{
    "uniprot_canonical_ac": "F7F0H6-1",
    "uniprot_ac": "F7F0H6",
    "uniprot_id": "F7F0H6_RAT",
    "mass": {
        "chemical_mass": 51208.0,
        "monoisotopic_mass": 51208.0
    },
    "refseq": {
        "ac": "NP_001012353",
        "name": "interferon-gamma-inducible GTPase 2 like 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012353"
    },
    "gene_names": [
        {
            "name": "Ifgga2l1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/F7F0H6",
            "id": "F7F0H6"
        },
        {
            "name": "Ifgga2l1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012353",
            "id": "NP_001012353"
        },
        {
            "name": "Ifgga2l; Ifgga3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012353",
            "id": "NP_001012353"
        },
        {
            "name": "Ifgga2l",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/F7F0H6",
            "id": "F7F0H6"
        },
        {
            "name": "Ifgga3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/F7F0H6",
            "id": "F7F0H6"
        },
        {
            "name": "LOC100910979",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/F7F0H6",
            "id": "F7F0H6"
        },
        {
            "name": "MGC108823",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/F7F0H6",
            "id": "F7F0H6"
        }
    ],
    "protein_names": [
        {
            "name": "Similar to interferon-inducible GTPase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "F7F0H6"
        },
        {
            "name": "interferon-gamma-inducible GTPase 2 like 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012353",
            "id": "NP_001012353"
        },
        {
            "name": "interferon-gamma-inducible GTPase Ifgga3 protein; Interferon-inducible GTPase 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012353",
            "id": "NP_001012353"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0080208",
            "recommended_name": {
                "id": "DOID:0080208",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080208",
                "name": "metabolic dysfunction-associated steatotic liver disease",
                "description": "A steatotic liver disease characterized by at least one of five cardiometabolic risk factors (adjusted for age, sex and ethnicity), alcohol consumption below 140g/week (female) or 210g/week (male), and no other discernible cause. The five cardiometabolic risk factors are:(1) Body mass index  25 kg/m2 (adult), 23 kg/m2 (adult Asian), or 85th percentile (pediatric); waist circumference > 94 cm (adult male), 80 cm (adult female), or 95th percentile (pediatric); or ethnicity adjusted equivalents.(2) Fasting serum glucose  5.6 mmol/L, 2-hr post-load glucose levels  7.8 mmol/L, glycated hemoglobin (HbA1c)  5.7% (39 mmol/L), type 2 diabetes, treatment for type 2 diabetes, previously diagnosed or treated type 2 diabetes (pediatric only), or serum glucose  11.1 mmol/L (pediatric only).(3) Blood pressure  lower of 130/85 mmHg or 95th percentile (age < 13 years), or 130/85 mmHg (age  13 years); or specific hypertensive drug treatment.(4) Plasma triglycerides  1.15 mmol/L (age < 10 years) or 1.70 mmol/L (age  10 years); or lipid lowering treatment.(5) Plasma high-density lipoprotein cholesterol  1.0 mmol/L (adult male, pediatric) or 1.3 mmol/L (adult female); or lipid lowering treatment."
            },
            "synonyms": [
                {
                    "id": "DOID:0080208",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080208",
                    "name": "non-alcoholic fatty liver disease",
                    "description": ""
                },
                {
                    "id": "DOID:0080208",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080208",
                    "name": "NAFLD",
                    "description": ""
                },
                {
                    "id": "DOID:0080208",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080208",
                    "name": "metabolic dysfunction-associated fatty liver disease",
                    "description": ""
                },
                {
                    "id": "DOID:0080208",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080208",
                    "name": "metabolic dysfunction-related steatotic liver disease",
                    "description": ""
                },
                {
                    "id": "DOID:0080208",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080208",
                    "name": "MAFLD",
                    "description": ""
                },
                {
                    "id": "DOID:0080208",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080208",
                    "name": "MASLD",
                    "description": ""
                },
                {
                    "id": "DOID:0080208",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080208",
                    "name": "metabolic-associated fatty liver disease",
                    "description": ""
                },
                {
                    "id": "DOID:0080208",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080208",
                    "name": "nonalcoholic fatty liver disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0013246",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013246",
                    "name": "fatty liver disease, nonalcoholic, susceptibility to, 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0013246",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013246",
                    "name": "NAFLD2",
                    "description": ""
                },
                {
                    "id": "MONDO:0013246",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013246",
                    "name": "fatty liver disease, nonalcoholic, susceptibility to, 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0021105",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021105",
                    "name": "NAFLD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0021105",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021105",
                    "name": "NAFLD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0021105",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021105",
                    "name": "fatty liver disease, nonalcoholic, susceptibility to, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0021105",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021105",
                    "name": "liver disease, alcoholic, susceptibility to, 1",
                    "description": ""
                },
                {
                    "id": "MIM:613282",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/613282",
                    "name": "Non-alcoholic fatty liver disease 1",
                    "description": "Non-alcoholic fatty liver disease 1"
                }
            ],
            "evidence": [
                {
                    "id": "0080208",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080208"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F7F0H6",
                    "url": "https://www.uniprot.org/uniprot/F7F0H6"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Ifgga2l1",
            "url": "https://www.uniprot.org/uniprot/F7F0H6",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000019542",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019542",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd04104",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04104",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "307414",
            "url": "https://www.ncbi.nlm.nih.gov/gene/307414",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR007743",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007743",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR030385",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR030385",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:307414",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:307414",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "TMSHICK",
            "url": "https://omabrowser.org/oma/group/TMSHICK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4586265at2759",
            "url": "http://www.orthodb.org/?query=4586265at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR32341",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32341",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR32341:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32341:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05049",
            "url": "http://pfam.xfam.org/family/PF05049",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1359421",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359421",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "6495625",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=6495625",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "F7F0H6",
            "url": "https://www.uniprot.org/uniprot/F7F0H6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F7F0H6-1",
            "url": "https://www.uniprot.org/uniprot/F7F0H6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5FVQ6",
            "url": "https://www.uniprot.org/uniprot/Q5FVQ6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5FVQ6-1",
            "url": "https://www.uniprot.org/uniprot/Q5FVQ6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MFQTEGLHLCLLTSKRLKWLYLLEVMGQWFSSKNEQHQDLASSFKEYFKKFKTGHKIISEEIITSVELSMTKGNIQMANSTISEALRDIDGTPLNVAVTGESGAGKSSFINALRGIGHEEEGAAEIGVVETTAERWPYKHPSMPNVVIWDLPGIGTTNFPPKTYLEKMKFYEYDFFIIISATRFKKTDTDLAKAISMMKKDFYFVRTKVDSDLRNEENTKPRSFDREKVLQNIRLNCVKHFKENGMDEPPIFLISNIDLSDYDFPILMDKLISDLPVYKRHTFMLSLPNITDSTIEMKRQCLKQRIWLEAFAADLLRILPSLTFLLDSDLETLKKCLKFYRTVFGVDDAALQSLAKDWQMPLVELEAMMKSPIVFKPTDEETIHERLSRYYHDYCSANGHLFTDDRDLREISYLKYYFLDIVTEDAKTLLKEICVRNKLVSN",
        "length": 442,
        "header": "tr|F7F0H6-1|F7F0H6_RAT Isoform 1 of Similar to interferon-inducible GTPase  OS=Rattus norvegicus OX=10116 GN=Ifgga2l1 PE=1 SV=1 CANONICAL=F7F0H6-1"
    },
    "isoforms": [
        {
            "isoform_ac": "F7F0H6-1",
            "url": "",
            "sequence": {
                "sequence": "MFQTEGLHLCLLTSKRLKWLYLLEVMGQWFSSKNEQHQDLASSFKEYFKKFKTGHKIISEEIITSVELSMTKGNIQMANSTISEALRDIDGTPLNVAVTGESGAGKSSFINALRGIGHEEEGAAEIGVVETTAERWPYKHPSMPNVVIWDLPGIGTTNFPPKTYLEKMKFYEYDFFIIISATRFKKTDTDLAKAISMMKKDFYFVRTKVDSDLRNEENTKPRSFDREKVLQNIRLNCVKHFKENGMDEPPIFLISNIDLSDYDFPILMDKLISDLPVYKRHTFMLSLPNITDSTIEMKRQCLKQRIWLEAFAADLLRILPSLTFLLDSDLETLKKCLKFYRTVFGVDDAALQSLAKDWQMPLVELEAMMKSPIVFKPTDEETIHERLSRYYHDYCSANGHLFTDDRDLREISYLKYYFLDIVTEDAKTLLKEICVRNKLVSN",
                "length": 442,
                "header": "tr|F7F0H6-1|F7F0H6_RAT Isoform 1 of Similar to interferon-inducible GTPase  OS=Rattus norvegicus OX=10116 GN=Ifgga2l1 PE=1 SV=1 CANONICAL=F7F0H6-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 53769959,
                "end_pos": 53748636,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000050063.4",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000050063.4"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000049863.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000049863.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q5FVQ6-1",
            "url": "",
            "sequence": {
                "sequence": "MGQWFSSKNEQHQDLASSFKEYFKKFKTGHKIISEEIITSVELSMTKGNIQMANSTISEALRDIDGTPLNVAVTGESGAGKSSFINALRGIGHEEEGAAEIGVVETTAERWPYKHPSMPNVVIWDLPGIGTTNFPPKTYLEKMKFYEYDFFIIISATRFKKTDTDLAKAISMMKKDFYFVRTKVDSDLRNEENTKPRSFDREKVLQNIRLNCVKHFKENGMDEPPIFLISNIDLSDYDFPILMDKLISDLPVYKRHTFMLSLPNITDSTIEMKRQCLKQRIWLEAFAADLLRILPSLTFLLDSDLETLKKCLKFYRTVFGVDDAALQSLAKDWQMPLVELEAMMKSPIVFKPTDEETIHERLSRYYHDYCSANGHLFTDDRDLREISYLKYYFLDIVTEDAKTLLKEICVRNKLVSN",
                "length": 417,
                "header": "tr|Q5FVQ6-1|F7F0H6_RAT Computationally mapped isoform of Similar to interferon-inducible GTPase  OS=Rattus norvegicus OX=10116 GN=Ifgga2l1 PE=1 SV=1 CANONICAL=F7F0H6-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 53769959,
                "end_pos": 53768709,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000117683.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000117683.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000082693.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000082693.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Comparative genomic analysis of eutherian interferon-gamma-inducible GTPases.",
            "journal": "Funct. Integr. Genomics",
            "date": "2012",
            "authors": "Premzl M",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5FVQ6",
                    "url": "https://www.uniprot.org/uniprot/Q5FVQ6"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22892676",
                    "url": "https://glygen.org/publication/PubMed/22892676"
                }
            ]
        },
        {
            "title": "Curated eutherian third party data gene data sets.",
            "journal": "Data Brief",
            "date": "2016",
            "authors": "Premzl M",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5FVQ6",
                    "url": "https://www.uniprot.org/uniprot/Q5FVQ6"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26862561",
                    "url": "https://glygen.org/publication/PubMed/26862561"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:307414",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:307414",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q3UED7-1",
            "protein_name": "Predicted gene 4951",
            "gene_name": "Iigp1c",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MGQLFSSRRSEDQDLSSSFIEYLKECEKGINIIPHEIITSIEINMKKGNIQEVNSTVRDMLREIDNTPLNVALTGETGSGKSSFINTLRGIGHEEGGAAHTGVTDKTKERHPYEHPKMPNVVFWDLPGTGSEDFQPKTYLEKMKFYEYDFFIIISATRFKKNDIDLAKAIGIMKKEFYFVRTQVDSDLRNEEDFKPQTFDREKVLQDIRLNCVNTFRENGIAEPPIFLISNKNVCHYDFPVLMDKLISDLPVFKRQNFMFSLPNITDSVIEKKRNFLRWKTWLEGFADGLLSFFLESDLETLEKSMKFYRTVFGVDDASLQRLARAWEIDQVDQVRAMIKSPAVFTPTDEETIQERLSRYNQEFCLANGYLLPKNHCREILYLKLYFLDMVTEDAKTLLKEICLRN",
                "length": 406
            },
            "evidence": [
                {
                    "id": "45227453",
                    "url": "http://www.informatics.jax.org/homology/45227453",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9QZ85-1",
            "protein_name": "Interferon-inducible GTPase 1",
            "gene_name": "Iigp1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MGQLFSSPKSDENNDLPSSFTGYFKKFNTGRKIISQEILNLIELRMRKGNIQLTNSAISDALKEIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVEVTMERHPYKHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRFKKNDIDIAKAISMMKKEFYFVRTKVDSDITNEADGKPQTFDKEKVLQDIRLNCVNTFRENGIAEPPIFLLSNKNVCHYDFPVLMDKLISDLPIYKRHNFMVSLPNITDSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVFGVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDEETIQERLSRYIQEFCLANGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICLRN",
                "length": 413
            },
            "evidence": [
                {
                    "id": "45227448",
                    "url": "http://www.informatics.jax.org/homology/45227448",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "defense response to other organism",
                        "id": "GO:0098542",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098542",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7F0H6",
                                "url": "https://www.uniprot.org/uniprot/F7F0H6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "defense response",
                        "id": "GO:0006952",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7F0H6",
                                "url": "https://www.uniprot.org/uniprot/F7F0H6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to interferon-beta",
                        "id": "GO:0035458",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7F0H6",
                                "url": "https://www.uniprot.org/uniprot/F7F0H6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "GTPase activity",
                        "id": "GO:0003924",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F7F0H6",
                                "url": "https://www.uniprot.org/uniprot/F7F0H6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GTP binding",
                        "id": "GO:0005525",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525",
                        "evidence": [
                            {
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