{ "uniprot_canonical_ac": "O08747-1", "uniprot_ac": "O08747", "uniprot_id": "UNC5C_MOUSE", "mass": { "chemical_mass": 103063.0, "monoisotopic_mass": 103063.0 }, "refseq": { "ac": "NP_033498", "name": "netrin receptor UNC5C isoform 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033498" }, "gene_names": [ { "name": "Unc5c", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O08747", "id": "O08747" }, { "name": "B130051O18Rik; rcm; Unc5h3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033498", "id": "NP_033498" }, { "name": "Rcm", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O08747", "id": "O08747" }, { "name": "Unc5c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033498", "id": "NP_033498" }, { "name": "Unc5h3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O08747", "id": "O08747" } ], "protein_names": [ { "name": "Netrin receptor UNC5C", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O08747" }, { "name": "Protein unc-5 homolog 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08747" }, { "name": "Protein unc-5 homolog C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08747" }, { "name": "Rostral cerebellar malformation protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08747" }, { "name": "netrin receptor UNC5C isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033498", "id": "NP_033498" }, { "name": "netrin receptor UNC5C; rostral cerebellar malformation protein; unc5 homolog 3; UNC-5 homolog 3; unc-5 homolog C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033498", "id": "NP_033498" } ], "function": [ { "annotation": "Receptor for netrin required for axon guidance (PubMed:22685302, PubMed:10399920). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:10399920, PubMed:22685302). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (PubMed:10399920). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (PubMed:22685302). Also involved in corticospinal tract axon guidance independently of DCC (PubMed:9126743, PubMed:9389662, PubMed:12451134). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747#function" }, { "database": "UniProtKB", "id": "Q761X5", "url": "https://www.uniprot.org/uniprot/Q761X5#function" }, { "database": "PubMed", "id": "9126743", "url": "https://glygen.org/publication/PubMed/9126743" }, { "database": "PubMed", "id": "9389662", "url": "https://glygen.org/publication/PubMed/9389662" }, { "database": "PubMed", "id": "12451134", "url": "https://glygen.org/publication/PubMed/12451134" }, { "database": "PubMed", "id": "28483977", "url": "https://glygen.org/publication/PubMed/28483977" }, { "database": "PubMed", "id": "10399920", "url": "https://glygen.org/publication/PubMed/10399920" }, { "database": "PubMed", "id": "22685302", "url": "https://glygen.org/publication/PubMed/22685302" }, { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185#function" } ] }, { "annotation": "Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.", "evidence": [ { "database": "UniProtKB", "id": "E9PVI4", "url": "https://www.uniprot.org/uniprot/E9PVI4#function" }, { "database": "UniProtKB", "id": "RU367033", "url": "https://www.uniprot.org/uniprot/RU367033#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 568, "end_pos": 568, "sequence_org": "Y", "sequence_mut": "F", "comment": "Abolishes interaction with PTPN11, leading to an increased level of phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" }, { "database": "PubMed", "id": "11533026", "url": "https://glygen.org/publication/PubMed/11533026" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Unc5c", "url": "https://www.uniprot.org/uniprot/O08747", "locus": { "chromosome": "3", "start_pos": 141540685, "end_pos": 141170977, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000059921", "url": "https://www.ensembl.org/id/ENSMUSG00000059921" } ] } } ], "crossref": [ { "id": "ENSMUSG00000059921", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000059921", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08799", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08799", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "22253", "url": "https://www.ncbi.nlm.nih.gov/gene/22253", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0002365", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002365", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0003052", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003052", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0003053", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0003053", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "O08747", "url": "https://www.ebi.ac.uk/intact/interactors/id:O08747*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:22253", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22253", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1095412", "url": "http://www.informatics.jax.org/marker/MGI:1095412", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "CECQAWS", "url": "https://omabrowser.org/oma/group/CECQAWS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2971005at2759", "url": "http://www.orthodb.org/?query=2971005at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12582", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12582", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12582:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12582:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "http://pfam.xfam.org/family/PF00090", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00531", "url": "http://pfam.xfam.org/family/PF00531", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00791", "url": "http://pfam.xfam.org/family/PF00791", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "http://pfam.xfam.org/family/PF07679", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17217", "url": "http://pfam.xfam.org/family/PF17217", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O08747", "url": "http://purl.obolibrary.org/obo/PR_O08747", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_033498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033498", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E9PVI4", "url": "https://www.uniprot.org/uniprot/E9PVI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PVI4-1", "url": "https://www.uniprot.org/uniprot/E9PVI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08747-1", "url": "https://www.uniprot.org/uniprot/O08747-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08747-2", "url": "https://www.uniprot.org/uniprot/O08747-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDEFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY", "length": 931, "header": "sp|O08747-1|UNC5C_MOUSE Isoform 1 of Netrin receptor UNC5C OS=Mus musculus OX=10090 GN=Unc5c PE=1 SV=1 CANONICAL=O08747-1" }, "isoforms": [ { "isoform_ac": "E9PVI4-1", "url": "", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQGFIYPISTEHRPQNEYGFSSAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY", "length": 876, "header": "tr|E9PVI4-1|E9PVI4_MOUSE Computationally mapped isoform of Netrin receptor UNC5 OS=Mus musculus OX=10090 GN=Unc5c PE=1 SV=1 CANONICAL=O08747-1" }, "locus": { "chromosome": "3", "start_pos": 141534330, "end_pos": 141171475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000130636.8", "url": "https://www.ensembl.org/id/ENSMUST00000130636.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000117487.2", "url": "https://www.ensembl.org/id/ENSMUSP00000117487.2" } ] } }, { "isoform_ac": "O08747-1", "url": "", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDEFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY", "length": 931, "header": "sp|O08747-1|UNC5C_MOUSE Isoform 1 of Netrin receptor UNC5C OS=Mus musculus OX=10090 GN=Unc5c PE=1 SV=1 CANONICAL=O08747-1" }, "locus": { "chromosome": "3", "start_pos": 141534330, "end_pos": 141171475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106236", "url": "https://www.ensembl.org/id/ENSMUST00000106236" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101843", "url": "https://www.ensembl.org/id/ENSMUSP00000101843" } ] } }, { "isoform_ac": "O08747-2", "url": "", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDEFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQGFIYPISTEHRPQNEYGFSSAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY", "length": 950, "header": "sp|O08747-2|UNC5C_MOUSE Isoform 2 of Netrin receptor UNC5C OS=Mus musculus OX=10090 GN=Unc5c PE=1 SV=1 CANONICAL=O08747-1" }, "locus": { "chromosome": "3", "start_pos": 141534330, "end_pos": 141171475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000075282", "url": "https://www.ensembl.org/id/ENSMUST00000075282" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000074758", "url": "https://www.ensembl.org/id/ENSMUSP00000074758" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 236, "start_aa": "Asn", "end_pos": 236, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn236", "evidence": [ { "id": "O08747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08747#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 361, "start_aa": "Asn", "end_pos": 361, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn361", "evidence": [ { "id": "O08747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08747#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 502, "end_pos": 502, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O08747", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08747" } ], "site_lbl": "Ser502" }, { "start_pos": 568, "end_pos": 568, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" }, { "database": "PubMed", "id": "11533026", "url": "https://glygen.org/publication/PubMed/11533026" }, { "database": "iPTMnet", "id": "O08747", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08747" } ], "site_lbl": "Tyr568" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.", "journal": "Cell", "date": "1999", "authors": "Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" } ], "reference": [ { "type": "PubMed", "id": "10399920", "url": "https://glygen.org/publication/PubMed/10399920" } ] }, { "title": "Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Tong J, Killeen M, Steven R, Binns KL, Culotti J, Pawson T", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" }, { "database": "iPTMnet", "id": "O08747", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08747" } ], "reference": [ { "type": "PubMed", "id": "11533026", "url": "https://glygen.org/publication/PubMed/11533026" } ] }, { "title": "The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons.", "journal": "J. Neurosci.", "date": "2002", "authors": "Johnson K., Harris B., Bronson R.T., Ackerman S.L., Finger J.H., Przyborski S.A.", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" } ], "reference": [ { "type": "PubMed", "id": "12451134", "url": "https://glygen.org/publication/PubMed/12451134" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" }, { "database": "iPTMnet", "id": "O08747", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08747" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development.", "journal": "Neuron", "date": "2012", "authors": "O'Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates JR 3rd, Ghosh A", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" } ], "reference": [ { "type": "PubMed", "id": "22405201", "url": "https://glygen.org/publication/PubMed/22405201" } ] }, { "title": "Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.", "journal": "J. Biol. Chem.", "date": "2012", "authors": "Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" } ], "reference": [ { "type": "PubMed", "id": "22685302", "url": "https://glygen.org/publication/PubMed/22685302" } ] }, { "title": "A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.", "journal": "Nat. Med.", "date": "2014", "authors": "Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" } ], "reference": [ { "type": "PubMed", "id": "25419706", "url": "https://glygen.org/publication/PubMed/25419706" } ] }, { "title": "Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.", "journal": "J. Neurosci.", "date": "2017", "authors": "Shao Q, Yang T, Huang H, Alarmanazi F, Liu G", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" } ], "reference": [ { "type": "PubMed", "id": "28483977", "url": "https://glygen.org/publication/PubMed/28483977" } ] }, { "title": "The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein.", "journal": "Nature", "date": "1997", "authors": "Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB, Knowles BB", "evidence": [ { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747" } ], "reference": [ { "type": "PubMed", "id": "9126743", "url": "https://glygen.org/publication/PubMed/9126743" } ] }, { "title": "Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary.", "journal": "Development", "date": "1998", "authors": "Ackerman S.L., Knowles B.B., Przyborski S.A.", "evidence": [ 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