{
    "uniprot_canonical_ac": "F7FD47-1",
    "uniprot_ac": "F7FD47",
    "uniprot_id": "F7FD47_RAT",
    "mass": {
        "chemical_mass": 29085.0,
        "monoisotopic_mass": 29085.0
    },
    "refseq": {
        "ac": "NP_001094365",
        "name": "cyclic AMP-dependent transcription factor ATF-1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094365"
    },
    "gene_names": [
        {
            "name": "Atf1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/F7FD47",
            "id": "F7FD47"
        },
        {
            "name": "Atf-1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094365",
            "id": "NP_001094365"
        },
        {
            "name": "Atf1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094365",
            "id": "NP_001094365"
        }
    ],
    "protein_names": [
        {
            "name": "Activating transcription factor 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "F7FD47"
        },
        {
            "name": "cyclic AMP-dependent transcription factor ATF-1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094365",
            "id": "NP_001094365"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0080322",
            "recommended_name": {
                "id": "DOID:0080322",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080322",
                "name": "polycystic kidney disease",
                "description": "A cystic kidney disease that is characterized by the growth of fluid-filled cysts in the kidneys that reduces kidney function and may lead to kidney failure."
            },
            "synonyms": [
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "polycystic kidney disease 1",
                    "description": "Any autosomal dominant polycystic kidney disease in which the cause of the disease is a mutation in the PKD1 gene."
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "APKD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "PKD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "PKD1 autosomal dominant polycystic kidney disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "autosomal dominant polycystic kidney disease caused by mutation in PKD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "polycystic kidney disease 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "polycystic kidney disease type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "polycystic kidney disease, adult, type I",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "Potter type 3 polycystic kidney disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "Potter type 3 polycystic kidney disease, formerly",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "polycystic kidney disease 1 with or without polycystic liver disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "polycystic kidney disease, adult",
                    "description": ""
                },
                {
                    "id": "MONDO:0008263",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008263",
                    "name": "polycystic kidney disease, adult, type 1",
                    "description": ""
                },
                {
                    "id": "MIM:173900",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/173900",
                    "name": "Polycystic kidney disease 1 with or without polycystic liver disease",
                    "description": "Polycystic kidney disease 1 with or without polycystic liver disease"
                }
            ],
            "evidence": [
                {
                    "id": "0080322",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080322"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F7FD47",
                    "url": "https://www.uniprot.org/uniprot/F7FD47"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Atf1",
            "url": "https://www.uniprot.org/uniprot/F7FD47",
            "locus": {
                "chromosome": "7",
                "start_pos": 131404670,
                "end_pos": 131362450,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000061088",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000061088"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000061088",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000061088",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd14690",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14690",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "315305",
            "url": "https://www.ncbi.nlm.nih.gov/gene/315305",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001630",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001630",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003102",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003102",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR004827",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR046347",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:315305",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315305",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "THISHIA",
            "url": "https://omabrowser.org/oma/group/THISHIA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3137625at2759",
            "url": "http://www.orthodb.org/?query=3137625at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45879",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45879",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45879:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45879:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00170",
            "url": "http://pfam.xfam.org/family/PF00170",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02173",
            "url": "http://pfam.xfam.org/family/PF02173",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-199920",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-199920",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001094365",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094365",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1307360",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307360",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "F7FD47",
            "url": "https://www.uniprot.org/uniprot/F7FD47",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F7FD47-1",
            "url": "https://www.uniprot.org/uniprot/F7FD47-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MEDSHKSNTSETASQPGSTVPGIISQIVHQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENPSISAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGPDGVQALQTLTMTNSSSAQQGAILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTMVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSHKSV",
        "length": 268,
        "header": "tr|F7FD47-1|F7FD47_RAT Isoform 1 of Activating transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Atf1 PE=4 SV=1 CANONICAL=F7FD47-1"
    },
    "isoforms": [
        {
            "isoform_ac": "F7FD47-1",
            "url": "",
            "sequence": {
                "sequence": "MEDSHKSNTSETASQPGSTVPGIISQIVHQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENPSISAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGPDGVQALQTLTMTNSSSAQQGAILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTMVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSHKSV",
                "length": 268,
                "header": "tr|F7FD47-1|F7FD47_RAT Isoform 1 of Activating transcription factor 1  OS=Rattus norvegicus OX=10116 GN=Atf1 PE=4 SV=1 CANONICAL=F7FD47-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 131403426,
                "end_pos": 131369422,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000087298.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000087298.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000073278.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000073278.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:315305",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315305",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-199920",
            "name": "CREB phosphorylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-199920",
            "resource": "Reactome",
            "description": "CREB phosphorylation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P18846-1",
            "protein_name": "Cyclic AMP-dependent transcription factor ATF-1",
            "gene_name": "ATF1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV",
                "length": 271
            },
            "evidence": [
                {
                    "id": "45236802",
                    "url": "http://www.informatics.jax.org/homology/45236802",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P81269-1",
            "protein_name": "Cyclic AMP-dependent transcription factor ATF-1",
            "gene_name": "Atf1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MEDSHKSNTTETASQPGSTVAGPHVSQIVHQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGEGENPSISAITSMSVPAPIYQTSSGQYIAIAPNGALQLASPSTDGVQALQTLTMTNSSSTQQGTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLASQTTKTDDPQLRREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSHKSV",
                "length": 269
            },
            "evidence": [
                {
                    "id": "45236802",
                    "url": "http://www.informatics.jax.org/homology/45236802",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 8,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein-containing complex binding",
                        "id": "GO:0044877",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
                        "id": "GO:0000978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific DNA binding",
                        "id": "GO:0043565",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific",
                        "id": "GO:0001228",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription regulator complex",
                        "id": "GO:0005667",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II transcription regulator complex",
                        "id": "GO:0090575",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATF1-ATF4 transcription factor complex",
                        "id": "GO:1990590",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990590",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATF4-CREB1 transcription factor complex",
                        "id": "GO:1990589",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990589",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of neuron projection development",
                        "id": "GO:0010976",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to purine-containing compound",
                        "id": "GO:0014074",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014074",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7FD47",
                                "url": "https://www.uniprot.org/uniprot/F7FD47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
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                                "database": "UniProtKB",
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