{
    "uniprot_canonical_ac": "E9PU29-1",
    "uniprot_ac": "E9PU29",
    "uniprot_id": "E9PU29_RAT",
    "mass": {
        "chemical_mass": 119245.0,
        "monoisotopic_mass": 119245.0
    },
    "refseq": {
        "ac": "NP_001102338",
        "name": "E3 ubiquitin-protein ligase RNF31",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102338"
    },
    "gene_names": [
        {
            "name": "Rnf31",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/E9PU29",
            "id": "E9PU29"
        },
        {
            "name": "Rnf31",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102338",
            "id": "NP_001102338"
        }
    ],
    "protein_names": [
        {
            "name": "RBR-type E3 ubiquitin transferase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "E9PU29"
        },
        {
            "name": "2.3.2.31",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "E9PU29"
        },
        {
            "name": "E3 ubiquitin-protein ligase RNF31",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102338",
            "id": "NP_001102338"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E9PU29",
                    "url": "https://www.uniprot.org/uniprot/E9PU29"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Rnf31",
            "url": "https://www.uniprot.org/uniprot/E9PU29",
            "locus": {
                "chromosome": "15",
                "start_pos": 29101915,
                "end_pos": 29083631,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000019438",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000019438"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000019438",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019438",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd14325",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14325",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd16631",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16631",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd19815",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19815",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd20337",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20337",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd20351",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20351",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "364386",
            "url": "https://www.ncbi.nlm.nih.gov/gene/364386",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001876",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001876",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002867",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002867",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015940",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017907",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018997",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018997",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR026254",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026254",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR032065",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032065",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036339",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036339",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036443",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036443",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR040641",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR040641",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041031",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041031",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR044066",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR044066",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047539",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047539",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047540",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047540",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047541",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047541",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047542",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047542",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047543",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047543",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:364386",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:364386",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "YNTFYAK",
            "url": "https://omabrowser.org/oma/group/YNTFYAK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2909614at2759",
            "url": "http://www.orthodb.org/?query=2909614at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR16004",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16004",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR16004:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16004:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01485",
            "url": "http://pfam.xfam.org/family/PF01485",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF09409",
            "url": "http://pfam.xfam.org/family/PF09409",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF16678",
            "url": "http://pfam.xfam.org/family/PF16678",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF18091",
            "url": "http://pfam.xfam.org/family/PF18091",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF18486",
            "url": "http://pfam.xfam.org/family/PF18486",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5357786",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357786",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5357905",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357905",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5357956",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357956",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001102338",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102338",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1305513",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305513",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6A2Y9",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A2Y9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A2Y9-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A2Y9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AV12",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AV12",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AV12-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AV12-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9PU29",
            "url": "https://www.uniprot.org/uniprot/E9PU29",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9PU29-1",
            "url": "https://www.uniprot.org/uniprot/E9PU29-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPGDEERAFLAAREELASALRWDSAQVFPLEQLTPLLATSLPLSSRYRQLDAGRLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRSVKFNNPVFRSTVDAVQGGRDVLRLYGYTEERPDGLSFPGGQEEPDEYQVAIVTLEVLLLRTELNLLLQNTHPRQNALDQLLRDSVEDDMLQLSEFHPLLREIVPGPLPSAPGHTPGPCFLCGSAPGTLHCPACNQASCPACDLLFHGHPSRAHHLRHTLPGAHQTTNLSSSLPASSQPRPHSSSLAMGDSSLSSPDPANACLPWHCPTCATLNEPWAVFCAACSQPKGCKVRGRESSQGTGVLEPEPARDQWACQSCTFENEAAAVLCAICERPRLAQPPSLVVDSHDAGVYQQPLKQEDTLLSAAQSQVWHCDHCTFCNSGPVWVCAMCNRTRSPIPAQPYPSSLEKGLSQPGSSQHLSSSLPASCGDPEKQRQDKMRKESLQLVNMIQEGEAAGASPEEIFSALQYSGTEVPLQWLRSELSYVLEMVAELAGQRDPELGAFSCQEARKAWLDRHGNLDEAVEECVRARRRKVQELQSLGFEPKEGSLQALFQHGGDVARALTELQRQRLEPFHQRLWGRDPEPTPCWDGLDRQSLVRRLLAVYTLPSWGRAELALALLQETPRNYELLDVVEAVRHSQDRAFLRRLLAQECAVCGWALPRNRMQALISCECTICPECFRQHFTIALKEKHITDMVCPACGRPDLTDDAQLLSYFSTLDIQLRESLEPDAYALFHKKLTEAVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPDPNCKVKKSLHGHHPRDCLFYLRDWPAARLQKLLQDNNVMFNTEPPAGTRAVPGGGCRVMEQKEVPSGFRDEACGKETPPGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATARYLHLTPQPMDGEDLPAYQARLLQKLREEVPLGQSIARRRK",
        "length": 1062,
        "header": "tr|E9PU29-1|E9PU29_RAT Isoform 1 of RBR-type E3 ubiquitin transferase  OS=Rattus norvegicus OX=10116 GN=Rnf31 PE=3 SV=2 CANONICAL=E9PU29-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6A2Y9-1",
            "url": "",
            "sequence": {
                "sequence": "MPGDEERAFLAAREELASALRWDSAQVFPLEQLTPLLATSLPLSSRYRQLDAGRLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRSVKFNNPVFRSTVDAVQGGRDVLRLYGYTEERPDGLSFPGGQEEPDEYQVAIVTLEVLLLRTELNLLLQNTHPRQNALDQLLRDSVEDDMLQLSEFHPLLREIVPGPLPSAPGHTPGPCFLCGSAPGTLHCPACNQASCPACDLLFHGHPSRAHHLRHTLPGAHQTTNLSSSLPASSQPRPHSSSLAMGDSSLSSPDPANACLPWHCPTCATLNEPWAVFCAACSQPKGCKVRGRESSQGTGVLEPEPARDQWACQSCTFENEAAAVLCAICERPRLAQPPSLVVDSHDAGVYQQPLKQEDTLLSAAQSQVWHCDHCTFCNSGPVWVCAMCNRTRSPIPAQPYPSSLEKGLSQPGSSQHLSSSLPASCGDPEKQRQDKMRKESLQLVNMIQEGEAAGASPEEIFSALQYSGTEVPLQWLRSELSYVLEMVAELAGQRDPELGAFSCQEARKAWLDRHGNLDEAVEECVRARRRKVQELQSLGFEPKEGSLQALFQHGGDVARALTELQRQRLEPFHQRLWGRDPEPTPCWDGLDRQSLVRRLLAVYTLPSWGRAELALALLQETPRNYELLDVVEAVRHSQDRAFLRRLLAQECAVCGWALPRNRMQALISCECTICPECFRQHFTIALKEKHITDMVCPACGRPDLTDDAQLLSYFSTLDIQLRESLEPDAYALFHKKLTEAVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPDPNCKVKKSLHGHHPRDCLFYLRDWPAARLQKLLQDNNVMFNTEPPAGTRAVPGGGCRVMEQKEVPSGFRDEACGKETPPGYAGLCQ",
                "length": 989,
                "header": "tr|A0A8I6A2Y9-1|E9PU29_RAT Computationally mapped isoform of RBR-type E3 ubiquitin transferase  OS=Rattus norvegicus OX=10116 GN=Rnf31 PE=3 SV=1 CANONICAL=E9PU29-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 29094388,
                "end_pos": 29083784,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000104607.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000104607.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000086116.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000086116.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6AV12-1",
            "url": "",
            "sequence": {
                "sequence": "MRQQPCSVPSVSDLGWPSLPAWWWIPMTLVFTNSPLSRRILCSPLPSLRCGTVTIVPSAIQALSGCVPCVTGLAAPSLHSPIPAPWRRDSHSQGPHNTSAPPCLLPVEIQRNSAKIRCGRKVSS",
                "length": 124,
                "header": "tr|A0A8I6AV12-1|A0A8I6AV12_RAT Computationally mapped isoform of Ring finger protein 31  OS=Rattus norvegicus OX=10116 GN=Rnf31 PE=4 SV=1 CANONICAL=E9PU29-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 29087706,
                "end_pos": 29087168,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000112002.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000112002.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000097858.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000097858.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9PU29-1",
            "url": "",
            "sequence": {
                "sequence": "MPGDEERAFLAAREELASALRWDSAQVFPLEQLTPLLATSLPLSSRYRQLDAGRLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRSVKFNNPVFRSTVDAVQGGRDVLRLYGYTEERPDGLSFPGGQEEPDEYQVAIVTLEVLLLRTELNLLLQNTHPRQNALDQLLRDSVEDDMLQLSEFHPLLREIVPGPLPSAPGHTPGPCFLCGSAPGTLHCPACNQASCPACDLLFHGHPSRAHHLRHTLPGAHQTTNLSSSLPASSQPRPHSSSLAMGDSSLSSPDPANACLPWHCPTCATLNEPWAVFCAACSQPKGCKVRGRESSQGTGVLEPEPARDQWACQSCTFENEAAAVLCAICERPRLAQPPSLVVDSHDAGVYQQPLKQEDTLLSAAQSQVWHCDHCTFCNSGPVWVCAMCNRTRSPIPAQPYPSSLEKGLSQPGSSQHLSSSLPASCGDPEKQRQDKMRKESLQLVNMIQEGEAAGASPEEIFSALQYSGTEVPLQWLRSELSYVLEMVAELAGQRDPELGAFSCQEARKAWLDRHGNLDEAVEECVRARRRKVQELQSLGFEPKEGSLQALFQHGGDVARALTELQRQRLEPFHQRLWGRDPEPTPCWDGLDRQSLVRRLLAVYTLPSWGRAELALALLQETPRNYELLDVVEAVRHSQDRAFLRRLLAQECAVCGWALPRNRMQALISCECTICPECFRQHFTIALKEKHITDMVCPACGRPDLTDDAQLLSYFSTLDIQLRESLEPDAYALFHKKLTEAVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPDPNCKVKKSLHGHHPRDCLFYLRDWPAARLQKLLQDNNVMFNTEPPAGTRAVPGGGCRVMEQKEVPSGFRDEACGKETPPGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATARYLHLTPQPMDGEDLPAYQARLLQKLREEVPLGQSIARRRK",
                "length": 1062,
                "header": "tr|E9PU29-1|E9PU29_RAT Isoform 1 of RBR-type E3 ubiquitin transferase  OS=Rattus norvegicus OX=10116 GN=Rnf31 PE=3 SV=2 CANONICAL=E9PU29-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 29095238,
                "end_pos": 29083784,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000026333.8",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000026333.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000026333.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000026333.5"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "rno:364386",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:364386",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-5357786",
            "name": "TNFR1-induced proapoptotic signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357786",
            "resource": "Reactome",
            "description": "TNFR1-induced proapoptotic signaling"
        },
        {
            "id": "R-RNO-5357905",
            "name": "Regulation of TNFR1 signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357905",
            "resource": "Reactome",
            "description": "Regulation of TNFR1 signaling"
        },
        {
            "id": "R-RNO-5357956",
            "name": "TNFR1-induced NF-kappa-B signaling pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357956",
            "resource": "Reactome",
            "description": "TNFR1-induced NF-kappa-B signaling pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q924T7-1",
            "protein_name": "E3 ubiquitin-protein ligase RNF31",
            "gene_name": "Rnf31",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MPGDEERGFLAAREELASALRWDSAQVFPLEQLMPLLATSLPPAARYLQLDAGRLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRSVKFNNPVFRSTVDAVQGGRDVLRLYGYTEERPDGLSFPEGQEEPDEYQVAVVTLEVLLLRTELSLLLQNTHPRQNALDQLLRESVEDGMLQLSEFHPLLREIVPGPRPSAQGSTPGPCFLCGSAPGTLHCPACNQVSCPACDILFHGHPSRAHHLRQALPGSHQTASLSSSLPASSQPRPPSSSLALGDSSLSSPDPANACLPWHCLTCATLNEPWAVFCAVCSQPKGCKVPGIEGSHGTGGLEPEPARDQWACQSCTFENEAAAVLCAICERPRLAQPPSLVVDSHDAGVCQQSLKQEDPLLTAAQPQVWYCDHCTFCNSGPVWVCAMCNRTRDPIPTQPALQSYPSSLEKGRPKPGSSQHLGSSLPASCGDPEKQRQDKMRKEGLQLVSMIQEGETAGASPEEVFSALQYSGTEVPLQWLRSELSYVLEMVAELAGQQDPELGAFSCQEARKAWLDRHGNLDEAVEECVRARRRKVHELQSLGFGPKEGSLQALFQHGGDVARALTELQRQRLEPFHQRLWDRDPEPTPCWDGLDRQSLVRRLLAVYTLPSWGRAELALALLQETPRNYELLDVVEAVRHSQDRAFLRRLLAQECAVCGWALPRNRMQALISCECTICPECFRQHFTIALKEKHITDMVCPACGRPDLTDDAQLLSYFSTLDIQLRESLDPDAYALFHKKLTEAVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPDPNCKVKKSLHGHHPRDCLFYLRDWTAARLQKLLQDNNVMFNTEPPAGTRAVPGGGCRVMEQKEVHSGFRDEACGKETPPGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATIRYLHLAPQPADGEDLPAYQARLLQKLREEVPLGQSIARRRK",
                "length": 1066
            },
            "evidence": [
                {
                    "id": "45243513",
                    "url": "http://www.informatics.jax.org/homology/45243513",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "protein linear polyubiquitination",
                        "id": "GO:0097039",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097039",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "CD40 signaling pathway",
                        "id": "GO:0023035",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023035",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of NF-kappaB transcription factor activity",
                        "id": "GO:0051092",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051092",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "T cell receptor signaling pathway",
                        "id": "GO:0050852",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of I-kappaB kinase/NF-kappaB signaling",
                        "id": "GO:0043123",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "defense response to bacterium",
                        "id": "GO:0042742",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein polyubiquitination",
                        "id": "GO:0000209",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of necroptotic process",
                        "id": "GO:0060546",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060546",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of xenophagy",
                        "id": "GO:1904417",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904417",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 9,
                "go_terms": [
                    {
                        "name": "K48-linked polyubiquitin modification-dependent protein binding",
                        "id": "GO:0036435",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036435",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase binding",
                        "id": "GO:0031625",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase activity",
                        "id": "GO:0061630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-protein transferase activity",
                        "id": "GO:0004842",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin binding",
                        "id": "GO:0043130",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "K63-linked polyubiquitin modification-dependent protein binding",
                        "id": "GO:0070530",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070530",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "linear polyubiquitin binding",
                        "id": "GO:1990450",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990450",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic side of plasma membrane",
                        "id": "GO:0009898",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "CD40 receptor complex",
                        "id": "GO:0035631",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035631",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "LUBAC complex",
                        "id": "GO:0071797",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071797",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "E9PU29",
                                "url": "https://www.uniprot.org/uniprot/E9PU29"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 263,
            "end_pos": 265,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 427,
            "end_pos": 429,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "R-RNO-5357776",
            "name": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9QY78-1",
                "Q62921-1",
                "B2GUZ1-1",
                "Q5U349-1",
                "B2GUX4-1",
                "Q66H62-1",
                "A0A8I6ANR6-1",
                "D3ZNC0-1",
                "Q9R0I6-1",
                "E9PU29-1",
                "A0A8I6AL23-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5357776",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357776"
                }
            ]
        },
        {
            "id": "R-RNO-5357860",
            "name": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "B2GUZ1-1",
                "Q5U349-1",
                "B2GUX4-1",
                "Q66H62-1",
                "D3ZNC0-1",
                "Q9R0I6-1",
                "P0C8E4-1",
                "E9PU29-1",
                "A0A8I6AL23-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5357860",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357860"
                }
            ]
        },
        {
            "id": "R-RNO-5357904",
            "name": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5357904",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357904"
                }
            ]
        },
        {
            "id": "R-RNO-5661517",
            "name": "LUBAC binds OTULIN",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "B0BMY6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5661517",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5661517"
                }
            ]
        },
        {
            "id": "R-RNO-83582",
            "name": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-:TNF-R1 complex.",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "Q9R0I6-1",
                "Q68LP1-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-83582",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-83582"
                }
            ]
        },
        {
            "id": "R-RNO-9793680",
            "name": "OPTN binds polyUb-RIPK1 within the TNFR1 complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9793680",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9793680"
                }
            ]
        },
        {
            "id": "R-RNO-9796379",
            "name": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9796379",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9796379"
                }
            ]
        },
        {
            "id": "R-RNO-9796691",
            "name": "SPATA2 links CYLD to LUBAC",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9796691",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9796691"
                }
            ]
        },
        {
            "id": "R-RNO-9817397",
            "name": "TBK1, IKBKE phosphorylate RIPK1 at T189",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9817397",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9817397"
                }
            ]
        },
        {
            "id": "R-RNO-9817400",
            "name": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9817400",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9817400"
                }
            ]
        },
        {
            "id": "R-RNO-9817411",
            "name": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9817411",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9817411"
                }
            ]
        },
        {
            "id": "R-RNO-9818789",
            "name": "CHUK, IKBKB phosphorylate RIPK1 at S25",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9QY78-1",
                "Q62921-1",
                "Q66H62-1",
                "A0A8I6ANR6-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9818789",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9818789"
                }
            ]
        },
        {
            "id": "R-RNO-9818975",
            "name": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9818975",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9818975"
                }
            ]
        },
        {
            "id": "R-RNO-9824874",
            "name": "OPTN recruits CYLD to the TNFR1 complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q62921-1",
                "Q66H62-1",
                "Q9R0I6-1",
                "E9PU29-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-9824874",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9824874"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A0A8I6AL23",
            "gene_name": "Tnfaip3",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "A0A8I6AL23",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I6AL23"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A8I6AL23",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I6AL23"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A0A8I6ANR6",
            "gene_name": "Chuk",
            "activity": [
                {
                    "ec_number": "2.7.11.10",
                    "activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].",
                    "evidence": [
                        {
                            "id": "A0A8I6ANR6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I6ANR6"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.10",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A8I6ANR6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I6ANR6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "B0BMY6",
            "gene_name": "Otulin",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "B0BMY6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B0BMY6"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "B0BMY6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B0BMY6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "B2GUX4",
            "gene_name": "Usp21",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "B2GUX4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B2GUX4"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "B2GUX4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B2GUX4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "B2GUZ1",
            "gene_name": "Usp4",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "B2GUZ1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B2GUZ1"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "B2GUZ1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B2GUZ1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "D3ZNC0",
            "gene_name": "Otud1",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "D3ZNC0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D3ZNC0"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "D3ZNC0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D3ZNC0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "E9PU29",
            "gene_name": "Rnf31",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "E9PU29",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9PU29"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9PU29",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9PU29"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P0C8E4",
            "gene_name": "Map3k7",
            "activity": [
                {
                    "ec_number": "2.7.11.25",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "P0C8E4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P0C8E4"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.25",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P0C8E4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P0C8E4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5U349",
            "gene_name": "Usp2",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "Q5U349",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5U349"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5U349",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5U349"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q62921",
            "gene_name": "Rbck1",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q62921",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62921"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q62921",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62921"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q66H62",
            "gene_name": "Cyld",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "Q66H62",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q66H62"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q66H62",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q66H62"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q68LP1",
            "gene_name": "Mib2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q68LP1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q68LP1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q68LP1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q68LP1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QY78",
            "gene_name": "Ikbkb",
            "activity": [
                {
                    "ec_number": "2.7.11.10",
                    "activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].",
                    "evidence": [
                        {
                            "id": "Q9QY78",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QY78"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "Q9QY78",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QY78"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.10",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QY78",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QY78"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9R0I6",
            "gene_name": "Xiap",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9R0I6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9R0I6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9R0I6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9R0I6"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
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                    "count": 0
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                {
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                {
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            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
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                {
                    "field": "total_sites",
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            "sort_fields": []
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        {
            "table_id": "glycosylation_predicted",
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                {
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            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
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                {
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                    "count": 0
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                {
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                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
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            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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