{
    "uniprot_canonical_ac": "F1LV76-1",
    "uniprot_ac": "F1LV76",
    "uniprot_id": "F1LV76_RAT",
    "mass": {
        "chemical_mass": 65095.0,
        "monoisotopic_mass": 65095.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Cdkal1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/F1LV76",
            "id": "F1LV76"
        },
        {
            "name": "LOC120093069",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/F1LV76",
            "id": "F1LV76"
        }
    ],
    "protein_names": [
        {
            "name": "tRNA-t(6)A37 methylthiotransferase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "F1LV76"
        },
        {
            "name": "2.8.4.5",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "F1LV76"
        }
    ],
    "function": [
        {
            "annotation": "Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F1LV76",
                    "url": "https://www.uniprot.org/uniprot/F1LV76#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU368081",
                    "url": "https://www.uniprot.org/uniprot/RU368081#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00002399",
                    "url": "https://www.uniprot.org/uniprot/ARBA00002399#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:11714",
            "recommended_name": {
                "id": "DOID:11714",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:11714",
                "name": "gestational diabetes",
                "description": "A diabetes mellitus that manifests during pregnancy."
            },
            "synonyms": [
                {
                    "id": "DOID:11714",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11714",
                    "name": "GDM",
                    "description": ""
                },
                {
                    "id": "DOID:11714",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11714",
                    "name": "Gestational diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "DOID:11714",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11714",
                    "name": "Maternal gestational diabetes mellitus",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "11714",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:11714"
                }
            ]
        },
        {
            "disease_id": "DOID:9351",
            "recommended_name": {
                "id": "DOID:9351",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9351",
                "name": "diabetes mellitus",
                "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."
            },
            "synonyms": [
                {
                    "id": "DOID:9351",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9351",
                    "name": "diabetes",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "9351",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9351"
                }
            ]
        },
        {
            "disease_id": "DOID:9352",
            "recommended_name": {
                "id": "DOID:9352",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9352",
                "name": "type 2 diabetes mellitus",
                "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin."
            },
            "synonyms": [
                {
                    "id": "DOID:9352",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9352",
                    "name": "NIDDM",
                    "description": ""
                },
                {
                    "id": "DOID:9352",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9352",
                    "name": "non-insulin-dependent diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "DOID:9352",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9352",
                    "name": "type 2 diabetes",
                    "description": ""
                },
                {
                    "id": "DOID:9352",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9352",
                    "name": "type II diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "DOID:9352",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9352",
                    "name": "insulin resistance",
                    "description": ""
                },
                {
                    "id": "MONDO:0011955",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011955",
                    "name": "diabetes mellitus, noninsulin-dependent, 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011955",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011955",
                    "name": "diabetes mellitus, noninsulin-dependent, 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011955",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011955",
                    "name": "diabetes mellitus, noninsulin-dependent, type 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011955",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011955",
                    "name": "Niddm4",
                    "description": ""
                },
                {
                    "id": "MONDO:0011955",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011955",
                    "name": "noninsulin-dependent diabetes mellitus 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "type 2 diabetes mellitus",
                    "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity."
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "NIDDM",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "T2DM - type 2 diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "adult onset diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "adult-onset diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitis type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitis type II",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, noninsulin-dependent",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, noninsulin-dependent, association with",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, noninsulin-dependent, late onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, type II",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes, type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "insulin resistance, severe, digenic",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "non-insulin dependent diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "non-insulin dependent diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "non-insulin-dependent diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "noninsulin dependent diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "noninsulin-dependent diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "type 2 diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "type 2 diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "type 2 diabetes mellitus non-insulin dependent",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "type II diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "type II diabetes mellitus",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, noninsulin-dependent, 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, non-insulin-dependent, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, noninsulin-dependent, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, type 2, protection against",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, type 2, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "diabetes mellitus, type II, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "hypertension, insulin resistance-related, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "insulin resistance, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "maturity-onset diabetes",
                    "description": ""
                },
                {
                    "id": "MONDO:0005148",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005148",
                    "name": "type 2 diabetes mellitus, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0011027",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011027",
                    "name": "diabetes mellitus, noninsulin-dependent, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011027",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011027",
                    "name": "diabetes mellitus, noninsulin-dependent 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011027",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011027",
                    "name": "diabetes mellitus, noninsulin-dependent, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011027",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011027",
                    "name": "diabetes mellitus, noninsulin-dependent, type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011027",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011027",
                    "name": "NIDDM1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011027",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011027",
                    "name": "noninsulin-dependent diabetes mellitus 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011072",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011072",
                    "name": "diabetes mellitus, noninsulin-dependent, 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011072",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011072",
                    "name": "NIDDM2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011072",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011072",
                    "name": "diabetes mellitus, noninsulin-dependent, 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011072",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011072",
                    "name": "noninsulin-dependent diabetes mellitus 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011363",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011363",
                    "name": "diabetes mellitus, noninsulin-dependent, 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0011363",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011363",
                    "name": "diabetes mellitus, noninsulin-dependent, 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0011363",
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                    "url": "https://monarchinitiative.org/disease/MONDO:0011363",
                    "name": "diabetes mellitus, noninsulin-dependent, type 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0011363",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011363",
                    "name": "type 2 diabetes mellitus 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0011363",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011363",
                    "name": "NIDDM3",
                    "description": ""
                },
                {
                    "id": "MONDO:0011363",
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                    "url": "https://monarchinitiative.org/disease/MONDO:0011363",
                    "name": "noninsulin-dependent diabetes mellitus 3",
                    "description": ""
                },
                {
                    "id": "MIM:125853",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/125853",
                    "name": "Type 2 diabetes mellitus",
                    "description": "Type 2 diabetes mellitus"
                },
                {
                    "id": "MIM:601283",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/601283",
                    "name": "Type 2 diabetes mellitus 1",
                    "description": "Type 2 diabetes mellitus 1"
                }
            ],
            "evidence": [
                {
                    "id": "9352",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9352"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
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                    "database": "UniProtKB",
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                    "url": "https://www.uniprot.org/uniprot/F1LV76"
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            ],
            "common_name": "Rat"
        }
    ],
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                ]
            }
        }
    ],
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        {
            "id": "ENSRNOG00000018381",
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        },
        {
            "id": "cd01335",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01335",
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            "categories": [
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        },
        {
            "id": "IPR002792",
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        },
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        },
        {
            "id": "IPR007197",
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        },
        {
            "id": "IPR013848",
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            "categories": [
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            ]
        },
        {
            "id": "IPR020612",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020612",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023404",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023404",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038135",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038135",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "HYAYPTG",
            "url": "https://omabrowser.org/oma/group/HYAYPTG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11918",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11918",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11918:SF45",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11918:SF45",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00919",
            "url": "http://pfam.xfam.org/family/PF00919",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01938",
            "url": "http://pfam.xfam.org/family/PF01938",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04055",
            "url": "http://pfam.xfam.org/family/PF04055",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_006222444",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006222444",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1310246",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310246",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "41313473",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=41313473",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "37075",
            "url": "https://www.rhea-db.org/rhea/37075",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A8I5ZT83",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZT83",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZT83-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZT83-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GBE9",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GBE9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GBE9-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GBE9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1LV76",
            "url": "https://www.uniprot.org/uniprot/F1LV76",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1LV76-1",
            "url": "https://www.uniprot.org/uniprot/F1LV76-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0R837",
            "url": "https://www.uniprot.org/uniprot/M0R837",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0R837-1",
            "url": "https://www.uniprot.org/uniprot/M0R837-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPSASCDVLLDDIEDIISQEDSKPQDRHFSRKHVFPKVRRRNTQKYLQEEPSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAHEENKKVVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKESGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVERAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKAKQVPAHVKKQRTKDLSRVFHSYNPYDHKIGERQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPAFMGKMVEVDIYESGKHFLKGQPVSETRVYTPSICKPLAKGEVSGLTTEFRNRLGDRLNSTSGTCPAPPQGSACSRMALQTSQYDCALKVAAGLALIALLLHFWPESMFTM",
        "length": 578,
        "header": "tr|F1LV76-1|F1LV76_RAT Isoform 1 of tRNA-t(6)A37 methylthiotransferase  OS=Rattus norvegicus OX=10116 GN=Cdkal1 PE=3 SV=4 CANONICAL=F1LV76-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I5ZT83-1",
            "url": "",
            "sequence": {
                "sequence": "MPSASCDVLLDDIEDIISQEDSKPQDRHFSRKHVFPKVRRRNTQKYLQEEPSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITGNKTEINLRAFRMEFSLTTQN",
                "length": 115,
                "header": "tr|A0A8I5ZT83-1|F1LV76_RAT Computationally mapped isoform of tRNA-t(6)A37 methylthiotransferase  OS=Rattus norvegicus OX=10116 GN=Cdkal1 PE=3 SV=1 CANONICAL=F1LV76-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 34735880,
                "end_pos": 34723968,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000116835.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000116835.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000081920.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000081920.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6GBE9-1",
            "url": "",
            "sequence": {
                "sequence": "MPSASCDVLLDDIEDIISQEDSKPQDRHFSRKHVFPKVRRRNTQKYLQEEPSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITAQCGKSQAWASWKSFTVVFCFSGAHCPSPRQLQGLKALL",
                "length": 133,
                "header": "tr|A0A8I6GBE9-1|F1LV76_RAT Computationally mapped isoform of tRNA-t(6)A37 methylthiotransferase  OS=Rattus norvegicus OX=10116 GN=Cdkal1 PE=3 SV=1 CANONICAL=F1LV76-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 34768709,
                "end_pos": 34723968,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000111226.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000111226.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000084071.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000084071.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F1LV76-1",
            "url": "",
            "sequence": {
                "sequence": "MPSASCDVLLDDIEDIISQEDSKPQDRHFSRKHVFPKVRRRNTQKYLQEEPSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAHEENKKVVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKESGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVERAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKAKQVPAHVKKQRTKDLSRVFHSYNPYDHKIGERQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPAFMGKMVEVDIYESGKHFLKGQPVSETRVYTPSICKPLAKGEVSGLTTEFRNRLGDRLNSTSGTCPAPPQGSACSRMALQTSQYDCALKVAAGLALIALLLHFWPESMFTM",
                "length": 578,
                "header": "tr|F1LV76-1|F1LV76_RAT Isoform 1 of tRNA-t(6)A37 methylthiotransferase  OS=Rattus norvegicus OX=10116 GN=Cdkal1 PE=3 SV=4 CANONICAL=F1LV76-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 35270605,
                "end_pos": 34723968,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000024854.8",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000024854.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000024854.8",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000024854.8"
                    }
                ]
            }
        },
        {
            "isoform_ac": "M0R837-1",
            "url": "",
            "sequence": {
                "sequence": "MAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKAKQVPAHVKKQRTKDLSRVFHSYNPYDHKIGERQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPAFMGKMVEVDIYESGKHFLKGQPVSETRVYTPSICKPLAKGEVSGLTTALDYL",
                "length": 217,
                "header": "tr|M0R837-1|F1LV76_RAT Computationally mapped isoform of tRNA-t(6)A37 methylthiotransferase  OS=Rattus norvegicus OX=10116 GN=Cdkal1 PE=3 SV=6 CANONICAL=F1LV76-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 35407521,
                "end_pos": 35067236,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000071408.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000071408.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000065627.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000065627.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "rough endoplasmic reticulum",
                        "id": "GO:0005791",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005791",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "4 iron, 4 sulfur cluster binding",
                        "id": "GO:0051539",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "N6-threonylcarbomyladenosine methylthiotransferase activity",
                        "id": "GO:0035598",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035598",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "iron-sulfur cluster binding",
                        "id": "GO:0051536",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051536",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase",
                        "id": "GO:0061712",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061712",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "maintenance of translational fidelity",
                        "id": "GO:1990145",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990145",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "tRNA methylthiolation",
                        "id": "GO:0035600",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035600",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LV76",
                                "url": "https://www.uniprot.org/uniprot/F1LV76"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 526,
            "end_pos": 528,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 75,
            "end_pos": 77,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 96,
            "end_pos": 98,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "37075",
            "name": "",
            "equation": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "F1LV76-1",
                "Q5VV42-1",
                "Q91WE6-1",
                "Q7K4W1-1"
            ],
            "evidence": [
                {
                    "id": "37075",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/37075"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "F1LV76",
            "gene_name": "Cdkal1",
            "activity": [
                {
                    "ec_number": "2.8.4.5",
                    "activity": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine.",
                    "evidence": [
                        {
                            "id": "F1LV76",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/F1LV76"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.4.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "F1LV76",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/F1LV76"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5VV42",
            "gene_name": "CDKAL1",
            "activity": [
                {
                    "ec_number": "2.8.4.5",
                    "activity": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine.",
                    "evidence": [
                        {
                            "id": "Q5VV42",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5VV42"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.4.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5VV42",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5VV42"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q7K4W1",
            "gene_name": "",
            "activity": [
                {
                    "ec_number": "2.8.4.5",
                    "activity": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine.",
                    "evidence": [
                        {
                            "id": "Q7K4W1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7K4W1"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.4.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q7K4W1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7K4W1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q91WE6",
            "gene_name": "Cdkal1",
            "activity": [
                {
                    "ec_number": "2.8.4.5",
                    "activity": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine.",
                    "evidence": [
                        {
                            "id": "Q91WE6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91WE6"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.4.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q91WE6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91WE6"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
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            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
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                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
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