{ "uniprot_canonical_ac": "O55029-1", "uniprot_ac": "O55029", "uniprot_id": "COPB2_MOUSE", "mass": { "chemical_mass": 102449.0, "monoisotopic_mass": 102449.0 }, "refseq": { "ac": "NP_056642", "name": "coatomer subunit beta'", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642" }, "gene_names": [ { "name": "Copb2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O55029", "id": "O55029" }, { "name": "Copb2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642", "id": "NP_056642" } ], "protein_names": [ { "name": "Coatomer subunit beta'", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O55029" }, { "name": "Beta'-COP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O55029" }, { "name": "Beta'-coat protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O55029" }, { "name": "coatomer subunit beta'", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642", "id": "NP_056642" }, { "name": "p102; beta'-COP; beta'-coat protein; coatomer protein complex, subunit beta 2 (beta prime)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642", "id": "NP_056642" }, { "name": "p102", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O55029" } ], "function": [ { "annotation": "Beta-COP Suppresses the Surface Expression of the TREK2. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_056642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642" }, { "database": "PubMed", "id": "37296621", "url": "https://glygen.org/publication/PubMed/37296621" } ] }, { "annotation": "COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.", "evidence": [ { "database": "RefSeq", "id": "NP_056642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642" }, { "database": "PubMed", "id": "34450031", "url": "https://glygen.org/publication/PubMed/34450031" } ] }, { "annotation": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029#function" }, { "database": "UniProtKB", "id": "P35606", "url": "https://www.uniprot.org/uniprot/P35606#function" } ] }, { "annotation": "This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029#function" } ] } ], "disease": [ { "disease_id": "DOID:0070281", "recommended_name": { "id": "DOID:0070281", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070281", "name": "primary autosomal recessive microcephaly 19", "description": "A primary autosomal recessive microcephaly that has_material_basis_in homozygous or compound heterozygous mutation in the COPB2 gene on chromosome 3q23." }, "synonyms": [ { "id": "DOID:0070281", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070281", "name": "MCPH19", "description": "" }, { "id": "MONDO:0054716", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054716", "name": "microcephaly 19, primary, autosomal recessive", "description": "" }, { "id": "MONDO:0054716", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054716", "name": "MCPH19", "description": "" }, { "id": "MONDO:0054716", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054716", "name": "microcephaly 19, PRIMARY, autosomal recessive", "description": "" }, { "id": "MONDO:0054716", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054716", "name": "primary autosomal recessive microcephaly 19", "description": "" }, { "id": "MIM:617800", "resource": "MIM", "url": "https://www.omim.org/entry/617800", "name": "Microcephaly 19, primary, autosomal recessive", "description": "Microcephaly 19, primary, autosomal recessive" } ], "evidence": [ { "id": "0070281", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070281" } ] }, { "disease_id": "DOID:10907", "recommended_name": { "id": "DOID:10907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10907", "name": "microcephaly", "description": "A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants." }, "synonyms": [ { "id": "DOID:10907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10907", "name": "Microcephalus", "description": "" }, { "id": "DOID:10907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10907", "name": "microencephaly", "description": "" } ], "evidence": [ { "id": "10907", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10907" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 254, "end_pos": 254, "sequence_org": "R", "sequence_mut": "C", "comment": "No effect on protein abundance. Mice homozygous for that mutation do not display any developmental abnormality.", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" }, { "database": "PubMed", "id": "29036432", "url": "https://glygen.org/publication/PubMed/29036432" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Copb2", "url": "https://www.uniprot.org/uniprot/O55029", "locus": { "chromosome": "9", "start_pos": 98470435, "end_pos": 98445774, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000032458", "url": "https://www.ensembl.org/id/ENSMUSG00000032458" } ] } } ], "crossref": [ { "id": "ENSMUSG00000032458", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000032458", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22947", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22947", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "50797", "url": "https://www.ncbi.nlm.nih.gov/gene/50797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O55029", "url": "https://www.ebi.ac.uk/intact/interactors/id:O55029*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006692", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006692", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:50797", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:50797", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1354962", "url": "http://www.informatics.jax.org/marker/MGI:1354962", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "NVFWNES", "url": "https://omabrowser.org/oma/group/NVFWNES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "20819at2759", "url": "http://www.orthodb.org/?query=20819at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19876", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19876", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19876:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19876:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5A1U", "url": "https://www.rcsb.org/structure/5A1U", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5A1V", "url": "https://www.rcsb.org/structure/5A1V", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5A1W", "url": "https://www.rcsb.org/structure/5A1W", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5A1X", "url": "https://www.rcsb.org/structure/5A1X", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5A1Y", "url": "https://www.rcsb.org/structure/5A1Y", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5NZR", "url": "https://www.rcsb.org/structure/5NZR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5NZS", "url": "https://www.rcsb.org/structure/5NZS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5NZT", "url": "https://www.rcsb.org/structure/5NZT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5NZU", "url": "https://www.rcsb.org/structure/5NZU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5NZV", "url": "https://www.rcsb.org/structure/5NZV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00400", "url": "http://pfam.xfam.org/family/PF00400", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF04053", "url": "http://pfam.xfam.org/family/PF04053", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O55029", "url": "http://purl.obolibrary.org/obo/PR_O55029", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6807878", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6811434", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_056642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O55029-1", "url": "https://www.uniprot.org/uniprot/O55029-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWENTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFSLAQECLHHAQDYGGLLLLATASGNASMVNKLAEGAERDGKNNVAFMSYFLQGKLDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKGFQPSRPTAQQEPDGKPASSPVIMASQTTHKEEKSLLELEVDLDNLELEDIDTTDINLDEDILDD", "length": 905, "header": "sp|O55029-1|COPB2_MOUSE Isoform 1 of Coatomer subunit beta' OS=Mus musculus OX=10090 GN=Copb2 PE=1 SV=2 CANONICAL=O55029-1" }, "isoforms": [ { "isoform_ac": "O55029-1", "url": "", "sequence": { "sequence": "MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWENTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFSLAQECLHHAQDYGGLLLLATASGNASMVNKLAEGAERDGKNNVAFMSYFLQGKLDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKGFQPSRPTAQQEPDGKPASSPVIMASQTTHKEEKSLLELEVDLDNLELEDIDTTDINLDEDILDD", "length": 905, "header": "sp|O55029-1|COPB2_MOUSE Isoform 1 of Coatomer subunit beta' OS=Mus musculus OX=10090 GN=Copb2 PE=1 SV=2 CANONICAL=O55029-1" }, "locus": { "chromosome": "9", "start_pos": 98470190, "end_pos": 98445874, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000035033", "url": "https://www.ensembl.org/id/ENSMUST00000035033" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000035033", "url": "https://www.ensembl.org/id/ENSMUSP00000035033" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 859, "end_pos": 859, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "site_lbl": "Ser859" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Differential localization of coatomer complex isoforms within the Golgi apparatus.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Moelleken J, Malsam J, Betts MJ, Movafeghi A, Reckmann I, Meissner I, Hellwig A, Russell RB, Sollner T, Brugger B, Wieland FT", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "reference": [ { "type": "PubMed", "id": "17360540", "url": "https://glygen.org/publication/PubMed/17360540" } ] }, { "title": "Copb2 is essential for embryogenesis and hypomorphic mutations cause human microcephaly.", "journal": "Hum. Mol. Genet.", "date": "2017", "authors": "DiStasio A, Driver A, Sund K, Donlin M, Muraleedharan RM, Pooya S, Kline-Fath B, Kaufman KM, Prows CA, Schorry E, Dasgupta B, Stottmann RW", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "reference": [ { "type": "PubMed", "id": "29036432", "url": "https://glygen.org/publication/PubMed/29036432" } ] }, { "title": "COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.", "journal": "American journal of human genetics", "date": "2021", "authors": "Marom R, Burrage LC, Venditti R, Clement A, Blanco-Sanchez B, Jain M, Scott DA, Rosenfeld JA, Sutton VR, Shinawi M, Mirzaa G, DeVile C, Roberts R, Calder AD, Allgrove J, Grafe I, Lanza DG, Li X, Joeng KS, Lee YC, Song IW, Sliepka JM, Batkovskyte D, Washington M, Dawson BC, Jin Z, Jiang MM, Chen S, Chen Y, Tran AA, Emrick LT, Murdock DR, Hanchard NA, Zapata GE, Mehta NR, Weis MA, Scott AA, Tremp BA, Phillips JB, Wegner J, Taylor-Miller T, Gibbs RA, Muzny DM, Jhangiani SN, Hicks J, Stottmann RW, Dickinson ME, Seavitt JR, Heaney JD, Eyre DR, Westerfield M, De Matteis MA, Lee B", "evidence": [ { "database": "RefSeq", "id": "NP_056642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642" } ], "reference": [ { "type": "PubMed", "id": "34450031", "url": "https://glygen.org/publication/PubMed/34450031" } ] }, { "title": "\u03b2-COP Suppresses the Surface Expression of the TREK2.", "journal": "Cells", "date": "2023-05-29", "authors": "Kim Seong-Seop, Park Jimin, Kim Eunju, Hwang Eun Mi, Park Jae-Yong", "evidence": [ { "database": "RefSeq", "id": "NP_056642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642" } ], "reference": [ { "type": "PubMed", "id": "37296621", "url": "https://glygen.org/publication/PubMed/37296621" } ] } ], "pathway": [ { "id": "mmu:50797", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:50797", "resource": "KEGG Pathway" }, { "id": "R-MMU-6807878", "name": "COPI-mediated anterograde transport", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-MMU-6811434", "name": "COPI-dependent Golgi-to-ER retrograde traffic", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6811434", "resource": "Reactome", "description": "COPI-dependent Golgi-to-ER retrograde traffic" } ], "orthologs": [ { "uniprot_canonical_ac": "O35142-1", "protein_name": "Coatomer subunit beta'", "gene_name": "Copb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLRLDIKRKLTAMSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTPEGHAQNVSCATFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSVVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWENTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFSLAQECLHHAQDYGGLLLLATASGNASMVNKLAEGAERDGKNNVAFMSYFLQGKLDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKRFQPSRATAQQEPDGKPASSPVIMASQTTHKEEKSFQELEDDLDTMELEDIDTTDINLDEDILDD", "length": 905 }, "evidence": [ { "id": "45226276", "url": "http://www.informatics.jax.org/homology/45226276", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O62621-1", "protein_name": "Coatomer subunit beta'", "gene_name": "beta'COP", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPLKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEKMWACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYHGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGTYRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQVNLKTIADGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRNKAFGSAQEFVWALESNEYAIRENNGTVRLFRNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYDWETLQLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNVLGEVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELNVISFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHKFDLALQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQLLEVVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRIVELWREKLGKVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPARLAANLPLNSERHPLQELFAAEQGAAGQHLEEKVKPAYVPAQAVVSSSQVAEPTSAADDDDDLDLEIDGITLDDNIDTTDVNLDDDFLSDD", "length": 914 }, "evidence": [ { "id": "O55029", "url": "https://omabrowser.org/oma/group/O55029/", "database": "OMA" } ], "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P35606-1", "protein_name": "Coatomer subunit beta'", "gene_name": "COPB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAERDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEGKDFQPSRSTAQQELDGKPASPTPVIVASHTANKEEKSLLELEVDLDNLELEDIDTTDINLDEDILDD", "length": 906 }, "evidence": [ { "id": "45226276", "url": "http://www.informatics.jax.org/homology/45226276", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P41811-1", "protein_name": "Coatomer subunit beta'", "gene_name": "SEC27", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTNSNGDEASGYTLLFNKDAYLEAANNGNIDDSEGVDEAFDVLYELSESITSGKWVGDVFIFTTATNRLNYFVGGKTYNLAHYTKEMYLLGYLARDNKVYLADREVHVYGYEISLEVLEFQTLTLRGEIEEAIENVLPNVEGKDSLTKIARFLEGQEYYEEALNISPDQDQKFELALKVGQLTLARDLLTDESAEMKWRALGDASLQRFNFKLAVEAFTNAHDLESLFLLHSSFNNKEGLVTLAKDAERAGKFNLAFNAYWIAGDIQGAKDLLIKSQRFSEAAFLGSTYGLGDDAVNDIVTKWKENLILNGKNTVSERVCGAEGLPGSSSSGDAQPLIDLDSTPAPEQADENKEAEVEDSEFKESNSEAVEAEKKEEEAPQQQQSEQQPEQGEAVPEPVEEES", "length": 889 }, "evidence": [ { "id": "O55029", "url": "https://omabrowser.org/oma/group/O55029/", "database": "OMA" } ], "common_name": "Yeast" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" }, { "name": "COPI vesicle coat", "id": "GO:0030126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030126", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" }, { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" }, { "name": "intra-Golgi vesicle-mediated transport", "id": "GO:0006891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006891", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase C binding", "id": "GO:0005080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005080", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "O55029", "url": "https://www.uniprot.org/uniprot/O55029" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" }, { "start_pos": 776, "end_pos": 778, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", 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[] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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