{ "uniprot_canonical_ac": "O35954-1", "uniprot_ac": "O35954", "uniprot_id": "PITM1_MOUSE", "mass": { "chemical_mass": 134940.0, "monoisotopic_mass": 134940.0 }, "refseq": { "ac": "NP_032877", "name": "membrane-associated phosphatidylinositol transfer protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877" }, "gene_names": [ { "name": "Pitpnm1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O35954", "id": "O35954" }, { "name": "DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9; RdgB; RdgB1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877", "id": "NP_032877" }, { "name": "Dres9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O35954", "id": "O35954" }, { "name": "Mpt1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O35954", "id": "O35954" }, { "name": "Nir2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O35954", "id": "O35954" }, { "name": "Pitpnm1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877", "id": "NP_032877" }, { "name": "Pitpnm", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O35954", "id": "O35954" } ], "protein_names": [ { "name": "Membrane-associated phosphatidylinositol transfer protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O35954" }, { "name": "Drosophila retinal degeneration B homolog 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35954" }, { "name": "Mpt-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35954" }, { "name": "NIR-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35954" }, { "name": "PITPnm 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35954" }, { "name": "Phosphatidylinositol transfer protein, membrane-associated 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35954" }, { "name": "Pyk2 N-terminal domain-interacting receptor 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35954" }, { "name": "RdgB1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35954" }, { "name": "drosophila retinal degeneration B homolog 1; pyk2 N-terminal domain-interacting receptor 2; retinal degeneration 9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877", "id": "NP_032877" }, { "name": "membrane-associated phosphatidylinositol transfer protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877", "id": "NP_032877" } ], "function": [ { "annotation": "Catalyzes the transfer of phosphatidylinositol (PI) between membranes (By similarity). Binds PI (PubMed:10400687). Also binds phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (By similarity). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (By similarity). Necessary for normal completion of cytokinesis (By similarity). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (By similarity). Required for protein export from the endoplasmic reticulum and the Golgi (By similarity). Binds calcium ions (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954#function" }, { "database": "PubMed", "id": "10400687", "url": "https://glygen.org/publication/PubMed/10400687" }, { "database": "UniProtKB", "id": "O00562", "url": "https://www.uniprot.org/uniprot/O00562#function" } ] }, { "annotation": "Pitpnm1 null mice showed no hearing defects.", "evidence": [ { "database": "RefSeq", "id": "NP_032877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877" }, { "database": "PubMed", "id": "23820044", "url": "https://glygen.org/publication/PubMed/23820044" } ] }, { "annotation": "Results suggest that Nir2 not only enhances EMT in vitro and breast cancer metastasis in animal models, but also contributes to breast cancer progression in human patients. Erratum:[J Cell Sci. 2019 Mar 7;132(5):. PMID: 30846603]", "evidence": [ { "database": "RefSeq", "id": "NP_032877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877" }, { "database": "PubMed", "id": "25179602", "url": "https://glygen.org/publication/PubMed/25179602" } ] }, { "annotation": "The VAP-interacting membrane-associated phosphatidylinositol (PtdIns) transfer proteins PYK2 N-terminal domain-interacting receptor 2 (Nir2) and Nir3 specifically associate with Kv2.1 complexes.", "evidence": [ { "database": "RefSeq", "id": "NP_032877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877" }, { "database": "PubMed", "id": "31594866", "url": "https://glygen.org/publication/PubMed/31594866" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3389472094", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389472094" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1085, "end_pos": 1085, "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFP->NFT).", "chr_id": "19", "chr_pos": "4162424", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P1085", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3389530540", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389530540" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 162, "end_pos": 162, "sequence_org": "Y", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (YRS->NRS).", "chr_id": "19", "chr_pos": "4153329", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "Y162", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Pitpnm1", "url": "https://www.uniprot.org/uniprot/O35954", "locus": { "chromosome": "19", "start_pos": 4163965, "end_pos": 4149998, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000024851", "url": "https://www.ensembl.org/id/ENSMUSG00000024851" } ] } } ], "crossref": [ { "id": "ENSMUSG00000024851", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024851", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08889", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08889", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "18739", "url": "https://www.ncbi.nlm.nih.gov/gene/18739", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O35954", "url": "https://www.ebi.ac.uk/intact/interactors/id:O35954*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:18739", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18739", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1197524", "url": "http://www.informatics.jax.org/marker/MGI:1197524", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "O35954", "url": "https://oglcnac.org/atlas/detail/O35954", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O35954", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O35954", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "EVGDFFM", "url": "https://omabrowser.org/oma/group/EVGDFFM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3946034at2759", "url": "http://www.orthodb.org/?query=3946034at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10658", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10658", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10658:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10658:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02121", "url": "http://pfam.xfam.org/family/PF02121", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02862", "url": "http://pfam.xfam.org/family/PF02862", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O35954", "url": "http://purl.obolibrary.org/obo/PR_O35954", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1483226", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1483226", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_032877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "38691", "url": "https://www.rhea-db.org/rhea/38691", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A494B9B7", "url": "https://www.uniprot.org/uniprot/A0A494B9B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B9B7-1", "url": "https://www.uniprot.org/uniprot/A0A494B9B7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBA1", "url": "https://www.uniprot.org/uniprot/A0A494BBA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBA1-1", "url": "https://www.uniprot.org/uniprot/A0A494BBA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YXW5", "url": "https://www.uniprot.org/uniprot/D3YXW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YXW5-1", "url": "https://www.uniprot.org/uniprot/D3YXW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O35954-1", "url": "https://www.uniprot.org/uniprot/O35954-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGNGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRIVDTIDIVRDAVAPGEYKAEEDPRLYRSAKTGRGPLADDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWIELSMADIRALEEETARMLAQRMAKCNTGSEGPEAQTPGKSSTEARPGTSTAGTPDGPEAPPGPDASPDASFGKQWSSSSRSSYSSQHGGGVSPQSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSDEVFPKEMTKWNSNDFIDAFASPTEVEGVPDPTVMATKGIEDGARAPRDSEGLDGAGDLVVEACSVHALFLILHSGSILDSGPGDTNSKQADVQTLSTAFEAVTRVHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYAAFLRSSEGTGFCGQVVLIGDGVGGILGFDALCHSASAGPGSRGSSRRGSMNNEMLSPEVGPVRDPLADGVEVLGRASPEPSALPAQRTFSDMANPDPDGSQNSLQVASTATSSGEPRRASTASCPPASSEAPDGPTNAARLDFKVSGFFLFGSPLGLVLALRKTVMPALEVAQLRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMMVPSTPTSASGAFWKGSELGNEPASQTAAPSTTSEVVKILDRWWGNKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQLTECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRPQVLNGRFMYGPLDVVTLTGEKVDVYVMTQPLSGKWIHFGTEVTNSSGRLTFPVPSERALGIGVYPVRMVVRGDHTYAECCLTVVSRGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHAPSGPPRAALAKSSYAVAAPVDFLRKQSQLLRSRGPSQVDREGPGTPPTTLARGKTRSISLKLDSEE", "length": 1243, "header": "sp|O35954-1|PITM1_MOUSE Isoform 1 of Membrane-associated phosphatidylinositol transfer protein 1 OS=Mus musculus OX=10090 GN=Pitpnm1 PE=1 SV=1 CANONICAL=O35954-1" }, "isoforms": [ { "isoform_ac": "A0A494B9B7-1", "url": "", "sequence": { "sequence": "TNSSGRLTFPVPSERALGIGVYPVRMVVRGDHTYAECCLTVVSRGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEGYP", "length": 143, "header": "tr|A0A494B9B7-1|PITM1_MOUSE Computationally mapped isoform of Membrane-associated phosphatidylinositol transfer protein 1 OS=Mus musculus OX=10090 GN=Pitpnm1 PE=1 SV=1 CANONICAL=O35954-1" }, "locus": { "chromosome": "19", "start_pos": 4162670, "end_pos": 4161929, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000127056.2", "url": "https://www.ensembl.org/id/ENSMUST00000127056.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157582.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157582.2" } ] } }, { "isoform_ac": "A0A494BBA1-1", "url": "", "sequence": { "sequence": "AIAPLAVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMMVPSTPTSASGAFWKGSELGNEPASQTAAPSTTSEVVKTTGNQRM", "length": 85, "header": "tr|A0A494BBA1-1|PITM1_MOUSE Computationally mapped isoform of Membrane-associated phosphatidylinositol transfer protein 1 OS=Mus musculus OX=10090 GN=Pitpnm1 PE=1 SV=1 CANONICAL=O35954-1" }, "locus": { "chromosome": "19", "start_pos": 4160967, "end_pos": 4159927, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000145214.9", "url": "https://www.ensembl.org/id/ENSMUST00000145214.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158424.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158424.2" } ] } }, { "isoform_ac": "D3YXW5-1", "url": "", "sequence": { "sequence": "MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGNGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRIVDTIDIVRDAVAPGEYKAEEDPRLYRSAKTGRGPLADDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWIELSMADIRALEEETARML", "length": 252, "header": "tr|D3YXW5-1|PITM1_MOUSE Computationally mapped isoform of Membrane-associated phosphatidylinositol transfer protein 1 OS=Mus musculus OX=10090 GN=Pitpnm1 PE=1 SV=1 CANONICAL=O35954-1" }, "locus": { "chromosome": "19", "start_pos": 4154929, "end_pos": 4151185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000131265.8", "url": "https://www.ensembl.org/id/ENSMUST00000131265.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000120563.2", "url": "https://www.ensembl.org/id/ENSMUSP00000120563.2" } ] } }, { "isoform_ac": "O35954-1", "url": "", "sequence": { "sequence": "MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGNGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRIVDTIDIVRDAVAPGEYKAEEDPRLYRSAKTGRGPLADDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWIELSMADIRALEEETARMLAQRMAKCNTGSEGPEAQTPGKSSTEARPGTSTAGTPDGPEAPPGPDASPDASFGKQWSSSSRSSYSSQHGGGVSPQSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSDEVFPKEMTKWNSNDFIDAFASPTEVEGVPDPTVMATKGIEDGARAPRDSEGLDGAGDLVVEACSVHALFLILHSGSILDSGPGDTNSKQADVQTLSTAFEAVTRVHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYAAFLRSSEGTGFCGQVVLIGDGVGGILGFDALCHSASAGPGSRGSSRRGSMNNEMLSPEVGPVRDPLADGVEVLGRASPEPSALPAQRTFSDMANPDPDGSQNSLQVASTATSSGEPRRASTASCPPASSEAPDGPTNAARLDFKVSGFFLFGSPLGLVLALRKTVMPALEVAQLRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMMVPSTPTSASGAFWKGSELGNEPASQTAAPSTTSEVVKILDRWWGNKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQLTECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRPQVLNGRFMYGPLDVVTLTGEKVDVYVMTQPLSGKWIHFGTEVTNSSGRLTFPVPSERALGIGVYPVRMVVRGDHTYAECCLTVVSRGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHAPSGPPRAALAKSSYAVAAPVDFLRKQSQLLRSRGPSQVDREGPGTPPTTLARGKTRSISLKLDSEE", "length": 1243, "header": "sp|O35954-1|PITM1_MOUSE Isoform 1 of Membrane-associated phosphatidylinositol transfer protein 1 OS=Mus musculus OX=10090 GN=Pitpnm1 PE=1 SV=1 CANONICAL=O35954-1" }, "locus": { "chromosome": "19", "start_pos": 4163745, "end_pos": 4151185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000049658", "url": "https://www.ensembl.org/id/ENSMUST00000049658" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000054309", "url": "https://www.ensembl.org/id/ENSMUSP00000054309" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1226, "start_aa": "Thr", "end_pos": 1226, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1226", "evidence": [ { "id": "O35954", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O35954" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O35954", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O35954" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] } ], "phosphorylation": [ { "start_pos": 1236, "end_pos": 1236, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Ser1236" }, { "start_pos": 282, "end_pos": 282, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "site_lbl": "Thr282" }, { "start_pos": 287, "end_pos": 287, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "site_lbl": "Thr287" }, { "start_pos": 300, "end_pos": 300, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "phospho.ELM", "id": "O35954", "url": "http://phospho.elm.eu.org/byAccession/O35954.html" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ], "site_lbl": "Ser300" }, { "start_pos": 304, "end_pos": 304, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "site_lbl": "Ser304" }, { "start_pos": 319, "end_pos": 319, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "site_lbl": "Ser319" }, { "start_pos": 326, "end_pos": 326, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "site_lbl": "Ser326" }, { "start_pos": 329, "end_pos": 329, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "site_lbl": "Ser329" }, { "start_pos": 342, "end_pos": 342, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Ser342" }, { "start_pos": 345, "end_pos": 345, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Ser345" }, { "start_pos": 346, "end_pos": 346, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Ser346" }, { "start_pos": 373, "end_pos": 373, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "site_lbl": "Ser373" }, { "start_pos": 382, "end_pos": 382, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CDK1", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Ser382" }, { "start_pos": 593, "end_pos": 593, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "site_lbl": "Ser593" }, { "start_pos": 59, "end_pos": 59, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Thr59" }, { "start_pos": 600, "end_pos": 600, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Ser600" }, { "start_pos": 621, "end_pos": 621, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Ser621" }, { "start_pos": 895, "end_pos": 895, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "site_lbl": "Ser895" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Involvement of PITPnm, a mammalian homologue of Drosophila rdgB, in phosphoinositide synthesis on Golgi membranes.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Kondo H., Watanabe T., Aikawa Y., Kuraoka A., Kawabuchi M.", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "reference": [ { "type": "PubMed", "id": "10400687", "url": "https://glygen.org/publication/PubMed/10400687" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" }, { "database": "iPTMnet", "id": "O35954", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O35954" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "O35954", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O35954" }, { "database": "O-GlcNAc Atlas", "id": "O35954", "url": "https://oglcnac.org/atlas/detail/O35954" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Pitpnm1 is expressed in hair cells during development but is not required for hearing.", "journal": "Neuroscience", "date": "2013", "authors": "Carlisle FA, Pearson S, Steel KP, Lewis MA", "evidence": [ { "database": "RefSeq", "id": "NP_032877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877" } ], "reference": [ { "type": "PubMed", "id": "23820044", "url": "https://glygen.org/publication/PubMed/23820044" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis.", "journal": "Journal of cell science", "date": "2014", "authors": "Keinan O, Kedan A, Gavert N, Selitrennik M, Kim S, Karn T, Becker S, Lev S", "evidence": [ { "database": "RefSeq", "id": "NP_032877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877" } ], "reference": [ { "type": "PubMed", "id": "25179602", "url": "https://glygen.org/publication/PubMed/25179602" } ] }, { "title": "Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis.", "journal": "The Journal of biological chemistry", "date": "2019", "authors": "Kirmiz M, Gillies TE, Dickson EJ, Trimmer JS", "evidence": [ { "database": "RefSeq", "id": "NP_032877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877" } ], "reference": [ { "type": "PubMed", "id": "31594866", "url": "https://glygen.org/publication/PubMed/31594866" } ] }, { "title": "Novel Antibodies for the Simple and Efficient Enrichment of Native O-GlcNAc Modified Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA", "evidence": [ { "database": "O-GlcNAc Database", "id": "O35954", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O35954" }, { "database": "O-GlcNAc Atlas", "id": "O35954", "url": "https://oglcnac.org/atlas/detail/O35954" } ], "reference": [ { "type": "PubMed", "id": "34678516", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "title": "Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1997", "authors": "Aikawa Y, Hara H, Watanabe T", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "reference": [ { "type": "PubMed", "id": "9245688", "url": "https://glygen.org/publication/PubMed/9245688" } ] }, { "title": "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms.", "journal": "Genes Funct.", "date": "1997", "authors": "Ballabio A., Borsani G., Rubboli F., Zollo M., Banfi S., Marchitiello A., Bulfone A., Bogni S.", "evidence": [ { "database": "UniProtKB", "id": "O35954", "url": "https://www.uniprot.org/uniprot/O35954" } ], "reference": [ { "type": "PubMed", "id": "9680295", "url": "https://glygen.org/publication/PubMed/9680295" } ] } ], "pathway": [ { "id": "mmu:18739", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18739", "resource": "KEGG Pathway" }, { "id": "R-MMU-1483226", "name": "Synthesis of PI", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1483226", "resource": "Reactome", "description": "Synthesis of PI" } ], "orthologs": [ { "uniprot_canonical_ac": "O00562-1", "protein_name": "Membrane-associated phosphatidylinositol transfer protein 1", "gene_name": "PITPNM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGSGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPRLYHSVKTGRGPLSDDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWTELSMADIRALEEETARMLAQRMAKCNTGSEGSEAQPPGKPSTEARSAASNTGTPDGPEAPPGPDASPDASFGKQWSSSSRSSYSSQHGGAVSPQSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSEEVFPKEMTKWNSNDFIDAFASPVEAEGTPEPGAEAAKGIEDGAQAPRDSEGLDGAGELGAEACAVHALFLILHSGNILDSGPGDANSKQADVQTLSSAFEAVTRIHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYSAFLRSPEGAGFCGQVALIGDGVGGILGFDALCHSANAGTGSRGSSRRGSMNNELLSPEFGPVRDPLADGVEGLGRGSPEPSALPPQRIPSDMASPEPEGSQNSLQAAPATTSSWEPRRASTAFCPPAASSEAPDGPSSTARLDFKVSGFFLFGSPLGLVLALRKTVMPALEAAQMRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLTVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMLVPSTPTSTSGAFWKGSELATDPPAQPAAPSTTSEVVKILERWWGTKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQLAECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRPQVLSGRFMYGPLDVVTLTGEKVDVYIMTQPLSGKWIHFGTEVTNSSGRLTFPVPPERALGIGVYPVRMVVRGDHTYAECCLTVVARGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHASSGPPRAALGKSSYGVAAPVDFLRKQSQLLRSRGPSQAEREGPGTPPTTLARGKARSISLKLDSEE", 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"MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGNGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPRLYRSVKTGRGPLADDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWIELSMADIRALEEETARMLAQRMAKCNTGSEGPEAQTPGKPSTETQPGTRTAGTPDGPEAPPGPDASPDASFGKQWSSSSRSSYSSQHGGGVSPQSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSDEVFPKEMTKWNSNDFIDAFASPTEVEGVPDPAIMATKGIEDEARAPRDSEGLDGTGDLGVEACSVHALFLILHSGSILDSGPGDTNSKQADVQTLSTAFEAVTRVHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYAAFLRSSEGTGFCGQVVLIGDGVGGILGFDALCHSASAGTGSRGSSRRGSMNNEMLSPEVGPVRDPLADGVEVLGRASPEPSALPAQRTSSDMANPDPDGSQNSLQVAPTVTSGEPRRASTASCPPASSEAPDGPTNAARLDFKVSGFFLFGSPLGLVLALRKTVMPALEVAQMRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMMVPSTPTSASGAFWKGNELGNEPAAQPAAPSTTSEVVKILDRWWGNKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQLTECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRPQVLNGRFMYGPLDVVTLTGEKVDVYVMTQPLSGKWIHFGTEVTNSSGRLTFPVPSERALGIGVYPVRMVVRGDHTYAECCLTVVSRGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHAPSGPPRAALAKSSYAVAAPVDFLRKQSQLLRSRGPSQVDLEGPGTPPTTLARGKTRSISLKLDSEE", 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