{ "uniprot_canonical_ac": "G3V7X8-1", "uniprot_ac": "G3V7X8", "uniprot_id": "CP26B_RAT", "mass": { "chemical_mass": 57352.0, "monoisotopic_mass": 57352.0 }, "refseq": { "ac": "NP_851601", "name": "cytochrome P450 26B1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851601" }, "gene_names": [ { "name": "Cyp26b1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/G3V7X8", "id": "G3V7X8" }, { "name": "Cyp26b1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851601", "id": "NP_851601" } ], "protein_names": [ { "name": "Cytochrome P450 26B1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "G3V7X8" }, { "name": "1.14.13.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "G3V7X8" }, { "name": "cytochrome P450 26B1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851601", "id": "NP_851601" } ], "function": [ { "annotation": "5ML induces CYP26B1-dependent angiogenesis in vitro, and arteriogenesis in vivo.", "evidence": [ { "database": "RefSeq", "id": "NP_851601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851601" }, { "database": "PubMed", "id": "23554885", "url": "https://glygen.org/publication/PubMed/23554885" } ] }, { "annotation": "A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (By similarity). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (By similarity). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (By similarity). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Essential for postnatal survival (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8#function" }, { "database": "UniProtKB", "id": "Q811W2", "url": "https://www.uniprot.org/uniprot/Q811W2#function" }, { "database": "UniProtKB", "id": "Q9NR63", "url": "https://www.uniprot.org/uniprot/Q9NR63#function" } ] }, { "annotation": "Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8#function" }, { "database": "UniProtKB", "id": "Q9NR63", "url": "https://www.uniprot.org/uniprot/Q9NR63#function" } ] } ], "disease": [ { "disease_id": "DOID:2256", "recommended_name": { "id": "DOID:2256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2256", "name": "osteochondrodysplasia", "description": "A bone development disease that results_in defective development of cartilage or bone." }, "synonyms": [ { "id": "DOID:2256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2256", "name": "Cartilage Development disorder", "description": "" }, { "id": "DOID:2256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2256", "name": "Congenital anomaly of cartilage", "description": "" }, { "id": "DOID:2256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2256", "name": "Osteochondrodysplasia syndrome", "description": "" }, { "id": "DOID:2256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2256", "name": "chondrodystrophy", "description": "" }, { "id": "DOID:2256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2256", "name": "skeletal dysplasia", "description": "" } ], "evidence": [ { "id": "2256", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2256" } ] }, { "disease_id": "DOID:2340", "recommended_name": { "id": "DOID:2340", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2340", "name": "craniosynostosis", "description": "A synostosis that results_in premature fusion located_in skull." }, "synonyms": [ { "id": "DOID:2340", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2340", "name": "Premature closure of cranial sutures", "description": "" }, { "id": "MONDO:0014128", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014128", "name": "TCF12-related craniosynostosis", "description": "Any syndromic craniosynostosis in which the cause of the disease is a mutation in the TCF12 gene." }, { "id": "MONDO:0014128", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014128", "name": "TCF12 craniosynostosis", "description": "" }, { "id": "MONDO:0014128", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014128", "name": "TCF12-related craniosynostosis", "description": "" }, { "id": "MONDO:0014128", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014128", "name": "craniosynostosis 3", "description": "" }, { "id": "MONDO:0014128", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014128", "name": "craniosynostosis caused by mutation in TCF12", "description": "" }, { "id": "MONDO:0014128", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014128", "name": "craniosynostosis type 3", "description": "" }, { "id": "MONDO:0014128", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014128", "name": "CRS3", "description": "" }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "craniosynostosis 2", "description": "A form of syndromic craniosynostosis, characterized by a highly variable craniosynostosis with frontal bossing, turribrachycephaly and cloverleaf skull anomaly. Hypoplasia of the supraorbital ridges, cleft palate, extra teeth and limb anomalies (triphalangeal thumb, 3-4 syndactyly of the hands, a short first metatarsal, middle phalangeal agenesis in the feet) have also been described. Associated problems include headache, poor vision, and seizures. Intelligence is normal." }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "CRS2", "description": "" }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "MSX2-related craniosynostosis", "description": "" }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "Warman-Mulliken-Hayward syndrome", "description": "" }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "craniosynostosis 2", "description": "" }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "craniosynostosis type 2", "description": "" }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "craniosynostosis, Warman type", "description": "" }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "Warman Mulliken Hayward syndrome", "description": "" }, { "id": "MONDO:0011481", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011481", "name": "craniosynostosis Warman type", "description": "" }, { "id": "MONDO:0010929", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010929", "name": "craniosynostosis 4", "description": "Any craniosynostosis in which the cause of the disease is a mutation in the ERF gene." }, { "id": "MONDO:0010929", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010929", "name": "ERF craniosynostosis", "description": "" }, { "id": "MONDO:0010929", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010929", "name": "ERF-related craniosynostosis", "description": "" }, { "id": "MONDO:0010929", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010929", "name": "craniosynostosis 4", "description": "" }, { "id": "MONDO:0010929", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010929", "name": "craniosynostosis caused by mutation in ERF", "description": "" }, { "id": "MONDO:0010929", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010929", "name": "craniosynostosis type 4", "description": "" }, { "id": "MONDO:0010929", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010929", "name": "CRS4", "description": "" }, { "id": "MONDO:0010903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010903", "name": "craniosynostosis, Adelaide type", "description": "" }, { "id": "MONDO:0010903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010903", "name": "craniosynostosis, Adelaide type", "description": "" }, { "id": "MONDO:0010903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010903", "name": "CRSA", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "Shprintzen-Goldberg syndrome", "description": "Shprintzen-Goldberg syndrome (SGS) is a very rare genetic disorder characterized by craniosynostosis, craniofacial and skeletal abnormalities, marfanoid habitus, cardiac anomalies, neurological abnormalities, and intellectual disability." }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "Marfanoid craniosynostosis syndrome", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "SGS", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "Shprintzen-Goldberg syndrome", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "Marfanoid disorder with craniosynostosis type 1", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "Marfanoid disorder with craniosynostosis, type 1", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "Marfanoid-craniosynostosis syndrome", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "Shprintzen-Goldberg craniosynostosis syndrome", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "Shprintzen-Goldberg marfanoid syndrome", "description": "" }, { "id": "MONDO:0008426", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008426", "name": "craniosynostosis with arachnodactyly and abdominal hernias", "description": "" }, { "id": "MONDO:0007399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007399", "name": "TWIST1-related craniosynostosis", "description": "Any craniosynostosis in which the cause of the disease is a mutation in the TWIST1 gene." }, { "id": "MONDO:0007399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007399", "name": "TWIST1-related craniosynostosis", "description": "" }, { "id": "MONDO:0007399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007399", "name": "craniosynostosis 1", "description": "" }, { "id": "MONDO:0007399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007399", "name": "craniosynostosis type 1", "description": "" }, { "id": "MONDO:0007399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007399", "name": "CRS", "description": "" }, { "id": "MONDO:0007399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007399", "name": "CRS1", "description": "" }, { "id": "MONDO:0007399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007399", "name": "craniostenosis", "description": "" }, { "id": "MIM:615314", "resource": "MIM", "url": "https://www.omim.org/entry/615314", "name": "Craniosynostosis 3", "description": "Craniosynostosis 3" }, { "id": "MIM:604757", "resource": "MIM", "url": "https://www.omim.org/entry/604757", "name": "Craniosynostosis 2", "description": "Craniosynostosis 2" }, { "id": "MIM:600775", "resource": "MIM", "url": "https://www.omim.org/entry/600775", "name": "Craniosynostosis 4", "description": "Craniosynostosis 4" }, { "id": "MIM:182212", "resource": "MIM", "url": "https://www.omim.org/entry/182212", "name": "Shprintzen-Goldberg craniosynostosis syndrome", "description": "Shprintzen-Goldberg craniosynostosis syndrome" }, { "id": "MIM:123100", "resource": "MIM", "url": "https://www.omim.org/entry/123100", "name": "Craniosynostosis 1", "description": "Craniosynostosis 1" } ], "evidence": [ { "id": "2340", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2340" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": 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"database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "http://pfam.xfam.org/family/PF00067", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_G3V7X8", "url": "http://purl.obolibrary.org/obo/PR_G3V7X8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-211916", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211916", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5365859", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_851601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851601", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "631379", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=631379", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "51984", "url": "https://www.rhea-db.org/rhea/51984", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55856", "url": "https://www.rhea-db.org/rhea/55856", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I6AMJ8", "url": "https://www.uniprot.org/uniprot/A0A8I6AMJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AMJ8-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AMJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V7X8-1", "url": "https://www.uniprot.org/uniprot/G3V7X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGNLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDMLSGLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV", "length": 512, "header": "sp|G3V7X8-1|CP26B_RAT Isoform 1 of Cytochrome P450 26B1 OS=Rattus norvegicus OX=10116 GN=Cyp26b1 PE=2 SV=1 CANONICAL=G3V7X8-1" }, "isoforms": [ { "isoform_ac": "A0A8I6AMJ8-1", "url": "", "sequence": { "sequence": "MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGNLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDMLSGLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV", "length": 437, "header": "tr|A0A8I6AMJ8-1|CP26B_RAT Computationally mapped isoform of Cytochrome P450 26B1 OS=Rattus norvegicus OX=10116 GN=Cyp26b1 PE=2 SV=1 CANONICAL=G3V7X8-1" }, "locus": { "chromosome": "4", "start_pos": 117058472, "end_pos": 117044666, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000114567.1", "url": "https://www.ensembl.org/id/ENSRNOT00000114567.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000094593.1", "url": "https://www.ensembl.org/id/ENSRNOP00000094593.1" } ] } }, { "isoform_ac": "G3V7X8-1", "url": "", "sequence": { "sequence": "MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGNLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDMLSGLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV", "length": 512, "header": "sp|G3V7X8-1|CP26B_RAT Isoform 1 of Cytochrome P450 26B1 OS=Rattus norvegicus OX=10116 GN=Cyp26b1 PE=2 SV=1 CANONICAL=G3V7X8-1" }, "locus": { "chromosome": "4", "start_pos": 117058472, "end_pos": 117044666, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000020505", "url": "https://www.ensembl.org/id/ENSRNOT00000020505" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000020505", "url": "https://www.ensembl.org/id/ENSRNOP00000020505" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo.", "journal": "PloS one", "date": "2013", "authors": "Messner B, Kern J, Wiedemann D, Schwaiger S, Turkcan A, Ploner C, Trockenbacher A, Aumayr K, Bonaros N, Laufer G, Stuppner H, Untergasser G, Bernhard D", "evidence": [ { "database": "RefSeq", "id": "NP_851601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851601" } ], "reference": [ { "type": "PubMed", "id": "23554885", "url": "https://glygen.org/publication/PubMed/23554885" } ] } ], "pathway": [ { "id": "rno:312495", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:312495", "resource": "KEGG Pathway" }, { "id": "R-RNO-211916", "name": "Vitamins", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211916", "resource": "Reactome", "description": "Vitamins" }, { "id": "R-RNO-5365859", "name": "RA biosynthesis pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5365859", "resource": "Reactome", "description": "RA biosynthesis pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q811W2-1", "protein_name": "Cytochrome P450 26B1", "gene_name": "Cyp26b1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGHLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDTLSSLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV", "length": 512 }, "evidence": [ { "id": "45226843", "url": "http://www.informatics.jax.org/homology/45226843", "database": "MGI" }, { "id": "G3V7X8", "url": "https://omabrowser.org/oma/group/G3V7X8/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NR63-1", "protein_name": "Cytochrome P450 26B1", "gene_name": "CYP26B1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV", "length": 512 }, "evidence": [ { "id": "45226843", "url": "http://www.informatics.jax.org/homology/45226843", "database": "MGI" }, { "id": "G3V7X8", "url": "https://omabrowser.org/oma/group/G3V7X8/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "retinoic acid 4-hydroxylase activity", "id": "GO:0008401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008401", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen", "id": "GO:0016709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016709", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "retinoic acid binding", "id": "GO:0001972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001972", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "all-trans retinoic acid 18-hydroxylase activity", "id": "GO:0062183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062183", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "establishment of skin barrier", "id": "GO:0061436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061436", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "retinoic acid metabolic process", "id": "GO:0042573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042573", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "embryonic limb morphogenesis", "id": "GO:0030326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030326", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "response to retinoic acid", "id": "GO:0032526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032526", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "proximal/distal pattern formation", "id": "GO:0009954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009954", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "response to vitamin A", "id": "GO:0033189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033189", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "regulation of T cell differentiation", "id": "GO:0045580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045580", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "retinoic acid receptor signaling pathway", "id": "GO:0048384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048384", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "sterol metabolic process", "id": "GO:0016125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016125", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "bone morphogenesis", "id": "GO:0060349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060349", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "male meiotic nuclear division", "id": "GO:0007140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "regulation of retinoic acid receptor signaling pathway", "id": "GO:0048385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048385", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "cell fate determination", "id": "GO:0001709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001709", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "establishment of T cell polarity", "id": "GO:0001768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001768", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "negative regulation of retinoic acid receptor signaling pathway", "id": "GO:0048387", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048387", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "cornification", "id": "GO:0070268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070268", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "tongue morphogenesis", "id": "GO:0043587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043587", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "positive regulation of tongue muscle cell differentiation", "id": "GO:2001037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001037", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" }, { "name": "retinoic acid catabolic process", "id": "GO:0034653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034653", "evidence": [ { "database": "UniProtKB", "id": "G3V7X8", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "51984", "name": "", "equation": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3V7X8-1", "P08684-1", "P10632-1", "P24462-1", "P20815-1", "Q96SQ9-1", "Q9NR63-1", "P33260-1", "Q8TAV3-1", "Q6V0L0-1", "Q811W2-1", "Q9DBX6-1", "E9Q816-1", "B2RXA7-1" ], "evidence": [ { "id": "51984", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51984" } ] }, { "id": "55856", "name": "", "equation": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3V7X8-1", "P24462-1", "O43174-1", "Q9NR63-1", "O55127-1", "Q811W2-1" ], "evidence": [ { "id": "55856", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55856" } ] }, { "id": "R-RNO-212007", "name": "CYP26A1,B1 4-hydroxylate atRA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3V7X8-1" ], "evidence": [ { "id": "R-RNO-212007", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-212007" } ] }, { "id": "R-RNO-5362525", "name": "CYP26A1,B1,C1 4-hydroxylate atRA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-5362521", "R-RNO-5334807" ], "enzyme_list": [ "G3V7X8-1" ], "evidence": [ { "id": "R-RNO-5362525", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5362525" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5362521", "participant_name": "4OH-atRA [cytosol]", "crossref": [ { "id": "63795", "database": "ChEBI", "url": "" }, { "id": "C16677", "database": "COMPOUND", "url": "" }, { "id": "HMDB0006254", "database": "HMDB Metabolite", "url": "" }, { "id": "000012496833", "database": "ZINC", "url": "" }, { "id": "000012496837", "database": "ZINC", "url": "" }, { "id": "63795", "database": "ChEBI", "url": "" }, { "id": "C16677", "database": "COMPOUND", "url": "" }, { "id": "HMDB0006254", "database": "HMDB Metabolite", "url": "" }, { "id": "000012496833", "database": "ZINC", "url": "" }, { "id": "000012496837", "database": "ZINC", "url": "" }, { "id": "63795", "database": "ChEBI", "url": "" }, { "id": "C16677", "database": "COMPOUND", "url": "" }, { "id": "HMDB0006254", "database": "HMDB Metabolite", "url": "" }, { "id": "000012496833", "database": "ZINC", "url": "" }, { "id": "000012496837", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-RNO-5334807", "participant_name": "SUMO-K-CRABP1 [cytosol]", "crossref": [ { "id": "P62966", "database": "UniProt", "url": "" }, { "id": "P62966", "database": "PRO", "url": "" }, { "id": "ENSRNOG00000023633", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000031175", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000033840", "database": "Ensembl", "url": "" }, { "id": "NP_001099186.1", "database": "RefSeq", "url": "" }, { "id": "2400", "database": "RGD", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "B2RXA7", "gene_name": "Cyp26c1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] } ] }, { "uniprot_ac": "E9Q816", "gene_name": "Cyp2w1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "E9Q816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q816" } ] } ] }, { "uniprot_ac": "G3V7X8", "gene_name": "Cyp26b1", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "G3V7X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7X8" } ] } ] }, { "uniprot_ac": "O43174", "gene_name": "CYP26A1", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "O43174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43174" } ] } ] }, { "uniprot_ac": "O55127", "gene_name": "Cyp26a1", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "O55127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55127" } ] } ] }, { "uniprot_ac": "P08684", "gene_name": "CYP3A4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.55", "activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.56", "activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.73", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] } ] }, { "uniprot_ac": "P10632", "gene_name": "CYP2C8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] } ] }, { "uniprot_ac": "P20815", "gene_name": "CYP3A5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] } ] }, { "uniprot_ac": "P24462", "gene_name": "CYP3A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] } ] }, { "uniprot_ac": "P33260", "gene_name": "CYP2C18", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] } ] }, { "uniprot_ac": "Q6V0L0", "gene_name": "CYP26C1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6V0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6V0L0" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q6V0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6V0L0" } ] } ] }, { "uniprot_ac": "Q811W2", "gene_name": "Cyp26b1", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "Q811W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811W2" } ] } ] }, { "uniprot_ac": "Q8TAV3", "gene_name": "CYP2W1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q8TAV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TAV3" } ] } ] }, { "uniprot_ac": "Q96SQ9", "gene_name": "CYP2S1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q96SQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96SQ9" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q96SQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96SQ9" } ] }, { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "Q96SQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96SQ9" } ] } ] }, { "uniprot_ac": "Q9DBX6", "gene_name": "Cyp2s1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] } ] }, { "uniprot_ac": "Q9NR63", "gene_name": "CYP26B1", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "Q9NR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR63" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }