{
    "uniprot_canonical_ac": "O35602-1",
    "uniprot_ac": "O35602",
    "uniprot_id": "RX_MOUSE",
    "mass": {
        "chemical_mass": 36335.0,
        "monoisotopic_mass": 36335.0
    },
    "refseq": {
        "ac": "NP_038861",
        "name": "retinal homeobox protein Rx",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038861"
    },
    "gene_names": [
        {
            "name": "Rax",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/O35602",
            "id": "O35602"
        },
        {
            "name": "7530406A22Rik; E130303K03Rik; ey-1; ey1; Rx",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038861",
            "id": "NP_038861"
        },
        {
            "name": "Rax",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038861",
            "id": "NP_038861"
        },
        {
            "name": "Rx",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O35602",
            "id": "O35602"
        }
    ],
    "protein_names": [
        {
            "name": "Retinal homeobox protein Rx",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "O35602"
        },
        {
            "name": "Retina and anterior neural fold homeobox protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O35602"
        },
        {
            "name": "Rx/rax homeoprotein; retina and anterior neural fold homeobox protein; eyeless 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038861",
            "id": "NP_038861"
        },
        {
            "name": "retinal homeobox protein Rx",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038861",
            "id": "NP_038861"
        }
    ],
    "function": [
        {
            "annotation": "Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35602",
                    "url": "https://www.uniprot.org/uniprot/O35602#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0060842",
            "recommended_name": {
                "id": "DOID:0060842",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0060842",
                "name": "isolated microphthalmia 3",
                "description": "An isolated microphthalmia characterized by clinical anophthalmia and/or microphthalmia that has_material_basis_in compound heterozygous mutation in the RAX gene on chromosome 18q21."
            },
            "synonyms": [
                {
                    "id": "DOID:0060842",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060842",
                    "name": "MCOP3",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "isolated microphthalmia 3",
                    "description": "Any isolated microphthalmia in which the cause of the disease is a mutation in the RAX gene."
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "MCOP3",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "RAX isolated microphthalmia",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "isolated microphthalmia 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "isolated microphthalmia caused by mutation in RAX",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "isolated microphthalmia caused by mutation in rax",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "isolated microphthalmia type 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "microphthalmia, isolated type 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "rax isolated microphthalmia",
                    "description": ""
                },
                {
                    "id": "MONDO:0012604",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012604",
                    "name": "microphthalmia, isolated 3",
                    "description": ""
                },
                {
                    "id": "MIM:611038",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/611038",
                    "name": "Microphthalmia, syndromic 16",
                    "description": "Microphthalmia, syndromic 16"
                }
            ],
            "evidence": [
                {
                    "id": "0060842",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060842"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35602",
                    "url": "https://www.uniprot.org/uniprot/O35602"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Rax",
            "url": "https://www.uniprot.org/uniprot/O35602",
            "locus": {
                "chromosome": "18",
                "start_pos": 66061348,
                "end_pos": 66072858,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000024518",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000024518"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000024518",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024518",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00086",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "19434",
            "url": "https://www.ncbi.nlm.nih.gov/gene/19434",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "O35602",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:O35602*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001356",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003654",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003654",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017970",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR043562",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043562",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:19434",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:19434",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "109632",
            "url": "http://www.informatics.jax.org/marker/MGI:109632",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "VMMMDER",
            "url": "https://omabrowser.org/oma/group/VMMMDER/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3042435at2759",
            "url": "http://www.orthodb.org/?query=3042435at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46271",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46271",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46271:SF3",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46271:SF3",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00046",
            "url": "http://pfam.xfam.org/family/PF00046",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF03826",
            "url": "http://pfam.xfam.org/family/PF03826",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_O35602",
            "url": "http://purl.obolibrary.org/obo/PR_O35602",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_038861",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038861",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494B9Q2",
            "url": "https://www.uniprot.org/uniprot/A0A494B9Q2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494B9Q2-1",
            "url": "https://www.uniprot.org/uniprot/A0A494B9Q2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494BB35",
            "url": "https://www.uniprot.org/uniprot/A0A494BB35",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494BB35-1",
            "url": "https://www.uniprot.org/uniprot/A0A494BB35-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494BBH8",
            "url": "https://www.uniprot.org/uniprot/A0A494BBH8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494BBH8-1",
            "url": "https://www.uniprot.org/uniprot/A0A494BBH8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O35602",
            "url": "https://www.uniprot.org/uniprot/O35602",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O35602-1",
            "url": "https://www.uniprot.org/uniprot/O35602-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKEDGILDTFPAERSSRSSKERDPRLGAQPACPKAPAGGSESSPPAAPGFVPEYEATRPCYPKEQGEARPSPGLSVGPAAGDSKLSEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSSALAPLGTGPGSGSGPPGSALPLEPWLGPPLPGGGATALQSLPGFGPPGQGLPASYTPPPPFLNSAPLGPGLQQLGPPPAYPCAPAFGDKFSLEEAYPRNSSIAALRLKAKEHIQAIGKPWQAL",
        "length": 342,
        "header": "sp|O35602-1|RX_MOUSE Isoform 1 of Retinal homeobox protein Rx  OS=Mus musculus OX=10090 GN=Rax PE=2 SV=2 CANONICAL=O35602-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A494B9Q2-1",
            "url": "",
            "sequence": {
                "sequence": "MRGRLREDSNRKACEQSPRVIRKVYSRSWSFQVPEDGPECKALGDAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKEDGILDTFPAERSSRSSKERDPRLGAQPACPKAPAGGSESSPPAAPGFVPEYEATRPCYPKEQGEARPSPGLSVGPAAGDSKLSEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEV",
                "length": 215,
                "header": "tr|A0A494B9Q2-1|RX_MOUSE Computationally mapped isoform of Retinal homeobox protein Rx  OS=Mus musculus OX=10090 GN=Rax PE=2 SV=1 CANONICAL=O35602-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 66072596,
                "end_pos": 66071100,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000237506.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000237506.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000157707.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000157707.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A494BB35-1",
            "url": "",
            "sequence": {
                "sequence": "MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKEDGILDTFPAERSSRSSKERDPRLGAQPACPKAPAGGSESSPPAAPGFVPEYEGMVPEPTG",
                "length": 104,
                "header": "tr|A0A494BB35-1|RX_MOUSE Computationally mapped isoform of Retinal homeobox protein Rx  OS=Mus musculus OX=10090 GN=Rax PE=2 SV=1 CANONICAL=O35602-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 66071885,
                "end_pos": 66068538,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000238035.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000238035.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000158348.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000158348.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A494BBH8-1",
            "url": "",
            "sequence": {
                "sequence": "XSRLHSIEAILGFTKEDGILDTFPAERSSRSSKERDPRLGAQPACPKAPAGGSESSPPAAPGFVPEYEATRPCYPKEQGEARPSPGLSVGPAAGDSKLSEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQSSVKNLGGLPS",
                "length": 164,
                "header": "tr|A0A494BBH8-1|RX_MOUSE Computationally mapped isoform of Retinal homeobox protein Rx  OS=Mus musculus OX=10090 GN=Rax PE=2 SV=1 CANONICAL=O35602-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 66071799,
                "end_pos": 66070477,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000235720.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000235720.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000158513.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000158513.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "O35602-1",
            "url": "",
            "sequence": {
                "sequence": "MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKEDGILDTFPAERSSRSSKERDPRLGAQPACPKAPAGGSESSPPAAPGFVPEYEATRPCYPKEQGEARPSPGLSVGPAAGDSKLSEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSSALAPLGTGPGSGSGPPGSALPLEPWLGPPLPGGGATALQSLPGFGPPGQGLPASYTPPPPFLNSAPLGPGLQQLGPPPAYPCAPAFGDKFSLEEAYPRNSSIAALRLKAKEHIQAIGKPWQAL",
                "length": 342,
                "header": "sp|O35602-1|RX_MOUSE Isoform 1 of Retinal homeobox protein Rx  OS=Mus musculus OX=10090 GN=Rax PE=2 SV=2 CANONICAL=O35602-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 66071885,
                "end_pos": 66068078,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000025396",
                        "url": "https://www.ensembl.org/id/ENSMUST00000025396"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000025396",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000025396"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "1997",
            "authors": "Furukawa T, Kozak CA, Cepko CL",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35602",
                    "url": "https://www.uniprot.org/uniprot/O35602"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9096350",
                    "url": "https://glygen.org/publication/PubMed/9096350"
                }
            ]
        },
        {
            "title": "The Rx homeobox gene is essential for vertebrate eye development.",
            "journal": "Nature",
            "date": "1997",
            "authors": "Mathers PH, Grinberg A, Mahon KA, Jamrich M",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35602",
                    "url": "https://www.uniprot.org/uniprot/O35602"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9177348",
                    "url": "https://glygen.org/publication/PubMed/9177348"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:19434",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:19434",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9JLT7-1",
            "protein_name": "Retinal homeobox protein Rx",
            "gene_name": "Rax",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MHLPGCPPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKEDGILDTFPAERSSRGSKERDPRLGARSACPKAPAGGSESSPPAAPGLVPEFEATRPCYPKEQGEARPSPGLPVGPAAGDSKLSEEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSSALAPLGGPGSGSGPPGSALPLEPWLGPPLPGGGATALQSLPGFGPPGQGLPASYTPPPPFLNSAPLGPGLQQLGPPPAYPCAPAFGDKFSLEEAYPRNSSIAALRLKAKEHIQAIGKPWQAL",
                "length": 342
            },
            "evidence": [
                {
                    "id": "45224174",
                    "url": "http://www.informatics.jax.org/homology/45224174",
                    "database": "MGI"
                },
                {
                    "id": "O35602",
                    "url": "https://omabrowser.org/oma/group/O35602/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9Y2V3-1",
            "protein_name": "Retinal homeobox protein Rx",
            "gene_name": "RAX",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKDDGILGTFPAERGARGAKERDRRLGARPACPKAPEEGSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLPVGPATGEAKLSEEEQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALPLESWLGPPLPGGGATALQSLPGFGPPAQSLPASYTPPPPPPPFLNSPPLGPGLQPLAPPPPSYPCGPGFGDKFPLDEADPRNSSIAALRLKAKEHIQAIGKPWQAL",
                "length": 346
            },
            "evidence": [
                {
                    "id": "45224174",
                    "url": "http://www.informatics.jax.org/homology/45224174",
                    "database": "MGI"
                },
                {
                    "id": "O35602",
                    "url": "https://omabrowser.org/oma/group/O35602/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
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