{ "uniprot_canonical_ac": "O35902-1", "uniprot_ac": "O35902", "uniprot_id": "DSG3_MOUSE", "mass": { "chemical_mass": 107889.0, "monoisotopic_mass": 107889.0 }, "refseq": { "ac": "NP_085099", "name": "desmoglein-3 preproprotein", "summary": "This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein exhibit loss of keratinocyte cell adhesion resulting in a phenotype that resembles that of patients with pemphigus vulgaris. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099" }, "gene_names": [ { "name": "Dsg3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O35902", "id": "O35902" }, { "name": "Dsg3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099", "id": "NP_085099" }, { "name": "bal", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099", "id": "NP_085099" } ], "protein_names": [ { "name": "Desmoglein-3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O35902" }, { "name": "130 kDa pemphigus vulgaris antigen homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099", "id": "NP_085099" }, { "name": "130 kDa pemphigus vulgaris antigen homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35902" }, { "name": "desmoglein-3 preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099", "id": "NP_085099" } ], "function": [ { "annotation": "Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902#function" } ] }, { "annotation": "IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3-Specific B Cell Receptor Knock-in Mouse.", "evidence": [ { "database": "RefSeq", "id": "NP_085099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099" }, { "database": "PubMed", "id": "34996836", "url": "https://glygen.org/publication/PubMed/34996836" } ] }, { "annotation": "T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_085099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099" }, { "database": "PubMed", "id": "36539957", "url": "https://glygen.org/publication/PubMed/36539957" } ] }, { "annotation": "This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein exhibit loss of keratinocyte cell adhesion resulting in a phenotype that resembles that of patients with pemphigus vulgaris. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_085099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099" } ] } ], "disease": [ { "disease_id": "DOID:0060851", "recommended_name": { "id": "DOID:0060851", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060851", "name": "pemphigus vulgaris", "description": "A pemphigus characterized by autosomal dominant blisters and erosions on the skin and mucous membranes erosions cause by autoantibodies to intercellular cement substance." }, "synonyms": [ { "id": "DOID:0060851", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060851", "name": "familial pemphigus vulgaris", "description": "" }, { "id": "MONDO:0008219", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008219", "name": "pemphigus vulgaris", "description": "Pemphigus is a group of chronic autoimmune skin diseases characterized by blister formations on the outer layer of the skin and the mucous membranes. Three clinical forms have been characterized, of which pemphigus vulgaris is the most frequent (75%)." }, { "id": "MONDO:0008219", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008219", "name": "familial pemphigus vulgaris", "description": "" }, { "id": "MONDO:0008219", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008219", "name": "pemphigus vulgaris, familial", "description": "" } ], "evidence": [ { "id": "0060851", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060851" } ] } ], "snv": [ { "evidence": [ { "id": "rs3389483635", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389483635" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 694, "end_pos": 694, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGA->NGT).", "chr_id": "18", "chr_pos": "20670344", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A694", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Dsg3", "url": "https://www.uniprot.org/uniprot/O35902", "locus": { "chromosome": "18", "start_pos": 20680516, "end_pos": 20643331, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000056632", "url": "https://www.ensembl.org/id/ENSMUSG00000056632" } ] } } ], "crossref": [ { "id": "ENSMUSG00000056632", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000056632", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "13512", "url": "https://www.ncbi.nlm.nih.gov/gene/13512", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:13512", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13512", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "99499", "url": "http://www.informatics.jax.org/marker/MGI:99499", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "CQCDNRD", "url": "https://omabrowser.org/oma/group/CQCDNRD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5314152at2759", "url": "http://www.orthodb.org/?query=5314152at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24025:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24025:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "http://pfam.xfam.org/family/PF00028", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O35902", "url": "http://purl.obolibrary.org/obo/PR_O35902", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-351906", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-351906", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6805567", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6809371", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_085099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q4EGP6", "url": "https://www.uniprot.org/uniprot/A0A3Q4EGP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q4EGP6-1", "url": "https://www.uniprot.org/uniprot/A0A3Q4EGP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O35902-1", "url": "https://www.uniprot.org/uniprot/O35902-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O35902-2", "url": "https://www.uniprot.org/uniprot/O35902-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UFC6", "url": "https://www.uniprot.org/uniprot/Q3UFC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UFC6-1", "url": "https://www.uniprot.org/uniprot/Q3UFC6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTCLFPRALGSLALLMVVLLVQGELHVKPGGQHREDGTALQLAKRRYKREWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAATGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTTNGADFMESSEVCTNTYAGGTMVEGASGMEMITKLGGATGATAALGPCSLGYSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSLAYAEEEDEREVNDCLLIYDDEGEDAAPHSPTLSSCSIFGDDLDDNFLDSLGPKFKKLAEICLGIDDEAKQAKPGPKDSGSGADTCARSMEVPQSGSNRYQTLPGSLEVTQTGSKICHTLSGNQETSVMSTSGSVHPAVAIPDPLQLGNYLLTETYSTSGSFAQPTTVTFDPHVTQNVTVTERVICPLPSASSSIVAPTELRGSYNMLYTKETCSHL", "length": 993, "header": "sp|O35902-1|DSG3_MOUSE Isoform 1 of Desmoglein-3 OS=Mus musculus OX=10090 GN=Dsg3 PE=2 SV=1 CANONICAL=O35902-1" }, "isoforms": [ { "isoform_ac": "A0A3Q4EGP6-1", "url": "", "sequence": { "sequence": "MTCLFPRALGSLALLMVVLLVQGELHVKPGGQHREDGTALQLAKRRYKREWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAATGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTTNGADFMESSEVCTNTYAGGTMVEGASGMEMITKLGGATGATAALGPCSLGYSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSLAYAEEEDEREVNDCLLIYDDEGEDAAPHSPTLSSCSIFADDLDDNFLDSLGPKFKKLAEICLGIDDEAKQAKPGPKDSGSGADTCARSMEVPQSGSNRQYLFLLLPSNEEAGARIHRAPSTNPRLLLLCLVHSEQRSVHSQYGSDAQGMNTL", "length": 929, "header": "tr|A0A3Q4EGP6-1|A0A3Q4EGP6_MOUSE Computationally mapped isoform of Desmoglein 3 OS=Mus musculus OX=10090 GN=Dsg3 PE=1 SV=1 CANONICAL=O35902-1" }, "locus": { "chromosome": "18", "start_pos": 20679913, "end_pos": 20643432, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000234945.2", "url": "https://www.ensembl.org/id/ENSMUST00000234945.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157289.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157289.2" } ] } }, { "isoform_ac": "O35902-1", "url": "", "sequence": { "sequence": "MTCLFPRALGSLALLMVVLLVQGELHVKPGGQHREDGTALQLAKRRYKREWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAATGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTTNGADFMESSEVCTNTYAGGTMVEGASGMEMITKLGGATGATAALGPCSLGYSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSLAYAEEEDEREVNDCLLIYDDEGEDAAPHSPTLSSCSIFGDDLDDNFLDSLGPKFKKLAEICLGIDDEAKQAKPGPKDSGSGADTCARSMEVPQSGSNRYQTLPGSLEVTQTGSKICHTLSGNQETSVMSTSGSVHPAVAIPDPLQLGNYLLTETYSTSGSFAQPTTVTFDPHVTQNVTVTERVICPLPSASSSIVAPTELRGSYNMLYTKETCSHL", "length": 993, "header": "sp|O35902-1|DSG3_MOUSE Isoform 1 of Desmoglein-3 OS=Mus musculus OX=10090 GN=Dsg3 PE=2 SV=1 CANONICAL=O35902-1" }, "locus": {} }, { "isoform_ac": "O35902-2", "url": "", "sequence": { "sequence": "MTCLFPRALGSLALLMVVLLVQGELHVKPGGQHREDGTALQLAKRRYKREWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAATGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTTNGADFMESSEVCTNTYAGGTMVEGASGMEMITKLGGATGATAALGPCSLGYSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSLAYAEEEDEREVNDCLLIYDDEGEDAAPHSPTLSSCSIFGDDLDDNFLDSLGPKFKKLAEICLGIDDEAKQAKPGPKDSGSGADTCARSMEVPQSGSNRQYLFLLLPSNEEAGARIHRAPSTNPRLLLLCLVHSEQRSVHSQYGSDAQGMNTL", "length": 929, "header": "sp|O35902-2|DSG3_MOUSE Isoform 2 of Desmoglein-3 OS=Mus musculus OX=10090 GN=Dsg3 PE=2 SV=1 CANONICAL=O35902-1" }, "locus": {} }, { "isoform_ac": "Q3UFC6-1", "url": "", "sequence": { "sequence": "MTCLFPRALGSLALLMVVLLVQGELHVKPGGQHREDGTALQLAKRRYKREWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAATGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTTNGADFMESSEVCTNTYAGGTMVEGASGMEMITKLGGATGATAALGPCSLGYSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSLAYAEEEDEREVNDCLLIYDDEGEDAAPHSPTLSSCSIFADDLDDNFLDSLGPKFKKLAEICLGIDDEAKQAKPGPKDSGSGADTCARSMEVPQSGSNRYQTLPGSLEVTQTGSKICHTLSGNQETSVMSTSGSVHPAVAIPDPLQLGNYLLTETYSTSGSFAQPTTVTFDPHVTQNVTVTERVICPLPSASSSIVAPTELRGSYNMLYTKETCSHL", "length": 993, "header": "tr|Q3UFC6-1|DSG3_MOUSE Computationally mapped isoform of Desmoglein-3 OS=Mus musculus OX=10090 GN=Dsg3 PE=2 SV=1 CANONICAL=O35902-1" }, "locus": { "chromosome": "18", "start_pos": 20673309, "end_pos": 20643432, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000070892.8", "url": "https://www.ensembl.org/id/ENSMUST00000070892.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000064718.7", "url": "https://www.ensembl.org/id/ENSMUSP00000064718.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "O35902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35902#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "O35902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35902#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 459, "start_aa": "Asn", "end_pos": 459, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn459", "evidence": [ { "id": "O35902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35902#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 546, "start_aa": "Asn", "end_pos": 546, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn546", "evidence": [ { "id": "O35902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35902#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6.", "journal": "J. Invest. Dermatol.", "date": "2003", "authors": "Whittock NV", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "reference": [ { "type": "PubMed", "id": "12787123", "url": "https://glygen.org/publication/PubMed/12787123" } ] }, { "title": "IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3-Specific B Cell Receptor Knock-in Mouse.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2022", "authors": "Nomura H, Wada N, Takahashi H, Kase Y, Yamagami J, Egami S, Iriki H, Mukai M, Kamata A, Ito H, Fujii H, Ishikura T, Koseki H, Watanabe T, Yamada T, Ohara O, Koyasu S, Amagai M", "evidence": [ { "database": "RefSeq", "id": "NP_085099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099" } ], "reference": [ { "type": "PubMed", "id": "34996836", "url": "https://glygen.org/publication/PubMed/34996836" } ] }, { "title": "T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen.", "journal": "The Journal of dermatology", "date": "2022-12-20", "authors": "Takahashi Hayato, Iriki Hisato, Asahina Yasuhiko", "evidence": [ { "database": "RefSeq", "id": "NP_085099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085099" } ], "reference": [ { "type": "PubMed", "id": "36539957", "url": "https://glygen.org/publication/PubMed/36539957" } ] }, { "title": "cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen.", "journal": "Mamm. Genome", "date": "1994", "authors": "Ishikawa H, Silos SA, Tamai K, Copeland NG, Gilbert DJ, Jenkins NA, Uitto J", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "reference": [ { "type": "PubMed", "id": "7894164", "url": "https://glygen.org/publication/PubMed/7894164" } ] } ], "pathway": [ { "id": "mmu:13512", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13512", "resource": "KEGG Pathway" }, { "id": "R-MMU-351906", "name": "Apoptotic cleavage of cell adhesion proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-351906", "resource": "Reactome", "description": "Apoptotic cleavage of cell adhesion proteins" }, { "id": "R-MMU-6805567", "name": "Keratinization", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-MMU-6809371", "name": "Formation of the cornified envelope", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZL74-1", "protein_name": "Desmoglein 3", "gene_name": "Dsg3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACLFPRALRLLSLLMVVLMVYGELHIESGGQHREDRMALQLTKRRYKREWVKFAKPCREREDNSKRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNAPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQVGSYHLIVSGADNDGTGLSTQCECSIKIKDVNDNFPVLTDSQYSARIEENTLNSELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKLVKVLDYEQMQSMQFSIAVRNKAEFHQSVISQYQVQSTPVTIQVINVQEGISFRPPSRTFTVQRGVSINKLAGYILGTYQATDEDTGKAASSVRYVLGRNDGGFLVIDSKTAEIKFVKNINRDSTFIVNKTISAEVLAIDENTGKTSTGTVYVEVPSFNENCPSVVLEKREICTSSPSVTLSVRTLDRAKYTGPYTVSLEEQPLKLPVVWTITTLNATSALLQAQQHISPGVYNVPVIVKDNQDGQCDTLESLTLTVCQCDDRSMCRAPGPSREPFIREESTWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAGTGGFVPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTSNGADFMESSEVCTNTYAGGTLVEGASGMEMTTKLGGATGSGAAVALGLGHSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSSAYAEEEDDREVNDCLLIYDDEGEDAAPRSPALSSCSFMADDLDDSFLDSLGPKFKKLAEICLGVDDEAKQVKPGPKDSSSGADACARPTEALQAGSNRYQTLPGSLEVTQSGSSRYQTLPGGLEVTQSGSNRYQTLPGGLEVTQSGSNRYQTLPGGLEVTQSGSKVCHVLPGNQDTSVLSSSGSVHPAIAIPDPLQLGNYLLTETYTTSGSFVQPTTATFDPHVTQNVTVTERVICPLPSASGSIVAPTELRGSYSMLYTKEACSHL", "length": 1043 }, "evidence": [ { "id": "45236969", "url": "http://www.informatics.jax.org/homology/45236969", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P32926-1", "protein_name": "Desmoglein-3", "gene_name": "DSG3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 999 }, "evidence": [ { "id": "45236969", "url": "http://www.informatics.jax.org/homology/45236969", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "pmid": "" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "pmid": "" }, { "name": "spot adherens junction", "id": "GO:0005914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005914", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "O35902", "url": "https://www.uniprot.org/uniprot/O35902" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 546, "end_pos": 548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 764, "end_pos": 766, "annotation": "n_glycosylation_sequon" }, { "start_pos": 953, "end_pos": 955, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", 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