{ "uniprot_canonical_ac": "J3QMI4-1", "uniprot_ac": "J3QMI4", "uniprot_id": "CAHM3_MOUSE", "mass": { "chemical_mass": 39328.0, "monoisotopic_mass": 39328.0 }, "refseq": {}, "gene_names": [ { "name": "Calhm3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/J3QMI4", "id": "J3QMI4" } ], "protein_names": [ { "name": "Calcium homeostasis modulator protein 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "J3QMI4" } ], "function": [ { "annotation": "Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP (PubMed:29681531). Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (PubMed:29681531). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances (PubMed:29681531).", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4#function" }, { "database": "PubMed", "id": "29681531", "url": "https://glygen.org/publication/PubMed/29681531" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 219, "end_pos": 219, "sequence_org": "Y", "sequence_mut": "A", "comment": "Affects basolateral membrane sorting in vitro but not in vivo; when associated with 76-A-A-77 and A-222.", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" }, { "database": "PubMed", "id": "30804437", "url": "https://glygen.org/publication/PubMed/30804437" } ] }, { "start_pos": 222, "end_pos": 222, "sequence_org": "L", "sequence_mut": "A", "comment": "Affects basolateral membrane sorting in vitro but not in vivo; when associated with 76-A-A-77 and A-219.", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" }, { "database": "PubMed", "id": "30804437", "url": "https://glygen.org/publication/PubMed/30804437" } ] }, { "start_pos": 76, "end_pos": 77, "sequence_org": "LM", "sequence_mut": "AA", "comment": "Affects basolateral membrane sorting in vitro but not in vivo; when associated with A-219 and A-222.", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" }, { "database": "PubMed", "id": "30804437", "url": "https://glygen.org/publication/PubMed/30804437" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Calhm3", "url": "https://www.uniprot.org/uniprot/J3QMI4", "locus": { "chromosome": "19", "start_pos": 47140048, "end_pos": 47146203, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000094219", "url": "https://www.ensembl.org/id/ENSMUSG00000094219" } ] } } ], "crossref": [ { "id": "ENSMUSG00000094219", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000094219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "3645665", "url": "http://www.informatics.jax.org/marker/MGI:3645665", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "RCWSQAL", "url": "https://omabrowser.org/oma/group/RCWSQAL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR32261", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32261:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14798", "url": "http://pfam.xfam.org/family/PF14798", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_J3QMI4", "url": "http://purl.obolibrary.org/obo/PR_J3QMI4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QMI4-1", "url": "https://www.uniprot.org/uniprot/J3QMI4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRFRMLFQHLQSSSESVMNGICLLLAAVTVKIYSSLDFNCPCLERYNALYGLGLLLTPPLALFLCGLLVNRQSVLMVEEWRRPAGHRRKDLGIIRYMCSSVLQRALAAPLVWILLALLDGKCFVCAFSNSVDPEKFLDFANMTPRQVQLFLAKVPCKEDELVKNSPARKAVSRYLRCLSQAIGWSITLLVIVVAFLARCLRPCFDQTVFLQRRYWSNYMDLEQKLFDETCCEHARDFAHRCVLHFFANMQSELRALGLRRDPAGGIPESQESSEPPELREDRDSGNGKAHLRAISSREQVDQLLSTWYSSKPPLDLAASPRRWGPGLNHRAPIAAPGTKLCHQLNV", "length": 347, "header": "sp|J3QMI4-1|CAHM3_MOUSE Isoform 1 of Calcium homeostasis modulator protein 3 OS=Mus musculus OX=10090 GN=Calhm3 PE=1 SV=1 CANONICAL=J3QMI4-1" }, "isoforms": [ { "isoform_ac": "J3QMI4-1", "url": "", "sequence": { "sequence": "MDRFRMLFQHLQSSSESVMNGICLLLAAVTVKIYSSLDFNCPCLERYNALYGLGLLLTPPLALFLCGLLVNRQSVLMVEEWRRPAGHRRKDLGIIRYMCSSVLQRALAAPLVWILLALLDGKCFVCAFSNSVDPEKFLDFANMTPRQVQLFLAKVPCKEDELVKNSPARKAVSRYLRCLSQAIGWSITLLVIVVAFLARCLRPCFDQTVFLQRRYWSNYMDLEQKLFDETCCEHARDFAHRCVLHFFANMQSELRALGLRRDPAGGIPESQESSEPPELREDRDSGNGKAHLRAISSREQVDQLLSTWYSSKPPLDLAASPRRWGPGLNHRAPIAAPGTKLCHQLNV", "length": 347, "header": "sp|J3QMI4-1|CAHM3_MOUSE Isoform 1 of Calcium homeostasis modulator protein 3 OS=Mus musculus OX=10090 GN=Calhm3 PE=1 SV=1 CANONICAL=J3QMI4-1" }, "locus": { "chromosome": "19", "start_pos": 47146203, "end_pos": 47140051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000178630", "url": "https://www.ensembl.org/id/ENSMUST00000178630" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000136302", "url": "https://www.ensembl.org/id/ENSMUSP00000136302" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes.", "journal": "Neuron", "date": "2018", "authors": "Ma Z, Taruno A, Ohmoto M, Jyotaki M, Lim JC, Miyazaki H, Niisato N, Marunaka Y, Lee RJ, Hoff H, Payne R, Demuro A, Parker I, Mitchell CH, Henao-Mejia J, Tanis JE, Matsumoto I, Tordoff MG, Foskett JK", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "reference": [ { "type": "PubMed", "id": "29681531", "url": "https://glygen.org/publication/PubMed/29681531" } ] }, { "title": "CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.", "journal": "Sci. Rep.", "date": "2019", "authors": "Kashio M, Wei-Qi G, Ohsaki Y, Kido MA, Taruno A", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "reference": [ { "type": "PubMed", "id": "30804437", "url": "https://glygen.org/publication/PubMed/30804437" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q86XJ0-1", "protein_name": "Calcium homeostasis modulator protein 3", "gene_name": "CALHM3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDKFRMLFQHFQSSSESVMNGICLLLAAVTVKLYSSFDFNCPCLVHYNALYGLGLLLTPPLALFLCGLLANRQSVVMVEEWRRPAGHRRKDPGIIRYMCSSVLQRALAAPLVWILLALLDGKCFVCAFSSSVDPEKFLDFANMTPSQVQLFLAKVPCKEDELVRDSPARKAVSRYLRCLSQAIGWSVTLLLIIAAFLARCLRPCFDQTVFLQRRYWSNYVDLEQKLFDETCCEHARDFAHRCVLHFFASMRSELQARGLRRGNAGRRLELPAVPEPPEGLDSGSGKAHLRAISSREQVDRLLSTWYSSKPPLDLAASPGLCGGGLSHRAPTLALGTRLSQHTDV", "length": 344 }, "evidence": [ { "id": "J3QMI4", "url": "https://omabrowser.org/oma/group/J3QMI4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein heterooligomerization", "id": "GO:0051291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051291", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "pmid": "" }, { "name": "sensory perception of taste", "id": "GO:0050909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050909", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "pmid": "" }, { "name": "response to stimulus", "id": "GO:0050896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050896", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "pmid": "" }, { "name": "ATP transport", "id": "GO:0015867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015867", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "voltage-gated monoatomic ion channel activity", "id": "GO:0005244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005244", "evidence": [ { "database": "UniProtKB", "id": "J3QMI4", "url": "https://www.uniprot.org/uniprot/J3QMI4" } ], "pmid": "" }, { "name": "monoatomic cation channel 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