{ "uniprot_canonical_ac": "O54826-1", "uniprot_ac": "O54826", "uniprot_id": "AF10_MOUSE", "mass": { "chemical_mass": 113029.0, "monoisotopic_mass": 113029.0 }, "refseq": { "ac": "NP_001239490", "name": "protein AF-10 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, "gene_names": [ { "name": "Mllt10", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O54826", "id": "O54826" }, { "name": "Af10; B130021D15Rik; D630001B22Rik; mKIAA4140", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490", "id": "NP_001239490" }, { "name": "Af10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O54826", "id": "O54826" }, { "name": "Mllt10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490", "id": "NP_001239490" } ], "protein_names": [ { "name": "Protein AF-10", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O54826" }, { "name": "protein AF-10 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489", "id": "NP_001239489" }, { "name": "protein AF-10 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490", "id": "NP_001239490" }, { "name": "protein AF-10; myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489", "id": "NP_001239489" } ], "function": [ { "annotation": "Conclude that Mllt10/Af10-Dot1l are essential, largely dedicated activators of Wnt-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis Erratum:[PLoS Biol. 2017 Feb 7;15(2):e1002596. PMID: 28170393] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "PubMed", "id": "21103407", "url": "https://glygen.org/publication/PubMed/21103407" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ] }, { "annotation": "Further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "PubMed", "id": "21681188", "url": "https://glygen.org/publication/PubMed/21681188" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ] }, { "annotation": "In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT.", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "PubMed", "id": "30102091", "url": "https://glygen.org/publication/PubMed/30102091" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ] }, { "annotation": "Probably involved in transcriptional regulation. Binds to cruciform DNA (By similarity). In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826#function" }, { "database": "UniProtKB", "id": "P55197", "url": "https://www.uniprot.org/uniprot/P55197#function" } ] }, { "annotation": "The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "PubMed", "id": "37082953", "url": "https://glygen.org/publication/PubMed/37082953" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ] }, { "annotation": "The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "PubMed", "id": "34226546", "url": "https://glygen.org/publication/PubMed/34226546" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ] }, { "annotation": "Together these data are the first to demonstrate that Af10-dependent H3K79me is essential for development of nasal processes and adjacent tissues, and consequent midfacial formation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "PubMed", "id": "28931923", "url": "https://glygen.org/publication/PubMed/28931923" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ] } ], "disease": [ { "disease_id": "DOID:8864", "recommended_name": { "id": "DOID:8864", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8864", "name": "acute monocytic leukemia", "description": "A monocytic leukemia where the majority of monocytic cells are promonocytes." }, "synonyms": [ { "id": "DOID:8864", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8864", "name": "acute Monoblastic Leukemia and acute Monocytic Leukemia", "description": "" }, { "id": "DOID:8864", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8864", "name": "acute monocytic leukaemia without mention of remission", "description": "" }, { "id": "DOID:8864", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8864", "name": "acute monocytic leukaemia", "description": "" }, { "id": "DOID:8864", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8864", "name": "acute monocytic leukemia, FAB M5", "description": "" }, { "id": "DOID:8864", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8864", "name": "acute monocytic leukemia, morphology", "description": "" }, { "id": "DOID:8864", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8864", "name": "acute monocytic leukemia without mention of remission", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukemia", "description": "Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11)." }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "monocytic leukaemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "monocytic leukemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "AML M5", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monoblastic leukaemia and acute monocytic leukaemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monoblastic leukemia and acute monocytic leukemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukaemia (FAB M5B)", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukaemia (FAB M5b)", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukaemia without mention of remission", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukemia (FAB M5B)", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukemia (FAB M5b)", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukemia without mention of remission", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukemia, FAB M5", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukemia, morphology", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monocytic leukemia, morphology (morphologic abnormality)", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "leukemia, monocytic, malignant", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "monocytic leukemia, acute", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "AML-M5", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monoblastic leukaemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monoblastic leukemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monoblastic/monocytic leukaemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute monoblastic/monocytic leukemia", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute myeloblastic leukaemia type 5", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "acute myeloblastic leukemia type 5", "description": "" }, { "id": "MONDO:0007896", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007896", "name": "leukemia, acute monocytic", "description": "" } ], "evidence": [ { "id": "8864", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8864" } ] }, { "disease_id": "DOID:9119", "recommended_name": { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells." }, "synonyms": [ { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "AML - acute Myeloid Leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "Leukemia, Myelocytic, acute", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections." }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML - acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML - acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "ANLL", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute Nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute Nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemias", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, reduced survival in, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, myelocytic, acute", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "myeloid leukemia, acute", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "myeloid leukemia, acute, M4/M4Eo subtype, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myelogenous", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, susceptibility to", "description": "" }, { "id": "MIM:601626", "resource": "MIM", "url": "https://www.omim.org/entry/601626", "name": "Leukemia, acute myelogenous", "description": "Leukemia, acute myelogenous" } ], "evidence": [ { "id": "9119", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ] } ], "snv": [ { "evidence": [ { "id": "rs222352592", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs222352592" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 384, "end_pos": 384, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SDS->NDS).", "chr_id": "2", "chr_pos": "18167227", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S384", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mllt10", "url": "https://www.uniprot.org/uniprot/O54826", "locus": { "chromosome": "2", "start_pos": 18217199, "end_pos": 18060048, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000026743", "url": "https://www.ensembl.org/id/ENSMUSG00000026743" } ] } } ], "crossref": [ { "id": "ENSMUSG00000026743", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026743", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15574", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15574", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15708", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15708", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20901", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20901", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "17354", "url": "https://www.ncbi.nlm.nih.gov/gene/17354", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O54826", "url": "https://www.ebi.ac.uk/intact/interactors/id:O54826*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:17354", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17354", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1329038", "url": "http://www.informatics.jax.org/marker/MGI:1329038", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "O54826", "url": "https://oglcnac.org/atlas/detail/O54826", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O54826", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O54826", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "XFSELLN", "url": "https://omabrowser.org/oma/group/XFSELLN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13831", "url": "http://pfam.xfam.org/family/PF13831", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13832", "url": "http://pfam.xfam.org/family/PF13832", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O54826", "url": "http://purl.obolibrary.org/obo/PR_O54826", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A2AS70", "url": "https://www.uniprot.org/uniprot/A2AS70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AS70-1", "url": "https://www.uniprot.org/uniprot/A2AS70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AS72", "url": "https://www.uniprot.org/uniprot/A2AS72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AS72-1", "url": "https://www.uniprot.org/uniprot/A2AS72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O54826-1", "url": "https://www.uniprot.org/uniprot/O54826-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYEQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDVSEARGSEGKGKKSSAHSSGQRGRKPGAGRNPGTAVSASSPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRSDSYTHTQQPSSTKDVHKGESGSQEAAVNSFSSLVGHPVTSTVISQPKSFDNSPGELGSSSLPTAGYKRAQTSGIEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTVSGSSLSQAPAHMYGSRLNQNPSMAVLIAQSESSQTDQDLGDNARSLGGRGSSPRGSLSPRSPVSNLQLRYDQPSNSSLETVPPVAASIEQLLERQWSEGQQFLLEQGTPGDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQMHTYTAQTAPPPDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQSSGVSGVQQVNGVTVGALASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFIQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQLQLPGPTQIPINNLLAGAQAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS", "length": 1068, "header": "sp|O54826-1|AF10_MOUSE Isoform 1 of Protein AF-10 OS=Mus musculus OX=10090 GN=Mllt10 PE=1 SV=2 CANONICAL=O54826-1" }, "isoforms": [ { "isoform_ac": "A2AS70-1", "url": "", "sequence": { "sequence": "MKRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYEQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDVSEARGSEGKGKKSSAHSSGQRGRKPGAGRNPGTAVSASSPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRSDSYTHTQQPSSTKDVHKGESGSQEAAVNSFSSLVGHPVTSTVISQPKSFDNSPGELGSSSLPTAGYKRAQTSGIEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTVSGSSLSQAPAHMYGSRLNQNPSMAVLIAQSESSQTDQDLGDNARSLGGRGSSPRGSLSPRSPVSNLQLRYDQPSNSSLETVPPVAASIEQLLERQWSEGQQFLLEQGTPGDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQMHTYTAQTAPPPDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQSSGVSGVQQVNGVTVGALASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFIQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQLQLPGPTQIPINNLLAGAQAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS", "length": 990, "header": "tr|A2AS70-1|A2AS70_MOUSE Computationally mapped isoform of Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 OS=Mus musculus OX=10090 GN=Mllt10 PE=1 SV=1 CANONICAL=O54826-1" }, "locus": { "chromosome": "2", "start_pos": 18215620, "end_pos": 18097640, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114671.8", "url": "https://www.ensembl.org/id/ENSMUST00000114671.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110319.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110319.2" } ] } }, { "isoform_ac": "A2AS72-1", "url": "", "sequence": { "sequence": "MQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTVSGSSLSQAPAHMYGSRLNQNPSMAVLIAQSESSQTDQDLGDNARSLGGRGSSPRGSLSPRSPVSNLQLRYDQPSNSSLETVPPVAASIEQLLERQWSEGQQFLLEQGTPGDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQMHTYTAQTAPPPDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQSSGVSGVQQVNGVTVGALASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFIQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQLQLPGPTQIPINNLLAGAQAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS", "length": 525, "header": "tr|A2AS72-1|A2AS72_MOUSE Computationally mapped isoform of Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 OS=Mus musculus OX=10090 GN=Mllt10 PE=1 SV=1 CANONICAL=O54826-1" }, "locus": { "chromosome": "2", "start_pos": 18215620, "end_pos": 18175073, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114669.2", "url": "https://www.ensembl.org/id/ENSMUST00000114669.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110317.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110317.2" } ] } }, { "isoform_ac": "O54826-1", "url": "", "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYEQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDVSEARGSEGKGKKSSAHSSGQRGRKPGAGRNPGTAVSASSPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRSDSYTHTQQPSSTKDVHKGESGSQEAAVNSFSSLVGHPVTSTVISQPKSFDNSPGELGSSSLPTAGYKRAQTSGIEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTVSGSSLSQAPAHMYGSRLNQNPSMAVLIAQSESSQTDQDLGDNARSLGGRGSSPRGSLSPRSPVSNLQLRYDQPSNSSLETVPPVAASIEQLLERQWSEGQQFLLEQGTPGDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQMHTYTAQTAPPPDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQSSGVSGVQQVNGVTVGALASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFIQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQLQLPGPTQIPINNLLAGAQAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS", "length": 1068, "header": "sp|O54826-1|AF10_MOUSE Isoform 1 of Protein AF-10 OS=Mus musculus OX=10090 GN=Mllt10 PE=1 SV=2 CANONICAL=O54826-1" }, "locus": { "chromosome": "2", "start_pos": 18215620, "end_pos": 18069846, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000028076", "url": "https://www.ensembl.org/id/ENSMUST00000028076" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000028076", "url": "https://www.ensembl.org/id/ENSMUSP00000028076" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 266, "start_aa": "Thr", "end_pos": 266, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr266", "evidence": [ { "id": "O54826", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O54826" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 269, "start_aa": "Ser", "end_pos": 269, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser269", "evidence": [ { "id": "O54826", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O54826" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 271, "start_aa": "Ser", "end_pos": 271, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser271", "evidence": [ { "id": "O54826", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O54826" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 340, "start_aa": "Thr", "end_pos": 340, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr340", "evidence": [ { "id": "O54826", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O54826" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 343, "start_aa": "Ser", "end_pos": 343, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser343", "evidence": [ { "id": "O54826", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O54826" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 496, "start_aa": "Ser", "end_pos": 496, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser496", "evidence": [ { "id": "O54826", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O54826" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 503, "start_aa": "Ser", "end_pos": 503, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser503", "evidence": [ { "id": "O54826", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O54826" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] } ], "phosphorylation": [ { "start_pos": 217, "end_pos": 217, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" } ], "site_lbl": "Ser217" }, { "start_pos": 252, "end_pos": 252, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" } ], "site_lbl": "Ser252" }, { "start_pos": 436, "end_pos": 436, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O54826", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54826" } ], "site_lbl": "Ser436" }, { "start_pos": 532, "end_pos": 532, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O54826", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54826" } ], "site_lbl": "Ser532" }, { "start_pos": 686, "end_pos": 686, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O54826", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54826" } ], "site_lbl": "Ser686" }, { "start_pos": 688, "end_pos": 688, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O54826", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54826" } ], "site_lbl": "Ser688" }, { "start_pos": 691, "end_pos": 691, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O54826", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54826" } ], "site_lbl": "Ser691" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis.", "journal": "PLoS biology", "date": "2010", "authors": "Mahmoudi T, Boj SF, Hatzis P, Li VS, Taouatas N, Vries RG, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJ, Clevers H", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ], "reference": [ { "type": "PubMed", "id": "21103407", "url": "https://glygen.org/publication/PubMed/21103407" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O54826", "url": "https://www.uniprot.org/uniprot/O54826" }, { "database": "iPTMnet", "id": "O54826", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O54826" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice.", "journal": "Leukemia", "date": "2011", "authors": "Deshpande AJ, Rouhi A, Lin Y, Stadler C, Greif PA, Arseni N, Opatz S, Quintanilla-Fend L, Holzmann K, Hiddemann W, Dohner K, Dohner H, Xu G, Armstrong SA, Bohlander SK, Buske C", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ], "reference": [ { "type": "PubMed", "id": "21681188", "url": "https://glygen.org/publication/PubMed/21681188" } ] }, { "title": "Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development.", "journal": "Scientific reports", "date": "2017", "authors": "Ogoh H, Yamagata K, Nakao T, Sandell LL, Yamamoto A, Yamashita A, Tanga N, Suzuki M, Abe T, Kitabayashi I, Watanabe T, Sakai D", "evidence": [ { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" }, { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" } ], "reference": [ { "type": "PubMed", "id": "28931923", "url": "https://glygen.org/publication/PubMed/28931923" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O54826", "url": "https://oglcnac.org/atlas/detail/O54826" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "MLLT10 promotes tumor migration, invasion, and metastasis in human colorectal cancer.", "journal": "Scandinavian journal of gastroenterology", "date": "2018", "authors": "Jing X, Wu H, Cheng X, Chen X, Zhang Y, Shi M, Zhang T, Wang X, Zhao R", "evidence": [ { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" }, { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" } ], "reference": [ { "type": "PubMed", "id": "30102091", "url": "https://glygen.org/publication/PubMed/30102091" } ] }, { "title": "The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.", "journal": "Nature communications", "date": "2021", "authors": "Klein BJ, Deshpande A, Cox KL, Xuan F, Zandian M, Barbosa K, Khanal S, Tong Q, Zhang Y, Zhang P, Sinha A, Bohlander SK, Shi X, Wen H, Poirier MG, Deshpande AJ, Kutateladze TG", "evidence": [ { "database": "RefSeq", "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489" }, { "database": "RefSeq", "id": "NP_001239490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239490" } ], "reference": [ { "type": "PubMed", "id": "34226546", "url": "https://glygen.org/publication/PubMed/34226546" } ] }, { "title": "Chemoproteomic and Transcriptomic Analysis Reveals that O-GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2023-02-27", "authors": "Hao Yi, Li Xiang, Qin Ke, Shi Yujie, He Yanwen, Zhang Che, Cheng Bo, Zhang Xiwen, Hu Guangyu, Liang Shuyu, Tang Qi, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "O54826", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O54826" } ], "reference": [ { "type": "PubMed", "id": "36852467", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "title": "The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.", "journal": "Development (Cambridge, England)", "date": "2023-04-21", "authors": "Lin Huijuan, Cossu Isabella G, Leu N Adrian, Deshpande Aniruddha J, Bernt Kathrin M, Luo Mengcheng, Wang P Jeremy", 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