{ "uniprot_canonical_ac": "O43298-1", "uniprot_ac": "O43298", "uniprot_id": "ZBT43_HUMAN", "mass": { "chemical_mass": 52630.0, "monoisotopic_mass": 52630.0 }, "refseq": { "ac": "NP_001129248", "name": "zinc finger and BTB domain-containing protein 43", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129248" }, "gene_names": [ { "name": "ZBTB43", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43298", "id": "O43298" }, { "name": "KIAA0414", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43298", "id": "O43298" }, { "name": "ZBTB22B; ZNF-X; ZNF297B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129248", "id": "NP_001129248" }, { "name": "ZBTB22B", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43298", "id": "O43298" }, { "name": "ZBTB43", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129248", "id": "NP_001129248" }, { "name": "ZNF297B", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43298", "id": "O43298" } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 43", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43298" }, { "name": "Zinc finger and BTB domain-containing protein 22B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43298" }, { "name": "Zinc finger protein 297B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43298" }, { "name": "ZnF-x", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43298" }, { "name": "zinc finger and BTB domain-containing protein 43", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129248", "id": "NP_001129248" }, { "name": "zinc finger protein 297B; zinc finger and BTB domain-containing protein 22B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129248", "id": "NP_001129248" } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298#function" } ] }, { "annotation": "Observational study and genome-wide association study of gene-disease association. 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"0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "75.43", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "79.36", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "78.25", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "79.71", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "69.67", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "76.91", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "76.33", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "71.81", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "81.59", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "75.15", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000169155", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000169155" } ] }, { "tissue": { "name": "Thoracic mammary 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"description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" 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"isoform_ac": "Q5JU97-1", "url": "", "sequence": { "sequence": "MEPGTNSFRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSSYNGLVESFELGSGGHTDFPKAQELRDGENEEESTKDELSSQLTEHEYL", "length": 195, "header": "tr|Q5JU97-1|Q5JU97_HUMAN Computationally mapped isoform of Zinc finger and BTB domain containing 43 OS=Homo sapiens OX=9606 GN=ZBTB43 PE=1 SV=8 CANONICAL=O43298-1" }, "locus": { "chromosome": "9", "start_pos": 126833094, "end_pos": 126832510, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000450858.1", "url": "https://www.ensembl.org/id/ENST00000450858.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000412145.1", "url": "https://www.ensembl.org/id/ENSP00000412145.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 423, "end_pos": 423, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O43298", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43298" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr423" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB.", "journal": "Biol. Chem.", "date": "2006", "authors": "Schoenen F, Wirth B", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" } ], "reference": [ { "type": "PubMed", "id": "16542149", "url": "https://glygen.org/publication/PubMed/16542149" } ] }, { "title": "Detecting rare variants for complex traits using family and unrelated data.", "journal": "Genetic epidemiology", "date": "2010", "authors": "Zhu X, Feng T, Li Y, Lu Q, Elston RC", "evidence": [ { "database": "RefSeq", "id": "NP_001129248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129248" } ], "reference": [ { "type": "PubMed", "id": "19847924", "url": "https://glygen.org/publication/PubMed/19847924" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O43298", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43298" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" }, { "database": "iPTMnet", "id": "O43298", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43298" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Uncovering global SUMOylation signaling networks in a site-specific manner.", "journal": "Nat. Struct. Mol. Biol.", "date": "2014", "authors": "Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" } ], "reference": [ { "type": "PubMed", "id": "25218447", "url": "https://glygen.org/publication/PubMed/25218447" } ] }, { "title": "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.", "journal": "Mol. Cell. Proteomics", "date": "2015", "authors": "Hendriks I.A., Olsen J.V., Vertegaal A.C., Chang J.G., Sigurdsson J.O., Xiao Z., Sigurethsson J.O.", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" } ], "reference": [ { "type": "PubMed", "id": "25755297", "url": "https://glygen.org/publication/PubMed/25755297" } ] } ], "pathway": [ { "id": "hsa:23099", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:23099", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AFN4-1", "protein_name": "Zinc finger and BTB domain containing 43", "gene_name": "Zbtb43", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPGTNSFQVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLFSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSNYNGLAESFELGSGGHTDFPKAQELRDGENEEESTKDELSSQVTEHEYLPSNSSTEHDRLSTEMASQDGEEGTNDSTEFHYTRPLYSKPSIMPHRRWIHVKPERLEQPWDGMDVHAAYDEHQVSESVNTMQTDHSAQPSGAEEEFQIVEKKVEVEFDEHAEGSNYDEQVDFYGSSMEEFSGEKLGGGLIGHKQETALAAGYSENIEMVMGIKEEASHLGFSATDKLYPCQCGKSFTHKSQRDRHMSMHLGLRPYGCSVCGKKFKMKHHLVGHMKIHTGIKPYECNICAKRFMWRDSFHRHVTSCTKSYEAAKAGQNTTEAN", "length": 467 }, "evidence": [ { "id": "45238377", "url": "http://www.informatics.jax.org/homology/45238377", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DAI4-1", "protein_name": "Zinc finger and BTB domain-containing protein 43", "gene_name": "Zbtb43", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPGTNSFQVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFQAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLFSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSNYNGLVESFELGSGGHTDFPKAQELRDGENEEESTKDELSSQVTEHEYLPSNSSTEHDRLSTEMASQDGEEGTNDSTEFHYTRPLYSKPSIMAHRRWIHVKPERLEQAWDGMDVHAAYDEHQVTESVNTMQTDHSAQPSGAEEEFQIVEKKVEVEFDEQAEGSSYDEQVDFYGSSMEEFSGEKLGGNLIGHKQEAALAAGYSENIEMAMGIKEEASHLGFSATDKLYPCQCGKSFTHKSQRDRHMSMHLGLRPYGCSVCGKKFKMKHHLVGHMKIHTGIKPYECNICAKRFMWRDSFHRHVTSCTKSYEAAKAEQNTTEAN", "length": 467 }, "evidence": [ { "id": "45238377", "url": "http://www.informatics.jax.org/homology/45238377", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O43298", "url": "https://www.uniprot.org/uniprot/O43298" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": 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