{ "uniprot_canonical_ac": "O08662-1", "uniprot_ac": "O08662", "uniprot_id": "PI4KA_RAT", "mass": { "chemical_mass": 236920.0, "monoisotopic_mass": 236920.0 }, "refseq": {}, "gene_names": [ { "name": "Pi4ka", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O08662", "id": "O08662" }, { "name": "Pik4ca", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O08662", "id": "O08662" } ], "protein_names": [ { "name": "Phosphatidylinositol 4-kinase alpha", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O08662" }, { "name": "2.7.1.67", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08662" }, { "name": "PI4-kinase alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08662" }, { "name": "PI4K-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08662" }, { "name": "PtdIns-4-kinase alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08662" } ], "function": [ { "annotation": "Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662#function" }, { "database": "PubMed", "id": "8662589", "url": "https://glygen.org/publication/PubMed/8662589" } ] } ], "disease": [ { "disease_id": "DOID:0060413", "recommended_name": { "id": "DOID:0060413", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060413", "name": "chromosome 22q11.2 deletion syndrome, distal", "description": "A chromosomal deletion syndrome that has_material_basis_in deletion of the chromosome 22q11.2 region, distinct from DiGeorge syndrome and velocardiofacial syndrome." }, "synonyms": [ { "id": "DOID:0060413", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060413", "name": "22q11.2 deletion syndrome", "description": "" }, { "id": "DOID:0060413", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060413", "name": "distal 22q11.2 microdeletion syndrome", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "chromosome 22q11.2 deletion syndrome, distal", "description": "Distal 22q11.2 microdeletion syndrome is a rare chromosomal anomaly syndrome resulting from the partial deletion of the long arm of chromosome 22 with a highly variable phenotype characterized by prematurity, pre- and post-natal growth retardation, developmental delay (particularly speech), mild intellectual disability, variable cardiac defects, and minor skeletal anomalies (such as clinodactyly). Dysmorphic features include prominent forehead, arched eyebrows, deep set eyes, narrow upslanting palpebral fissures, ear abnormalities, hypoplastic alae nasi, smooth philtrum, down-turned mouth, thin upper lip, retro/micrognatia and pointed chin. For certain very distal deletions, there is a risk of developing malignant rhabdoid tumors." }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "chromosome 22q11.2 deletion syndrome, distal", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "distal 22q11.2 microdeletion syndrome", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "distal del(22)(q11.2)", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "distal monosomy 22q11.2", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "distal chromosome 22Q11.2 deletion syndrome", "description": "" } ], "evidence": [ { "id": "0060413", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060413" } ] }, { "disease_id": "DOID:0112347", "recommended_name": { "id": "DOID:0112347", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112347", "name": "hereditary spastic paraplegia 84", "description": "A hereditary spastic paraplegia characterized by onset in the first 2 decades of life of slowly progressive walking difficulties due to lower limb weakness, stiffness, and spasticity that has_material_basis_in homozygous or compound heterozygous mutation in the PI4KA gene on chromosome 22q11.21." }, "synonyms": [ { "id": "DOID:0112347", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112347", "name": "SPG84", "description": "" }, { "id": "DOID:0112347", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112347", "name": "spastic paraplegia 84 autosomal recessive", "description": "" }, { "id": "MONDO:0030482", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030482", "name": "spastic paraplegia 84, autosomal recessive", "description": "" }, { "id": "MONDO:0030482", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030482", "name": "SPG84", "description": "" }, { "id": "MIM:619621", "resource": "MIM", "url": "https://www.omim.org/entry/619621", "name": "Spastic paraplegia 84, autosomal recessive", "description": "Spastic paraplegia 84, autosomal recessive" } ], "evidence": [ { "id": "0112347", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112347" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "common_name": "Rat" } ], "gene": [ { "name": "Pi4ka", "url": "https://www.uniprot.org/uniprot/O08662", "locus": { "chromosome": "11", "start_pos": 83724080, "end_pos": 83609069, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000060045", "url": "https://www.ensembl.org/id/ENSRNOG00000060045" } ] } } ], "crossref": [ { "id": "ENSRNOG00000060045", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060045", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00871", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00871", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05167", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "64161", "url": "https://www.ncbi.nlm.nih.gov/gene/64161", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O08662", "url": "https://www.ebi.ac.uk/intact/interactors/id:O08662*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001263", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001263", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:64161", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64161", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TIEVWQS", "url": "https://omabrowser.org/oma/group/TIEVWQS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "147843at2759", "url": "http://www.orthodb.org/?query=147843at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10048:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10048:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00454", "url": "http://pfam.xfam.org/family/PF00454", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00613", "url": "http://pfam.xfam.org/family/PF00613", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19274", "url": "http://pfam.xfam.org/family/PF19274", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O08662", "url": "http://purl.obolibrary.org/obo/PR_O08662", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-1483248", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1483248", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1660514", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660514", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_071637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071637", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "621213", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621213", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "19877", "url": "https://www.rhea-db.org/rhea/19877", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A140TAJ5", "url": "https://www.uniprot.org/uniprot/A0A140TAJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TAJ5-1", "url": "https://www.uniprot.org/uniprot/A0A140TAJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08662-1", "url": "https://www.uniprot.org/uniprot/O08662-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAGARGTGGSGSSSGSSTSRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCIVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEALLQVLHVLLGMCQALEIQEKEYLCKYAIPCLIGISRSFGRYSNSEESLLSKLFPKVPPHSLRIPEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTTLEPEYYFSTISSSFSVSPLFNGITYKEFYIPLEMLRELLNLVKKIVEEPVLKSLDAAVARVMEANPSADLYYTTFSDPVYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSEMSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELNELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGVTQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSAETKEADPLAASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLHIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWTISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDTEDECRRQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKIIQNCFLSNRSRTYDMIQYYQNDIPY", "length": 2096, "header": "sp|O08662-1|PI4KA_RAT Isoform 1 of Phosphatidylinositol 4-kinase alpha OS=Rattus norvegicus OX=10116 GN=Pi4ka PE=1 SV=2 CANONICAL=O08662-1" }, "isoforms": [ { "isoform_ac": "A0A140TAJ5-1", "url": "", "sequence": { "sequence": "MAAAGARGGGGAGAAGARGGGGAGAGTGGSGSSSGSSTSRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCIVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEALLQVLHVLLGMCQALEIQEKEYLCKYAIPCLIGISRSFGRYSNSEESLLSKLFPKVPPHSLRIPEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTTLEPEYYFSTISSSFSVSPLFNGITYKEFYIPLEMLRELLNLVKKIVEEPVLKSLDAAVARVMEANPSADLYYTTFSDPVYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSEMSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELNELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGVTQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSAETKEADPLAASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLHIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWTISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDTEDECRRQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKIIQNCFLSNRSRTYDMIQYYQNDIPY", "length": 2114, "header": "tr|A0A140TAJ5-1|A0A140TAJ5_RAT Computationally mapped isoform of 1-phosphatidylinositol 4-kinase OS=Rattus norvegicus OX=10116 GN=Pi4ka PE=1 SV=2 CANONICAL=O08662-1" }, "locus": { "chromosome": "11", "start_pos": 83723737, "end_pos": 83609202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000091117.2", "url": "https://www.ensembl.org/id/ENSRNOT00000091117.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072265.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072265.2" } ] } }, { "isoform_ac": "O08662-1", "url": "", "sequence": { "sequence": "MAAAGARGTGGSGSSSGSSTSRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCIVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEALLQVLHVLLGMCQALEIQEKEYLCKYAIPCLIGISRSFGRYSNSEESLLSKLFPKVPPHSLRIPEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTTLEPEYYFSTISSSFSVSPLFNGITYKEFYIPLEMLRELLNLVKKIVEEPVLKSLDAAVARVMEANPSADLYYTTFSDPVYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSEMSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELNELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGVTQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSAETKEADPLAASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLHIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWTISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDTEDECRRQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKIIQNCFLSNRSRTYDMIQYYQNDIPY", "length": 2096, "header": "sp|O08662-1|PI4KA_RAT Isoform 1 of Phosphatidylinositol 4-kinase alpha OS=Rattus norvegicus OX=10116 GN=Pi4ka PE=1 SV=2 CANONICAL=O08662-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1430, "end_pos": 1430, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O08662", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08662" } ], "site_lbl": "Ser1430" }, { "start_pos": 224, "end_pos": 224, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "site_lbl": "Ser224" }, { "start_pos": 250, "end_pos": 250, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "site_lbl": "Ser250" }, { "start_pos": 251, "end_pos": 251, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "site_lbl": "Ser251" }, { "start_pos": 253, "end_pos": 253, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "site_lbl": "Ser253" }, { "start_pos": 254, "end_pos": 254, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O08662", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08662" } ], "site_lbl": "Ser254" }, { "start_pos": 256, "end_pos": 256, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "site_lbl": "Ser256" }, { "start_pos": 259, "end_pos": 259, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O08662", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08662" } ], "site_lbl": "Ser259" }, { "start_pos": 423, "end_pos": 423, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "site_lbl": "Ser423" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" }, { "database": "UniProtKB", "id": "A0A140TAJ5", "url": "https://www.uniprot.org/uniprot/A0A140TAJ5" }, { "database": "iPTMnet", "id": "O08662", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08662" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity.", "journal": "J. Cell Biol.", "date": "2012", "authors": "Nakatsu F, Baskin JM, Chung J, Tanner LB, Shui G, Lee SY, Pirruccello M, Hao M, Ingolia NT, Wenk MR, De Camilli P", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "reference": [ { "type": "PubMed", "id": "23229899", "url": "https://glygen.org/publication/PubMed/23229899" } ] }, { "title": "Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase.", "journal": "J. Biol. Chem.", "date": "1996", "authors": "Nakagawa T, Goto K, Kondo H", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "reference": [ { "type": "PubMed", "id": "8662589", "url": "https://glygen.org/publication/PubMed/8662589" } ] } ], "pathway": [ { "id": "rno:64161", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64161", "resource": "KEGG Pathway" }, { "id": "R-RNO-1483248", "name": "Synthesis of PIPs at the ER membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1483248", "resource": "Reactome", "description": "Synthesis of PIPs at the ER membrane" }, { "id": "R-RNO-1660514", "name": "Synthesis of PIPs at the Golgi membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660514", "resource": "Reactome", "description": "Synthesis of PIPs at the Golgi membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "E9Q3L2-1", "protein_name": "Phosphatidylinositol 4-kinase alpha", "gene_name": "Pi4ka", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAGARGGGGGGGGGGGGGSGSSSGSSTSRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEAILQVLHVLLGMCQALEIQEKEYLCKYAIPCLIGISRSFGRYSNSEESLLSKLFPKVSPHSLRIPEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGIPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSISPLFNGITYKEFCIPLEMLRELLNLVKKIVEEPVLKSLDAIVAGVMEANPSADLYYTTFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSEMSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSVETKEADPLAASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDAEDECFSQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQNCFLSNRSRTYDMIQYYQNDIPY", "length": 2105 }, "evidence": [ { "id": "45230262", "url": "http://www.informatics.jax.org/homology/45230262", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P42356-1", "protein_name": "Phosphatidylinositol 4-kinase alpha", "gene_name": "PI4KA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDIPY", "length": 2102 }, "evidence": [ { "id": "45230262", "url": "http://www.informatics.jax.org/homology/45230262", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" }, { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" }, { "name": "1-phosphatidylinositol 4-kinase activity", "id": "GO:0004430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004430", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" }, { "name": "Golgi-associated vesicle membrane", "id": "GO:0030660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030660", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" }, { "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate biosynthetic process", "id": "GO:0046854", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046854", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" }, { "name": "modulation by host of viral process", "id": "GO:0044788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044788", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" }, { "name": "reorganization of cellular membranes to establish viral sites of replication", "id": "GO:0140754", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140754", "evidence": [ { "database": "UniProtKB", "id": "O08662", "url": "https://www.uniprot.org/uniprot/O08662" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1111, "end_pos": 1113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1361, "end_pos": 1363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1737, "end_pos": 1739, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2058, "end_pos": 2060, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2079, "end_pos": 2081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 847, "end_pos": 849, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19877", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08662-1", "Q5XIL2-1", "O08561-1", "Q99M64-1", "Q9BTU6-1", "Q8TCG2-1", "Q9UBF8-1", "P42356-1", "Q8CBQ5-1", "E9Q3L2-1", "Q8BKC8-1", "Q2TBE6-1", "P32600-1", "P39104-1", "P42951-1", "P37297-1", "P54677-1", "Q9VND3-1" ], "evidence": [ { "id": "19877", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19877" } ] }, { "id": "R-RNO-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08662-1", "Q5XIL2-1" ], "evidence": [ { "id": "R-RNO-1675813", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1675813" } ] }, { "id": "R-RNO-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08662-1", "Q99M64-1", "Q5XIL2-1" ], "evidence": [ { "id": "R-RNO-1676185", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1676185" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E9Q3L2", "gene_name": "Pi4ka", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "E9Q3L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q3L2" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "E9Q3L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q3L2" } ] } ] }, { "uniprot_ac": "O08561", "gene_name": "Pi4kb", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "O08561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08561" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "O08561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08561" } ] } ] }, { "uniprot_ac": "O08662", "gene_name": "Pi4ka", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "O08662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08662" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "O08662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08662" } ] } ] }, { "uniprot_ac": "P32600", "gene_name": "TOR2", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] } ] }, { "uniprot_ac": "P37297", "gene_name": "STT4", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P37297", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37297" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P37297", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37297" } ] } ] }, { "uniprot_ac": "P39104", "gene_name": "PIK1", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P39104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39104" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P39104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39104" } ] } ] }, { "uniprot_ac": "P42356", "gene_name": "PI4KA", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42356", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42356" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P42356", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42356" } ] } ] }, { "uniprot_ac": "P42951", "gene_name": "LSB6", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42951" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P42951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42951" } ] } ] }, { "uniprot_ac": "P54677", "gene_name": "pikD", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P54677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54677" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P54677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54677" } ] } ] }, { "uniprot_ac": "Q2TBE6", "gene_name": "Pi4k2a", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q2TBE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TBE6" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q2TBE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TBE6" } ] } ] }, { "uniprot_ac": "Q5XIL2", "gene_name": "Pi4k2b", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q5XIL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIL2" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q5XIL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIL2" } ] } ] }, { "uniprot_ac": "Q8BKC8", "gene_name": "Pi4kb", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q8BKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKC8" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q8BKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKC8" } ] } ] }, { "uniprot_ac": "Q8CBQ5", "gene_name": "Pi4k2b", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q8CBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBQ5" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q8CBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBQ5" } ] } ] }, { "uniprot_ac": "Q8TCG2", "gene_name": "PI4K2B", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q8TCG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TCG2" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q8TCG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TCG2" } ] } ] }, { "uniprot_ac": "Q99M64", "gene_name": "Pi4k2a", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q99M64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99M64" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q99M64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99M64" } ] } ] }, { "uniprot_ac": "Q9BTU6", "gene_name": "PI4K2A", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q9BTU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BTU6" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q9BTU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BTU6" } ] } ] }, { "uniprot_ac": "Q9UBF8", "gene_name": "PI4KB", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q9UBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBF8" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q9UBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBF8" } ] } ] }, { "uniprot_ac": "Q9VND3", "gene_name": "Pi4KIIalpha", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q9VND3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VND3" } ] }, { "ec_number": "2.7.1.67", "activity": "", 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"table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }