{ "uniprot_canonical_ac": "O08561-1", "uniprot_ac": "O08561", "uniprot_id": "PI4KB_RAT", "mass": { "chemical_mass": 91655.0, "monoisotopic_mass": 91655.0 }, "refseq": { "ac": "NP_112345", "name": "phosphatidylinositol 4-kinase beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" }, "gene_names": [ { "name": "Pi4kb", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O08561", "id": "O08561" }, { "name": "Pik4cb", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O08561", "id": "O08561" } ], "protein_names": [ { "name": "Phosphatidylinositol 4-kinase beta", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O08561" }, { "name": "2.7.1.67", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08561" }, { "name": "PI4K-beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08561" }, { "name": "PI4Kbeta; PI4K-beta; ptdIns 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide; catalytic phosphatidylinositol 4-kinase beta", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345", "id": "NP_112345" }, { "name": "PI4Kbeta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08561" }, { "name": "PtdIns 4-kinase beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O08561" }, { "name": "phosphatidylinositol 4-kinase beta", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345", "id": "NP_112345" } ], "function": [ { "annotation": "NCS-1 protein and 1-phosphatidylinositol 4-kinase b interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" }, { "database": "PubMed", "id": "12244129", "url": "https://glygen.org/publication/PubMed/12244129" } ] }, { "annotation": "Overexpression of a PI4K beta mutant in rat mast cells inhibits IgE receptor-triggered phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and exocytosis.", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" }, { "database": "PubMed", "id": "14607934", "url": "https://glygen.org/publication/PubMed/14607934" } ] }, { "annotation": "Phosphatidylinositol-4 kinase in basolateral membranes from kidney cells is activated by sphingosine-1-phosphate", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" }, { "database": "PubMed", "id": "14607979", "url": "https://glygen.org/publication/PubMed/14607979" } ] }, { "annotation": "Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) (PubMed:8973579). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (PubMed:8973579). May play an important role in the inner ear development.", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561#function" }, { "database": "PubMed", "id": "8973579", "url": "https://glygen.org/publication/PubMed/8973579" }, { "database": "UniProtKB", "id": "Q9UBF8", "url": "https://www.uniprot.org/uniprot/Q9UBF8#function" } ] }, { "annotation": "There is a physical and functional relationship between eEF1A2 and PI4KIIIbeta", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" }, { "database": "PubMed", "id": "17088255", "url": "https://glygen.org/publication/PubMed/17088255" } ] }, { "annotation": "These results suggest that the anti-inflammatory effects of sanguinarine on PtdIns 3-kinase signaling pathway are more likely an indirect effect and emphasize the importance of the cross talk between type II PtdIns 4-kinases and PtdIns 3-kinases.", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" }, { "database": "PubMed", "id": "23899475", "url": "https://glygen.org/publication/PubMed/23899475" } ] }, { "annotation": "Work suggests an important role for both eEF1A2 and PI4KIIIbeta in the control of PI(4,5)P(2) signaling and actin remodeling.", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" }, { "database": "PubMed", "id": "18474610", "url": "https://glygen.org/publication/PubMed/18474610" } ] } ], "disease": [ { "disease_id": "DOID:0050564", "recommended_name": { "id": "DOID:0050564", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050564", "name": "autosomal dominant nonsyndromic deafness", "description": "A nonsyndromic deafness characterized by an autosomal dominant inheritance mode." }, "synonyms": [ { "id": "DOID:0050564", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050564", "name": "autosomal dominant deafness", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant nonsyndromic hearing loss 1", "description": "Any autosomal dominant nonsyndromic deafness in which the cause of the disease is a mutation in the DIAPH1 gene." }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "Konigsmark syndrome", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "LFHL1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "hereditary low frequency hearing loss 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "DFNA1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "DIAPH1 autosomal dominant nonsyndromic deafness", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant deafness 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant nonsyndromic deafness 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant nonsyndromic deafness caused by mutation in DIAPH1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "autosomal dominant nonsyndromic deafness type 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "deafness, autosomal dominant 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "deafness, autosomal dominant 1, with or without thrombocytopenia", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "deafness, autosomal dominant type 1", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "deafness, progressive Low tone", "description": "" }, { "id": "MONDO:0007424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007424", "name": "hereditary Low frequency hearing loss", "description": "" }, { "id": "MIM:124900", "resource": "MIM", "url": "https://www.omim.org/entry/124900", "name": "Deafness, autosomal dominant 1, with or without thrombocytopenia", "description": "Deafness, autosomal dominant 1, with or without thrombocytopenia" } ], "evidence": [ { "id": "0050564", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050564" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "common_name": "Rat" } ], "gene": [ { "name": "Pi4kb", "url": "https://www.uniprot.org/uniprot/O08561", "locus": { "chromosome": "2", "start_pos": 182588488, "end_pos": 182540567, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000021024", "url": "https://www.ensembl.org/id/ENSRNOG00000021024" } ] } } ], "crossref": [ { "id": "ENSRNOG00000021024", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000021024", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05168", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05168", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22246", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22246", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "81747", "url": "https://www.ncbi.nlm.nih.gov/gene/81747", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O08561", "url": "https://www.ebi.ac.uk/intact/interactors/id:O08561*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001263", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001263", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:81747", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:81747", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GNKMFSF", "url": "https://omabrowser.org/oma/group/GNKMFSF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "147843at2759", "url": "http://www.orthodb.org/?query=147843at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10048:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10048:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00454", "url": "http://pfam.xfam.org/family/PF00454", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O08561", "url": "http://purl.obolibrary.org/obo/PR_O08561", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-1660514", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660514", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "621214", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621214", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "19877", "url": "https://www.rhea-db.org/rhea/19877", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JYH1", "url": "https://www.uniprot.org/uniprot/A0A0G2JYH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JYH1-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JYH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZT79", "url": "https://www.uniprot.org/uniprot/A0A8I5ZT79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZT79-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZT79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AD21", "url": "https://www.uniprot.org/uniprot/A0A8I6AD21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AD21-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AD21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ALD3", "url": "https://www.uniprot.org/uniprot/A0A8I6ALD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ALD3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ALD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ASK5", "url": "https://www.uniprot.org/uniprot/A0A8I6ASK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ASK5-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ASK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2QJX4", "url": "https://www.uniprot.org/uniprot/A0A8L2QJX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2QJX4-1", "url": "https://www.uniprot.org/uniprot/A0A8L2QJX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O08561-1", "url": "https://www.uniprot.org/uniprot/O08561-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 816, "header": "sp|O08561-1|PI4KB_RAT Isoform 1 of Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=1 CANONICAL=O08561-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JYH1-1", "url": "", "sequence": { "sequence": "MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGCRRCSGASLSGPVVTVAQVICSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 822, "header": "tr|A0A0G2JYH1-1|PI4KB_RAT Computationally mapped isoform of Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=2 CANONICAL=O08561-1" }, "locus": { "chromosome": "2", "start_pos": 182571999, "end_pos": 182549058, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000080966.2", "url": "https://www.ensembl.org/id/ENSRNOT00000080966.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070653.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070653.2" } ] } }, { "isoform_ac": "A0A8I5ZT79-1", "url": "", "sequence": { "sequence": "MPSFLHLLMSSGFSNSLEARSLAVAMGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 826, "header": "tr|A0A8I5ZT79-1|A0A8I5ZT79_RAT Computationally mapped isoform of Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=1 CANONICAL=O08561-1" }, "locus": { "chromosome": "2", "start_pos": 182571999, "end_pos": 182546205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000103639.1", "url": "https://www.ensembl.org/id/ENSRNOT00000103639.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000082231.1", "url": "https://www.ensembl.org/id/ENSRNOP00000082231.1" } ] } }, { "isoform_ac": "A0A8I6AD21-1", "url": "", "sequence": { "sequence": "MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGCRRCSGASLSGPVVTVAQVICSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 837, "header": "tr|A0A8I6AD21-1|A0A8I6AD21_RAT Computationally mapped isoform of Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=1 CANONICAL=O08561-1" }, "locus": { "chromosome": "2", "start_pos": 182571999, "end_pos": 182549058, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000118319.1", "url": "https://www.ensembl.org/id/ENSRNOT00000118319.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000089657.1", "url": "https://www.ensembl.org/id/ENSRNOP00000089657.1" } ] } }, { "isoform_ac": "A0A8I6ALD3-1", "url": "", "sequence": { "sequence": "MPSFLHLLMSSGFSNSLEARSLAVAMGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 841, "header": "tr|A0A8I6ALD3-1|A0A8I6ALD3_RAT Computationally mapped isoform of Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=1 CANONICAL=O08561-1" }, "locus": { "chromosome": "2", "start_pos": 182571999, "end_pos": 182546205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000112810.1", "url": "https://www.ensembl.org/id/ENSRNOT00000112810.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093461.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093461.1" } ] } }, { "isoform_ac": "A0A8I6ASK5-1", "url": "", "sequence": { "sequence": "MVISLEARSLAVAMGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 814, "header": "tr|A0A8I6ASK5-1|A0A8I6ASK5_RAT Computationally mapped isoform of Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=1 CANONICAL=O08561-1" }, "locus": { "chromosome": "2", "start_pos": 182571999, "end_pos": 182544282, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000112486.1", "url": "https://www.ensembl.org/id/ENSRNOT00000112486.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095998.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095998.1" } ] } }, { "isoform_ac": "A0A8L2QJX4-1", "url": "", "sequence": { "sequence": "ILEARSLAVAMGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 826, "header": "tr|A0A8L2QJX4-1|A0A8L2QJX4_RAT Computationally mapped isoform of Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=1 CANONICAL=O08561-1" }, "locus": { "chromosome": "2", "start_pos": 182571999, "end_pos": 182548848, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000040501.3", "url": "https://www.ensembl.org/id/ENSRNOT00000040501.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000039342.2", "url": "https://www.ensembl.org/id/ENSRNOP00000039342.2" } ] } }, { "isoform_ac": "O08561-1", "url": "", "sequence": { "sequence": "MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 816, "header": "sp|O08561-1|PI4KB_RAT Isoform 1 of Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=1 CANONICAL=O08561-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 258, "end_pos": 258, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Ser258" }, { "start_pos": 263, "end_pos": 263, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Thr263" }, { "start_pos": 266, "end_pos": 266, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Ser266" }, { "start_pos": 275, "end_pos": 275, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Ser275" }, { "start_pos": 277, "end_pos": 277, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Ser277" }, { "start_pos": 284, "end_pos": 284, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Ser284" }, { "start_pos": 294, "end_pos": 294, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Ser294" }, { "start_pos": 428, "end_pos": 428, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O08561", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08561" } ], "site_lbl": "Ser428" }, { "start_pos": 438, "end_pos": 438, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Thr438" }, { "start_pos": 511, "end_pos": 511, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "O08561", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08561" } ], "site_lbl": "Ser511" }, { "start_pos": 517, "end_pos": 517, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Thr517" }, { "start_pos": 519, "end_pos": 519, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "site_lbl": "Thr519" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Zhao X, Varnai P, Tuymetova G, Balla A, Toth ZE, Oker-Blom C, Roder J, Jeromin A, Balla T", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "reference": [ { "type": "PubMed", "id": "11526106", "url": "https://glygen.org/publication/PubMed/11526106" } ] }, { "title": "Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.", "journal": "Journal of cell science", "date": "2002", "authors": "Taverna E, Francolini M, Jeromin A, Hilfiker S, Roder J, Rosa P", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" } ], "reference": [ { "type": "PubMed", "id": "12244129", "url": "https://glygen.org/publication/PubMed/12244129" } ] }, { "title": "Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2003", "authors": "Kapp-Barnea Y, Melnikov S, Shefler I, Jeromin A, Sagi-Eisenberg R", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" } ], "reference": [ { "type": "PubMed", "id": "14607934", "url": "https://glygen.org/publication/PubMed/14607934" } ] }, { "title": "Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids.", "journal": "Journal of biochemistry", "date": "2003", "authors": "Einicker-Lamas M, Wenceslau LD, Bernardo RR, Nogaroli L, Guilherme A, Oliveira MM, Vieyra A", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" } ], "reference": [ { "type": "PubMed", "id": "14607979", "url": "https://glygen.org/publication/PubMed/14607979" } ] }, { "title": "Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Jeganathan S, Lee JM", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" } ], "reference": [ { "type": "PubMed", "id": "17088255", "url": "https://glygen.org/publication/PubMed/17088255" } ] }, { "title": "Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation.", "journal": "Molecular and cellular biology", "date": "2008", "authors": "Jeganathan S, Morrow A, Amiri A, Lee JM", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" } ], "reference": [ { "type": "PubMed", "id": "18474610", "url": "https://glygen.org/publication/PubMed/18474610" } ] }, { "title": "Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2009", "authors": "Mikhaylova M, Reddy PP, Munsch T, Landgraf P, Suman SK, Smalla KH, Gundelfinger ED, Sharma Y, Kreutz MR", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "reference": [ { "type": "PubMed", "id": "19458041", "url": "https://glygen.org/publication/PubMed/19458041" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" }, { "database": "UniProtKB", "id": "A0A0G2JYH1", "url": "https://www.uniprot.org/uniprot/A0A0G2JYH1" }, { "database": "iPTMnet", "id": "O08561", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O08561" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Sanguinarine suppresses IgE induced inflammatory responses through inhibition of type II PtdIns 4-kinase(s).", "journal": "Archives of biochemistry and biophysics", "date": "2013", "authors": "Bojjireddy N, Sinha RK, Panda D, Subrahmanyam G", "evidence": [ { "database": "RefSeq", "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345" } ], "reference": [ { "type": "PubMed", "id": "23899475", "url": "https://glygen.org/publication/PubMed/23899475" } ] }, { "title": "Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase.", "journal": "Biochem. J.", "date": "1996", "authors": "Nakagawa T, Goto K, Kondo H", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "reference": [ { "type": "PubMed", "id": "8973579", "url": "https://glygen.org/publication/PubMed/8973579" } ] } ], "pathway": [ { "id": "rno:81747", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:81747", "resource": "KEGG Pathway" }, { "id": "R-RNO-1660514", "name": "Synthesis of PIPs at the Golgi membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660514", "resource": "Reactome", "description": "Synthesis of PIPs at the Golgi membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8BKC8-1", "protein_name": "Phosphatidylinositol 4-kinase beta", "gene_name": "Pi4kb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGTPLELVNGDGVDNEIRCLDDPPAQIREEEDEMGAGVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFYFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 816 }, "evidence": [ { "id": "45230040", "url": "http://www.informatics.jax.org/homology/45230040", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UBF8-1", "protein_name": "Phosphatidylinositol 4-kinase beta", "gene_name": "PI4KB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM", "length": 816 }, "evidence": [ { "id": "45230040", "url": "http://www.informatics.jax.org/homology/45230040", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate biosynthetic process", "id": "GO:0046854", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046854", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "inner ear development", "id": "GO:0048839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048839", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phosphatidylinositol kinase activity", "id": "GO:0052742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052742", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "14-3-3 protein binding", "id": "GO:0071889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071889", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "1-phosphatidylinositol 4-kinase activity", "id": "GO:0004430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004430", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" }, { "name": "rough endoplasmic reticulum membrane", "id": "GO:0030867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030867", "evidence": [ { "database": "UniProtKB", "id": "O08561", "url": "https://www.uniprot.org/uniprot/O08561" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19877", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08662-1", "Q5XIL2-1", "O08561-1", "Q99M64-1", "Q9BTU6-1", "Q8TCG2-1", "Q9UBF8-1", "P42356-1", "Q8CBQ5-1", "E9Q3L2-1", "Q8BKC8-1", "Q2TBE6-1", "P32600-1", "P39104-1", "P42951-1", "P37297-1", "P54677-1", "Q9VND3-1" ], "evidence": [ { "id": "19877", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19877" } ] }, { "id": "R-RNO-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1806217" ], "enzyme_list": [ "O08561-1", "P84079-1" ], "evidence": [ { "id": "R-RNO-1675883", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1675883" } ] }, { "id": "R-RNO-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08561-1", "P84079-1" ], "evidence": [ { "id": "R-RNO-1676152", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1676152" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1806217", "participant_name": "PI4P [Golgi membrane]", "crossref": [ { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E9Q3L2", "gene_name": "Pi4ka", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "E9Q3L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q3L2" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "E9Q3L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q3L2" } ] } ] }, { "uniprot_ac": "O08561", "gene_name": "Pi4kb", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "O08561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08561" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "O08561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08561" } ] } ] }, { "uniprot_ac": "O08662", "gene_name": "Pi4ka", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "O08662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08662" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "O08662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08662" } ] } ] }, { "uniprot_ac": "P32600", "gene_name": "TOR2", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] } ] }, { "uniprot_ac": "P37297", "gene_name": "STT4", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P37297", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37297" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P37297", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37297" } ] } ] }, { "uniprot_ac": "P39104", "gene_name": "PIK1", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P39104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39104" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P39104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39104" } ] } ] }, { "uniprot_ac": "P42356", "gene_name": "PI4KA", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42356", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42356" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P42356", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42356" } ] } ] }, { "uniprot_ac": "P42951", "gene_name": "LSB6", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42951" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P42951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42951" } ] } ] }, { "uniprot_ac": "P54677", "gene_name": "pikD", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P54677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54677" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P54677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54677" } ] } ] }, { "uniprot_ac": "P84079", "gene_name": "Arf1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P84079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P84079" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P84079" } ] } ] }, { "uniprot_ac": "Q2TBE6", "gene_name": "Pi4k2a", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q2TBE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TBE6" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q2TBE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TBE6" } ] } ] }, { "uniprot_ac": "Q5XIL2", "gene_name": "Pi4k2b", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q5XIL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIL2" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q5XIL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIL2" } ] } ] }, { "uniprot_ac": "Q8BKC8", "gene_name": "Pi4kb", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q8BKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKC8" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q8BKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKC8" } ] } ] }, { "uniprot_ac": "Q8CBQ5", "gene_name": "Pi4k2b", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q8CBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBQ5" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q8CBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBQ5" } ] } ] }, { "uniprot_ac": "Q8TCG2", "gene_name": "PI4K2B", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q8TCG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TCG2" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q8TCG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TCG2" } ] } ] }, { "uniprot_ac": "Q99M64", "gene_name": "Pi4k2a", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q99M64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99M64" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q99M64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99M64" } ] } ] }, { "uniprot_ac": "Q9BTU6", "gene_name": "PI4K2A", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q9BTU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BTU6" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "Q9BTU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BTU6" } ] } ] }, { "uniprot_ac": "Q9UBF8", "gene_name": "PI4KB", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q9UBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBF8" } ] }, { "ec_number": "2.7.1.67", "activity": "", 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