{ "uniprot_canonical_ac": "G3V7L5-1", "uniprot_ac": "G3V7L5", "uniprot_id": "PO4F2_RAT", "mass": { "chemical_mass": 43230.0, "monoisotopic_mass": 43230.0 }, "refseq": { "ac": "NP_599182", "name": "POU domain, class 4, transcription factor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182" }, "gene_names": [ { "name": "Pou4f2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/G3V7L5", "id": "G3V7L5" }, { "name": "Brn-3.2; Brn-3B; Brn3b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182", "id": "NP_599182" }, { "name": "Brn3b", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/G3V7L5", "id": "G3V7L5" }, { "name": "Pou4f2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182", "id": "NP_599182" } ], "protein_names": [ { "name": "POU domain, class 4, transcription factor 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "G3V7L5" }, { "name": "Brain-3B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "G3V7L5" }, { "name": "Brain-specific homeobox/POU domain protein 3B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "G3V7L5" }, { "name": "Brn-3.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "G3V7L5" }, { "name": "Brn-3B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "G3V7L5" }, { "name": "POU domain, class 4, transcription factor 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182", "id": "NP_599182" }, { "name": "brain-3B; brain-specific homeobox/POU domain protein 3B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182", "id": "NP_599182" } ], "function": [ { "annotation": "A potential role for Brn-3b in neurodegenerative diseases in which hypoxia/ischemia contribute to pathophysiology of the disease.", "evidence": [ { "database": "RefSeq", "id": "NP_599182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182" }, { "database": "PubMed", "id": "25786379", "url": "https://glygen.org/publication/PubMed/25786379" } ] }, { "annotation": "Hearts from male Brn-3b KO mutant mice display contractile dysfunction at baseline but also attenuated hypertrophic responses to AngII treatment. Hearts from AngII-treated male Brn-3b KO mice develop further contractile dysfunction linked to extensive fibrosis/remodelling. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_599182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182" }, { "database": "PubMed", "id": "31413277", "url": "https://glygen.org/publication/PubMed/31413277" } ] }, { "annotation": "Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation.", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5#function" }, { "database": "UniProtKB", "id": "Q63934", "url": "https://www.uniprot.org/uniprot/Q63934#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "common_name": "Rat" } ], "gene": [ { "name": "Pou4f2", "url": "https://www.uniprot.org/uniprot/G3V7L5", "locus": { "chromosome": "19", "start_pos": 29490327, "end_pos": 29486686, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000012167", "url": "https://www.ensembl.org/id/ENSRNOG00000012167" } ] } } ], "crossref": [ { "id": "ENSRNOG00000012167", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012167", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "171355", "url": "https://www.ncbi.nlm.nih.gov/gene/171355", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:171355", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:171355", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "THAPHMA", "url": "https://omabrowser.org/oma/group/THAPHMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4250502at2759", "url": "http://www.orthodb.org/?query=4250502at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11636", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11636", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11636:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11636:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "http://pfam.xfam.org/family/PF00046", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00157", "url": "http://pfam.xfam.org/family/PF00157", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_G3V7L5", "url": "http://purl.obolibrary.org/obo/PR_G3V7L5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804759", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_599182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "620075", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620075", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V7L5-1", "url": "https://www.uniprot.org/uniprot/G3V7L5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSASSPSSSSNAGSGGGGGGGGGGGGGGRSSSSSSSGSGGGGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI", "length": 412, "header": "sp|G3V7L5-1|PO4F2_RAT Isoform 1 of POU domain, class 4, transcription factor 2 OS=Rattus norvegicus OX=10116 GN=Pou4f2 PE=1 SV=1 CANONICAL=G3V7L5-1" }, "isoforms": [ { "isoform_ac": "G3V7L5-1", "url": "", "sequence": { "sequence": "MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSASSPSSSSNAGSGGGGGGGGGGGGGGRSSSSSSSGSGGGGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI", "length": 412, "header": "sp|G3V7L5-1|PO4F2_RAT Isoform 1 of POU domain, class 4, transcription factor 2 OS=Rattus norvegicus OX=10116 GN=Pou4f2 PE=1 SV=1 CANONICAL=G3V7L5-1" }, "locus": { "chromosome": "19", "start_pos": 29488593, "end_pos": 29486926, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000016422", "url": "https://www.ensembl.org/id/ENSRNOT00000016422" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000016422", "url": "https://www.ensembl.org/id/ENSRNOP00000016422" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression.", "journal": "Cell Stress Chaperones", "date": "2008", "authors": "Farooqui-Kabir SR, Diss JK, Henderson D, Marber MS, Latchman DS, Budhram-Mahadeo V, Heads RJ", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "reference": [ { "type": "PubMed", "id": "18368538", "url": "https://glygen.org/publication/PubMed/18368538" } ] }, { "title": "Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia.", "journal": "Cellular and molecular neurobiology", "date": "2015", "authors": "Phatak NR, Stankowska DL, Krishnamoorthy RR", "evidence": [ { "database": "RefSeq", "id": "NP_599182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182" } ], "reference": [ { "type": "PubMed", "id": "25786379", "url": "https://glygen.org/publication/PubMed/25786379" } ] }, { "title": "The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart.", "journal": "Cell death & disease", "date": "2019", "authors": "Mele L, Maskell LJ, Stuckey DJ, Clark JE, Heads RJ, Budhram-Mahadeo VS", "evidence": [ { "database": "RefSeq", "id": "NP_599182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182" } ], "reference": [ { "type": "PubMed", "id": "31413277", "url": "https://glygen.org/publication/PubMed/31413277" } ] }, { "title": "Alternative splicing of the Brn-3a and Brn-3b transcription factor RNAs is regulated in neuronal cells.", "journal": "J. Mol. Neurosci.", "date": "1996", "authors": "Latchman D.S., Dawson S.J., Liu Y.Z.", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "reference": [ { "type": "PubMed", "id": "8835784", "url": "https://glygen.org/publication/PubMed/8835784" } ] } ], "pathway": [ { "id": "rno:171355", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:171355", "resource": "KEGG Pathway" }, { "id": "R-RNO-6804759", "name": "Regulation of TP53 Activity through Association with Co-factors", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804759", "resource": "Reactome", "description": "Regulation of TP53 Activity through Association with Co-factors" } ], "orthologs": [ { "uniprot_canonical_ac": "Q12837-1", "protein_name": "POU domain, class 4, transcription factor 2", "gene_name": "POU4F2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI", "length": 409 }, "evidence": [ { "id": "45225730", "url": "http://www.informatics.jax.org/homology/45225730", "database": "MGI" }, { "id": "G3V7L5", "url": "https://omabrowser.org/oma/group/G3V7L5/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q63934-1", "protein_name": "POU domain, class 4, transcription factor 2", "gene_name": "Pou4f2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSASSPSSSSNAGGGGGGGGGGGGGGRSSSSSSSGSGGSGGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI", "length": 411 }, "evidence": [ { "id": "45225730", "url": "http://www.informatics.jax.org/homology/45225730", "database": "MGI" }, { "id": "G3V7L5", "url": "https://omabrowser.org/oma/group/G3V7L5/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 35, "go_terms": [ { "name": "negative regulation of amacrine cell differentiation", "id": "GO:1902870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902870", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "neuromuscular process controlling balance", "id": "GO:0050885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050885", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "MAPK cascade", "id": "GO:0000165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "positive regulation of cell differentiation", "id": "GO:0045597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045597", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "positive regulation of axon extension", "id": "GO:0045773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045773", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway by p53 class mediator", "id": "GO:0072332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072332", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "cellular response to cytokine stimulus", "id": "GO:0071345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071345", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "positive regulation of glucose import", "id": "GO:0046326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046326", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "negative regulation of cell differentiation", "id": "GO:0045596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045596", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "cellular response to estradiol stimulus", "id": "GO:0071392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071392", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle cell apoptotic process", "id": "GO:0010666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010666", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "intracellular estrogen receptor signaling pathway", "id": "GO:0030520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030520", "evidence": [ { "database": "UniProtKB", "id": "G3V7L5", "url": "https://www.uniprot.org/uniprot/G3V7L5" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": 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