A0A1X7SC99-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKA", "length": 612, "header": "tr|A0A1X7SC99-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144399351, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000637267.2", "url": "https://www.ensembl.org/id/ENST00000637267.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000490293.2", "url": "https://www.ensembl.org/id/ENSP00000490293.2" } ] } }, { "isoform_ac": "A0A2R8YDQ8-1", "url": "", "sequence": { "sequence": "RKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTATIGTSLKASFPL", "length": 79, "header": "tr|A0A2R8YDQ8-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144398318, "end_pos": 144394443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000647488.1", "url": "https://www.ensembl.org/id/ENST00000647488.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000494820.1", "url": "https://www.ensembl.org/id/ENSP00000494820.1" } ] } }, { "isoform_ac": "A0A6Q8PH34-1", "url": "", "sequence": { "sequence": "MKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM", "length": 391, "header": "tr|A0A6Q8PH34-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144398717, "end_pos": 144389454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000675069.1", "url": "https://www.ensembl.org/id/ENST00000675069.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502467.1", "url": "https://www.ensembl.org/id/ENSP00000502467.1" } ] } }, { "isoform_ac": "A0A8I5KV18-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNENQMKKSYSKW", "length": 35, "header": "tr|A0A8I5KV18-1|A0A8I5KV18_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=4 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144430024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000689298.1", "url": "https://www.ensembl.org/id/ENST00000689298.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508434.1", "url": "https://www.ensembl.org/id/ENSP00000508434.1" } ] } }, { "isoform_ac": "A0JP08-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM", "length": 1213, "header": "tr|A0JP08-1|A0JP08_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144389454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000303660.8", "url": "https://www.ensembl.org/id/ENST00000303660.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000302501.4", "url": "https://www.ensembl.org/id/ENSP00000302501.4" } ] } }, { "isoform_ac": "C9JU62-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREG", "length": 91, "header": "tr|C9JU62-1|C9JU62_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144429827, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000435831.5", "url": "https://www.ensembl.org/id/ENST00000435831.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000400993.1", "url": "https://www.ensembl.org/id/ENSP00000400993.1" } ] } }, { "isoform_ac": "C9JUQ1-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPA", "length": 63, "header": "tr|C9JUQ1-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144429911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000444559.5", "url": "https://www.ensembl.org/id/ENST00000444559.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000399451.1", "url": "https://www.ensembl.org/id/ENSP00000399451.1" } ] } }, { "isoform_ac": "E7ESP8-1", "url": "", "sequence": { "sequence": "MCVSEIEPACCRSRAPSPCELPSDPLLSMKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHL", "length": 467, "header": "tr|E7ESP8-1|E7ESP8_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=2 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144518148, "end_pos": 144399870, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000392861.6", "url": "https://www.ensembl.org/id/ENST00000392861.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000376601.3", "url": "https://www.ensembl.org/id/ENSP00000376601.3" } ] } }, { "isoform_ac": "E7EUW9-1", "url": "", "sequence": { "sequence": "MTHFEDIEPACCRSRAPSPCELPSDPLLSMKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSN", "length": 731, "header": "tr|E7EUW9-1|E7EUW9_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=2 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517676, "end_pos": 144399081, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000427902.5", "url": "https://www.ensembl.org/id/ENST00000427902.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000395496.2", "url": "https://www.ensembl.org/id/ENSP00000395496.2" } ] } }, { "isoform_ac": "E7EVG9-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPVKNANCTSDF", "length": 120, "header": "tr|E7EVG9-1|E7EVG9_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=2 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144404996, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000409211.5", "url": "https://www.ensembl.org/id/ENST00000409211.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000387256.2", "url": "https://www.ensembl.org/id/ENSP00000387256.2" } ] } }, { "isoform_ac": "H7C0G0-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGT", "length": 220, "header": "tr|H7C0G0-1|H7C0G0_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=2 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144388878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000419938.5", "url": "https://www.ensembl.org/id/ENST00000419938.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000394777.2", "url": "https://www.ensembl.org/id/ENSP00000394777.2" } ] } }, { "isoform_ac": "O60315-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM", "length": 1214, "header": "sp|O60315-1|ZEB2_HUMAN Isoform 1 of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144389454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000409487.7", "url": "https://www.ensembl.org/id/ENST00000409487.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000386854.2", "url": "https://www.ensembl.org/id/ENSP00000386854.2" } ] } }, { "isoform_ac": "O60315-2", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM", "length": 1190, "header": "sp|O60315-2|ZEB2_HUMAN Isoform 2 of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144389454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000539609.7", "url": "https://www.ensembl.org/id/ENST00000539609.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000443792.2", "url": "https://www.ensembl.org/id/ENSP00000443792.2" } ] } }, { "isoform_ac": "U3KPV5-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFA", "length": 184, "header": "tr|U3KPV5-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=2 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144404099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000431672.4", "url": "https://www.ensembl.org/id/ENST00000431672.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000475267.2", "url": "https://www.ensembl.org/id/ENSP00000475267.2" } ] } }, { "isoform_ac": "U3KPX6-1", "url": "", "sequence": { "sequence": "MTHFEDIEPACCRSRAPSPCELPSDPLLSMKQPIMADGPRCKRRKQANPRRKNALESEMSTRSGRCPAAACHRCGPFVTCKVCCFCP", "length": 87, "header": "tr|U3KPX6-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517676, "end_pos": 144513697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000470879.5", "url": "https://www.ensembl.org/id/ENST00000470879.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000475329.2", "url": "https://www.ensembl.org/id/ENSP00000475329.2" } ] } }, { "isoform_ac": "U3KQ33-1", "url": "", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNALESEMSTRSGRCPAAACHRCGPFVTCKVCCFCP", "length": 58, "header": "tr|U3KQ33-1|U3KQ33_HUMAN Computationally mapped isoform of Zinc finger E-box binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=4 SV=1 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144517350, "end_pos": 144513697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000465070.5", "url": "https://www.ensembl.org/id/ENST00000465070.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000475502.1", "url": "https://www.ensembl.org/id/ENSP00000475502.1" } ] } }, { "isoform_ac": "U3KQ51-1", "url": "", "sequence": { "sequence": "MVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM", "length": 955, "header": "tr|U3KQ51-1|ZEB2_HUMAN Computationally mapped isoform of Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=3 CANONICAL=O60315-1" }, "locus": { "chromosome": "2", "start_pos": 144403945, "end_pos": 144389454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000440875.6", "url": "https://www.ensembl.org/id/ENST00000440875.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000475553.3", "url": "https://www.ensembl.org/id/ENSP00000475553.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1122, "end_pos": 1122, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" } ], "site_lbl": "Ser1122" }, { "start_pos": 1124, "end_pos": 1124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "site_lbl": "Ser1124" }, { "start_pos": 1203, "end_pos": 1203, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser1203" }, { "start_pos": 142, "end_pos": 142, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" } ], "site_lbl": "Ser142" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "site_lbl": "Ser356" }, { "start_pos": 360, "end_pos": 360, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" } ], "site_lbl": "Ser360" }, { "start_pos": 364, "end_pos": 364, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "site_lbl": "Ser364" }, { "start_pos": 647, "end_pos": 647, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" } ], "site_lbl": "Ser647" }, { "start_pos": 731, "end_pos": 731, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "site_lbl": "Ser731" }, { "start_pos": 780, "end_pos": 780, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "site_lbl": "Ser780" }, { "start_pos": 782, "end_pos": 782, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ], "site_lbl": "Thr782" }, { "start_pos": 784, "end_pos": 784, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ], "site_lbl": "Ser784" }, { "start_pos": 841, "end_pos": 841, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O60315", "url": "http://phospho.elm.eu.org/byAccession/O60315.html" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser841" }, { "start_pos": 843, "end_pos": 843, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O60315", "url": "http://phospho.elm.eu.org/byAccession/O60315.html" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser843" }, { "start_pos": 848, "end_pos": 848, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O60315", "url": "http://phospho.elm.eu.org/byAccession/O60315.html" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser848" }, { "start_pos": 853, "end_pos": 853, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O60315", "url": "http://phospho.elm.eu.org/byAccession/O60315.html" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser853" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease.", "journal": "Nat. Genet.", "date": "2001", "authors": "Wakamatsu N, Yamada Y, Yamada K, Ono T, Nomura N, Taniguchi H, Kitoh H, Mutoh N, Yamanaka T, Mushiake K, Kato K, Sonta S, Nagaya M", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "11279515", "url": "https://glygen.org/publication/PubMed/11279515" } ] }, { "title": "The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.", "journal": "Molecular cell", "date": "2001", "authors": "Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, Mareel M, Huylebroeck D, van Roy F", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" } ], "reference": [ { "type": "PubMed", "id": "11430829", "url": "https://glygen.org/publication/PubMed/11430829" } ] }, { "title": "Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease.", "journal": "Hum. Mol. Genet.", "date": "2001", "authors": "Cacheux V, Dastot-Le Moal F, Kaariainen H, Bondurand N, Rintala R, Boissier B, Wilson M, Mowat D, Goossens M", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "11448942", "url": "https://glygen.org/publication/PubMed/11448942" } ] }, { "title": "Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B.", "journal": "Neurology", "date": "2002", "authors": "Yoneda M, Fujita T, Yamada Y, Yamada K, Fujii A, Inagaki T, Nakagawa H, Shimada A, Kishikawa M, Nagaya M, Azuma T, Kuriyama M, Wakamatsu N", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "12451214", "url": "https://glygen.org/publication/PubMed/12451214" } ] }, { "title": "Ocular coloboma and high myopia with Hirschsprung disease associated with a novel ZFHX1B missense mutation and trisomy 21.", "journal": "Am. J. Med. Genet. A", "date": "2004", "authors": "Gregory-Evans CY, Vieira H, Dalton R, Adams GG, Salt A, Gregory-Evans K", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "15384097", "url": "https://glygen.org/publication/PubMed/15384097" } ] }, { "title": "The identification of Hoxc8 target genes.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005-02-15", "authors": "Lei Haiyan, Wang Hailong, Juan Aster H, Ruddle Frank H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "15699330", "url": "https://glygen.org/publication/PubMed/15699330" } ] }, { "title": "Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Long J, Zuo D, Park M", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "16061479", "url": "https://glygen.org/publication/PubMed/16061479" } ] }, { "title": "A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotype.", "journal": "Am. J. Med. Genet. A", "date": "2006", "authors": "Heinritz W, Zweier C, Froster UG, Strenge S, Kujat A, Syrbe S, Rauch A, Schuster V", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "16688751", "url": "https://glygen.org/publication/PubMed/16688751" } ] }, { "title": "Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006-07-05", "authors": "Lei Haiyan, Juan Aster H, Kim Moo-Sang, Ruddle Frank H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "16793922", "url": "https://glygen.org/publication/PubMed/16793922" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O60315-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.", "journal": "Science", "date": "2009", "authors": "Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "UniProtKB", "id": "E7ESP8", "url": "https://www.uniprot.org/uniprot/E7ESP8" }, { "database": "UniProtKB", "id": "A0JP08", "url": "https://www.uniprot.org/uniprot/A0JP08" }, { "database": "UniProtKB", "id": "A0A1B0GVV8", "url": "https://www.uniprot.org/uniprot/A0A1B0GVV8" }, { "database": "UniProtKB", "id": "A0A1X7SC99", "url": "https://www.uniprot.org/uniprot/A0A1X7SC99" }, { "database": "UniProtKB", "id": "U3KQ51", "url": "https://www.uniprot.org/uniprot/U3KQ51" }, { "database": "UniProtKB", "id": "A0A1B0GV02", "url": "https://www.uniprot.org/uniprot/A0A1B0GV02" }, { "database": "UniProtKB", "id": "A0A1B0GW50", "url": "https://www.uniprot.org/uniprot/A0A1B0GW50" }, { "database": "UniProtKB", "id": "E7EUW9", "url": "https://www.uniprot.org/uniprot/E7EUW9" } ], "reference": [ { "type": "PubMed", "id": "19608861", "url": "https://glygen.org/publication/PubMed/19608861" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O60315-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.", "journal": "Cell stem cell", "date": "2010-01-08", "authors": "Chng Zhenzhi, Teo Adrian, Pedersen Roger A, Vallier Ludovic", "evidence": [ { "database": "Reactome", "id": "R-HSA-9823739", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9823739" } ], "reference": [ { "type": "PubMed", "id": "20074535", "url": "https://glygen.org/publication/PubMed/20074535" } ] }, { "title": "Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221.", "journal": "Mol. Cell. Biol.", "date": "2010", "authors": "Chen Y, Banda M, Speyer CL, Smith JS, Rabson AB, Gorski DH", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "20516212", "url": "https://glygen.org/publication/PubMed/20516212" } ] }, { "title": "ZEB2 upregulates integrin \u03b15 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells.", "journal": "Carcinogenesis", "date": "2012-03", "authors": "Nam Eun-Hee, Lee Yunhee, Park Young-Kyu, Lee Jung Weon, Kim Semi", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "22227038", "url": "https://glygen.org/publication/PubMed/22227038" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "iPTMnet", "id": "O60315", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60315" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin \u03b15 expression.", "journal": "Carcinogenesis", "date": "2014-02", "authors": "Nam Eun-Hee, Lee Yunhee, Zhao Xue-Feng, Park Young-Kyu, Lee Jung Weon, Kim Semi", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "24130169", "url": "https://glygen.org/publication/PubMed/24130169" } ] }, { "title": "HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression.", "journal": "Oncotarget", "date": "2014-05-15", "authors": "Li Yong, Chao Fengmei, Huang Bei, Liu Dahai, Kim Jaejik, Huang Shuang", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "24810778", "url": "https://glygen.org/publication/PubMed/24810778" } ] }, { "title": "Uncovering global SUMOylation signaling networks in a site-specific manner.", "journal": "Nat. Struct. Mol. Biol.", "date": "2014", "authors": "Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "UniProtKB", "id": "E7ESP8", "url": "https://www.uniprot.org/uniprot/E7ESP8" }, { "database": "UniProtKB", "id": "A0JP08", "url": "https://www.uniprot.org/uniprot/A0JP08" }, { "database": "UniProtKB", "id": "A0A1B0GVV8", "url": "https://www.uniprot.org/uniprot/A0A1B0GVV8" }, { "database": "UniProtKB", "id": "A0A1X7SC99", "url": "https://www.uniprot.org/uniprot/A0A1X7SC99" }, { "database": "UniProtKB", "id": "U3KQ51", "url": "https://www.uniprot.org/uniprot/U3KQ51" }, { "database": "UniProtKB", "id": "A0A1B0GV02", "url": "https://www.uniprot.org/uniprot/A0A1B0GV02" }, { "database": "UniProtKB", "id": "A0A1B0GW50", "url": "https://www.uniprot.org/uniprot/A0A1B0GW50" }, { "database": "UniProtKB", "id": "E7EUW9", "url": "https://www.uniprot.org/uniprot/E7EUW9" } ], "reference": [ { "type": "PubMed", "id": "25218447", "url": "https://glygen.org/publication/PubMed/25218447" } ] }, { "title": "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.", "journal": "Cell Rep.", "date": "2015", "authors": "Hendriks I.A., Olsen J.V., Vertegaal A.C., Treffers L.W., Verlaan-de Vries M.", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "UniProtKB", "id": "E7ESP8", "url": "https://www.uniprot.org/uniprot/E7ESP8" }, { "database": "UniProtKB", "id": "A0JP08", "url": "https://www.uniprot.org/uniprot/A0JP08" }, { "database": "UniProtKB", "id": "A0A1B0GVV8", "url": "https://www.uniprot.org/uniprot/A0A1B0GVV8" }, { "database": "UniProtKB", "id": "A0A1X7SC99", "url": "https://www.uniprot.org/uniprot/A0A1X7SC99" }, { "database": "UniProtKB", "id": "U3KQ51", "url": "https://www.uniprot.org/uniprot/U3KQ51" }, { "database": "UniProtKB", "id": "A0A1B0GV02", "url": "https://www.uniprot.org/uniprot/A0A1B0GV02" }, { "database": "UniProtKB", "id": "A0A1B0GW50", "url": "https://www.uniprot.org/uniprot/A0A1B0GW50" }, { "database": "UniProtKB", "id": "E7EUW9", "url": "https://www.uniprot.org/uniprot/E7EUW9" } ], "reference": [ { "type": "PubMed", "id": "25772364", "url": "https://glygen.org/publication/PubMed/25772364" } ] }, { "title": "Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor.", "journal": "Stem cell reports", "date": "2016-04-12", "authors": "Shahbazi Ebrahim, Moradi Sharif, Nemati Shiva, Satarian Leila, Basiri Mohsen, Gourabi Hamid, Zare Mehrjardi Narges, G\u00fcnther Patrick, Lampert Angelika, H\u00e4ndler Kristian, Hatay Firuze Fulya, Schmidt Diana, Molcanyi Marek, Hescheler J\u00fcrgen, Schultze Joachim L, Saric Tomo, Baharvand Hossein", "evidence": [ { "database": "Reactome", "id": "R-HSA-9823739", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9823739" } ], "reference": [ { "type": "PubMed", "id": "27052315", "url": "https://glygen.org/publication/PubMed/27052315" } ] }, { "title": "TGF-beta1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation.", "journal": "Cellular signalling", "date": "2018", "authors": "Cheng JC, Yi Y, Chang HM, Leung PCK", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "29269046", "url": "https://glygen.org/publication/PubMed/29269046" } ] }, { "title": "Interleukin enhancer-binding factor 3 and HOXC8 co-activate cadherin 11 transcription to promote breast cancer cells proliferation and migration.", "journal": "Oncotarget", "date": "2017-12-08", "authors": "Zhang Yang, Yang Chenchen, Zhang Mingsheng, Liu Houli, Gong Chen, Zhang Jie, Xu Shanshan, Zou Jin, Kai Yuanzhong, Li Yong", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "29296180", "url": "https://glygen.org/publication/PubMed/29296180" } ] }, { "title": "FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts.", "journal": "Cell reports", "date": "2018", "authors": "Black M, Milewski D, Le T, Ren X, Xu Y, Kalinichenko VV, Kalin TV", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "29642003", "url": "https://glygen.org/publication/PubMed/29642003" } ] }, { "title": "Charactering tumor microenvironment reveals stromal-related transcription factors promote tumor carcinogenesis in gastric cancer.", "journal": "Cancer medicine", "date": "2020-07", "authors": "Liu Haining, Ni Shujuan, Wang Hanbo, Zhang Qiongyan, Weng Weiwei", "evidence": [ { "database": "Reactome", "id": "R-HSA-9762293", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293" } ], "reference": [ { "type": "PubMed", "id": "32463580", "url": "https://glygen.org/publication/PubMed/32463580" } ] }, { "title": "Association of Polymorphisms in ZFHX1B and PAX6 With Anisometropia in Chinese Children: The Hong Kong Children Eye Genetics Study.", "journal": "Investigative ophthalmology & visual science", "date": "2023-06-01", "authors": "Wang Yu Yao, Zhang Xiu Juan, Kam Ka Wai, Chen Zhen Ji, Zhang Yuzhou, Tang Fang Yao, Li Fen Fen, Tam Pancy O S, Yip Wilson W K, Young Alvin L, Tham Clement C, Pang Chi Pui, Yam Jason C, Chen Li Jia", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" } ], "reference": [ { "type": "PubMed", "id": "37266952", "url": "https://glygen.org/publication/PubMed/37266952" } ] }, { "title": "MiR-454-3p promotes apoptosis and autophagy of AML cells by targeting ZEB2 and regulating AKT/mTOR pathway.", "journal": "Hematology (Amsterdam, Netherlands)", "date": "2023-12", "authors": "Wang Xiao, Zhong Liang, Dan Wenran, Chu Xuan, Luo Xu, Liu Chen, Wan Peng, Lu Yang, Liu Zhenyan, Zhang Zhonghui, Liu Beizhong", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" } ], "reference": [ { "type": "PubMed", "id": "37313984", "url": "https://glygen.org/publication/PubMed/37313984" } ] }, { "title": "MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC.", "journal": "Cell reports", "date": "2023-08-29", "authors": "Zhao Kaiqiang, Zheng Mingyue, Su Zezhuo, Ghosh Shrestha, Zhang Chao, Zhong Wenzhao, Ho Joshua Wing Kei, Jin Guoxiang, Zhou Zhongjun", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" } ], "reference": [ { "type": "PubMed", "id": "37566546", "url": "https://glygen.org/publication/PubMed/37566546" } ] }, { "title": "Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis.", "journal": "International journal of medical sciences", "date": "2023", "authors": "Zhai Duanyang, Zhou Yu, Kuang Xiaying, Shao Fangyuan, Zhen Tiantian, Lin Ying, Wang Qing, Shao Nan", "evidence": [ { "database": "RefSeq", "id": "NP_001165124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165124" } ], "reference": [ { "type": "PubMed", "id": "37575267", "url": "https://glygen.org/publication/PubMed/37575267" } ] }, { "title": "Selection system for genes encoding nuclear-targeted proteins.", "journal": "Nat. Biotechnol.", "date": "1998", "authors": "Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "reference": [ { "type": "PubMed", "id": "9853615", "url": "https://glygen.org/publication/PubMed/9853615" } ] } ], "pathway": [ { "id": "hsa:9839", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9839", "resource": "KEGG Pathway" }, { "id": "R-HSA-9762293", "name": "Regulation of CDH11 gene transcription", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9762293", "resource": "Reactome", "description": "Regulation of CDH11 gene transcription" }, { "id": "R-HSA-9823739", "name": "Formation of the anterior neural plate", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9823739", "resource": "Reactome", "description": "Formation of the anterior neural plate" }, { "id": "R-HSA-9832991", "name": "Formation of the posterior neural plate", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9832991", "resource": "Reactome", "description": "Formation of the posterior neural plate" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GES1-1", "protein_name": "Zinc finger E-box binding homeobox 2", "gene_name": "Zeb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDAGSETDEEDKLHIAEDDGIANPLDQETSPASMPNHESSPHMSQGLLPREEEEDEIRESVVEHSWHSGEILQASVDGPEEMKEDYDALGPEATIQTTINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGLEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKTEDISKLKGYHMKDPCSQPEEQGVTSPSIPAVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHSIPTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGLTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSSSRSPSLERNSKPLAPNSNPTTKDSLLPRSPVKPMDSITSPSIAELHNSVTSCDPPLRLTKSSHFTNIKAVDKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMREPKSIIATKNKTKATSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFGMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDLTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEEGYGKLRRRDGDEEEEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGME", "length": 1215 }, "evidence": [ { "id": "45229823", "url": "http://www.informatics.jax.org/homology/45229823", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9R0G7-1", "protein_name": "Zinc finger E-box-binding homeobox 2", "gene_name": "Zeb2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDAGSETDEEDKLHIAEDDSLANPLDQDTSPASMPNHESSPHMSQGLLPREEEEEELRESVVEHSWHSGEILQASVAGPEEMKEDYDAMGPEATIQTTINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGSSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKTEDISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHSISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGLTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERTSKPLAPNSNPTTKDSLLPRSPVKPMDSITSPSIAELHNSVTSCDPPLRLTKSSHFTNIKAVDKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMREPKGIIATKNKTKATSINLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSNNPVFGMNPFSAKPLYTPLPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGDLLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEEGYGKLRRRDGDEEEEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGME", "length": 1215 }, "evidence": [ { "id": "45229823", "url": "http://www.informatics.jax.org/homology/45229823", "database": "MGI" }, { "id": "O60315", "url": "https://omabrowser.org/oma/group/O60315/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "negative regulation of fibroblast migration", "id": "GO:0010764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010764", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "astrocyte activation", "id": "GO:0048143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048143", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "endothelial cell migration", "id": "GO:0043542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043542", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "positive regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030511", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "anatomical structure development", "id": "GO:0048856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048856", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "endothelial cell proliferation", "id": "GO:0001935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001935", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "pyroptosis", "id": "GO:0070269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070269", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "stress fiber assembly", "id": "GO:0043149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043149", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "positive regulation of melanocyte differentiation", "id": "GO:0045636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045636", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "positive regulation of melanin biosynthetic process", "id": "GO:0048023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048023", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "developmental pigmentation", "id": "GO:0048066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048066", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "regulation of melanosome organization", "id": "GO:1903056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903056", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "fibroblast activation", "id": "GO:0072537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072537", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "melanocyte migration", "id": "GO:0097324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097324", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "regulation of blood-brain barrier permeability", "id": "GO:1905603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905603", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "positive regulation of myofibroblast contraction", "id": "GO:1904330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904330", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "response to oxygen-glucose deprivation", "id": "GO:0090649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090649", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "myofibroblast differentiation", "id": "GO:0036446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036446", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "regulation of myofibroblast cell apoptotic process", "id": "GO:1904520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904520", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "cellular nitrogen compound biosynthetic process", "id": "GO:0044271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044271", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "phosphatase regulator activity", "id": "GO:0019208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019208", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1169, "end_pos": 1171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 787, "end_pos": 789, "annotation": "n_glycosylation_sequon" }, { "start_pos": 835, "end_pos": 837, "annotation": "n_glycosylation_sequon" }, { "start_pos": 861, "end_pos": 863, "annotation": "n_glycosylation_sequon" }, { "start_pos": 877, "end_pos": 879, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.", "evidence": [ { "database": "UniProtKB", "id": "O60315", "url": "https://www.uniprot.org/uniprot/O60315" }, { "database": "PubMed", "id": "16061479", "url": "https://glygen.org/publication/PubMed/16061479" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 16 }, { "field": "total_sites", "count": 16 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 32 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }