{
    "uniprot_canonical_ac": "O35116-1",
    "uniprot_ac": "O35116",
    "uniprot_id": "CTND2_RAT",
    "mass": {
        "chemical_mass": 28928.0,
        "monoisotopic_mass": 28928.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Ctnnd2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/O35116",
            "id": "O35116"
        }
    ],
    "protein_names": [
        {
            "name": "Catenin delta-2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "O35116"
        }
    ],
    "function": [
        {
            "annotation": "Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35116",
                    "url": "https://www.uniprot.org/uniprot/O35116#function"
                },
                {
                    "database": "PubMed",
                    "id": "25807484",
                    "url": "https://glygen.org/publication/PubMed/25807484"
                },
                {
                    "database": "PubMed",
                    "id": "20623542",
                    "url": "https://glygen.org/publication/PubMed/20623542"
                },
                {
                    "database": "UniProtKB",
                    "id": "O35927",
                    "url": "https://www.uniprot.org/uniprot/O35927#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9UQB3",
                    "url": "https://www.uniprot.org/uniprot/Q9UQB3#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:1470",
            "recommended_name": {
                "id": "DOID:1470",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1470",
                "name": "major depressive disorder",
                "description": "A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality."
            },
            "synonyms": [
                {
                    "id": "DOID:1470",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1470",
                    "name": "clinical depression",
                    "description": ""
                },
                {
                    "id": "DOID:1470",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1470",
                    "name": "recurrent major depression",
                    "description": ""
                },
                {
                    "id": "DOID:1470",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1470",
                    "name": "single major depressive episode",
                    "description": ""
                },
                {
                    "id": "DOID:1470",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1470",
                    "name": "unipolar depression",
                    "description": ""
                },
                {
                    "id": "DOID:1470",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1470",
                    "name": "major depression",
                    "description": ""
                },
                {
                    "id": "MONDO:0012100",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012100",
                    "name": "major depressive disorder 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012100",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012100",
                    "name": "MDD2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012100",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012100",
                    "name": "major depressive disorder 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012100",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012100",
                    "name": "major depressive disorder type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012100",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012100",
                    "name": "unipolar depression 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012050",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012050",
                    "name": "major depressive disorder 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0012050",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012050",
                    "name": "MDD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0012050",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012050",
                    "name": "major depressive disorder 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0012050",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012050",
                    "name": "major depressive disorder type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0012050",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012050",
                    "name": "unipolar depression 1",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "1470",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1470"
                }
            ]
        },
        {
            "disease_id": "DOID:2030",
            "recommended_name": {
                "id": "DOID:2030",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:2030",
                "name": "anxiety disorder",
                "description": "A cognitive disorder that involves an excessive, irrational dread of everyday situations."
            },
            "synonyms": [
                {
                    "id": "DOID:2030",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2030",
                    "name": "anxiety",
                    "description": ""
                },
                {
                    "id": "DOID:2030",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2030",
                    "name": "anxiety state",
                    "description": ""
                },
                {
                    "id": "MONDO:0011918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011918",
                    "name": "anxiety",
                    "description": ""
                },
                {
                    "id": "MONDO:0011918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011918",
                    "name": "anxiety",
                    "description": ""
                },
                {
                    "id": "MONDO:0011918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011918",
                    "name": "anxiety-related personality traits",
                    "description": ""
                },
                {
                    "id": "MONDO:0011918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011918",
                    "name": "harm avoidance",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "2030",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:2030"
                }
            ]
        },
        {
            "disease_id": "DOID:5419",
            "recommended_name": {
                "id": "DOID:5419",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:5419",
                "name": "schizophrenia",
                "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness."
            },
            "synonyms": [
                {
                    "id": "DOID:5419",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5419",
                    "name": "schizophrenia-1",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia",
                    "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality."
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia 12",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia (disease)",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia-1",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "SCZD",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizoaffective disorder",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia with or without an affective disorder",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MIM:181500",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/181500",
                    "name": "Schizophrenia",
                    "description": "Schizophrenia"
                }
            ],
            "evidence": [
                {
                    "id": "5419",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:5419"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35116",
                    "url": "https://www.uniprot.org/uniprot/O35116"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Ctnnd2",
            "url": "https://www.uniprot.org/uniprot/O35116",
            "locus": {
                "chromosome": "2",
                "start_pos": 82015764,
                "end_pos": 81167117,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000010649",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000010649"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000010649",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010649",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "114028",
            "url": "https://www.ncbi.nlm.nih.gov/gene/114028",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "O35116",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:O35116*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000225",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011989",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016024",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR028435",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028435",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:114028",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:114028",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "O35116",
            "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O35116",
            "database": "O-GlcNAc Database",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "GQSFSQX",
            "url": "https://omabrowser.org/oma/group/GQSFSQX/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5473239at2759",
            "url": "http://www.orthodb.org/?query=5473239at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10372",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10372",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10372:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10372:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00514",
            "url": "http://pfam.xfam.org/family/PF00514",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "620734",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620734",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6AP92",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AP92",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AP92-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AP92-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1M787",
            "url": "https://www.uniprot.org/uniprot/F1M787",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1M787-1",
            "url": "https://www.uniprot.org/uniprot/F1M787-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O35116",
            "url": "https://www.uniprot.org/uniprot/O35116",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O35116-1",
            "url": "https://www.uniprot.org/uniprot/O35116-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "FPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVG",
        "length": 264,
        "header": "sp|O35116-1|CTND2_RAT Isoform 1 of Catenin delta-2  OS=Rattus norvegicus OX=10116 GN=Ctnnd2 PE=1 SV=1 CANONICAL=O35116-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6AP92-1",
            "url": "",
            "sequence": {
                "sequence": "MFARKQSGAAPFGAMPVPDQPPSASEKNSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSISSAGEQFHWQTQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTSERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGDTAPSQLPARSTQARAAGQSFSQGTTGRSGHLAGSEPAPPPPPPREPFAPSLGSAFHLPDAPPAAAALYYSSSTLPAPPRGGSPLTTTQGGSPTKLQRGGSAPEGAAYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLAPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTFRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCASADSPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTGSKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYESAGNSATYHGTKGEHTSRKDTMTAQNTGVSTLYRNSYGAPAEDIKQNQVSTQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV",
                "length": 1222,
                "header": "tr|A0A8I6AP92-1|CTND2_RAT Computationally mapped isoform of Catenin delta-2  OS=Rattus norvegicus OX=10116 GN=Ctnnd2 PE=1 SV=1 CANONICAL=O35116-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 82014810,
                "end_pos": 81169126,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000119467.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000119467.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000096253.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000096253.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F1M787-1",
            "url": "",
            "sequence": {
                "sequence": "MFARKQSGAAPFGAMPVPDQPPSASEKNSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSISSAGEQFHWQTQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTSERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGDTAPSQLPARSTQARAAGQSFSQGTTGRSGHLAGSEPAPPPPPPREPFAPSLGSAFHLPDAPPAAAALYYSSSTLPAPPRGGSPLTTTQGGSPTKLQRGGSAPEGAAYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLAPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTFRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCASADSPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKGWAEDVAGMAYALRSLPEGAPCLPQWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTGSKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYESAGNSATYHGTKGEHTSRKDTMTAQNTGVSTLYRNSYGAPAEDIKQNQVSTQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV",
                "length": 1247,
                "header": "tr|F1M787-1|CTND2_RAT Computationally mapped isoform of Catenin delta-2  OS=Rattus norvegicus OX=10116 GN=Ctnnd2 PE=1 SV=4 CANONICAL=O35116-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 82014810,
                "end_pos": 81169126,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000044871.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000044871.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000045121.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000045121.5"
                    }
                ]
            }
        },
        {
            "isoform_ac": "O35116-1",
            "url": "",
            "sequence": {
                "sequence": "FPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVG",
                "length": 264,
                "header": "sp|O35116-1|CTND2_RAT Isoform 1 of Catenin delta-2  OS=Rattus norvegicus OX=10116 GN=Ctnnd2 PE=1 SV=1 CANONICAL=O35116-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "site_category": "reported_with_glycan",
            "site_seq": "",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
            "evidence": [
                {
                    "id": "O35116",
                    "database": "O-GlcNAc Database",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O35116"
                },
                {
                    "id": "18683930",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/18683930"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071.",
            "journal": "J. Biol. Chem.",
            "date": "2000",
            "authors": "Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35116",
                    "url": "https://www.uniprot.org/uniprot/O35116"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10896674",
                    "url": "https://glygen.org/publication/PubMed/10896674"
                }
            ]
        },
        {
            "title": "cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells.",
            "journal": "J. Cell. Biochem.",
            "date": "2007",
            "authors": "Munoz JP, Huichalaf CH, Orellana D, Maccioni RB",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35116",
                    "url": "https://www.uniprot.org/uniprot/O35116"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17009320",
                    "url": "https://glygen.org/publication/PubMed/17009320"
                }
            ]
        },
        {
            "title": "Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.",
            "journal": "Journal of the American Chemical Society",
            "date": "2008",
            "authors": "Clark PM, Dweck JF, Mason DE, Hart CR, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC",
            "evidence": [
                {
                    "database": "O-GlcNAc Database",
                    "id": "O35116",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O35116"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18683930",
                    "url": "https://glygen.org/publication/PubMed/18683930"
                }
            ]
        },
        {
            "title": "Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons.",
            "journal": "J. Neurosci. Res.",
            "date": "2010",
            "authors": "Bareiss S, Kim K, Lu Q",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35116",
                    "url": "https://www.uniprot.org/uniprot/O35116"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20623542",
                    "url": "https://glygen.org/publication/PubMed/20623542"
                }
            ]
        },
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F1M787",
                    "url": "https://www.uniprot.org/uniprot/F1M787"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        },
        {
            "title": "Loss of delta-catenin function in severe autism.",
            "journal": "Nature",
            "date": "2015",
            "authors": "Turner TN, Sharma K, Oh EC, Liu YP, Collins RL, Sosa MX, Auer DR, Brand H, Sanders SJ, Moreno-De-Luca D, Pihur V, Plona T, Pike K, Soppet DR, Smith MW, Cheung SW, Martin CL, State MW, Talkowski ME, Cook E, Huganir R, Katsanis N, Chakravarti A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35116",
                    "url": "https://www.uniprot.org/uniprot/O35116"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25807484",
                    "url": "https://glygen.org/publication/PubMed/25807484"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:114028",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:114028",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O35927-1",
            "protein_name": "Catenin delta-2",
            "gene_name": "Ctnnd2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MFARKQSGAAPFGAMPVPDQPPSASEKNSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSISSAGEQFHWQTQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTSERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGDTAPSQLPARSTQARAAGQSFSQGTTGRAGHLAGSEPAPPPPPPREPFAPSLGSAFHLPDAPPAAAALYYSSSTLPAPPRGGSPLTTTQGGSPTKLQRGGSAPEGAAYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLAPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTFRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCASVDSPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGETNGKDTESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKGWAEDVAGMAYALRSLPEGAPCLPQWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNSGSKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYESAGNNATYHGTKGEHTSRKDTMTAQNTGVSTLYRNSYGAPAEDIKQNQVSTQPVPQEPSRKDYETYQPFPNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV",
                "length": 1247
            },
            "evidence": [
                {
                    "id": "45225968",
                    "url": "http://www.informatics.jax.org/homology/45225968",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9UQB3-1",
            "protein_name": "Catenin delta-2",
            "gene_name": "CTNND2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLAAPQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYECTGSNATYHGAKGEHTSRKDAMTAQNTGISTLYRNSYGAPAEDIKHNQVSAQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV",
                "length": 1225
            },
            "evidence": [
                {
                    "id": "45225968",
                    "url": "http://www.informatics.jax.org/homology/45225968",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "perikaryon",
                        "id": "GO:0043204",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glutamatergic synapse",
                        "id": "GO:0098978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "adherens junction",
                        "id": "GO:0005912",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "postsynaptic density",
                        "id": "GO:0014069",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite",
                        "id": "GO:0030425",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 8,
                "go_terms": [
                    {
                        "name": "cell-cell adhesion",
                        "id": "GO:0098609",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of canonical Wnt signaling pathway",
                        "id": "GO:0060828",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060828",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendritic spine morphogenesis",
                        "id": "GO:0060997",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060997",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "learning",
                        "id": "GO:0007612",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007612",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synapse organization",
                        "id": "GO:0050808",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of synaptic plasticity",
                        "id": "GO:0048167",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "morphogenesis of a branching structure",
                        "id": "GO:0001763",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001763",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of postsynaptic membrane neurotransmitter receptor levels",
                        "id": "GO:0099072",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099072",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "beta-catenin binding",
                        "id": "GO:0008013",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "structural constituent of postsynaptic density",
                        "id": "GO:0098919",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098919",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O35116",
                                "url": "https://www.uniprot.org/uniprot/O35116"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
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        {
            "start_pos": 101,
            "end_pos": 103,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 152,
            "end_pos": 154,
            "annotation": "n_glycosylation_sequon"
        },
        {
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            "end_pos": 161,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 208,
            "end_pos": 210,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Phosphorylated by CDK5 (PubMed:17009320). Phosphorylated by GSK3B (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35116",
                    "url": "https://www.uniprot.org/uniprot/O35116"
                },
                {
                    "database": "PubMed",
                    "id": "17009320",
                    "url": "https://glygen.org/publication/PubMed/17009320"
                },
                {
                    "database": "PubMed",
                    "id": "O35927",
                    "url": "https://glygen.org/publication/PubMed/O35927"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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