{ "uniprot_canonical_ac": "F1LPI3-1", "uniprot_ac": "F1LPI3", "uniprot_id": "F1LPI3_RAT", "mass": { "chemical_mass": 55548.0, "monoisotopic_mass": 55548.0 }, "refseq": {}, "gene_names": [ { "name": "Gja10", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/F1LPI3", "id": "F1LPI3" } ], "protein_names": [ { "name": "Gap junction protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "F1LPI3" } ], "function": [ { "annotation": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3#function" }, { "database": "UniProtKB", "id": "RU000630", "url": "https://www.uniprot.org/uniprot/RU000630#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "common_name": "Rat" } ], "gene": [ { "name": "Gja10", "url": "https://www.uniprot.org/uniprot/F1LPI3", "locus": { "chromosome": "5", "start_pos": 46992946, "end_pos": 46996570, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000006478", "url": "https://www.ensembl.org/id/ENSRNOG00000006478" } ] } } ], "crossref": [ { "id": "IPR000500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:313126", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313126", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SPCPWDD", "url": "https://omabrowser.org/oma/group/SPCPWDD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5301774at2759", "url": "http://www.orthodb.org/?query=5301774at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00029", "url": "http://pfam.xfam.org/family/PF00029", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-112303", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112303", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-190861", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-190861", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_017448839", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017448839", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1309630", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309630", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LPI3-1", "url": "https://www.uniprot.org/uniprot/F1LPI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSSFACNTQQPGCSNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRDFEKQRQKKKLYLKAQMENPDLDLEEQQRVERELRRLEEQKRIQKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYGFQMHPIYKCTQAPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRALDGKSSSGNTENETGPPFHSTNYSGAQQCMVCSSLPERVSLLQANNKQQVIRVNIPRSKSVWQIPHPRQLEVDVSCGKRGWAERVENSEQLHVHSPCPHERSARIQHPGQQPCHSIVCPKNVMSQSWLGTMTASQHRPSSALETWERSQGPEVSGKPLTDRQSHFQGSDGSARESGVWTDRLGPGSRKASFLSRLISEKGQQHSDSGSSRSLNSSCLDFPHGENSPSPLPSATGHRASMNMLLELSSIMKK", "length": 492, "header": "tr|F1LPI3-1|F1LPI3_RAT Isoform 1 of Gap junction protein OS=Rattus norvegicus OX=10116 GN=Gja10 PE=3 SV=3 CANONICAL=F1LPI3-1" }, "isoforms": [ { "isoform_ac": "F1LPI3-1", "url": "", "sequence": { "sequence": "MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSSFACNTQQPGCSNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRDFEKQRQKKKLYLKAQMENPDLDLEEQQRVERELRRLEEQKRIQKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYGFQMHPIYKCTQAPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRALDGKSSSGNTENETGPPFHSTNYSGAQQCMVCSSLPERVSLLQANNKQQVIRVNIPRSKSVWQIPHPRQLEVDVSCGKRGWAERVENSEQLHVHSPCPHERSARIQHPGQQPCHSIVCPKNVMSQSWLGTMTASQHRPSSALETWERSQGPEVSGKPLTDRQSHFQGSDGSARESGVWTDRLGPGSRKASFLSRLISEKGQQHSDSGSSRSLNSSCLDFPHGENSPSPLPSATGHRASMNMLLELSSIMKK", "length": 492, "header": "tr|F1LPI3-1|F1LPI3_RAT Isoform 1 of Gap junction protein OS=Rattus norvegicus OX=10116 GN=Gja10 PE=3 SV=3 CANONICAL=F1LPI3-1" }, "locus": { "chromosome": "5", "start_pos": 46996570, "end_pos": 46992949, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000008469.6", "url": "https://www.ensembl.org/id/ENSRNOT00000008469.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000008469.5", "url": "https://www.ensembl.org/id/ENSRNOP00000008469.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:313126", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313126", "resource": "KEGG Pathway" }, { "id": "R-RNO-112303", "name": "Electric Transmission Across Gap Junctions", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112303", "resource": "Reactome", "description": "Electric Transmission Across Gap Junctions" }, { "id": "R-RNO-190861", "name": "Gap junction assembly", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-190861", "resource": "Reactome", "description": "Gap junction assembly" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cell-cell signaling", "id": "GO:0007267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" }, { "name": "synapse assembly", "id": "GO:0007416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" }, { "name": "response to light stimulus", "id": "GO:0009416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009416", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" }, { "name": "detection of light stimulus involved in visual perception", "id": "GO:0050908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050908", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" }, { "name": "gamete generation", "id": "GO:0007276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007276", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "gap junction", "id": "GO:0005921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005921", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" }, { "name": "connexin complex", "id": "GO:0005922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005922", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gap junction channel activity", "id": "GO:0005243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005243", "evidence": [ { "database": "UniProtKB", "id": "F1LPI3", "url": "https://www.uniprot.org/uniprot/F1LPI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", 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