{ "uniprot_canonical_ac": "O08962-1", "uniprot_ac": "O08962", "uniprot_id": "KCNH2_RAT", "mass": { "chemical_mass": 126952.0, "monoisotopic_mass": 126952.0 }, "refseq": { "ac": "XP_008760852", "name": "potassium voltage-gated channel subfamily H member 2 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008760852" }, "gene_names": [ { "name": "Kcnh2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O08962", "id": "O08962" }, { "name": "ERG1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008760852", "id": "XP_008760852" }, { "name": "Erg", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O08962", "id": "O08962" }, { "name": "Kcnh2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008760852", "id": "XP_008760852" } ], "protein_names": [ { "name": "Potassium voltage-gated channel subfamily H member 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O08962" }, { "name": "ERG-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08962" }, { "name": "Eag-related protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08962" }, { "name": "Ether-a-go-go-related gene potassium channel 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08962" }, { "name": "Ether-a-go-go-related protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08962" }, { "name": "RERG; r-ERG; eag-related protein 1; ether-a-go-go-related protein 1; ether-a-go-go-related gene potassium channel 1; voltage-gated potassium channel subunit Kv11.1; potassium channel, voltage gated eag related subfamily H, member 2; ERG-1; potassium voltage-gated channel, subfamily H (eag-related), member 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401", "id": "NP_446401" }, { "name": "RERG", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08962" }, { "name": "Voltage-gated potassium channel subunit Kv11.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08962" }, { "name": "potassium voltage-gated channel subfamily H member 2 isoform X3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008760852", "id": "XP_008760852" }, { "name": "potassium voltage-gated channel subfamily H member 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401", "id": "NP_446401" }, { "name": "r-ERG", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08962" } ], "function": [ { "annotation": "Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells.", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" }, { "database": "PubMed", "id": "32559772", "url": "https://glygen.org/publication/PubMed/32559772" } ] }, { "annotation": "ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" }, { "database": "PubMed", "id": "33426760", "url": "https://glygen.org/publication/PubMed/33426760" } ] }, { "annotation": "ERK-dependent induction of the immediate-early gene Egr1 and the late gene Gpr50 contribute to two distinct phases of PACAP Gs-GPCR signaling for neuritogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" }, { "database": "PubMed", "id": "35841324", "url": "https://glygen.org/publication/PubMed/35841324" } ] }, { "annotation": "Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction.", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" }, { "database": "PubMed", "id": "33263944", "url": "https://glygen.org/publication/PubMed/33263944" } ] }, { "annotation": "Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" }, { "database": "PubMed", "id": "32388931", "url": "https://glygen.org/publication/PubMed/32388931" } ] }, { "annotation": "Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962#function" }, { "database": "UniProtKB", "id": "Q12809", "url": "https://www.uniprot.org/uniprot/Q12809#function" } ] } ], "disease": [ { "disease_id": "DOID:0050793", "recommended_name": { "id": "DOID:0050793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050793", "name": "short QT syndrome", "description": "A heart conduction disease that is characterized by heart arrhythmia defined as a short QT interval on an EKG (less than 300 ms) that does not significantly change with heart rate, tall and peaked T waves, and a structurally normal heart." }, "synonyms": [ { "id": "MONDO:0012314", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012314", "name": "short QT syndrome type 3", "description": "Any short QT 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"DOID:10273", "recommended_name": { "id": "DOID:10273", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10273", "name": "heart conduction disease", "description": "A cardiovascular system disease that involves the heart's electrical conduction system." }, "synonyms": [ { "id": "DOID:10273", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10273", "name": "heart rhythm disease", "description": "" } ], "evidence": [ { "id": "10273", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10273" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "evidence": [ { "id": "1826", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] }, { "disease_id": "DOID:2843", "recommended_name": { "id": "DOID:2843", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2843", "name": "long QT syndrome", "description": "An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of 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"http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621414", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A6K570", "url": "https://www.uniprot.org/uniprot/A6K570", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6K570-1", "url": "https://www.uniprot.org/uniprot/A6K570-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LN86", "url": "https://www.uniprot.org/uniprot/F1LN86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LN86-1", "url": "https://www.uniprot.org/uniprot/F1LN86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08962-1", "url": "https://www.uniprot.org/uniprot/O08962-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPMRTGSTGSPGAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPASASPVASIPGPHPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPLPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDSPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS", "length": 1163, "header": "sp|O08962-1|KCNH2_RAT Isoform 1 of Potassium voltage-gated channel subfamily H member 2 OS=Rattus norvegicus OX=10116 GN=Kcnh2 PE=1 SV=1 CANONICAL=O08962-1" }, "isoforms": [ { "isoform_ac": "A6K570-1", "url": "", "sequence": { "sequence": "MAIPAGKESRTGALQTRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDSPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS", "length": 821, "header": "tr|A6K570-1|A6K570_RAT Computationally mapped isoform of Potassium voltage-gated channel subfamily H member 2 OS=Rattus norvegicus OX=10116 GN=Kcnh2 PE=2 SV=1 CANONICAL=O08962-1" }, "locus": { "chromosome": "4", "start_pos": 10858617, "end_pos": 10849331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084826.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084826.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073593.1", "url": "https://www.ensembl.org/id/ENSRNOP00000073593.1" } ] } }, { "isoform_ac": "F1LN86-1", "url": "", "sequence": { "sequence": "MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPMRTGSTGSPGAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPASASPVASIRGPHPSPPAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDSPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS", "length": 1163, "header": "tr|F1LN86-1|F1LN86_RAT Computationally mapped isoform of Potassium voltage-gated channel subfamily H member 2 OS=Rattus norvegicus OX=10116 GN=Kcnh2 PE=1 SV=1 CANONICAL=O08962-1" }, "locus": { "chromosome": "4", "start_pos": 10858617, "end_pos": 10827369, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000013800.5", "url": "https://www.ensembl.org/id/ENSRNOT00000013800.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000013800.3", "url": "https://www.ensembl.org/id/ENSRNOP00000013800.3" } ] } }, { "isoform_ac": "O08962-1", "url": "", "sequence": { "sequence": "MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPMRTGSTGSPGAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPASASPVASIPGPHPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPLPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDSPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS", "length": 1163, "header": "sp|O08962-1|KCNH2_RAT Isoform 1 of Potassium voltage-gated channel subfamily H member 2 OS=Rattus norvegicus OX=10116 GN=Kcnh2 PE=1 SV=1 CANONICAL=O08962-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 600, "start_aa": "Asn", "end_pos": 600, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn600", "evidence": [ { "id": "O08962", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08962#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 1141, "end_pos": 1141, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "site_lbl": "Ser1141" }, { "start_pos": 239, "end_pos": 239, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "site_lbl": "Ser239" }, { "start_pos": 245, "end_pos": 245, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "site_lbl": "Ser245" }, { "start_pos": 285, "end_pos": 285, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O08962", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08962" } ], "site_lbl": "Ser285" }, { "start_pos": 286, "end_pos": 286, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O08962", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08962" } ], "site_lbl": "Ser286" }, { "start_pos": 322, "end_pos": 322, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "site_lbl": "Ser322" }, { "start_pos": 353, "end_pos": 353, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O08962", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08962" } ], "site_lbl": "Ser353" }, { "start_pos": 873, "end_pos": 873, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "site_lbl": "Ser873" }, { "start_pos": 876, "end_pos": 876, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "site_lbl": "Ser876" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary.", "journal": "J. Neuroendocrinol.", "date": "2000", "authors": "Wulfsen I, Hauber HP, Schiemann D, Bauer CK, Schwarz JR", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "reference": [ { "type": "PubMed", "id": "10718922", "url": "https://glygen.org/publication/PubMed/10718922" } ] }, { "title": "Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers.", "journal": "Pflugers Arch.", "date": "2001", "authors": "Wimmers S, Wulfsen I, Bauer CK, Schwarz JR", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "reference": [ { "type": "PubMed", "id": "11212207", "url": "https://glygen.org/publication/PubMed/11212207" } ] }, { "title": "The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.", "journal": "FASEB J.", "date": "2003", "authors": "Hayashi K., Balser J.R., Chanthaphaychith S., George A.L. Jr., Johns D.C., Kupershmidt S., Petersen C.I., Roden D.M., Wei J., Yang I.C.-H.", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "reference": [ { "type": "PubMed", "id": "14525949", "url": "https://glygen.org/publication/PubMed/14525949" } ] }, { "title": "Fast erg K+ currents in rat embryonic serotonergic neurones.", "journal": "J. Physiol. (Lond.)", "date": "2005", "authors": "Hirdes W, Schweizer M, Schuricht KS, Guddat SS, Wulfsen I, Bauer CK, Schwarz JR", "evidence": [ { "database": "UniProtKB", "id": "A6K570", "url": "https://www.uniprot.org/uniprot/A6K570" } ], "reference": [ { "type": "PubMed", "id": "15677682", "url": "https://glygen.org/publication/PubMed/15677682" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" }, { "database": "UniProtKB", "id": "F1LN86", "url": "https://www.uniprot.org/uniprot/F1LN86" }, { "database": "iPTMnet", "id": "O08962", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08962" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.", "journal": "Genes, brain, and behavior", "date": "2020", "authors": "Zhao C, Chang L, Auger AP, Gammie SC, Riters LV", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" } ], "reference": [ { "type": "PubMed", "id": "32388931", "url": "https://glygen.org/publication/PubMed/32388931" } ] }, { "title": "Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells.", "journal": "Drug research", "date": "2020", "authors": "Hajimirzaei N, Khalili NP, Boroumand B, Safari F, Pourhosseini A, Judi-Chelan R, Tavakoli F", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" } ], "reference": [ { "type": "PubMed", "id": "32559772", "url": "https://glygen.org/publication/PubMed/32559772" } ] }, { "title": "Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction.", "journal": "Cell proliferation", "date": "2021", "authors": "Li Z, Meng Y, Liu C, Liu H, Cao W, Tong C, Lu M, Li L, Peng L", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" } ], "reference": [ { "type": "PubMed", "id": "33263944", "url": "https://glygen.org/publication/PubMed/33263944" } ] }, { "title": "ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling.", "journal": "Stem cells (Dayton, Ohio)", "date": "2021", "authors": "Wang D, Liu C, Liu H, Meng Y, Lin F, Gu Y, Wang H, Shang M, Tong C, Sachinidis A, Ying Q, Li L, Peng L", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" } ], "reference": [ { "type": "PubMed", "id": "33426760", "url": "https://glygen.org/publication/PubMed/33426760" } ] }, { "title": "ERK-dependent induction of the immediate-early gene Egr1 and the late gene Gpr50 contribute to two distinct phases of PACAP Gs-GPCR signaling for neuritogenesis.", "journal": "Journal of neuroendocrinology", "date": "2022", "authors": "Xu W, Dahlke SP, Sung M, Samal B, Emery AC, Elkahloun A, Eiden LE", "evidence": [ { "database": "RefSeq", "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401" } ], "reference": [ { "type": "PubMed", "id": "35841324", "url": "https://glygen.org/publication/PubMed/35841324" } ] }, { "title": "Tissue and species distribution of mRNA for the IKr-like K+ channel, erg.", "journal": "Circ. Res.", "date": "1997", "authors": "Dixon J.E., Cohen I.S., McKinnon D., Wymore R.S., Wymore R.T., Gintant G.A.", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "reference": [ { "type": "PubMed", "id": "9012748", "url": "https://glygen.org/publication/PubMed/9012748" } ] }, { "title": "RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells.", "journal": "Recept. Channels", "date": "1998", "authors": "Wulfsen I., Pongs O., Ludwig J., Bauer C.K., Schwarz J.R., Engeland B.", "evidence": [ { "database": "UniProtKB", "id": "O08962", "url": "https://www.uniprot.org/uniprot/O08962" } ], "reference": [ { "type": "PubMed", "id": "9664620", "url": "https://glygen.org/publication/PubMed/9664620" } ] } ], "pathway": [ { "id": "rno:117018", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:117018", "resource": "KEGG Pathway" }, { "id": "R-RNO-1296072", "name": "Voltage gated Potassium channels", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" }, { "id": "R-RNO-5576890", "name": "Phase 3 - rapid repolarisation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5576890", "resource": "Reactome", "description": "Phase 3 - rapid repolarisation" } ], "orthologs": [ { "uniprot_canonical_ac": "O35219-1", "protein_name": "Potassium voltage-gated channel subfamily H member 2", "gene_name": "Kcnh2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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