{ "uniprot_canonical_ac": "F7FHL6-1", "uniprot_ac": "F7FHL6", "uniprot_id": "F7FHL6_RAT", "mass": { "chemical_mass": 59523.0, "monoisotopic_mass": 59523.0 }, "refseq": {}, "gene_names": [ { "name": "Ppil2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/F7FHL6", "id": "F7FHL6" } ], "protein_names": [ { "name": "RING-type E3 ubiquitin transferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "F7FHL6" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "F7FHL6" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "common_name": "Rat" } ], "gene": [ { "name": "Ppil2", "url": "https://www.uniprot.org/uniprot/F7FHL6", "locus": { "chromosome": "11", "start_pos": 83922144, "end_pos": 83897764, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000026900", "url": "https://www.ensembl.org/id/ENSRNOG00000026900" } ] } } ], "crossref": [ { "id": "cd01923", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01923", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16663", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16663", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003613", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003613", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NFIKHCA", "url": "https://omabrowser.org/oma/group/NFIKHCA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45625:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45625:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00160", "url": "http://pfam.xfam.org/family/PF00160", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1309484", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309484", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I6ARD8", "url": "https://www.uniprot.org/uniprot/A0A8I6ARD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ARD8-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ARD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7FHL6-1", "url": "https://www.uniprot.org/uniprot/F7FHL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKRQHQKDKMYITCAEYTHFYGGRKPDITQTSFRRLPFDHCSLSLQPFVYPVCTPEGVVFDLLNIVPWLKKYGTDPSTGEKLDGKSLIKLNFAKNSEGQYHCPVLYSVFTDNTHIVAIRTTGNVYTYEVDPLAAVEQLNIKAKNLRDLLTDEPFSRQDIITLQDPTNLDKFNVSSFFHVKNNMRMIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGDEILAATMKPPEKKKVDQLNAAHYSTGKVSASFTSTAMVPETTHEAAVIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKQYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGVLSMANSGPNTNKSQFFITFRSCAYLDKKHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVRICTTTVFVDPYEEADAQIAQERKKTQHQVDPEAKAKTNQPQPGNQGPQTYRQGVGKYINPAATKRAAEEEPSTSTAIPTAKKRPSRGFGDFSSW", "length": 526, "header": "tr|F7FHL6-1|F7FHL6_RAT Isoform 1 of RING-type E3 ubiquitin transferase OS=Rattus norvegicus OX=10116 GN=Ppil2 PE=1 SV=1 CANONICAL=F7FHL6-1" }, "isoforms": [ { "isoform_ac": "A0A8I6ARD8-1", "url": "", "sequence": { "sequence": "LCWISVLFSLSLQPFVYPVCTPEGVVFDLLNIVPWLKKYGTDPSTGEKLDGKSLIKLNFAKNSEGQYHCPVLYSVFTDNTHIVAIRTTGNVYTYEAVEQLNIKAKNLRDLLTDEPFSRQDIITLQDPTNLDKFNVSSFFHVKNNMRMIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGDEILAATMKPPEKKKVDQLNAAHYSTGKVSASFTSTAMVPETTHEAAVIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKQYYDGTIFHRSIRNFVVSGTGWCGGESYWGKPFKDEFRPNLSHTGRGVLSMANSGPNTNKSQFFITFRSCAYLDKKHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVRICTTTVFVDPYEEADAQIAQERKKTQHQVDPEAKAKTNQPQPGNQGPQTYRQGVGKYINPAATKRAAEEEPSTSTAIPTAKKRPSRGFGDFSSW", "length": 483, "header": "tr|A0A8I6ARD8-1|A0A8I6ARD8_RAT Computationally mapped isoform of Peptidylprolyl isomerase like 2 OS=Rattus norvegicus OX=10116 GN=Ppil2 PE=1 SV=1 CANONICAL=F7FHL6-1" }, "locus": { "chromosome": "11", "start_pos": 83920197, "end_pos": 83903135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000104516.1", "url": "https://www.ensembl.org/id/ENSRNOT00000104516.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000097314.1", "url": "https://www.ensembl.org/id/ENSRNOP00000097314.1" } ] } }, { "isoform_ac": "F7FHL6-1", "url": "", "sequence": { "sequence": "MGKRQHQKDKMYITCAEYTHFYGGRKPDITQTSFRRLPFDHCSLSLQPFVYPVCTPEGVVFDLLNIVPWLKKYGTDPSTGEKLDGKSLIKLNFAKNSEGQYHCPVLYSVFTDNTHIVAIRTTGNVYTYEVDPLAAVEQLNIKAKNLRDLLTDEPFSRQDIITLQDPTNLDKFNVSSFFHVKNNMRMIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGDEILAATMKPPEKKKVDQLNAAHYSTGKVSASFTSTAMVPETTHEAAVIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKQYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGVLSMANSGPNTNKSQFFITFRSCAYLDKKHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVRICTTTVFVDPYEEADAQIAQERKKTQHQVDPEAKAKTNQPQPGNQGPQTYRQGVGKYINPAATKRAAEEEPSTSTAIPTAKKRPSRGFGDFSSW", "length": 526, "header": "tr|F7FHL6-1|F7FHL6_RAT Isoform 1 of RING-type E3 ubiquitin transferase OS=Rattus norvegicus OX=10116 GN=Ppil2 PE=1 SV=1 CANONICAL=F7FHL6-1" }, "locus": { "chromosome": "11", "start_pos": 83920197, "end_pos": 83897813, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000034506.5", "url": "https://www.ensembl.org/id/ENSRNOT00000034506.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000035467.5", "url": "https://www.ensembl.org/id/ENSRNOP00000035467.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" }, { "name": "protein peptidyl-prolyl isomerization", "id": "GO:0000413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000413", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" }, { "name": "ubiquitin-ubiquitin ligase activity", "id": "GO:0034450", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034450", "evidence": [ { "database": "UniProtKB", "id": "F7FHL6", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 381, "end_pos": 383, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }