{ "uniprot_canonical_ac": "F8VQK3-1", "uniprot_ac": "F8VQK3", "uniprot_id": "F8VQK3_MOUSE", "mass": { "chemical_mass": 81831.0, "monoisotopic_mass": 81831.0 }, "refseq": { "ac": "NP_001028494", "name": "guanylate cyclase soluble subunit alpha-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" }, "gene_names": [ { "name": "Gucy1a2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/F8VQK3", "id": "F8VQK3" }, { "name": "6330407I18Rik; A230060L24Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494", "id": "NP_001028494" }, { "name": "Gucy1a2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494", "id": "NP_001028494" } ], "protein_names": [ { "name": "guanylate cyclase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "F8VQK3" }, { "name": "4.6.1.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "F8VQK3" }, { "name": "guanylate cyclase soluble subunit alpha-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494", "id": "NP_001028494" } ], "function": [ { "annotation": "Circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential Loss.", "evidence": [ { "database": "RefSeq", "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" }, { "database": "PubMed", "id": "37277119", "url": "https://glygen.org/publication/PubMed/37277119" } ] }, { "annotation": "Requirement of both alpha-2 and alpha-1 guanylate cyclases for signaling in long-term potentiation (LTP) indicates the existence of two distinct nitric oxide/cGMP-mediated pathways, which have to work in concert for expression of LTP.", "evidence": [ { "database": "RefSeq", "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" }, { "database": "PubMed", "id": "17251421", "url": "https://glygen.org/publication/PubMed/17251421" } ] }, { "annotation": "The aim of this study was to investigate the role of Gucy1a2 in nitrergic regulation of gastric motility in male and female Gucy1a2 knock-out mice.", "evidence": [ { "database": "RefSeq", "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" }, { "database": "PubMed", "id": "17717014", "url": "https://glygen.org/publication/PubMed/17717014" } ] }, { "annotation": "These data suggests a novel physiological role for PDE5 in restricting the effects of NOS3/sGC/PKG signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC]", "evidence": [ { "database": "RefSeq", "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" }, { "database": "PubMed", "id": "19345227", "url": "https://glygen.org/publication/PubMed/19345227" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1134464420", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1134464420" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 318, "end_pos": 318, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (INT->NNT).", "chr_id": "9", "chr_pos": "3634910", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I318", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Gucy1a2", "url": "https://www.uniprot.org/uniprot/F8VQK3", "locus": { "chromosome": "9", "start_pos": 3894736, "end_pos": 3532778, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000041624", "url": "https://www.ensembl.org/id/ENSMUSG00000041624" } ] } } ], "crossref": [ { "id": "ENSMUSG00000041624", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041624", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07302", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07302", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "234889", "url": "https://www.ncbi.nlm.nih.gov/gene/234889", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "F8VQK3", "url": "https://www.ebi.ac.uk/intact/interactors/id:F8VQK3*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011644", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018297", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018297", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042463", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042463", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:234889", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:234889", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2660877", "url": "http://www.informatics.jax.org/marker/MGI:2660877", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "F8VQK3", "url": "https://oglcnac.org/atlas/detail/F8VQK3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "F8VQK3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=F8VQK3", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "SLMLHYF", "url": "https://omabrowser.org/oma/group/SLMLHYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2898719at2759", "url": "http://www.orthodb.org/?query=2898719at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45655", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45655", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45655:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45655:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00211", "url": "http://pfam.xfam.org/family/PF00211", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07700", "url": "http://pfam.xfam.org/family/PF07700", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07701", "url": "http://pfam.xfam.org/family/PF07701", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-445355", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-445355", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8VQK3-1", "url": "https://www.uniprot.org/uniprot/F8VQK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRKISSESFSSLSSDYLETSPEEEGECPLSRLCWNGSRSPPGPPGSREAAKAATSAPAASAAAASAAVAAEYKRAQRRGRVNLDSLGESISLLTAPLPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNISKRCSYADHSNKEEIEDVSGILQCTANVLGLQFQEIQERFGEEFFKICFDENERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESSSFLCKELPEGTLMLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKLCFDGSNPSNCSCLTFLIKECETTQITKDNPQGTSQVPADLRISINTFCRAFPFHLMFDSNMVVLQLGEGLRKQLRYDTHRALKFEDCFEIVSPMINATFDRVLLRLSTPFVIRTKPEASGTENEDKVMEIKGQMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTDPKPPKPSLSSSRIKKVSYNIGTMFLRETSL", "length": 730, "header": "tr|F8VQK3-1|F8VQK3_MOUSE Isoform 1 of guanylate cyclase OS=Mus musculus OX=10090 GN=Gucy1a2 PE=1 SV=1 CANONICAL=F8VQK3-1" }, "isoforms": [ { "isoform_ac": "F8VQK3-1", "url": "", "sequence": { "sequence": "MSRRKISSESFSSLSSDYLETSPEEEGECPLSRLCWNGSRSPPGPPGSREAAKAATSAPAASAAAASAAVAAEYKRAQRRGRVNLDSLGESISLLTAPLPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNISKRCSYADHSNKEEIEDVSGILQCTANVLGLQFQEIQERFGEEFFKICFDENERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESSSFLCKELPEGTLMLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKLCFDGSNPSNCSCLTFLIKECETTQITKDNPQGTSQVPADLRISINTFCRAFPFHLMFDSNMVVLQLGEGLRKQLRYDTHRALKFEDCFEIVSPMINATFDRVLLRLSTPFVIRTKPEASGTENEDKVMEIKGQMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTDPKPPKPSLSSSRIKKVSYNIGTMFLRETSL", "length": 730, "header": "tr|F8VQK3-1|F8VQK3_MOUSE Isoform 1 of guanylate cyclase OS=Mus musculus OX=10090 GN=Gucy1a2 PE=1 SV=1 CANONICAL=F8VQK3-1" }, "locus": { "chromosome": "9", "start_pos": 3894708, "end_pos": 3532803, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000115733.3", "url": "https://www.ensembl.org/id/ENSMUST00000115733.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000111398.2", "url": "https://www.ensembl.org/id/ENSMUSP00000111398.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 279, "start_aa": "Ser", "end_pos": 279, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser279", "evidence": [ { "id": "F8VQK3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=F8VQK3" }, { "id": "30016717", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30016717" }, { "id": "F8VQK3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/F8VQK3" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 282, "start_aa": "Ser", "end_pos": 282, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser282", "evidence": [ { "id": "F8VQK3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=F8VQK3" }, { "id": "30016717", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30016717" }, { "id": "F8VQK3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/F8VQK3" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 285, "start_aa": "Ser", "end_pos": 285, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser285", "evidence": [ { "id": "F8VQK3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=F8VQK3" }, { "id": "30016717", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30016717" }, { "id": "F8VQK3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/F8VQK3" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 288, "start_aa": "Thr", "end_pos": 288, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr288", "evidence": [ { "id": "F8VQK3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=F8VQK3" }, { "id": "30016717", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30016717" }, { "id": "F8VQK3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/F8VQK3" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2007", "authors": "Haghikia A, Mergia E, Friebe A, Eysel UT, Koesling D, Mittmann T", "evidence": [ { "database": "RefSeq", "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" } ], "reference": [ { "type": "PubMed", "id": "17251421", "url": "https://glygen.org/publication/PubMed/17251421" } ] }, { "title": "Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice.", "journal": "The Journal of physiology", "date": "2007", "authors": "Vanneste G, Dhaese I, Sips P, Buys E, Brouckaert P, Lefebvre RA", "evidence": [ { "database": "RefSeq", "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" } ], "reference": [ { "type": "PubMed", "id": "17717014", "url": "https://glygen.org/publication/PubMed/17717014" } ] }, { "title": "Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.", "journal": "Journal of molecular and cellular cardiology", "date": "2009", "authors": "Wang H, Kohr MJ, Traynham CJ, Ziolo MT", "evidence": [ { "database": "RefSeq", "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" } ], "reference": [ { "type": "PubMed", "id": "19345227", "url": "https://glygen.org/publication/PubMed/19345227" } ] }, { "title": "O-GlcNAcylation site mapping by (azide-alkyne) click chemistry and mass spectrometry following intensive fractionation of skeletal muscle cells proteins.", "journal": "Journal of proteomics", "date": "2018", "authors": "Deracinois B, Camoin L, Lambert M, Boyer JB, Dupont E, Bastide B, Cieniewski-Bernard C", "evidence": [ { "database": "O-GlcNAc Database", "id": "F8VQK3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=F8VQK3" }, { "database": "O-GlcNAc Atlas", "id": "F8VQK3", "url": "https://oglcnac.org/atlas/detail/F8VQK3" } ], "reference": [ { "type": "PubMed", "id": "30016717", "url": "https://glygen.org/publication/PubMed/30016717" } ] }, { "title": "circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by\u00a0Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential\u00a0Loss.", "journal": "Journal of investigative surgery : the official journal of the Academy of Surgical Research", "date": "2023-12", "authors": "Wang Fei, Ma Qian, Dong Xinglu, Wang Tinghuan, Ma Chao", "evidence": [ { "database": "RefSeq", "id": "NP_001028494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028494" } ], "reference": [ { "type": "PubMed", "id": "37277119", "url": "https://glygen.org/publication/PubMed/37277119" } ] } ], "pathway": [ { "id": "mmu:234889", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:234889", "resource": "KEGG Pathway" }, { "id": "R-MMU-445355", "name": "Smooth Muscle Contraction", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-445355", "resource": "Reactome", "description": "Smooth Muscle Contraction" } ], "orthologs": [ { "uniprot_canonical_ac": "P33402-1", "protein_name": "Guanylate cyclase soluble subunit alpha-2", "gene_name": "GUCY1A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL", "length": 732 }, "evidence": [ { "id": "45235044", "url": "http://www.informatics.jax.org/homology/45235044", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WVI4-1", "protein_name": "Guanylate cyclase soluble subunit alpha-2", "gene_name": "Gucy1a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRRKISSESFSSLGSDYLETSPEEEGECPLSKLCWNGSRSPPGPPGSRAAAMAATPVPAASVAAAAAAVAAGSKRAQRRRRVNLDSLGESISLLTAPSPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSSADHSNKEEIEDVSGILRCTANVLGLKFQEIQERFGEEFFKICFDENERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKFCSDGSTPSNYSCLTFLIKECETTQITKNIPQGTSQIPTDLRISINTFCRTFPFHLMFDPNMVVLQLGEGLRKQLRCDNHKVLKFEDCFEIVSPKVNATFDRVLLRLSTPFVIRTKPEASGTDNEDKVMEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINISPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL", "length": 730 }, "evidence": [ { "id": "45235044", "url": "http://www.informatics.jax.org/homology/45235044", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "guanylate cyclase activity", "id": "GO:0004383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004383", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "guanylate cyclase complex, soluble", "id": "GO:0008074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008074", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "nitric oxide mediated signal transduction", "id": "GO:0007263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007263", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" }, { "name": "cGMP-mediated signaling", "id": "GO:0019934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019934", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" }, { "name": "positive regulation of nitric oxide mediated signal transduction", "id": "GO:0010750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010750", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" }, { "name": "response to oxygen levels", "id": "GO:0070482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070482", "evidence": [ { "database": "UniProtKB", "id": "F8VQK3", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 638, "end_pos": 640, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-MMU-9620456", "name": "sGC stimulators bind sGC:NO", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ERL9-1", "F8VQK3-1", "O54865-1", "Q8BXH3-1" ], "evidence": [ { "id": "R-MMU-9620456", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9620456" } ] }, { "id": "R-MMU-9621179", "name": "Cinaciguat binds sGC:NO", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ERL9-1", "F8VQK3-1", "O54865-1", "Q8BXH3-1" ], "evidence": [ { "id": "R-MMU-9621179", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9621179" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F8VQK3", "gene_name": "Gucy1a2", "activity": [ { "ec_number": "4.6.1.2", "activity": "GTP = 3',5'-cyclic GMP + diphosphate.", "evidence": [ { "id": "F8VQK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ] }, { "ec_number": "4.6.1.2", "activity": "", "evidence": [ { "id": "F8VQK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VQK3" } ] } ] }, { "uniprot_ac": "O54865", "gene_name": "Gucy1b1", "activity": [ { "ec_number": "4.6.1.2", "activity": "GTP = 3',5'-cyclic GMP + diphosphate.", "evidence": [ { "id": "O54865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54865" } ] }, { "ec_number": "4.6.1.2", "activity": "", "evidence": [ { "id": "O54865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54865" } ] } ] }, { "uniprot_ac": "Q8BXH3", "gene_name": "Gucy1b2", "activity": [ { "ec_number": "4.6.1.2", "activity": "GTP = 3',5'-cyclic GMP + diphosphate.", "evidence": [ { "id": "Q8BXH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BXH3" } ] }, { "ec_number": "4.6.1.2", "activity": "", "evidence": [ { "id": "Q8BXH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BXH3" } ] } ] }, { "uniprot_ac": "Q9ERL9", "gene_name": "Gucy1a1", "activity": [ { "ec_number": "4.6.1.2", "activity": "GTP = 3',5'-cyclic GMP + diphosphate.", "evidence": [ { "id": "Q9ERL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERL9" } ] }, { "ec_number": "4.6.1.2", "activity": "", "evidence": [ { "id": "Q9ERL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERL9" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 4 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 4 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ 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