{ "uniprot_canonical_ac": "O35659-1", "uniprot_ac": "O35659", "uniprot_id": "GLP1R_MOUSE", "mass": { "chemical_mass": 53028.0, "monoisotopic_mass": 53028.0 }, "refseq": { "ac": "NP_067307", "name": "glucagon-like peptide 1 receptor precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307" }, "gene_names": [ { "name": "Glp1r", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O35659", "id": "O35659" }, { "name": "GLP-1R; GLP1Rc", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307", "id": "NP_067307" }, { "name": "Glp1r", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307", "id": "NP_067307" } ], "protein_names": [ { "name": "Glucagon-like peptide 1 receptor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O35659" }, { "name": "GLP-1 receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35659" }, { "name": "GLP-1-R; GLP-1 receptor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307", "id": "NP_067307" }, { "name": "GLP-1-R", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35659" }, { "name": "GLP-1R", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O35659" }, { "name": "glucagon-like peptide 1 receptor precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307", "id": "NP_067307" } ], "function": [ { "annotation": "Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-specific beta-arrestin 2 knockout mice.", "evidence": [ { "database": "RefSeq", "id": "NP_067307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307" }, { "database": "PubMed", "id": "37134170", "url": "https://glygen.org/publication/PubMed/37134170" } ] }, { "annotation": "G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:9568699). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (By similarity). Plays a role in regulating insulin secretion in response to GLP-1 (PubMed:9568699).", "evidence": [ { "database": "UniProtKB", "id": "O35659", "url": "https://www.uniprot.org/uniprot/O35659#function" }, { "database": "UniProtKB", "id": "P43220", "url": "https://www.uniprot.org/uniprot/P43220#function" }, { "database": "PubMed", "id": "9568699", "url": "https://glygen.org/publication/PubMed/9568699" } ] }, { "annotation": "The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice.", "evidence": [ { "database": "RefSeq", "id": "NP_067307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307" }, { "database": "PubMed", "id": "37182561", "url": "https://glygen.org/publication/PubMed/37182561" } ] } ], "disease": [ { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:4195", "recommended_name": { "id": "DOID:4195", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4195", "name": "hyperglycemia", "description": "" }, "synonyms": [], "evidence": [ { "id": "4195", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4195" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": 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[ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:14652", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14652", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "99571", "url": "http://www.informatics.jax.org/marker/MGI:99571", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "CFVNNEK", "url": "https://omabrowser.org/oma/group/CFVNNEK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4209404at2759", "url": "http://www.orthodb.org/?query=4209404at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "http://pfam.xfam.org/family/PF00002", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02793", "url": "http://pfam.xfam.org/family/PF02793", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O35659", "url": "http://purl.obolibrary.org/obo/PR_O35659", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-381676", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381676", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418555", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-420092", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_067307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O35659", "url": "https://www.uniprot.org/uniprot/O35659", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O35659-1", "url": "https://www.uniprot.org/uniprot/O35659-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTPSLLRLALLLLGAVGRAGPRPQGTTVSLSETVQKWREYRRQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLSECEESKRGERNFPEEQLLSLYIIYTVGYALSFSALVIASAILVGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKCWERWRLEHLNIQRDCSMKPLKCPTSSVSSGATVGSSVYAATCQSSYS", "length": 463, "header": "sp|O35659-1|GLP1R_MOUSE Isoform 1 of Glucagon-like peptide 1 receptor OS=Mus musculus OX=10090 GN=Glp1r PE=1 SV=2 CANONICAL=O35659-1" }, "isoforms": [ { "isoform_ac": "O35659-1", "url": "", "sequence": { "sequence": "MASTPSLLRLALLLLGAVGRAGPRPQGTTVSLSETVQKWREYRRQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLSECEESKRGERNFPEEQLLSLYIIYTVGYALSFSALVIASAILVGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKCWERWRLEHLNIQRDCSMKPLKCPTSSVSSGATVGSSVYAATCQSSYS", "length": 463, "header": "sp|O35659-1|GLP1R_MOUSE Isoform 1 of Glucagon-like peptide 1 receptor OS=Mus musculus OX=10090 GN=Glp1r PE=1 SV=2 CANONICAL=O35659-1" }, "locus": { "chromosome": "17", "start_pos": 31155403, "end_pos": 31120851, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114574", "url": "https://www.ensembl.org/id/ENSMUST00000114574" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110221", "url": "https://www.ensembl.org/id/ENSMUSP00000110221" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 115, "start_aa": "Asn", "end_pos": 115, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn115", "evidence": [ { "id": "O35659", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35659#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 63, "start_aa": "Asn", "end_pos": 63, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn63", "evidence": [ { "id": "O35659", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35659#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 82, "start_aa": "Asn", "end_pos": 82, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn82", "evidence": [ { "id": "O35659", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35659#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r).", "journal": "Am. J. Physiol.", "date": "2007", "authors": "Volaufova J., Kumar K.G., York B., Poole A.C., Richards B.K., Zuberi A.", "evidence": [ { "database": "UniProtKB", "id": "O35659", "url": "https://www.uniprot.org/uniprot/O35659" } ], "reference": [ { "type": "PubMed", "id": "16946080", "url": "https://glygen.org/publication/PubMed/16946080" } ] }, { "title": "Divergent acute versus prolonged pharmacological GLP-1R responses in adult \u03b2 cell-specific \u03b2-arrestin 2 knockout mice.", "journal": "Science advances", "date": "2023-05-03", "authors": "Bitsi Stavroula, El Eid Liliane, Manchanda Yusman, Oqua Affiong I, Mohamed Nimco, Hansen Ben, Suba Kinga, Rutter Guy A, Salem Victoria, Jones Ben, Tomas Alejandra", "evidence": [ { "database": "RefSeq", "id": "NP_067307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307" } ], "reference": [ { "type": "PubMed", "id": "37134170", "url": "https://glygen.org/publication/PubMed/37134170" } ] }, { "title": "The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice.", "journal": "Molecular metabolism", "date": "2023-07", "authors": "Montaner Mireia, Denom Jessica, Jiang Wanqing, Magnan Christophe, Trapp Stefan, Gurden Hirac", "evidence": [ { "database": "RefSeq", "id": "NP_067307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307" } ], "reference": [ { "type": "PubMed", "id": "37182561", "url": "https://glygen.org/publication/PubMed/37182561" } ] }, { "title": "Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.", "journal": "Diabetes", "date": "1998", "authors": "Drucker D.J., Schuit F., Pipeleers D., Scrocchi L.A., Flamez D., Quartier E., van Breusegem A.", "evidence": [ { "database": "UniProtKB", "id": "O35659", "url": "https://www.uniprot.org/uniprot/O35659" } ], "reference": [ { "type": "PubMed", "id": "9568699", "url": "https://glygen.org/publication/PubMed/9568699" } ] } ], "pathway": [ { "id": "mmu:14652", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14652", "resource": "KEGG Pathway" }, { "id": "R-MMU-381676", "name": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381676", "resource": "Reactome", "description": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion" }, { "id": "R-MMU-418555", "name": "G alpha (s) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-MMU-420092", "name": "Glucagon-type ligand receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-420092", "resource": "Reactome", "description": "Glucagon-type ligand receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "P32301-1", "protein_name": "Glucagon-like peptide 1 receptor", "gene_name": "Glp1r", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS", "length": 463 }, "evidence": [ { "id": "45236136", "url": "http://www.informatics.jax.org/homology/45236136", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P43220-1", "protein_name": "Glucagon-like peptide 1 receptor", "gene_name": "GLP1R", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS", "length": 463 }, "evidence": [ { "id": "45236136", "url": "http://www.informatics.jax.org/homology/45236136", "database": "MGI" }, { "id": "O35659", "url": "https://omabrowser.org/oma/group/O35659/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O35659", "url": 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