{
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"uniprot_ac": "O43255",
"uniprot_id": "SIAH2_HUMAN",
"mass": {
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"monoisotopic_mass": 34615.0
},
"refseq": {
"ac": "NP_005058",
"name": "E3 ubiquitin-protein ligase SIAH2",
"summary": "This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058"
},
"gene_names": [
{
"name": "SIAH2",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O43255",
"id": "O43255"
},
{
"name": "SIAH2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058",
"id": "NP_005058"
},
{
"name": "hSiah2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058",
"id": "NP_005058"
}
],
"protein_names": [
{
"name": "E3 ubiquitin-protein ligase SIAH2",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O43255"
},
{
"name": "2.3.2.27",
"resource": "UniProtKB",
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"url": "",
"id": "O43255"
},
{
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"resource": "RefSeq",
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"id": "NP_005058"
},
{
"name": "RING-type E3 ubiquitin transferase SIAH2",
"resource": "UniProtKB",
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"url": "",
"id": "O43255"
},
{
"name": "Seven in absentia homolog 2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O43255"
},
{
"name": "Siah-2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O43255"
},
{
"name": "hSiah2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O43255"
},
{
"name": "siah-2; seven in absentia homolog 2; RING-type E3 ubiquitin transferase SIAH2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058",
"id": "NP_005058"
}
],
"function": [
{
"annotation": "Decreased Expression of Programmed Death Ligand-L1 by Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell-Mediated Antitumor Activity. Erratum:[Front Immunol. 2022 Dec 08;13:1093403. PMID: 36591292] Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005058",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058"
},
{
"database": "PubMed",
"id": "35154166",
"url": "https://glygen.org/publication/PubMed/35154166"
}
]
},
{
"annotation": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.",
"evidence": [
{
"database": "UniProtKB",
"id": "C9J9D7",
"url": "https://www.uniprot.org/uniprot/C9J9D7#function"
},
{
"database": "UniProtKB",
"id": "RU201113",
"url": "https://www.uniprot.org/uniprot/RU201113#function"
},
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255#function"
},
{
"database": "PubMed",
"id": "12411493",
"url": "https://glygen.org/publication/PubMed/12411493"
},
{
"database": "PubMed",
"id": "11483518",
"url": "https://glygen.org/publication/PubMed/11483518"
},
{
"database": "PubMed",
"id": "22878263",
"url": "https://glygen.org/publication/PubMed/22878263"
},
{
"database": "PubMed",
"id": "9334332",
"url": "https://glygen.org/publication/PubMed/9334332"
},
{
"database": "UniProtKB",
"id": "Q06986",
"url": "https://www.uniprot.org/uniprot/Q06986#function"
},
{
"database": "PubMed",
"id": "26392558",
"url": "https://glygen.org/publication/PubMed/26392558"
},
{
"database": "PubMed",
"id": "28546513",
"url": "https://glygen.org/publication/PubMed/28546513"
},
{
"database": "PubMed",
"id": "19224863",
"url": "https://glygen.org/publication/PubMed/19224863"
}
]
},
{
"annotation": "Helicobacter pylori-induced gastric cancer is orchestrated by MRCKbeta-mediated Siah2 phosphorylation. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005058",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058"
},
{
"database": "PubMed",
"id": "33536006",
"url": "https://glygen.org/publication/PubMed/33536006"
}
]
},
{
"annotation": "SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005058",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058"
},
{
"database": "PubMed",
"id": "36155803",
"url": "https://glygen.org/publication/PubMed/36155803"
}
]
},
{
"annotation": "The role of Siah2 in tumorigenesis and cancer therapy. Review article",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005058",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058"
},
{
"database": "PubMed",
"id": "34687788",
"url": "https://glygen.org/publication/PubMed/34687788"
}
]
},
{
"annotation": "This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005058",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005058"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "O43255",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43255"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 279,
"end_pos": 279,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "T",
"sequence_mut": "M",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).",
"chr_id": "3",
"chr_pos": "150742280",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "T279",
"disease": [
{
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
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},
"synonyms": [
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
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"description": ""
},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
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"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
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},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
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},
{
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"resource": "MONDO",
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"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
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"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
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},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
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"description": ""
},
{
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"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
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}
]
},
{
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"url": "http://disease-ontology.org/term/DOID:9256",
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},
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},
{
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"description": ""
},
{
"id": "MONDO:0005575",
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"name": "cancer of large bowel",
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
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"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
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},
{
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},
{
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},
{
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
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},
{
"id": "MONDO:0005575",
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"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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"description": ""
},
{
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
},
{
"disease_id": "DOID:363",
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{
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{
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{
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{
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{
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{
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{
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}
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{
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{
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{
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{
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{
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{
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{
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},
{
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{
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{
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]
},
{
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{
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{
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]
}
],
"expression_tissue": [
{
"tissue": {
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"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "76.05",
"present": "MEDIUM",
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{
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
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]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
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"score": "84.88",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "85.21",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
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]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "84.19",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "88.33",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
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]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "86.42",
"present": "HIGH",
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{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
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},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "76.35",
"present": "MEDIUM",
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{
"database": "Bgee",
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "86.97",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
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"score": "77.06",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
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]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "77.71",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
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"score": "89.31",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "86.2",
"present": "HIGH",
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{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
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]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "84.04",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000181788",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000181788"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "down",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
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],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
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"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
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"synonyms": [
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},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:11054",
"recommended_name": {
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"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
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},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
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},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
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"name": "head and neck cancer",
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},
"synonyms": [
{
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"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
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},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
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"name": "head/neck neoplasm",
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},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
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"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "O43255",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43255"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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"date": "2002",
"authors": "Janes P.W., Ronai Z., Laine A., Bowtell D.D.L., Frew I.J., Habelhah H., Relaix F., Sassoon D.",
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"title": "Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss.",
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"date": "2003",
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"title": "U-box proteins as a new family of ubiquitin ligases.",
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"title": "Isolation and partial characterization of SAA-an amyloid-related protein from human serum.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
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"date": "2005",
"authors": "Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE",
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"date": "2014",
"authors": "Fan Y, Mao R, Yu Y, Liu S, Shi Z, Cheng J, Zhang H, An L, Zhao Y, Xu X, Chen Z, Kogiso M, Zhang D, Zhang H, Zhang P, Jung JU, Li X, Xu G, Yang J",
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"journal": "The Journal of biological chemistry",
"date": "2016",
"authors": "Noy PJ, Yang J, Reyat JS, Matthews AL, Charlton AE, Furmston J, Rogers DA, Rainger GE, Tomlinson MG",
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"date": "2016",
"authors": "Jouannet S, Saint-Pol J, Fernandez L, Nguyen V, Charrin S, Boucheix C, Brou C, Milhiet PE, Rubinstein E",
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"title": "Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies.",
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"title": "Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy.",
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"title": "The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling through mediating Wnt-induced Axin degradation.",
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"date": "2017",
"authors": "Ji L, Jiang B, Jiang X, Charlat O, Chen A, Mickanin C, Bauer A, Xu W, Yan X, Cong F",
"evidence": [
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"id": "O43255",
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"title": "Mutation in cystatin C gene causes hereditary brain haemorrhage.",
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"journal": "Proceedings of the National Academy of Sciences of the United States of America",
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"title": "An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.",
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"title": "Serum levels of beta 2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis.",
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"title": "Assignment of the human and mouse prion protein genes to homologous chromosomes.",
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"authors": "Sparkes RS, Simon M, Cohn VH, Fournier RE, Lem J, Klisak I, Heinzmann C, Blatt C, Lucero M, Mohandas T, et al.",
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"database": "Reactome",
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"title": "Variant apolipoprotein AI as a major constituent of a human hereditary amyloid.",
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"date": "2021",
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"title": "The role of Siah2 in tumorigenesis and cancer therapy.",
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"date": "2022",
"authors": "Zheng H, Zheng WJ, Wang ZG, Tao YP, Huang ZP, Yang L, Ouyang L, Duan ZQ, Zhang YN, Chen BN, Xiang DM, Jin G, Fang L, Zhou F, Liang B",
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"title": "SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination.",
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"date": "2022-10-14",
"authors": "Jeong Seo-Yeon, Hariharasudhan Gurusamy, Kim Min-Ji, Lim Ji-Yeon, Jung Sung Mi, Choi Eun-Ji, Chang In-Youb, Kee Younghoon, You Ho Jin, Lee Jung-Hee",
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"title": "Serum amyloid P component is the major calcium-dependent specific DNA binding protein of the serum.",
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"title": "Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T.",
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"id": "R-HSA-5689880",
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"title": "Binding of pentraxins to different nuclear structures: C-reactive protein binds to small nuclear ribonucleoprotein particles, serum amyloid P component binds to chromatin and nucleoli.",
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"title": "Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain.",
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"id": "R-HSA-977225",
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"title": "Structure of pentameric human serum amyloid P component.",
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"date": "1994",
"authors": "Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP",
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"title": "Pathogenic potential of human monoclonal immunoglobulin light chains: relationship of in vitro aggregation to in vivo organ deposition.",
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"id": "R-HSA-977225",
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"type": "PubMed",
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"title": "Human lysozyme gene mutations cause hereditary systemic amyloidosis.",
"journal": "Nature",
"date": "1993",
"authors": "Pepys MB, Hawkins PN, Booth DR, Vigushin DM, Tennent GA, Soutar AK, Totty N, Nguyen O, Blake CC, Terry CJ, et al.",
"evidence": [
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"database": "Reactome",
"id": "R-HSA-977225",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225"
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"type": "PubMed",
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"title": "The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.",
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"date": "1993",
"authors": "Jarrett JT, Berger EP, Lansbury PT Jr",
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"database": "Reactome",
"id": "R-HSA-977225",
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"type": "PubMed",
"id": "8490014",
"url": "https://glygen.org/publication/PubMed/8490014"
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]
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"title": "Localized amyloidosis of the seminal vesicle: identification of lactoferrin immunoreactivity in the amyloid material.",
"journal": "Pathology international",
"date": "1996",
"authors": "Tsutsumi Y, Serizawa A, Hori S",
"evidence": [
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"database": "Reactome",
"id": "R-HSA-977225",
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"type": "PubMed",
"id": "8870004",
"url": "https://glygen.org/publication/PubMed/8870004"
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]
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"title": "Prolactin-derived amyloid in the aging pituitary gland.",
"journal": "The American journal of pathology",
"date": "1997",
"authors": "Westermark P, Eriksson L, Engstrom U, Enestrom S, Sletten K",
"evidence": [
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"database": "Reactome",
"id": "R-HSA-977225",
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"type": "PubMed",
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]
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"title": "Kerato-epithelin mutations in four 5q31-linked corneal dystrophies.",
"journal": "Nature genetics",
"date": "1997",
"authors": "Munier FL, Korvatska E, Djemai A, Le Paslier D, Zografos L, Pescia G, Schorderet DF",
"evidence": [
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"database": "Reactome",
"id": "R-HSA-977225",
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"type": "PubMed",
"id": "9054935",
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]
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"title": "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.",
"journal": "Genes Dev.",
"date": "1997",
"authors": "Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER",
"evidence": [
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"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
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"reference": [
{
"type": "PubMed",
"id": "9334332",
"url": "https://glygen.org/publication/PubMed/9334332"
}
]
},
{
"title": "Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1997",
"authors": "Craiu A, Akopian T, Goldberg A, Rock KL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-983168",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168"
}
],
"reference": [
{
"type": "PubMed",
"id": "9380723",
"url": "https://glygen.org/publication/PubMed/9380723"
}
]
},
{
"title": "Characterization of human homologs of the Drosophila seven in absentia (sina) gene.",
"journal": "Genomics",
"date": "1997",
"authors": "Hu G., Look A.T., Fearon E.R., Valentine V., Glover T., Chung Y.-L.",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"reference": [
{
"type": "PubMed",
"id": "9403064",
"url": "https://glygen.org/publication/PubMed/9403064"
}
]
},
{
"title": "Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Beninga J, Rock KL, Goldberg AL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-983168",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168"
}
],
"reference": [
{
"type": "PubMed",
"id": "9668046",
"url": "https://glygen.org/publication/PubMed/9668046"
}
]
},
{
"title": "Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.",
"journal": "Molecular and cellular biology",
"date": "1999",
"authors": "Hu G, Fearon ER",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-373752",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373752"
}
],
"reference": [
{
"type": "PubMed",
"id": "9858595",
"url": "https://glygen.org/publication/PubMed/9858595"
}
]
},
{
"title": "Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.",
"journal": "FEBS letters",
"date": "1998",
"authors": "El-Agnaf OM, Jakes R, Curran MD, Wallace A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-977225",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225"
}
],
"reference": [
{
"type": "PubMed",
"id": "9862427",
"url": "https://glygen.org/publication/PubMed/9862427"
}
]
}
],
"pathway": [
{
"id": "hsa:6478",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6478",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-373752",
"name": "Netrin-1 signaling",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373752",
"resource": "Reactome",
"description": "Netrin-1 signaling"
},
{
"id": "R-HSA-5689880",
"name": "Ub-specific processing proteases",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880",
"resource": "Reactome",
"description": "Ub-specific processing proteases"
},
{
"id": "R-HSA-977225",
"name": "Amyloid fiber formation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225",
"resource": "Reactome",
"description": "Amyloid fiber formation"
},
{
"id": "R-HSA-983168",
"name": "Antigen processing: Ubiquitination & Proteasome degradation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168",
"resource": "Reactome",
"description": "Antigen processing: Ubiquitination & Proteasome degradation"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "Q06986-1",
"protein_name": "E3 ubiquitin-protein ligase SIAH2",
"gene_name": "Siah2",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGADPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ",
"length": 325
},
"evidence": [
{
"id": "45227266",
"url": "http://www.informatics.jax.org/homology/45227266",
"database": "MGI"
},
{
"id": "O43255",
"url": "https://omabrowser.org/oma/group/O43255/",
"database": "OMA"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "Q8R4T2-1",
"protein_name": "E3 ubiquitin-protein ligase SIAH2",
"gene_name": "Siah2",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ",
"length": 325
},
"evidence": [
{
"id": "45227266",
"url": "http://www.informatics.jax.org/homology/45227266",
"database": "MGI"
}
],
"common_name": "Rat"
}
],
"go_annotation": {
"categories": [
{
"name": "Cellular Component",
"total": 6,
"go_terms": [
{
"name": "nucleoplasm",
"id": "GO:0005654",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "early endosome",
"id": "GO:0005769",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "neuronal cell body",
"id": "GO:0043025",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "intracellular membrane-bounded organelle",
"id": "GO:0043231",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 6,
"go_terms": [
{
"name": "zinc ion binding",
"id": "GO:0008270",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "transcription corepressor activity",
"id": "GO:0003714",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "ubiquitin protein ligase activity",
"id": "GO:0061630",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "ubiquitin conjugating enzyme binding",
"id": "GO:0031624",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "ubiquitin-protein transferase activity",
"id": "GO:0004842",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "transferase activity",
"id": "GO:0016740",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 15,
"go_terms": [
{
"name": "negative regulation of apoptotic process",
"id": "GO:0043066",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "negative regulation of canonical Wnt signaling pathway",
"id": "GO:0090090",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "amyloid fibril formation",
"id": "GO:1990000",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990000",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "apoptotic process",
"id": "GO:0006915",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic process",
"id": "GO:0043154",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043154",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "proteasome-mediated ubiquitin-dependent protein catabolic process",
"id": "GO:0043161",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "small GTPase mediated signal transduction",
"id": "GO:0007264",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "protein ubiquitination",
"id": "GO:0016567",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "regulation of circadian rhythm",
"id": "GO:0042752",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042752",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "rhythmic process",
"id": "GO:0048511",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "cell cycle",
"id": "GO:0007049",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "canonical Wnt signaling pathway",
"id": "GO:0060070",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "negative regulation of extrinsic apoptotic signaling pathway",
"id": "GO:2001237",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "ubiquitin-dependent protein catabolic process",
"id": "GO:0006511",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
},
{
"name": "regulation of protein ubiquitination",
"id": "GO:0031396",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031396",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 316,
"end_pos": 318,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "Phosphorylated at Ser-28 by MAPK14, which mediates the degradation by the proteasome of EGLN3 (By similarity). Phosphorylated at Ser-28 by DYRK2; this increases the ubiquitin ligase activity and promotes degradation of EGLN3.",
"evidence": [
{
"database": "UniProtKB",
"id": "O43255",
"url": "https://www.uniprot.org/uniprot/O43255"
},
{
"database": "PubMed",
"id": "22878263",
"url": "https://glygen.org/publication/PubMed/22878263"
},
{
"database": "PubMed",
"id": "Q06986",
"url": "https://glygen.org/publication/PubMed/Q06986"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "R-HSA-374667",
"name": "DCC interaction with SIAH2",
"equation": "",
"summary": "Siah-2 binds to the DCC protein and promote its proteolysis via the ubiquitin-proteasome pathway.",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O43255-1"
],
"evidence": [
{
"id": "R-HSA-374667",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-374667"
}
]
},
{
"id": "R-HSA-5658092",
"name": "SIAH1, SIAH2 bind SNCAIP",
"equation": "",
"summary": "Seven in absentia homolog 1 (SIAH1) and 2 (SIAH2) are E3 ubiquitin-protein ligases that mediate ubiquitination of a number of target proteins including Synphilin-1 (SNCAIP) (Nagano et al. 2003) and alpha-synuclein (Liani et al. 2004). They are inhibited by the 1A isoform of SNCAIP (Szargel et al. 2009). When ubiquitinated by SIAH1, SNCAIP is targetted for proteasomal degradation (Nagano et al. 2003).
Synphilin-1 (SNCAIP) is a presynaptic protein that associates with synaptic vesicles (Ribeiro et al. 2002). It is present in many types of cytoplasmic inclusions, where it colocalizes with alpha-synuclein. It is associated with Parkinson's Disease (PD) because it is an intrinsic component of Lewy bodies (Wakabayashi et al. 2000) and a mutation of the SNCAIP gene has been identified in some PD patients (Marx et al. 2003), suggesting that accumulation of synphilin-1 and its interaction with alpha-synuclein may be relevant for Lewy body formation in PD.
Synphilin-1 (SNCAIP) is ubiquitinated by several other E3 ubiquitin-ligases, including Parkin (Chung et al. 2001) and Dorfin (Ito et al. 2003).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O43255-1",
"Q8IUQ4-1"
],
"evidence": [
{
"id": "R-HSA-5658092",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5658092"
}
]
},
{
"id": "R-HSA-5658496",
"name": "SIAH1:UBE2L6:Ubiquitin binds SNCA",
"equation": "",
"summary": "Seven in absentia homolog 1 (SIAH1) and 2 (SIAH2) are E3 ubiquitin-protein ligases that mediates ubiquitination of a number of target proteins including Synphilin-1 (SNCAIP) (Nagano et al. 2003) and alpha-synuclein (SNCA) (Liani et al. 2004, Lee et al. 2008). Ubiquitination of SNCA by SIAH1 is disrupted by the Parkinson's Disease (PD)-linked A30P mutation but not by the A53T mutation. SIAH1 binds the E2 ubiquitin-conjugating enzyme UBE2L6 (UBCH8) (Lee et al. 2008). This facilitates the mono- and di-ubiquitination of SNCA in vivo, but does not target SNCA for proteasomal degradation, rather it promotes SNCA aggregation and enhances toxicity (Lee et al. 2008). Monoubiquitinated SNCA may work as a seed for aggregation (Engelender 2008) and recruit other PD-related proteins, such as SNCAIP and UCHL1.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O43255-1",
"Q8IUQ4-1",
"O14933-1"
],
"evidence": [
{
"id": "R-HSA-5658496",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5658496"
}
]
},
{
"id": "R-HSA-5660753",
"name": "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA",
"equation": "",
"summary": "SIAH1 transfers ubiquitin from UBE2L6 to SNCA, generating monoubiquitinated SNCA (Ub-SNCA) (Liani et al 2004, Rott et al. 2008, Lee et al. 2008). Monoubiquitination of SNCA promotes its aggregation in vitro and in vivo, which is toxic to cells. Lewy Bodies, a characteristic of Parkinson's Disease, contain monoubiquitinted SNCA deposits (Hasegawa et al. 2002). Mass spectrometry analysis demonstrates that SIAH monoubiquitinates alpha-synuclein at lysines 12, 21, and 23 (Rott et al. 2008).
Monoubiquitination is generally thought to lead to degradation via the lysosomal pathway (d'Azzo et al. 2005) but monoubiquitinated SNCA appears to be preferentially targeted for degradation by the proteasome (Rott et al. 2011).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O43255-1",
"Q8IUQ4-1",
"O14933-1"
],
"evidence": [
{
"id": "R-HSA-5660753",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5660753"
}
]
},
{
"id": "R-HSA-5667107",
"name": "SIAH1, SIAH2 ubiquitinate SNCAIP",
"equation": "",
"summary": "Seven in absentia homolog (SIAH1) and 2 (SIAH2) are E3 ubiquitin-protein ligases that mediate ubiquitination of a number of target proteins including Synphilin-1 (SNCAIP) (Nagano et al. 2003, Liani et al. 2004). When ubiquitinated by SIAH1, SNCAIP is targetted for proteasomal degradation (Nagano et al. 2003). SIAH1 and SIAH2 are inhibited by the 1A isoform of SNCAIP (Szargel et al. 2009). SIAH1 can bind the brain-enriched E2 ubiquitin-conjugating enzyme UBE2L6 (Lee et al. 2008) but the E2 involved in SNCAIP ubiquitination has not been established.
Synphilin-1 (SNCAIP) is a presynaptic protein that associates with synaptic vesicles (Ribeiro et al. 2002). It is present in many types of cytoplasmic inclusions, where it colocalizes with alpha-synuclein. It is associated with Parkinson's Disease (PD) because it is an intrinsic component of Lewy bodies (Wakabayashi et al. 2000) and a mutation of the SNCAIP gene has been identified in some PD patients (Marx et al. 2003), suggesting that accumulation of synphilin-1 and its interaction with alpha-synuclein may be relevant for Lewy body formation in PD.
Synphilin-1 (SNCAIP) is ubiquitinated by several other E3 ubiquitin-ligases, including Parkin (Chung et al. 2001) and Dorfin (Ito et al. 2003).",
"cellular_location": "cytosol",
"input_participant_list": [
"R-HSA-5333629"
],
"output_participant_list": [
"R-HSA-5667104"
],
"enzyme_list": [
"O43255-1",
"Q8IUQ4-1"
],
"evidence": [
{
"id": "R-HSA-5667107",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5667107"
}
]
},
{
"id": "R-HSA-6781899",
"name": "USP13 binds SIAH2",
"equation": "",
"summary": "USP13 mediates stabilization of the E3-ligase SIAH2 independently of deubiquitinase activity by binding and impairing SIAH2 autoubiquitination (Scortegagna et al. 2011).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O43255-1",
"Q92995-1"
],
"evidence": [
{
"id": "R-HSA-6781899",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6781899"
}
]
},
{
"id": "R-HSA-983140",
"name": "Transfer of Ub from E2 to substrate and release of E2",
"equation": "",
"summary": "Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
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"Q9H832-1",
"Q969T4-1",
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"Q9UHC7-1",
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"Q9Y2X8-1",
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"Q9P2P5-1",
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"Q15034-1",
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"Q9BWF2-1",
"O94941-1",
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"Q5GLZ8-1",
"Q5U5R9-1",
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"Q9H9P5-4",
"Q8IWV7-1",
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"Q969M7-1",
"O00762-1",
"Q8WVN8-1"
],
"evidence": [
{
"id": "R-HSA-983140",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983140"
}
]
},
{
"id": "R-HSA-983147",
"name": "Release of E3 from polyubiquitinated substrate",
"equation": "",
"summary": "K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
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"Q9UHC7-1",
"Q96PU5-1",
"Q9Y4L5-1",
"Q8TDB6-1",
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"O43255-1",
"Q96BH1-1",
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"O60291-1",
"Q5U5Q3-1",
"Q96AX9-1",
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"Q7Z3V4-1",
"Q8IUQ4-1",
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"Q9UNE7-1",
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"Q8TC41-1",
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"Q8NG27-1",
"Q9BWF2-1",
"O94941-1",
"Q5GLZ8-1",
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"Q8IVU3-1",
"Q9ULT8-1",
"Q7Z6J0-1",
"Q9H9P5-4",
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],
"evidence": [
{
"id": "R-HSA-983147",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983147"
}
]
},
{
"id": "R-HSA-983156",
"name": "Polyubiquitination of substrate",
"equation": "",
"summary": "Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
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],
"evidence": [
{
"id": "R-HSA-983156",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983156"
}
]
},
{
"id": "R-HSA-983157",
"name": "Interaction of E3 with substrate and E2-Ub complex",
"equation": "",
"summary": "Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).",
"cellular_location": "cytosol",
"input_participant_list": [],
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"enzyme_list": [
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],
"evidence": [
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}
]
}
],
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{
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{
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},
{
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},
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},
{
"id": "NP_001295029.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9Y6H5",
"database": "PRO",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "O00762",
"gene_name": "UBE2C",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O00762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00762"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "O00762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00762"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "O00762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00762"
}
]
}
]
},
{
"uniprot_ac": "O14933",
"gene_name": "UBE2L6",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "O14933",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14933"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "O14933",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14933"
}
]
}
]
},
{
"uniprot_ac": "O15033",
"gene_name": "AREL1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O15033",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15033"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "O15033",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15033"
}
]
}
]
},
{
"uniprot_ac": "O43164",
"gene_name": "PJA2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O43164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43164"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O43164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43164"
}
]
}
]
},
{
"uniprot_ac": "O43255",
"gene_name": "SIAH2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O43255",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43255"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O43255",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43255"
}
]
}
]
},
{
"uniprot_ac": "O60260",
"gene_name": "PRKN",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "O60260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60260"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "O60260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60260"
}
]
},
{
"ec_number": "6.3.2.19",
"activity": "",
"evidence": [
{
"id": "O60260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60260"
}
]
}
]
},
{
"uniprot_ac": "O60291",
"gene_name": "MGRN1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O60291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60291"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O60291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60291"
}
]
}
]
},
{
"uniprot_ac": "O94822",
"gene_name": "LTN1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O94822",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94822"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O94822",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94822"
}
]
}
]
},
{
"uniprot_ac": "O94874",
"gene_name": "UFL1",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "O94874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94874"
}
]
}
]
},
{
"uniprot_ac": "O94941",
"gene_name": "UBOX5",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O94941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94941"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O94941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94941"
}
]
}
]
},
{
"uniprot_ac": "O94972",
"gene_name": "TRIM37",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O94972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94972"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O94972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94972"
}
]
}
]
},
{
"uniprot_ac": "O95376",
"gene_name": "ARIH2",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "O95376",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95376"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "O95376",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95376"
}
]
}
]
},
{
"uniprot_ac": "O95714",
"gene_name": "HERC2",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O95714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95714"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "O95714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95714"
}
]
}
]
},
{
"uniprot_ac": "P19474",
"gene_name": "TRIM21",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P19474",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19474"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "P19474",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19474"
}
]
}
]
},
{
"uniprot_ac": "P46934",
"gene_name": "NEDD4",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P46934",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46934"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "P46934",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46934"
}
]
}
]
},
{
"uniprot_ac": "P49427",
"gene_name": "CDC34",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P49427",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49427"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P49427",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49427"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P49427",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49427"
}
]
}
]
},
{
"uniprot_ac": "P49459",
"gene_name": "UBE2A",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P49459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49459"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P49459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49459"
}
]
}
]
},
{
"uniprot_ac": "P51668",
"gene_name": "UBE2D1",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P51668",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51668"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P51668",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51668"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P51668",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51668"
}
]
}
]
},
{
"uniprot_ac": "P51965",
"gene_name": "UBE2E1",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P51965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51965"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P51965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51965"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P51965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51965"
}
]
}
]
},
{
"uniprot_ac": "P60604",
"gene_name": "UBE2G2",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P60604",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60604"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P60604",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60604"
}
]
}
]
},
{
"uniprot_ac": "P61077",
"gene_name": "UBE2D3",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P61077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61077"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P61077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61077"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P61077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61077"
}
]
}
]
},
{
"uniprot_ac": "P61081",
"gene_name": "UBE2M",
"activity": [
{
"ec_number": "2.3.2.34",
"activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.",
"evidence": [
{
"id": "P61081",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61081"
}
]
},
{
"ec_number": "2.3.2.34",
"activity": "",
"evidence": [
{
"id": "P61081",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61081"
}
]
}
]
},
{
"uniprot_ac": "P61086",
"gene_name": "UBE2K",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P61086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61086"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P61086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61086"
}
]
}
]
},
{
"uniprot_ac": "P61088",
"gene_name": "UBE2N",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P61088",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61088"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P61088",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61088"
}
]
}
]
},
{
"uniprot_ac": "P62253",
"gene_name": "UBE2G1",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P62253",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62253"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P62253",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62253"
}
]
}
]
},
{
"uniprot_ac": "P62256",
"gene_name": "UBE2H",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P62256",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62256"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P62256",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62256"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P62256",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62256"
}
]
}
]
},
{
"uniprot_ac": "P62837",
"gene_name": "UBE2D2",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P62837",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62837"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P62837",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62837"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P62837",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62837"
}
]
}
]
},
{
"uniprot_ac": "P62877",
"gene_name": "RBX1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P62877",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62877"
}
]
},
{
"ec_number": "2.3.2.32",
"activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.",
"evidence": [
{
"id": "P62877",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62877"
}
]
},
{
"ec_number": "2.3.2.32",
"activity": "",
"evidence": [
{
"id": "P62877",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62877"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "P62877",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62877"
}
]
}
]
},
{
"uniprot_ac": "P63146",
"gene_name": "UBE2B",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P63146",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63146"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P63146",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63146"
}
]
}
]
},
{
"uniprot_ac": "P68036",
"gene_name": "UBE2L3",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "P68036",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68036"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "P68036",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68036"
}
]
}
]
},
{
"uniprot_ac": "P78317",
"gene_name": "RNF4",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P78317",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78317"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "P78317",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78317"
}
]
}
]
},
{
"uniprot_ac": "Q05086",
"gene_name": "UBE3A",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q05086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05086"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q05086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05086"
}
]
}
]
},
{
"uniprot_ac": "Q13049",
"gene_name": "TRIM32",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q13049",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13049"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q13049",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13049"
}
]
}
]
},
{
"uniprot_ac": "Q13191",
"gene_name": "CBLB",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q13191",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13191"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q13191",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13191"
}
]
}
]
},
{
"uniprot_ac": "Q14139",
"gene_name": "UBE4A",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q14139",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14139"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q14139",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14139"
}
]
}
]
},
{
"uniprot_ac": "Q14669",
"gene_name": "TRIP12",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q14669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14669"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q14669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14669"
}
]
}
]
},
{
"uniprot_ac": "Q15034",
"gene_name": "HERC3",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q15034",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15034"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q15034",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15034"
}
]
}
]
},
{
"uniprot_ac": "Q15386",
"gene_name": "UBE3C",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q15386",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15386"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q15386",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15386"
}
]
}
]
},
{
"uniprot_ac": "Q15751",
"gene_name": "HERC1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q15751",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15751"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q15751",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15751"
}
]
}
]
},
{
"uniprot_ac": "Q16763",
"gene_name": "UBE2S",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q16763",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16763"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q16763",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16763"
}
]
}
]
},
{
"uniprot_ac": "Q2Q1W2",
"gene_name": "TRIM71",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q2Q1W2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2Q1W2"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q2Q1W2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2Q1W2"
}
]
}
]
},
{
"uniprot_ac": "Q5GLZ8",
"gene_name": "HERC4",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5GLZ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5GLZ8"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q5GLZ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5GLZ8"
}
]
}
]
},
{
"uniprot_ac": "Q5T447",
"gene_name": "HECTD3",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5T447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T447"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q5T447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T447"
}
]
}
]
},
{
"uniprot_ac": "Q5T4S7",
"gene_name": "UBR4",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5T4S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T4S7"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q5T4S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T4S7"
}
]
}
]
},
{
"uniprot_ac": "Q5U5Q3",
"gene_name": "MEX3C",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5U5Q3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U5Q3"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q5U5Q3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U5Q3"
}
]
}
]
},
{
"uniprot_ac": "Q5U5R9",
"gene_name": "HECTD2",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5U5R9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U5R9"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q5U5R9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U5R9"
}
]
}
]
},
{
"uniprot_ac": "Q5VTB9",
"gene_name": "RNF220",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5VTB9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VTB9"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q5VTB9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VTB9"
}
]
}
]
},
{
"uniprot_ac": "Q5VVX9",
"gene_name": "UBE2U",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q5VVX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VVX9"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q5VVX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VVX9"
}
]
}
]
},
{
"uniprot_ac": "Q5XPI4",
"gene_name": "RNF123",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q5XPI4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XPI4"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q5XPI4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XPI4"
}
]
}
]
},
{
"uniprot_ac": "Q63HN8",
"gene_name": "RNF213",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
}
]
},
{
"uniprot_ac": "Q6Q0C0",
"gene_name": "TRAF7",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q6Q0C0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6Q0C0"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q6Q0C0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6Q0C0"
}
]
}
]
},
{
"uniprot_ac": "Q6UWE0",
"gene_name": "LRSAM1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q6UWE0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6UWE0"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q6UWE0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6UWE0"
}
]
}
]
},
{
"uniprot_ac": "Q6ZMZ0",
"gene_name": "RNF19B",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
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"database": "UniProtKB",
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}
]
},
{
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"activity": "",
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{
"id": "Q6ZMZ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZMZ0"
}
]
}
]
},
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{
"ec_number": "2.3.2.27",
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{
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"database": "UniProtKB",
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}
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},
{
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{
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}
]
}
]
},
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"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q712K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q712K3"
}
]
},
{
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"activity": "",
"evidence": [
{
"id": "Q712K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q712K3"
}
]
}
]
},
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{
"id": "Q7Z3V4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z3V4"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q7Z3V4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z3V4"
}
]
}
]
},
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"ec_number": "2.3.2.31",
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{
"id": "Q7Z419",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z419"
}
]
},
{
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"activity": "",
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{
"id": "Q7Z419",
"database": "UniProtKB",
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}
]
}
]
},
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"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z6E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6E9"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
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{
"id": "Q7Z6E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6E9"
}
]
}
]
},
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z6J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6J0"
}
]
},
{
"ec_number": "2.3.2.27",
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{
"id": "Q7Z6J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6J0"
}
]
}
]
},
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z6J8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6J8"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q7Z6J8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6J8"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q7Z6Z7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6Z7"
}
]
},
{
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"activity": "",
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{
"id": "Q7Z6Z7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6Z7"
}
]
}
]
},
{
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"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
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{
"id": "Q7Z7E8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z7E8"
}
]
},
{
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"activity": "",
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{
"id": "Q7Z7E8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z7E8"
}
]
}
]
},
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
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"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86WT6"
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]
},
{
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"activity": "",
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{
"id": "Q86WT6",
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"url": "https://www.uniprot.org/uniprot/Q86WT6"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
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"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XS8"
}
]
},
{
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"activity": "",
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{
"id": "Q86XS8",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q86XT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XT4"
}
]
},
{
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"activity": "",
"evidence": [
{
"id": "Q86XT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XT4"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q86Y13",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86Y13"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
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{
"id": "Q86Y13",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86Y13"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8IUQ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IUQ4"
}
]
},
{
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{
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8IVU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVU3"
}
]
},
{
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"activity": "",
"evidence": [
{
"id": "Q8IVU3",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8IWV7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWV7"
}
]
},
{
"ec_number": "2.3.2.27",
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{
"id": "Q8IWV7",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8IWV8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWV8"
}
]
},
{
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"id": "Q8IWV8",
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]
}
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},
{
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{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8IYU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYU2"
}
]
},
{
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{
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}
]
}
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},
{
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{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
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{
"id": "Q8N2K1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N2K1"
}
]
},
{
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"activity": "",
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{
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"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N2K1"
}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8N6D2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N6D2"
}
]
},
{
"ec_number": "2.3.2.27",
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{
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
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"url": "https://www.uniprot.org/uniprot/Q8N7E2"
}
]
},
{
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{
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8ND25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8ND25"
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]
},
{
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{
"id": "Q8ND25",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8NG27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NG27"
}
]
},
{
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{
"id": "Q8NG27",
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8NHG8",
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]
},
{
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{
"id": "Q8NHG8",
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8TBB1",
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"url": "https://www.uniprot.org/uniprot/Q8TBB1"
}
]
},
{
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{
"id": "Q8TBB1",
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
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{
"id": "Q8TC41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TC41"
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]
},
{
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{
"id": "Q8TC41",
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]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8TDB6",
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"url": "https://www.uniprot.org/uniprot/Q8TDB6"
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]
},
{
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{
"id": "Q8TDB6",
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}
]
}
]
},
{
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{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
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{
"id": "Q8WV44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WV44"
}
]
},
{
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{
"id": "Q8WV44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WV44"
}
]
}
]
},
{
"uniprot_ac": "Q8WVD3",
"gene_name": "RNF138",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8WVD3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVD3"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8WVD3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVD3"
}
]
}
]
},
{
"uniprot_ac": "Q8WVN8",
"gene_name": "UBE2Q2",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q8WVN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVN8"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q8WVN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVN8"
}
]
}
]
},
{
"uniprot_ac": "Q8WY64",
"gene_name": "MYLIP",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8WY64",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WY64"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q8WY64",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WY64"
}
]
}
]
},
{
"uniprot_ac": "Q92995",
"gene_name": "USP13",
"activity": [
{
"ec_number": "3.4.19.12",
"activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
"evidence": [
{
"id": "Q92995",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92995"
}
]
},
{
"ec_number": "3.4.19.12",
"activity": "",
"evidence": [
{
"id": "Q92995",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92995"
}
]
}
]
},
{
"uniprot_ac": "Q969K3",
"gene_name": "RNF34",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q969K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969K3"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q969K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969K3"
}
]
}
]
},
{
"uniprot_ac": "Q969M7",
"gene_name": "UBE2F",
"activity": [
{
"ec_number": "2.3.2.32",
"activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.",
"evidence": [
{
"id": "Q969M7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969M7"
}
]
},
{
"ec_number": "2.3.2.32",
"activity": "",
"evidence": [
{
"id": "Q969M7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969M7"
}
]
}
]
},
{
"uniprot_ac": "Q969Q1",
"gene_name": "TRIM63",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q969Q1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969Q1"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q969Q1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969Q1"
}
]
}
]
},
{
"uniprot_ac": "Q969T4",
"gene_name": "UBE2E3",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q969T4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969T4"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q969T4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q969T4"
}
]
}
]
},
{
"uniprot_ac": "Q96AX9",
"gene_name": "MIB2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96AX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96AX9"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q96AX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96AX9"
}
]
}
]
},
{
"uniprot_ac": "Q96B02",
"gene_name": "UBE2W",
"activity": [
{
"ec_number": "2.3.2.25",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].",
"evidence": [
{
"id": "Q96B02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96B02"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q96B02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96B02"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q96B02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96B02"
}
]
}
]
},
{
"uniprot_ac": "Q96BH1",
"gene_name": "RNF25",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96BH1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96BH1"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q96BH1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96BH1"
}
]
}
]
},
{
"uniprot_ac": "Q96F44",
"gene_name": "TRIM11",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96F44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96F44"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q96F44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96F44"
}
]
}
]
},
{
"uniprot_ac": "Q96J02",
"gene_name": "ITCH",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96J02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96J02"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q96J02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96J02"
}
]
}
]
},
{
"uniprot_ac": "Q96LR5",
"gene_name": "UBE2E2",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q96LR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96LR5"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q96LR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96LR5"
}
]
}
]
},
{
"uniprot_ac": "Q96PM5",
"gene_name": "RCHY1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96PM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PM5"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q96PM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PM5"
}
]
}
]
},
{
"uniprot_ac": "Q96PU5",
"gene_name": "NEDD4L",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.36",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.36",
"activity": "",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
}
]
},
{
"uniprot_ac": "Q9BV68",
"gene_name": "RNF126",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9BV68",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BV68"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9BV68",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BV68"
}
]
}
]
},
{
"uniprot_ac": "Q9BWF2",
"gene_name": "TRAIP",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9BWF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BWF2"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9BWF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BWF2"
}
]
}
]
},
{
"uniprot_ac": "Q9BYM8",
"gene_name": "RBCK1",
"activity": [
{
"ec_number": "2.3.2.31",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
"evidence": [
{
"id": "Q9BYM8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYM8"
}
]
},
{
"ec_number": "2.3.2.31",
"activity": "",
"evidence": [
{
"id": "Q9BYM8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYM8"
}
]
}
]
},
{
"uniprot_ac": "Q9C026",
"gene_name": "TRIM9",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9C026",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C026"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9C026",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C026"
}
]
}
]
},
{
"uniprot_ac": "Q9C037",
"gene_name": "TRIM4",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9C037",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C037"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9C037",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C037"
}
]
}
]
},
{
"uniprot_ac": "Q9C0C9",
"gene_name": "UBE2O",
"activity": [
{
"ec_number": "2.3.2.24",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9C0C9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C0C9"
}
]
},
{
"ec_number": "2.3.2.24",
"activity": "",
"evidence": [
{
"id": "Q9C0C9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C0C9"
}
]
}
]
},
{
"uniprot_ac": "Q9H0M0",
"gene_name": "WWP1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9H0M0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0M0"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q9H0M0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0M0"
}
]
}
]
},
{
"uniprot_ac": "Q9H4P4",
"gene_name": "RNF41",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9H4P4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4P4"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9H4P4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4P4"
}
]
}
]
},
{
"uniprot_ac": "Q9H832",
"gene_name": "UBE2Z",
"activity": [
{
"ec_number": "2.3.2.23",
"activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
"evidence": [
{
"id": "Q9H832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H832"
}
]
},
{
"ec_number": "2.3.2.23",
"activity": "",
"evidence": [
{
"id": "Q9H832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H832"
}
]
}
]
},
{
"uniprot_ac": "Q9H9P5",
"gene_name": "UNKL",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "Q9H9P5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H9P5"
}
]
}
]
},
{
"uniprot_ac": "Q9HAU4",
"gene_name": "SMURF2",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9HAU4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HAU4"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q9HAU4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HAU4"
}
]
}
]
},
{
"uniprot_ac": "Q9HCE7",
"gene_name": "SMURF1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
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