{
    "uniprot_canonical_ac": "F1LLW8-1",
    "uniprot_ac": "F1LLW8",
    "uniprot_id": "F1LLW8_RAT",
    "mass": {
        "chemical_mass": 62556.0,
        "monoisotopic_mass": 62556.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Ids",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/F1LLW8",
            "id": "F1LLW8"
        }
    ],
    "protein_names": [
        {
            "name": "Iduronate 2-sulfatase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "F1LLW8"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:12799",
            "recommended_name": {
                "id": "DOID:12799",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:12799",
                "name": "mucopolysaccharidosis II",
                "description": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme iduronate sulfatase."
            },
            "synonyms": [
                {
                    "id": "DOID:12799",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:12799",
                    "name": "Hunter syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:12799",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:12799",
                    "name": "Hunter's syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:12799",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:12799",
                    "name": "MPS II - Hunter syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:12799",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:12799",
                    "name": "Mucopolysaccharidosis, MPS-II",
                    "description": ""
                },
                {
                    "id": "DOID:12799",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:12799",
                    "name": "deficiency of iduronate-2-sulphatase",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis type 2",
                    "description": "A lysosomal storage disease leading to a massive accumulation of glycosaminoglycans and a wide variety of symptoms including distinctive coarse facial features, short stature, cardio-respiratory involvement and skeletal abnormalities. It manifests as a continuum varying from a severe to an attenuated form without neuronal involvement."
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "Hunter syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "Hunter's syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "I2S deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "IDS deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "MPS 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "MPS II",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "MPS II - Hunter syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "MPS with skin involvement",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "MPS2",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "MPSII",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "SIDS deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "attenuated MPS (subtype; formerly known as mild MPS II)",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "deficiency of iduronate-2-sulphatase",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "iduronate 2-sulfatase deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis II",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis II, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis type II",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis with skin involvement",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis, MPS-II",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis, type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "mucopolysaccharidosis, type II",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "severe MPS II",
                    "description": ""
                },
                {
                    "id": "MONDO:0010674",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010674",
                    "name": "sulfoiduronate sulfatase deficiency",
                    "description": ""
                },
                {
                    "id": "MIM:309900",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/309900",
                    "name": "Mucopolysaccharidosis 2",
                    "description": "Mucopolysaccharidosis 2"
                }
            ],
            "evidence": [
                {
                    "id": "12799",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:12799"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F1LLW8",
                    "url": "https://www.uniprot.org/uniprot/F1LLW8"
                }
            ],
            "common_name": "Rat"
        }
    ],
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        {
            "name": "Ids",
            "url": "https://www.uniprot.org/uniprot/F1LLW8",
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                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000001465",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000001465"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000001465",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001465",
            "database": "Bgee",
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            ]
        },
        {
            "id": "cd16030",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16030",
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                "Protein Classification"
            ]
        },
        {
            "id": "IPR000917",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000917",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017850",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850",
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            "categories": [
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            ]
        },
        {
            "id": "IPR024607",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024607",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035874",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035874",
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                "Protein Classification"
            ]
        },
        {
            "id": "PHLDAFA",
            "url": "https://omabrowser.org/oma/group/PHLDAFA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45953",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45953",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45953:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45953:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00884",
            "url": "http://pfam.xfam.org/family/PF00884",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-2024096",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2024096",
            "database": "Reactome",
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                "Protein Classification"
            ]
        },
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            "id": "R-RNO-2024101",
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            "database": "Reactome",
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                "Protein Classification"
            ]
        },
        {
            "id": "1560491",
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            ]
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            ]
        },
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            "database": "UniProtKB",
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            ]
        }
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        "length": 554,
        "header": "tr|F1LLW8-1|F1LLW8_RAT Isoform 1 of Iduronate 2-sulfatase  OS=Rattus norvegicus OX=10116 GN=Ids PE=3 SV=4 CANONICAL=F1LLW8-1"
    },
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        {
            "isoform_ac": "F1LLW8-1",
            "url": "",
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                "sequence": "MSPPPPPPPTTWRQLSFSLLLGFFCIALVSAAQGNSATDALNILLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSIVFENAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDYPYSWSFPPYHPSSEKYENTKTCKGQDGKLHTNLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLAPDPHVPDSLPPVAYNPWMDIREREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGKTALLPAAGEKLFPYQDPFDPASELMGAGRRTEDLVELVSLFPTLAGLAGMPVPPWCPIPSFHVELCREGHNLQRYLQLHDLEEDPYLFGNPRELIAYSQYPRPADFPQWNSDKPSLKDIKVMGYSIRTIDYRYTVWVGFSPTEFLANFSDIHAGELYFVDSDPLQDHNVYNDSQHGGLLLSLRP",
                "length": 554,
                "header": "tr|F1LLW8-1|F1LLW8_RAT Isoform 1 of Iduronate 2-sulfatase  OS=Rattus norvegicus OX=10116 GN=Ids PE=3 SV=4 CANONICAL=F1LLW8-1"
            },
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                "chromosome": "X",
                "start_pos": 149046430,
                "end_pos": 149029175,
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                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000042925.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000042925.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000050409.6",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000050409.6"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "R-RNO-2024096",
            "name": "HS-GAG degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2024096",
            "resource": "Reactome",
            "description": "HS-GAG degradation"
        },
        {
            "id": "R-RNO-2024101",
            "name": "CS/DS degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2024101",
            "resource": "Reactome",
            "description": "CS/DS degradation"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "iduronate-2-sulfatase activity",
                        "id": "GO:0004423",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004423",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium ion binding",
                        "id": "GO:0005509",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sulfuric ester hydrolase activity",
                        "id": "GO:0008484",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008484",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "dermatan sulfate catabolic process",
                        "id": "GO:0030209",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030209",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glycosaminoglycan catabolic process",
                        "id": "GO:0006027",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006027",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "heparan sulfate proteoglycan catabolic process",
                        "id": "GO:0030200",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030200",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lysosome",
                        "id": "GO:0005764",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lysosomal lumen",
                        "id": "GO:0043202",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043202",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "F1LLW8",
                                "url": "https://www.uniprot.org/uniprot/F1LLW8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 119,
            "end_pos": 121,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 148,
            "end_pos": 150,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 250,
            "end_pos": 252,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 284,
            "end_pos": 286,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 517,
            "end_pos": 519,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 541,
            "end_pos": 543,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
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                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
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