{ "uniprot_canonical_ac": "O43597-1", "uniprot_ac": "O43597", "uniprot_id": "SPY2_HUMAN", "mass": { "chemical_mass": 34688.0, "monoisotopic_mass": 34688.0 }, "refseq": { "ac": "NP_001305465", "name": "protein sprouty homolog 2", "summary": "This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465" }, "gene_names": [ { "name": "SPRY2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43597", "id": "O43597" }, { "name": "SPRY2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465", "id": "NP_001305465" }, { "name": "hSPRY2; IGAN3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465", "id": "NP_001305465" } ], "protein_names": [ { "name": "Protein sprouty homolog 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43597" }, { "name": "Spry-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43597" }, { "name": "protein sprouty homolog 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465", "id": "NP_001305465" } ], "function": [ { "annotation": "Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561).", "evidence": [ { "database": "UniProtKB", "id": "O43597", "url": "https://www.uniprot.org/uniprot/O43597#function" }, { "database": "PubMed", "id": "17974561", "url": "https://glygen.org/publication/PubMed/17974561" }, { "database": "UniProtKB", "id": "Q9QXV8", "url": "https://www.uniprot.org/uniprot/Q9QXV8#function" } ] }, { "annotation": "Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001305465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465" }, { "database": "PubMed", "id": "34685612", "url": "https://glygen.org/publication/PubMed/34685612" } ] }, { "annotation": "Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001305465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465" }, { "database": "PubMed", "id": "37507768", "url": "https://glygen.org/publication/PubMed/37507768" } ] }, { "annotation": "MicroRNA-124 facilitates lens epithelial cell apoptosis by inhibiting SPRY2 and MMP-2.", "evidence": [ { "database": "RefSeq", "id": "NP_001305465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465" }, { "database": "PubMed", "id": "33760112", "url": "https://glygen.org/publication/PubMed/33760112" } ] }, { "annotation": "SNHG12 regulates biological behaviors of ox-LDL-induced HA-VSMCs through upregulation of SPRY2 and NUB1.", "evidence": [ { "database": "RefSeq", "id": "NP_001305465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465" }, { "database": "PubMed", "id": "34847450", "url": "https://glygen.org/publication/PubMed/34847450" } ] }, { "annotation": "Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001305465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465" }, { "database": "PubMed", "id": "33684096", "url": "https://glygen.org/publication/PubMed/33684096" } ] }, { "annotation": "This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001305465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305465" } ] } ], "disease": [ { "disease_id": "MONDO:0014786", "recommended_name": { "id": "MONDO:0014786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014786", "name": "IgA nephropathy, susceptibility to, 3", "description": "Any IgA glomerulonephritis in which the cause of the disease is a mutation in the SPRY2 gene." }, "synonyms": [ { "id": "MONDO:0014786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014786", "name": "IGAN3", "description": "" }, { "id": "MONDO:0014786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014786", "name": "IgA glomerulonephritis caused by mutation in SPRY2", "description": "" }, { "id": "MONDO:0014786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014786", "name": "IgA nephropathy, susceptibility to, 3", "description": "" }, { "id": "MONDO:0014786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014786", "name": "IgA nephropathy, susceptibility to, 3; IGAN3", "description": "" }, { "id": "MONDO:0014786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014786", "name": "IgA nephropathy, susceptibility to, type 3", "description": "" }, { "id": "MONDO:0014786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014786", "name": "SPRY2 IgA glomerulonephritis", "description": "" }, { "id": "MONDO:0014786", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014786", "name": "susceptibility to IgA nephropathy 3", "description": "" }, { "id": "MIM:616818", "resource": "MIM", "url": "https://www.omim.org/entry/616818", "name": "IgA nephropathy 3", "description": "IgA nephropathy 3" } ], "evidence": [ { "id": "616818", "database": "MIM", "url": "https://www.omim.org/entry/616818" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 115, "end_pos": 115, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes interaction with GRB2.", "evidence": [ { "database": "UniProtKB", "id": "O43597", "url": "https://www.uniprot.org/uniprot/O43597" }, { "database": "PubMed", "id": "17974561", "url": "https://glygen.org/publication/PubMed/17974561" } ] }, { "start_pos": 144, "end_pos": 144, "sequence_org": "P", "sequence_mut": "L", "comment": "Inhibits cleavage by the prolyl endopeptidase FAP.", "evidence": [ { "database": "UniProtKB", "id": "O43597", "url": "https://www.uniprot.org/uniprot/O43597" }, { "database": "PubMed", "id": "21288888", "url": "https://glygen.org/publication/PubMed/21288888" } ] }, { "start_pos": 252, "end_pos": 252, "sequence_org": "R", "sequence_mut": "D", "comment": "Abolishes interaction with CAV1.", "evidence": [ { "database": "UniProtKB", "id": "O43597", "url": "https://www.uniprot.org/uniprot/O43597" }, { "database": "PubMed", "id": "16877379", "url": "https://glygen.org/publication/PubMed/16877379" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "82.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "80.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "88.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "77.2", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "95.62", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "92.92", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "94.92", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "89.64", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "89.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "90.09", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "87.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "88.38", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.57", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000136158", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000136158" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O43597", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43597" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial 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hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O43597", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43597" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O43597", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43597" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O43597", "url": 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"PRO", "id": "O43597", "url": "http://purl.obolibrary.org/obo/O43597" }, { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "19864419", "url": "https://glygen.org/publication/PubMed/19864419" } ], "site_lbl": "Ser112" }, { "start_pos": 115, "end_pos": 115, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "PRO", "id": "O43597", "url": "http://purl.obolibrary.org/obo/O43597" }, { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" } ], "site_lbl": "Ser115" }, { "start_pos": 121, "end_pos": 121, "kinase_uniprot_canonical_ac": "Q9BUB5-1", "kinase_gene_name": "MKNK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "19864419", "url": "https://glygen.org/publication/PubMed/19864419" } ], "site_lbl": "Ser121" }, { "start_pos": 121, "end_pos": 121, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "PRO", "id": "O43597", "url": "http://purl.obolibrary.org/obo/O43597" }, { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "19864419", "url": "https://glygen.org/publication/PubMed/19864419" }, { "database": "PubMed", "id": "29635363", "url": "https://glygen.org/publication/PubMed/29635363" } ], "site_lbl": "Ser121" }, { "start_pos": 139, "end_pos": 139, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "18578522", "url": "https://glygen.org/publication/PubMed/18578522" } ], "site_lbl": "Ser139" }, { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O43597", "url": "http://phospho.elm.eu.org/byAccession/O43597.html" }, { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "15637081", "url": "https://glygen.org/publication/PubMed/15637081" }, { "database": "PRO", "id": "O43597", "url": "http://purl.obolibrary.org/obo/O43597" }, { "database": "PubMed", "id": "16888801", "url": "https://glygen.org/publication/PubMed/16888801" } ], "site_lbl": "Tyr227" }, { "start_pos": 55, "end_pos": 55, "kinase_uniprot_canonical_ac": "P12931-1", "kinase_gene_name": "SRC", "residue": "Tyr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O43597", "url": "http://phospho.elm.eu.org/byAccession/O43597.html" }, { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "15564375", "url": "https://glygen.org/publication/PubMed/15564375" } ], "site_lbl": "Tyr55" }, { "start_pos": 55, "end_pos": 55, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "IntAct", "id": "O43597", "url": "https://www.ebi.ac.uk/intact/interactors/id:O43597*" }, { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "12815057", "url": "https://glygen.org/publication/PubMed/12815057" }, { "database": "phospho.ELM", "id": "O43597", "url": "http://phospho.elm.eu.org/byAccession/O43597.html" }, { "database": "PubMed", "id": "12593795", "url": "https://glygen.org/publication/PubMed/12593795" }, { "database": "PubMed", "id": "15637081", "url": "https://glygen.org/publication/PubMed/15637081" }, { "database": "PubMed", "id": "16000370", "url": "https://glygen.org/publication/PubMed/16000370" }, { "database": "PRO", "id": "O43597", "url": "http://purl.obolibrary.org/obo/O43597" }, { "database": "PubMed", "id": "16888801", "url": "https://glygen.org/publication/PubMed/16888801" }, { "database": "PubMed", "id": "20622121", "url": "https://glygen.org/publication/PubMed/20622121" }, { "database": "PubMed", "id": "30160357", "url": "https://glygen.org/publication/PubMed/30160357" } ], "site_lbl": "Tyr55" }, { "start_pos": 56, "end_pos": 56, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "20877636", "url": "https://glygen.org/publication/PubMed/20877636" } ], "site_lbl": "Thr56" }, { "start_pos": 75, "end_pos": 75, "kinase_uniprot_canonical_ac": "Q13627-1", "kinase_gene_name": "DYRK1A", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" }, { "database": "PubMed", "id": "18678649", "url": "https://glygen.org/publication/PubMed/18678649" }, { "database": "phospho.ELM", "id": "O43597", "url": "http://phospho.elm.eu.org/byAccession/O43597.html" } ], "site_lbl": "Thr75" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.", "journal": "Science (New York, N.Y.)", "date": "1999", "authors": "Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "10514377", "url": "https://glygen.org/publication/PubMed/10514377" } ] }, { "title": "Mapping of Eps15 domains involved in its targeting to clathrin-coated pits.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Benmerah A, Poupon V, Cerf-Bensussan N, Dautry-Varsat A", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "10652316", "url": "https://glygen.org/publication/PubMed/10652316" } ] }, { "title": "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Lim J, Wong ES, Ong SH, Yusoff P, Low BC, Guy GR", "evidence": [ { "database": "UniProtKB", "id": "O43597", "url": "https://www.uniprot.org/uniprot/O43597" }, { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "10887178", "url": "https://glygen.org/publication/PubMed/10887178" } ] }, { "title": "Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis.", "journal": "The Journal of cell biology", "date": "2000", "authors": "Confalonieri S, Salcini AE, Puri C, Tacchetti C, Di Fiore PP", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "10953014", "url": "https://glygen.org/publication/PubMed/10953014" } ] }, { "title": "Evidence for direct interaction between Sprouty and Cbl.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Wong ES, Lim J, Low BC, Chen Q, Guy GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "11053437", "url": "https://glygen.org/publication/PubMed/11053437" } ] }, { "title": "Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells.", "journal": "The Journal of cell biology", "date": "2001", "authors": "Impagnatiello MA, Weitzer S, Gannon G, Compagni A, Cotten M, Christofori G", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "11238463", "url": "https://glygen.org/publication/PubMed/11238463" } ] }, { "title": "The C terminus of sprouty is important for modulation of cellular migration and proliferation.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Yigzaw Y, Cartin L, Pierre S, Scholich K, Patel TB", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "11279012", "url": "https://glygen.org/publication/PubMed/11279012" } ] }, { "title": "Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Yusoff P, Lao DH, Ong SH, Wong ES, Lim J, Lo TL, Leong HF, Fong CW, Guy GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "11698404", "url": "https://glygen.org/publication/PubMed/11698404" } ] }, { "title": "A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.", "journal": "The EMBO journal", "date": "2002", "authors": "Waterman H, Katz M, Rubin C, Shtiegman K, Lavi S, Elson A, Jovin T, Yarden Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "11823423", "url": "https://glygen.org/publication/PubMed/11823423" } ] }, { "title": "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.", "journal": "Nature", "date": "2002", "authors": "Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "11894095", "url": "https://glygen.org/publication/PubMed/11894095" } ] }, { "title": "A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Klapisz E, Sorokina I, Lemeer S, Pijnenburg M, Verkleij AJ, van Bergen en Henegouwen PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "12072436", "url": "https://glygen.org/publication/PubMed/12072436" } ] }, { "title": "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Haglund K, Shimokawa N, Szymkiewicz I, Dikic I", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "12218189", "url": "https://glygen.org/publication/PubMed/12218189" } ] }, { "title": "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.", "journal": "The EMBO journal", "date": "2002", "authors": "Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "12234920", "url": "https://glygen.org/publication/PubMed/12234920" } ] }, { "title": "The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Lim J, Yusoff P, Wong ES, Chandramouli S, Lao DH, Fong CW, Guy GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "12391162", "url": "https://glygen.org/publication/PubMed/12391162" } ] }, { "title": "Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops.", "journal": "Current biology : CB", "date": "2003", "authors": "Rubin C, Litvak V, Medvedovsky H, Zwang Y, Lev S, Yarden Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" }, { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" } ], "reference": [ { "type": "PubMed", "id": "12593795", "url": "https://glygen.org/publication/PubMed/12593795" } ] }, { "title": "hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.", "journal": "Current biology : CB", "date": "2003", "authors": "Hall AB, Jura N, DaSilva J, Jang YJ, Gong D, Bar-Sagi D", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "12593796", "url": "https://glygen.org/publication/PubMed/12593796" } ] }, { "title": "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.", "journal": "Nat. Cell Biol.", "date": "2003", "authors": "Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A", "evidence": [ { "database": "UniProtKB", "id": "O43597", "url": "https://www.uniprot.org/uniprot/O43597" } ], "reference": [ { "type": "PubMed", "id": "12717443", "url": "https://glygen.org/publication/PubMed/12717443" } ] }, { "title": "Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Fong CW, Leong HF, Wong ES, Lim J, Yusoff P, Guy GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" }, { "database": "iPTMnet", "id": "O43597", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43597" } ], "reference": [ { "type": "PubMed", "id": "12815057", "url": "https://glygen.org/publication/PubMed/12815057" } ] }, { "title": "Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation.", "journal": "Cell", "date": "2003", "authors": "Wu WJ, Tu S, Cerione RA", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "14505571", "url": "https://glygen.org/publication/PubMed/14505571" } ] }, { "title": "Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Huang F, Khvorova A, Marshall W, Sorkin A", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "14985334", "url": "https://glygen.org/publication/PubMed/14985334" } ] }, { "title": "Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop.", "journal": "Molecular biology of the cell", "date": "2004", "authors": "Mason JM, Morrison DJ, Bassit B, Dimri M, Band H, Licht JD, Gross I", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "15004239", "url": "https://glygen.org/publication/PubMed/15004239" } ] }, { "title": "Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases.", "journal": "Oncogene", "date": "2004", "authors": "Marmor MD, Yarden Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "15021893", "url": "https://glygen.org/publication/PubMed/15021893" } ] }, { "title": "Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Hanafusa H, Torii S, Yasunaga T, Matsumoto K, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1295596" } ], "reference": [ { "type": "PubMed", "id": "15031289", "url": "https://glygen.org/publication/PubMed/15031289" } ] }, { "title": "Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kassenbrock CK, Anderson SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-182971" } ], "reference": [ { "type": "PubMed", "id": "15117950", "url": "https://glygen.org/publication/PubMed/15117950" } ] }, { "title": "Ubiquitin ligase activity of c-Cbl guides the 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