{
    "uniprot_canonical_ac": "F1LNX8-1",
    "uniprot_ac": "F1LNX8",
    "uniprot_id": "F1LNX8_RAT",
    "mass": {
        "chemical_mass": 66980.0,
        "monoisotopic_mass": 66980.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Cmahp",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/F1LNX8",
            "id": "F1LNX8"
        },
        {
            "name": "Cmah",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/F1LNX8",
            "id": "F1LNX8"
        }
    ],
    "protein_names": [
        {
            "name": "Cytidine monophosphate-N-acetylneuraminic acid hydroxylase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "F1LNX8"
        },
        {
            "name": "1.14.18.2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "F1LNX8"
        },
        {
            "name": "CMP-N-acetylneuraminate monooxygenase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "F1LNX8"
        },
        {
            "name": "CMP-Neu5Ac hydroxylase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "F1LNX8"
        },
        {
            "name": "CMP-NeuAc hydroxylase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "F1LNX8"
        }
    ],
    "function": [
        {
            "annotation": "Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F1LNX8",
                    "url": "https://www.uniprot.org/uniprot/F1LNX8#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00003414",
                    "url": "https://www.uniprot.org/uniprot/ARBA00003414#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F1LNX8",
                    "url": "https://www.uniprot.org/uniprot/F1LNX8"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Cmahp",
            "url": "https://www.uniprot.org/uniprot/F1LNX8",
            "locus": {
                "chromosome": "17",
                "start_pos": 40583667,
                "end_pos": 40642275,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000003094",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000003094"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000003094",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000003094",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd03473",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03473",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017941",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017941",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027033",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027033",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036866",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036922",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036922",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037339",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037339",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "WKSFLMC",
            "url": "https://omabrowser.org/oma/group/WKSFLMC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46522",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46522",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46522:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46522:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00355",
            "url": "http://pfam.xfam.org/family/PF00355",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13483",
            "url": "http://pfam.xfam.org/family/PF13483",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1311930",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311930",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "16145",
            "url": "https://www.rhea-db.org/rhea/16145",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A0G2JWT4",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWT4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JWT4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWT4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZY63",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZY63",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZY63-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZY63-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1LNX8",
            "url": "https://www.uniprot.org/uniprot/F1LNX8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1LNX8-1",
            "url": "https://www.uniprot.org/uniprot/F1LNX8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MMDSRKQTAETLLSLSPADVANLKEGVNFCRNKTTGKEYILYKEKDHLKACKNLCKHQGGLFMRDIEDLDGRSVKCTKHNWKLDVSTMKYTNPPGSFCQDELVVEMDENNGLCLVELNPPNPWDSDPRSPEELAFGEVQITYLTHACMDLKLGDKRMAFDPWLIGPAFARGWWLLHEPPSDWLERLCKADLIYISHMHSDHLSYPTLKQLSQRRPDIPIYVGDTERPVFWNLNHSGVQLTNINVVPFGIWQQVDKNLRFMILMDGVHPEMDTCIIVEYKGHKILNTVDCTRPNGGRLPEKVALMMSDFAGGASGFPMTFSGGKFTEEWKAQFIKAERRKLLNYKAQLVKDLQPRIYCPFAGYFVEAHPSDKYIKETNTKNDPNQLNNLIKKNSNVVTWTPRPGATLDLGRMLKDPTDSKGIVEPPEGTKIYKDSWDFEPYLKTLNSSVRDSIFLHSSWIKEYFTWAGFKNYNLVVRMIETDEDFSPVPGGYDYLVDFLDLSFPKERPSREHPYEEIRSRVDVIRHVVKNGLLWDDLYIGFQTRLQRDPDIYHHLFWNHFQIKLPLTPPNWKLFLMRCG",
        "length": 578,
        "header": "tr|F1LNX8-1|F1LNX8_RAT Isoform 1 of Cytidine monophosphate-N-acetylneuraminic acid hydroxylase  OS=Rattus norvegicus OX=10116 GN=Cmahp PE=3 SV=4 CANONICAL=F1LNX8-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JWT4-1",
            "url": "",
            "sequence": {
                "sequence": "MEVVEMDENNGLCLVELNPPNPWDSDPRSPEELAFGEVQITYLTHACMDLKLGDKRMAFDPWLIGPAFARGWWLLHEPPSDWLERLCKADLIYISHMHSDHLSYPTLKQLSQRRPDIPIYVGDTERPVFWNLNHSGVQLTNINVVPFGIWQQVDKNLRFMILMDGVHPEMDTCIIVEYKEEWKAQFIKAERRKLLNYKAQLVKDLQPRIYCPFAGYFVEAHPSDKYIKETNTKNDPNQLNNLIKKNSNVVTWTPRPGATLDLGRMLKDPTDSKGIVEPPEGTKIYKDSWDFEPYLKTLNSSVRDSIFLHSSWIKEYFTWAGFKNYNLVVRMIETDEDFSPVPGGYDYLVDFLDLSFPKERPSREHPYEEIRSRVDVIRHVVKNGLLWDDLYIGFQTRLQRDPDIYHHLFWNHFQIKLPLTPPNWKLFLMRCG",
                "length": 432,
                "header": "tr|A0A0G2JWT4-1|F1LNX8_RAT Computationally mapped isoform of Cytidine monophosphate-N-acetylneuraminic acid hydroxylase  OS=Rattus norvegicus OX=10116 GN=Cmahp PE=3 SV=2 CANONICAL=F1LNX8-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 40639454,
                "end_pos": 40586205,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000081105.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000081105.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000070006.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000070006.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5ZY63-1",
            "url": "",
            "sequence": {
                "sequence": "MSSGCCLGSCCALSECSLLPCMVLTFCILTMCLYFGKVFKNVIFSHAQMYFPLVLVVEMDENNGLCLVELNPPNPWDSDPRSPEELAFGEVQITYLTHACMDLKLGDKRMAFDPWLIGPAFARGWWLLHEPPSDWLERLCKADLIYISHMHSDHLSYPTLKQLSQRRPDIPIYVGDTERPVFWNLNHSGVQLTNINVVPFGIWQQVDKNLRFMILMDGVHPEMDTCIIVEYKGHKILNTVDCTRPNGGRLPEKVALMMSDFAGGASGFPMTFSGGKFTEEWKAQFIKAERRKLLNYKAQLVKDLQPRIYCPFAGYFVEAHPSDKYIKETNTKNDPNQLNNLIKKNSNVVTWTPRPGATLDLGRMLKDPTDSKGIVEPPEGTKIYKDSWDFEPYLKTLNSSVRDSIFLHSSWIKEYFTWAGFKNYNLVVRMIETDEDFSPVPGGYDYLVDFLDLSFPKERPSREHPYEEIRSRVDVIRHVVKNGLLWDDLYIGFQTRLQRDPDIYHHLFWNHFQIKLPLTPPNWKLFLMRCG",
                "length": 531,
                "header": "tr|A0A8I5ZY63-1|A0A8I5ZY63_RAT Computationally mapped isoform of Cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene  OS=Rattus norvegicus OX=10116 GN=Cmahp PE=3 SV=1 CANONICAL=F1LNX8-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 40628259,
                "end_pos": 40586205,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000106094.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000106094.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000083998.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000083998.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F1LNX8-1",
            "url": "",
            "sequence": {
                "sequence": "MMDSRKQTAETLLSLSPADVANLKEGVNFCRNKTTGKEYILYKEKDHLKACKNLCKHQGGLFMRDIEDLDGRSVKCTKHNWKLDVSTMKYTNPPGSFCQDELVVEMDENNGLCLVELNPPNPWDSDPRSPEELAFGEVQITYLTHACMDLKLGDKRMAFDPWLIGPAFARGWWLLHEPPSDWLERLCKADLIYISHMHSDHLSYPTLKQLSQRRPDIPIYVGDTERPVFWNLNHSGVQLTNINVVPFGIWQQVDKNLRFMILMDGVHPEMDTCIIVEYKGHKILNTVDCTRPNGGRLPEKVALMMSDFAGGASGFPMTFSGGKFTEEWKAQFIKAERRKLLNYKAQLVKDLQPRIYCPFAGYFVEAHPSDKYIKETNTKNDPNQLNNLIKKNSNVVTWTPRPGATLDLGRMLKDPTDSKGIVEPPEGTKIYKDSWDFEPYLKTLNSSVRDSIFLHSSWIKEYFTWAGFKNYNLVVRMIETDEDFSPVPGGYDYLVDFLDLSFPKERPSREHPYEEIRSRVDVIRHVVKNGLLWDDLYIGFQTRLQRDPDIYHHLFWNHFQIKLPLTPPNWKLFLMRCG",
                "length": 578,
                "header": "tr|F1LNX8-1|F1LNX8_RAT Isoform 1 of Cytidine monophosphate-N-acetylneuraminic acid hydroxylase  OS=Rattus norvegicus OX=10116 GN=Cmahp PE=3 SV=4 CANONICAL=F1LNX8-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 40639886,
                "end_pos": 40586205,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000018699.8",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000018699.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000018699.8",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000018699.8"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoskeleton",
                        "id": "GO:0005856",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "regulation of Wnt signaling pathway",
                        "id": "GO:0030111",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030111",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "CMP-N-acetylneuraminate metabolic process",
                        "id": "GO:0046381",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046381",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "N-acetylneuraminate metabolic process",
                        "id": "GO:0006054",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006054",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "CMP-N-acetylneuraminate monooxygenase activity",
                        "id": "GO:0030338",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030338",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "2 iron, 2 sulfur cluster binding",
                        "id": "GO:0051537",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051537",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LNX8",
                                "url": "https://www.uniprot.org/uniprot/F1LNX8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 233,
            "end_pos": 235,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 32,
            "end_pos": 34,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 445,
            "end_pos": 447,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "16145",
            "name": "",
            "equation": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "F1LNX8-1",
                "Q61419-1"
            ],
            "evidence": [
                {
                    "id": "16145",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/16145"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "F1LNX8",
            "gene_name": "Cmahp",
            "activity": [
                {
                    "ec_number": "1.14.18.2",
                    "activity": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O.",
                    "evidence": [
                        {
                            "id": "F1LNX8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/F1LNX8"
                        }
                    ]
                },
                {
                    "ec_number": "1.14.18.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "F1LNX8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/F1LNX8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q61419",
            "gene_name": "Cmah",
            "activity": [
                {
                    "ec_number": "1.14.18.2",
                    "activity": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O.",
                    "evidence": [
                        {
                            "id": "Q61419",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q61419"
                        }
                    ]
                },
                {
                    "ec_number": "1.14.18.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q61419",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q61419"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
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