{ "uniprot_canonical_ac": "O54943-1", "uniprot_ac": "O54943", "uniprot_id": "PER2_MOUSE", "mass": { "chemical_mass": 135881.0, "monoisotopic_mass": 135881.0 }, "refseq": { "ac": "NP_035196", "name": "period circadian protein homolog 2 isoform 1", "summary": "This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196" }, "gene_names": [ { "name": "Per2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O54943", "id": "O54943" }, { "name": "Per2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196", "id": "NP_035196" }, { "name": "mKIAA0347; mPer2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196", "id": "NP_035196" } ], "protein_names": [ { "name": "Period circadian protein homolog 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O54943" }, { "name": "Circadian clock protein PERIOD 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O54943" }, { "name": "mPER2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O54943" }, { "name": "period 2; period circadian protein homolog 2; circadian clock protein PERIOD 2; period homolog 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196", "id": "NP_035196" }, { "name": "period circadian protein homolog 2 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196", "id": "NP_035196" } ], "function": [ { "annotation": "Circadian regulation of mTORC1 signaling via Per2 dependent mechanism disrupts folliculogenesis and oocyte maturation in female mice.", "evidence": [ { "database": "RefSeq", "id": "NP_035196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196" }, { "database": "PubMed", "id": "37162693", "url": "https://glygen.org/publication/PubMed/37162693" } ] }, { "annotation": "Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep.", "evidence": [ { "database": "RefSeq", "id": "NP_035196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196" }, { "database": "PubMed", "id": "37769257", "url": "https://glygen.org/publication/PubMed/37769257" } ] }, { "annotation": "The differential vulnerabilities of Per2 knockout mice to the addictive properties of methamphetamine and cocaine.", "evidence": [ { "database": "RefSeq", "id": "NP_035196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196" }, { "database": "PubMed", "id": "37141987", "url": "https://glygen.org/publication/PubMed/37141987" } ] }, { "annotation": "This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_035196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196" } ] }, { "annotation": "Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943#function" }, { "database": "PubMed", "id": "20159955", "url": "https://glygen.org/publication/PubMed/20159955" }, { "database": "PubMed", "id": "22767893", "url": "https://glygen.org/publication/PubMed/22767893" }, { "database": "PubMed", "id": "23418588", "url": "https://glygen.org/publication/PubMed/23418588" }, { "database": "PubMed", "id": "21680841", "url": "https://glygen.org/publication/PubMed/21680841" }, { "database": "PubMed", "id": "19917250", "url": "https://glygen.org/publication/PubMed/19917250" }, { "database": "PubMed", "id": "21035761", "url": "https://glygen.org/publication/PubMed/21035761" }, { "database": "PubMed", "id": "17310242", "url": "https://glygen.org/publication/PubMed/17310242" }, { "database": "PubMed", "id": "21930935", "url": "https://glygen.org/publication/PubMed/21930935" }, { "database": "PubMed", "id": "22504074", "url": "https://glygen.org/publication/PubMed/22504074" }, { "database": "PubMed", "id": "24413057", "url": "https://glygen.org/publication/PubMed/24413057" }, { "database": "PubMed", "id": "23977055", "url": "https://glygen.org/publication/PubMed/23977055" }, { "database": "PubMed", "id": "11395012", "url": "https://glygen.org/publication/PubMed/11395012" }, { "database": "PubMed", "id": "17404161", "url": "https://glygen.org/publication/PubMed/17404161" }, { "database": "PubMed", "id": "21768648", "url": "https://glygen.org/publication/PubMed/21768648" }, { "database": "PubMed", "id": "16595674", "url": "https://glygen.org/publication/PubMed/16595674" }, { "database": "PubMed", "id": "19605937", "url": "https://glygen.org/publication/PubMed/19605937" }, { "database": "PubMed", "id": "10428031", "url": "https://glygen.org/publication/PubMed/10428031" } ] } ], "disease": [ { "disease_id": "DOID:0050628", "recommended_name": { "id": "DOID:0050628", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050628", "name": "advanced sleep phase syndrome", "description": "A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning." }, "synonyms": [ { "id": "DOID:0050628", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050628", "name": "familial advanced sleep-phase syndrome", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome 1", "description": "Any advanced sleep phase syndrome in which the cause of the disease is a mutation in the PER2 gene." }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "FASPS1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "PER2 advanced sleep phase syndrome", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome caused by mutation in PER2", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome type 1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome, familial, type 1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "familial advanced sleep phase syndrome 1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome, familial, 1", "description": "" }, { "id": "MIM:604348", "resource": "MIM", "url": "https://www.omim.org/entry/604348", "name": "Advanced sleep phase syndrome, familial, 1", "description": "Advanced sleep phase syndrome, familial, 1" } ], "evidence": [ { "id": "0050628", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050628" } ] }, { "disease_id": "DOID:0110011", "recommended_name": { "id": "DOID:0110011", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110011", "name": "advanced sleep phase syndrome 1", "description": "An advanced sleep phase syndrome that has_material_basis_in heterozygous mutation in the PER2 gene on chromosome 2q37." }, "synonyms": [ { "id": "DOID:0110011", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110011", "name": "FASPS1", "description": "" }, { "id": "DOID:0110011", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110011", "name": "familial advanced sleep phase syndrome 1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome 1", "description": "Any advanced sleep phase syndrome in which the cause of the disease is a mutation in the PER2 gene." }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "FASPS1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "PER2 advanced sleep phase syndrome", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome caused by mutation in PER2", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome type 1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome, familial, type 1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "familial advanced sleep phase syndrome 1", "description": "" }, { "id": "MONDO:0011442", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011442", "name": "advanced sleep phase syndrome, familial, 1", "description": "" }, { "id": "MIM:604348", "resource": "MIM", "url": "https://www.omim.org/entry/604348", "name": "Advanced sleep phase syndrome, familial, 1", "description": "Advanced sleep phase syndrome, familial, 1" } ], "evidence": [ { "id": "0110011", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110011" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 1052, "end_pos": 1055, "sequence_org": "NLLL", "sequence_mut": "EAAA", "comment": "No effect on interaction with PPARA. Abolishes interaction with PPARA and NR1D1 as well as reduces the amplitude of BMAL1 expression; when associated with 306-A--A-310.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "20159955", "url": "https://glygen.org/publication/PubMed/20159955" } ] }, { "start_pos": 1052, "end_pos": 1055, "sequence_org": "NLLL", "sequence_mut": "", "comment": "No effect on interaction with NR1D1.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "20159955", "url": "https://glygen.org/publication/PubMed/20159955" } ] }, { "start_pos": 113, "end_pos": 116, "sequence_org": "LKEL", "sequence_mut": "AKEA", "comment": "Accumulates in the nucleus. Exlcusively nuclear; when associated with 464-A--A-467 and 985-A--A-990.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "11889036", "url": "https://glygen.org/publication/PubMed/11889036" } ] }, { "start_pos": 306, "end_pos": 310, "sequence_org": "LCCLL", "sequence_mut": "ACCAA", "comment": "Abolishes interaction with PPARA and NR1D1. No effect on interaction with CRY1. Abolishes interaction with PPARA and NR1D1 as well as reduces the amplitude of BMAL1 expression; when associated with 1052-E--A-1055.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "20159955", "url": "https://glygen.org/publication/PubMed/20159955" } ] }, { "start_pos": 306, "end_pos": 310, "sequence_org": "LCCLL", "sequence_mut": "", "comment": "Abolishes interaction with NR1D1.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "20159955", "url": "https://glygen.org/publication/PubMed/20159955" } ] }, { "start_pos": 415, "end_pos": 415, "sequence_org": "F", "sequence_mut": "E", "comment": "Abolishes dimerization.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "19402751", "url": "https://glygen.org/publication/PubMed/19402751" } ] }, { "start_pos": 419, "end_pos": 419, "sequence_org": "W", "sequence_mut": "E", "comment": "Abolishes dimerization.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "19402751", "url": "https://glygen.org/publication/PubMed/19402751" } ] }, { "start_pos": 427, "end_pos": 427, "sequence_org": "I", "sequence_mut": "E", "comment": "Abolishes dimerization.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "19402751", "url": "https://glygen.org/publication/PubMed/19402751" } ] }, { "start_pos": 464, "end_pos": 467, "sequence_org": "IHRL", "sequence_mut": "AHRA", "comment": "Accumulates in the nucleus. Exlcusively nuclear; when associated with 113-A--A-116 and 985-A--A-990.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "11889036", "url": "https://glygen.org/publication/PubMed/11889036" } ] }, { "start_pos": 985, "end_pos": 990, "sequence_org": "LNLLQL", "sequence_mut": "ANAAQA", "comment": "Slightly accumulates in the nucleus. Exlcusively nuclear; when associated with 464-A--A-467 and 985-A--A-990.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "11889036", "url": "https://glygen.org/publication/PubMed/11889036" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Per2", "url": "https://www.uniprot.org/uniprot/O54943", "locus": { "chromosome": "1", "start_pos": 91343704, "end_pos": 91387046, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000055866", "url": "https://www.ensembl.org/id/ENSMUSG00000055866" } ] } } ], "crossref": [ { "id": "ENSMUSG00000055866", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000055866", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "18627", "url": "https://www.ncbi.nlm.nih.gov/gene/18627", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O54943", "url": "https://www.ebi.ac.uk/intact/interactors/id:O54943*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:18627", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18627", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1195265", "url": "http://www.informatics.jax.org/marker/MGI:1195265", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "ENCSMGR", "url": "https://omabrowser.org/oma/group/ENCSMGR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2971905at2759", "url": "http://www.orthodb.org/?query=2971905at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11269", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11269", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11269:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11269:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3GDI", "url": "https://www.rcsb.org/structure/3GDI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4CT0", "url": "https://www.rcsb.org/structure/4CT0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4U8H", "url": "https://www.rcsb.org/structure/4U8H", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF08447", "url": "http://pfam.xfam.org/family/PF08447", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12114", "url": "http://pfam.xfam.org/family/PF12114", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O54943", "url": "http://purl.obolibrary.org/obo/PR_O54943", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_035196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4J0U3", "url": "https://www.uniprot.org/uniprot/A0A0R4J0U3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4J0U3-1", "url": "https://www.uniprot.org/uniprot/A0A0R4J0U3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O54943-1", "url": "https://www.uniprot.org/uniprot/O54943-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGYVDFSPSPTSPTKEPGAPQPTQAVLQEDVDMSSGSSGNENCSTGRDSQGSDCDDNGKELRMLVESSNTHPSPDDAFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPCSVDVPSYSMEQVEGITSEYIVKNADMFAVAVSLVSGKILYISNQVASIFHCKKDAFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVCSGLDSFTQECMEEKSFFCRVSVGKHHENEIRYQPFRMTPYLVKVQEQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQAVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQAGGQPFDYSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAAPPCPEEKTPHPSVQELTEQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESHRRRSGIFKTSGKIQTKSHVSHESGGQKEASVAEMQSSPPAQVKAVTTIERDSSGASLPKASFPEELAYKNQPPCSYQQISCLDSVIRYLESCSEAATLKRKCEFPANIPSRKATVSPGLHSGEAARPSKVTSHTEVSAHLSSLTLPGKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDMASGPESLDGAAGGLSQEKGPLQKLGLTKEVLAAHTQKEEQGFLQRFREVSRLSALQAHCQNYLQERSRAQASDRGLRNTSGLESSWKKTGKNRKLKSKRVKTRDSSESTGSGGPVSHRPPLMGLNATAWSPSDTSQSSCPSAPFPTAVPAYPLPVFQAPGIVSTPGTVVAPPAATHTGFTMPVVPMGTQPEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNLPQAFLPSQPHFPAHPTLASEITPASQAEFPSRTSTLRQPCACPVTPPAGTVALGRASPPLFQSRGSSPLQLNLLQLEEAPEGSTGAAGTLGTTGTAASGLDCTSGTSRDRQPKAPPTCNEPSDTQNSDAISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGFGTSQSGAGSSDTSHTSKYFGSIDSSENNHKAKMIPDTEESEQFIKYVLQDPIWLLMANTDDSIMMTYQLPSRDLQAVLKEDQEKLKLLQRSQPRFTEGQRRELREVHPWVHTGGLPTAIDVTGCVYCESEEKGNICLPYEEDSPSPGLCDTSEAKEEEGEQLTGPRIEAQT", "length": 1257, "header": "sp|O54943-1|PER2_MOUSE Isoform 1 of Period circadian protein homolog 2 OS=Mus musculus OX=10090 GN=Per2 PE=1 SV=3 CANONICAL=O54943-1" }, "isoforms": [ { "isoform_ac": "A0A0R4J0U3-1", "url": "", "sequence": { "sequence": "MNGYVDFSPSPTSPTKEPGAPQPTQAVLQEDVDMSSGSSGNENCSTGRDSQGSDCDDNGKELRMLVESSNTHPSPDDAFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPCSVDVPSYSMEQVEGITSEYIVKNADMFAVAVSLVSGKILYISNQVASIFHCKKDAFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVCSGLDSFTQECMEEKSFFCRVSVGKHHENEIRYQPFRMTPYLVKVQEQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQAVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQAGGQPFDYSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAASPCPEEKTPHPSVQELTEQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESHRRRSGIFKTSGKIQTKSHVSHESGGQKEASVAEMQSSPPAQVKAVTTIERDSSGASLPKASFPEELAYKNQPPCSYQQISCLDSVIRYLESCSEAATLKRKCEFPANIPSRKATVSPGLHSGEAARPSKVTSHTEVSAHLSSLTLPGKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDMASGPESLDGAAGGLSQEKGPLQKLGLTKEVLAAHTQREEQGFLQRFREVSRLSALQAHCQNYLQERSRAQASDRGLRNTSGLESSWKKTGKNRKLKSKRVKTRDSSESTGSGGPVSHRPPLMGLNATAWSPSDTSQSSCPSAPFPTAVPAYPLPVFQAPGIVSTPGTVVAPPAATHTGFTMPVVPMGTQPEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNLPQAFLPSQPHFPAHPTLASEITPASQAEFPSRTSTLRQPCACPVTPPAGTVALGRASPPLFQSRGSSPLQLNLLQLEEAPEGSTGAAGTLGTTGTAASGLDCTSGTSRDRQPKAPPTCNEPSDTQNSDAISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGFGTSQSGAGSSDTSHTSKYFGSIDSSENNHKAKMIPDTEESEQFIKYVLQDPIWLLMANTDDSIMMTYQLPSRDLQAVLKEDQEKLKLLQRSQPRFTEGQRRELREVHPWVHTGGLPTAIDVTGCVYCESEEKGNICLPYEEDSPSPGLCDTSEAKEEEGEQLTGPRIEAQT", "length": 1257, "header": "tr|A0A0R4J0U3-1|A0A0R4J0U3_MOUSE Computationally mapped isoform of Period circadian clock 2 OS=Mus musculus OX=10090 GN=Per2 PE=1 SV=1 CANONICAL=O54943-1" }, "locus": { "chromosome": "1", "start_pos": 91378547, "end_pos": 91345596, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000069620.10", "url": "https://www.ensembl.org/id/ENSMUST00000069620.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000066620.9", "url": "https://www.ensembl.org/id/ENSMUSP00000066620.9" } ] } }, { "isoform_ac": "O54943-1", "url": "", "sequence": { "sequence": "MNGYVDFSPSPTSPTKEPGAPQPTQAVLQEDVDMSSGSSGNENCSTGRDSQGSDCDDNGKELRMLVESSNTHPSPDDAFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPCSVDVPSYSMEQVEGITSEYIVKNADMFAVAVSLVSGKILYISNQVASIFHCKKDAFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVCSGLDSFTQECMEEKSFFCRVSVGKHHENEIRYQPFRMTPYLVKVQEQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQAVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQAGGQPFDYSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAAPPCPEEKTPHPSVQELTEQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESHRRRSGIFKTSGKIQTKSHVSHESGGQKEASVAEMQSSPPAQVKAVTTIERDSSGASLPKASFPEELAYKNQPPCSYQQISCLDSVIRYLESCSEAATLKRKCEFPANIPSRKATVSPGLHSGEAARPSKVTSHTEVSAHLSSLTLPGKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDMASGPESLDGAAGGLSQEKGPLQKLGLTKEVLAAHTQKEEQGFLQRFREVSRLSALQAHCQNYLQERSRAQASDRGLRNTSGLESSWKKTGKNRKLKSKRVKTRDSSESTGSGGPVSHRPPLMGLNATAWSPSDTSQSSCPSAPFPTAVPAYPLPVFQAPGIVSTPGTVVAPPAATHTGFTMPVVPMGTQPEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNLPQAFLPSQPHFPAHPTLASEITPASQAEFPSRTSTLRQPCACPVTPPAGTVALGRASPPLFQSRGSSPLQLNLLQLEEAPEGSTGAAGTLGTTGTAASGLDCTSGTSRDRQPKAPPTCNEPSDTQNSDAISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGFGTSQSGAGSSDTSHTSKYFGSIDSSENNHKAKMIPDTEESEQFIKYVLQDPIWLLMANTDDSIMMTYQLPSRDLQAVLKEDQEKLKLLQRSQPRFTEGQRRELREVHPWVHTGGLPTAIDVTGCVYCESEEKGNICLPYEEDSPSPGLCDTSEAKEEEGEQLTGPRIEAQT", "length": 1257, "header": "sp|O54943-1|PER2_MOUSE Isoform 1 of Period circadian protein homolog 2 OS=Mus musculus OX=10090 GN=Per2 PE=1 SV=3 CANONICAL=O54943-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1126, "end_pos": 1126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser1126" }, { "start_pos": 478, "end_pos": 478, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" }, { "database": "PubMed", "id": "32354999", "url": "https://glygen.org/publication/PubMed/32354999" } ], "site_lbl": "Ser478" }, { "start_pos": 525, "end_pos": 525, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser525" }, { "start_pos": 528, "end_pos": 528, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser528" }, { "start_pos": 531, "end_pos": 531, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser531" }, { "start_pos": 538, "end_pos": 538, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser538" }, { "start_pos": 544, "end_pos": 544, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser544" }, { "start_pos": 545, "end_pos": 545, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" }, { "database": "PubMed", "id": "26279567", "url": "https://glygen.org/publication/PubMed/26279567" } ], "site_lbl": "Ser545" }, { "start_pos": 554, "end_pos": 554, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Thr554" }, { "start_pos": 659, "end_pos": 659, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "phospho.ELM", "id": "O54943", "url": "http://phospho.elm.eu.org/byAccession/O54943.html" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" }, { "database": "PubMed", "id": "16983144", "url": "https://glygen.org/publication/PubMed/16983144" }, { "database": "PubMed", "id": "29784789", "url": "https://glygen.org/publication/PubMed/29784789" } ], "site_lbl": "Ser659" }, { "start_pos": 662, "end_pos": 662, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" }, { "database": "PubMed", "id": "29784789", "url": "https://glygen.org/publication/PubMed/29784789" } ], "site_lbl": "Ser662" }, { "start_pos": 693, "end_pos": 693, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "phospho.ELM", "id": "O54943", "url": "http://phospho.elm.eu.org/byAccession/O54943.html" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser693" }, { "start_pos": 697, "end_pos": 697, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "phospho.ELM", "id": "O54943", "url": "http://phospho.elm.eu.org/byAccession/O54943.html" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser697" }, { "start_pos": 706, "end_pos": 706, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser706" }, { "start_pos": 758, "end_pos": 758, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser758" }, { "start_pos": 763, "end_pos": 763, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser763" }, { "start_pos": 858, "end_pos": 858, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Thr858" }, { "start_pos": 939, "end_pos": 939, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser939" }, { "start_pos": 964, "end_pos": 964, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Thr964" }, { "start_pos": 971, "end_pos": 971, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" }, { "database": "PubMed", "id": "16097765", "url": "https://glygen.org/publication/PubMed/16097765" }, { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "site_lbl": "Ser971" } ], "glycation": [], "keywords": [], "publication": [ { "title": "mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.", "journal": "Cell", "date": "1999", "authors": "Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "10428031", "url": "https://glygen.org/publication/PubMed/10428031" } ] }, { "title": "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon.", "journal": "Mol. Cell. Biol.", "date": "2000", "authors": "Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "10848614", "url": "https://glygen.org/publication/PubMed/10848614" } ] }, { "title": "Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.", "journal": "Neuron", "date": "2001", "authors": "Jin X., Reppert S.M., Weaver D.R., Hastings M.H., Maywood E.S., Bae K.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "11395012", "url": "https://glygen.org/publication/PubMed/11395012" } ] }, { "title": "Nuclear export of mammalian PERIOD proteins.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Vielhaber EL, Duricka D, Ullman KS, Virshup DM", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "11591712", "url": "https://glygen.org/publication/PubMed/11591712" } ] }, { "title": "Posttranslational mechanisms regulate the mammalian circadian clock.", "journal": "Cell", "date": "2001", "authors": "Lee C, Etchegaray JP, Cagampang FR, Loudon AS, Reppert SM", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "11779462", "url": "https://glygen.org/publication/PubMed/11779462" } ] }, { "title": "Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.", "journal": "Mol. Cell. 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Med.", "date": "2014", "authors": "Kim K., Kim K.H., Kim M.H., Kim S.E., Cho S., Han D.H., Kim C.J., Park N., Ko I.G., Kyoung Choe H., Noh J.Y.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "24603368", "url": "https://glygen.org/publication/PubMed/24603368" } ] }, { "title": "GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins.", "journal": "Cell reports", "date": "2015", "authors": "Mehta N, Cheng AH, Chiang CK, Mendoza-Viveros L, Ling HH, Patel A, Xu B, Figeys D, Cheng HY", "evidence": [ { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "reference": [ { "type": "PubMed", "id": "26279567", "url": "https://glygen.org/publication/PubMed/26279567" } ] }, { "title": "CK1delta/epsilon protein kinase primes the PER2 circadian phosphoswitch.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2018", "authors": "Narasimamurthy R, Hunt SR, Lu Y, Fustin JM, Okamura H, Partch CL, Forger DB, Kim JK, Virshup DM", "evidence": [ { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "reference": [ { "type": "PubMed", "id": "29784789", "url": "https://glygen.org/publication/PubMed/29784789" } ] }, { "title": "Autophagy regulates the liver clock and glucose metabolism by degrading CRY1.", "journal": "Cell Metab.", "date": "2018", "authors": "Toledo M, Batista-Gonzalez A, Merheb E, Aoun ML, Tarabra E, Feng D, Sarparanta J, Merlo P, Botre F, Schwartz GJ, Pessin JE, Singh R", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "29937374", "url": "https://glygen.org/publication/PubMed/29937374" } ] }, { "title": "Sirt6 deacetylase activity regulates circadian rhythms via Per2.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2019", "authors": "Sun S, Liu Z, Feng Y, Shi L, Cao X, Cai Y, Liu B", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "30782483", "url": "https://glygen.org/publication/PubMed/30782483" } ] }, { "title": "Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020-05-19", "authors": "Masuda Shusaku, Narasimamurthy Rajesh, Yoshitane Hikari, Kim Jae Kyoung, Fukada Yoshitaka, Virshup David M", "evidence": [ { "database": "iPTMnet", "id": "O54943", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54943" } ], "reference": [ { "type": "PubMed", "id": "32354999", "url": "https://glygen.org/publication/PubMed/32354999" } ] }, { "title": "The differential vulnerabilities of Per2 knockout mice to the addictive properties of methamphetamine and cocaine.", "journal": "Progress in neuro-psychopharmacology & biological psychiatry", "date": "2023-05-02", "authors": "Sayson Leandro Val, Lee Hyun Jun, Ortiz Darlene Mae, Kim Mikyung, Custodio Raly James Perez, Lee Chae Hyeon, Lee Yong Sup, Cheong Jae Hoon, Kim Hee Jin", "evidence": [ { "database": "RefSeq", "id": "NP_035196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196" } ], "reference": [ { "type": "PubMed", "id": "37141987", "url": "https://glygen.org/publication/PubMed/37141987" } ] }, { "title": "Circadian regulation of mTORC1 signaling via Per2 dependent mechanism disrupts folliculogenesis and oocyte maturation in female mice.", "journal": "Journal of molecular histology", "date": "2023-05-10", "authors": "Bora Gizem, \u00d6nel Tu\u011f\u00e7e, Y\u0131ld\u0131r\u0131m Ecem, Yaba Aylin", "evidence": [ { "database": "RefSeq", "id": "NP_035196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196" } ], "reference": [ { "type": "PubMed", "id": "37162693", "url": "https://glygen.org/publication/PubMed/37162693" } ] }, { "title": "Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2023-10-03", "authors": "Millius Arthur, Yamada Rikuhiro G, Fujishima Hiroshi, Maeda Kazuhiko, Standley Daron M, Sumiyama Kenta, Perrin Dimitri, Ueda Hiroki R", "evidence": [ { "database": "RefSeq", "id": "NP_035196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035196" } ], "reference": [ { "type": "PubMed", "id": "37769257", "url": "https://glygen.org/publication/PubMed/37769257" } ] }, { "title": "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.", "journal": "Neuron", "date": "1997", "authors": "Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr, Reppert SM", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "9427249", "url": "https://glygen.org/publication/PubMed/9427249" } ] }, { "title": "A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.", "journal": "Cell", "date": "1997", "authors": "Albrecht U, Sun ZS, Eichele G, Lee CC", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "reference": [ { "type": "PubMed", "id": "9428527", "url": "https://glygen.org/publication/PubMed/9428527" } ] }, { "title": "Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription.", "journal": "Neuron", "date": "1998", "authors": "Shimomura K., Takahashi J.S., Gekakis N., King D.P., Staknis D., Weitz C.J., Sangoram A.M., Young M.W., Antoch M.P., Saez L., Fruechte E.M., Vitaterna M.H., Whiteley A.", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": 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"length": 1257 }, "evidence": [ { "id": "45225370", "url": "http://www.informatics.jax.org/homology/45225370", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "pre-mRNA binding", "id": "GO:0036002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036002", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "histone 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"RNA polymerase binding", "id": "GO:0070063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070063", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "nuclear receptor binding", "id": "GO:0016922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016922", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "histone methyltransferase binding", "id": "GO:1990226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990226", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "transcription corepressor binding", "id": "GO:0001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001222", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "negative regulation of fat cell proliferation", "id": "GO:0070345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070345", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "negative regulation of termination of DNA-templated transcription", "id": "GO:0060567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060567", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "response to ischemia", "id": "GO:0002931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002931", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "white fat cell differentiation", "id": "GO:0050872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050872", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "regulation of vasoconstriction", "id": "GO:0019229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019229", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "gluconeogenesis", "id": "GO:0006094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006094", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "regulation of insulin secretion", "id": "GO:0050796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050796", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "circadian rhythm", "id": "GO:0007623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "regulation of circadian rhythm", "id": "GO:0042752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042752", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "glycogen biosynthetic process", "id": "GO:0005978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005978", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": "https://www.uniprot.org/uniprot/O54943" } ], "pmid": "" }, { "name": "negative regulation of protein ubiquitination", "id": "GO:0031397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "evidence": [ { "database": "UniProtKB", "id": "O54943", "url": 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