{ "uniprot_canonical_ac": "M0RCY0-1", "uniprot_ac": "M0RCY0", "uniprot_id": "M0RCY0_RAT", "mass": { "chemical_mass": 34114.0, "monoisotopic_mass": 34114.0 }, "refseq": {}, "gene_names": [ { "name": "Yju2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/M0RCY0", "id": "M0RCY0" }, { "name": "YJU2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/M0RCY0", "id": "M0RCY0" } ], "protein_names": [ { "name": "Splicing factor YJU2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "M0RCY0" } ], "function": [ { "annotation": "Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.", "evidence": [ { "database": "UniProtKB", "id": "M0RCY0", "url": "https://www.uniprot.org/uniprot/M0RCY0#function" }, { "database": "UniProtKB", "id": "MF_03226", "url": "https://www.uniprot.org/uniprot/MF_03226#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "M0RCY0", "url": "https://www.uniprot.org/uniprot/M0RCY0" } ], "common_name": "Rat" } ], "gene": [ { "name": "Yju2", "url": "https://www.uniprot.org/uniprot/M0RCY0", "locus": { "chromosome": "9", "start_pos": 799496, "end_pos": 789606, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000047456", "url": "https://www.ensembl.org/id/ENSRNOG00000047456" } ] } } ], "crossref": [ { "id": "IPR007590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LMTVRLM", "url": "https://omabrowser.org/oma/group/LMTVRLM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12111", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12111", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12111:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12111:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04502", "url": "http://pfam.xfam.org/family/PF04502", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1589601", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1589601", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "M0RCY0", "url": "https://www.uniprot.org/uniprot/M0RCY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0RCY0-1", "url": "https://www.uniprot.org/uniprot/M0RCY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRMQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLLQHRLSQEQWQQQQEEEDERETVALLEEARYRRLLDDSDSEDEAPPSQPQAAARPNPTAILDEVPKTKRKAEGLCRKAQLAGLVIPKKAKTEANRVSEQVRVPTTGESPSAVMGGNSASGTA", "length": 295, "header": "tr|M0RCY0-1|M0RCY0_RAT Isoform 1 of Splicing factor YJU2 OS=Rattus norvegicus OX=10116 GN=Yju2 PE=1 SV=1 CANONICAL=M0RCY0-1" }, "isoforms": [ { "isoform_ac": "M0RCY0-1", "url": "", "sequence": { "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRMQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLLQHRLSQEQWQQQQEEEDERETVALLEEARYRRLLDDSDSEDEAPPSQPQAAARPNPTAILDEVPKTKRKAEGLCRKAQLAGLVIPKKAKTEANRVSEQVRVPTTGESPSAVMGGNSASGTA", "length": 295, "header": "tr|M0RCY0-1|M0RCY0_RAT Isoform 1 of Splicing factor YJU2 OS=Rattus norvegicus OX=10116 GN=Yju2 PE=1 SV=1 CANONICAL=M0RCY0-1" }, "locus": { "chromosome": "9", "start_pos": 797511, "end_pos": 789711, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000072357.2", "url": "https://www.ensembl.org/id/ENSRNOT00000072357.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000067468.2", "url": "https://www.ensembl.org/id/ENSRNOP00000067468.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "M0RCY0", "url": "https://www.uniprot.org/uniprot/M0RCY0" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "generation of catalytic spliceosome for first transesterification step", "id": "GO:0000349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000349", "evidence": [ { "database": "UniProtKB", "id": "M0RCY0", "url": "https://www.uniprot.org/uniprot/M0RCY0" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "M0RCY0", "url": "https://www.uniprot.org/uniprot/M0RCY0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "M0RCY0", "url": "https://www.uniprot.org/uniprot/M0RCY0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "U2-type catalytic step 1 spliceosome", "id": "GO:0071006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071006", "evidence": [ { "database": "UniProtKB", "id": "M0RCY0", "url": "https://www.uniprot.org/uniprot/M0RCY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }