{ "uniprot_canonical_ac": "E9PU24-1", "uniprot_ac": "E9PU24", "uniprot_id": "E9PU24_RAT", "mass": { "chemical_mass": 515785.0, "monoisotopic_mass": 515785.0 }, "refseq": {}, "gene_names": [ { "name": "Dnah11", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/E9PU24", "id": "E9PU24" } ], "protein_names": [ { "name": "Dynein, axonemal, heavy chain 11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "E9PU24" } ], "function": [], "disease": [ { "disease_id": "DOID:0050144", "recommended_name": { "id": "DOID:0050144", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050144", "name": "Kartagener syndrome", "description": "A primary ciliary dyskinesia that is characterized by sinusitis, bronchiectasis and situs inversus with dextrocardia resulting from dysfunction of the cilia during embryologic development." }, "synonyms": [ { "id": "DOID:0050144", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050144", "name": "Kartagener's syndrome", "description": "" } ], "evidence": [ { "id": "0050144", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050144" } ] }, { "disease_id": "DOID:0050545", "recommended_name": { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "visceral heterotaxy", "description": "A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen." }, "synonyms": [ { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "heterotaxia", "description": "" }, { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "situs ambiguus", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "heterotaxy, visceral, 2, autosomal", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "DTGA2", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "heterotaxy, visceral, 2, autosomal", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "transposition of the great arteries, dextro-looped 2", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "HTX2", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "Htx", "description": "" }, { "id": "MONDO:0011659", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011659", "name": "heterotaxy, visceral, 3, autosomal", "description": "" }, { "id": "MONDO:0011659", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011659", "name": "HTX3", "description": "" }, { "id": "MONDO:0011659", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011659", "name": "heterotaxy, visceral, 3, autosomal", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked", "description": "X-linked visceral heterotaxy type 1 is a very rare form of heterotaxy that has only been reported in a few families. Heterotaxy is the right/left transposition of thoracic and/or abdominal organs. This condition is caused by mutations in the ZIC3 gene, is inherited in an X-linked recessive fashion, and is usually seen in males. Physical features include heart abnormalities such as dextrocardia, transposition of great vessels, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis ; situs inversus, and missing (asplenia) and/or extra spleens (polysplenia).Affected individualscan also experience abnormalities in the development of the midline of the body, which can cause holoprosencephaly, myelomeningocele, urological anomalies, widely spaced eyes (hypertelorism), cleft palate, and abnormalities of the sacral spine and anus. Heterotaxia with recurrent respiratory infections are called primary ciliary dyskinesia." }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "ZIC3 visceral heterotaxy", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "congenital heart defects, nonsyndromic, 1, X-linked, X-linked recessive", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked, X-linked recessive", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "visceral heterotaxy caused by mutation in ZIC3", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "HTX1", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "X-linked visceral heterotaxy 1", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "congenital heart defects, multiple types, 1, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "dextrocardia with Other Cardiac malformations", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "laterality, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "situs inversus, Complex Cardiac defects, and splenic defects, X-linked", "description": "" }, { "id": "MONDO:0013887", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013887", "name": "heterotaxy, visceral, 6, autosomal", "description": "" }, { "id": "MONDO:0013887", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013887", "name": "heterotaxy, visceral, 6, autosomal", "description": "" }, { "id": "MONDO:0013887", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013887", "name": "heterotaxy, visceral, 6, autosomal recessive", "description": "" }, { "id": "MONDO:0013887", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013887", "name": "HTX6", "description": "" }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "heterotaxy, visceral, 4, autosomal", "description": "Any visceral heterotaxy in which the cause of the disease is a mutation in the ACVR2B gene." }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "ACVR2B visceral heterotaxy", "description": "" }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "heterotaxy, visceral, 4, autosomal", "description": "" }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "visceral heterotaxy caused by mutation in ACVR2B", "description": "" }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "HTX4", "description": "" }, { "id": "MIM:605376", "resource": "MIM", "url": "https://www.omim.org/entry/605376", "name": "Heterotaxy, visceral, 2, autosomal", "description": "Heterotaxy, visceral, 2, autosomal" }, { "id": "MIM:306955", "resource": "MIM", "url": "https://www.omim.org/entry/306955", "name": "Heterotaxy, visceral, 1, X-linked", "description": "Heterotaxy, visceral, 1, X-linked" }, { "id": "MIM:614779", "resource": "MIM", "url": "https://www.omim.org/entry/614779", "name": "Heterotaxy, visceral, 6, autosomal", "description": "Heterotaxy, visceral, 6, autosomal" }, { "id": "MIM:613751", "resource": "MIM", "url": "https://www.omim.org/entry/613751", "name": "Heterotaxy, visceral, 4, autosomal", "description": "Heterotaxy, visceral, 4, autosomal" } ], "evidence": [ { "id": "0050545", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050545" } ] }, { "disease_id": "DOID:0050651", "recommended_name": { "id": "DOID:0050651", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050651", "name": "atrioventricular septal defect", "description": "A congenital heart septal defect characterized by an abnormal or inadequate fusion of the superior and inferior endocardial cushions with the mid portion of the atrial septum and the muscular portion of the ventricular septum, thus allowing extra blood to circulate the lungs." }, "synonyms": [ { "id": "DOID:0050651", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050651", "name": "AVCD", "description": "" }, { "id": "DOID:0050651", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050651", "name": "AVSD", "description": "" }, { "id": "DOID:0050651", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050651", "name": "ECD", "description": "" }, { "id": "DOID:0050651", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050651", "name": "atrioventricular canal defect", "description": "" }, { "id": "DOID:0050651", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050651", "name": "endocardial cushion defect", "description": "" }, { "id": "MONDO:0859565", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0859565", "name": "atrioventricular septal defect", "description": "" }, { "id": "MONDO:0013769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013769", "name": "atrioventricular septal defect 5", "description": "Any atrioventricular septal defect in which the cause of the disease is a mutation in the GATA6 gene." }, { "id": "MONDO:0013769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013769", "name": "GATA6 atrioventricular septal defect", "description": "" }, { "id": "MONDO:0013769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013769", "name": "atrioventricular septal defect 5", "description": "" }, { "id": "MONDO:0013769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013769", "name": "atrioventricular septal defect caused by mutation in GATA6", "description": "" }, { "id": "MONDO:0013769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013769", "name": "atrioventricular septal defect type 5", "description": "" }, { "id": "MONDO:0013769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013769", "name": "AVSD5", "description": "" }, { "id": "MONDO:0013747", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013747", "name": "atrioventricular septal defect 4", "description": "Any atrioventricular septal defect in which the cause of the disease is a mutation in the GATA4 gene." }, { "id": "MONDO:0013747", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013747", "name": "GATA4 atrioventricular septal defect", "description": "" }, { "id": "MONDO:0013747", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013747", "name": "atrioventricular septal defect 4", "description": "" }, { "id": "MONDO:0013747", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013747", "name": "atrioventricular septal defect caused by mutation in GATA4", "description": "" }, { "id": "MONDO:0013747", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013747", "name": "atrioventricular septal defect type 4", "description": "" }, { "id": "MONDO:0013747", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013747", "name": "AVSD4", "description": "" }, { "id": "MIM:614474", "resource": "MIM", "url": "https://www.omim.org/entry/614474", "name": "Atrioventricular septal defect 5", "description": "Atrioventricular septal defect 5" }, { "id": "MIM:614430", "resource": "MIM", "url": "https://www.omim.org/entry/614430", "name": "Atrioventricular septal defect 4", "description": "Atrioventricular septal defect 4" } ], "evidence": [ { "id": "0050651", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050651" } ] }, { "disease_id": "DOID:0110605", "recommended_name": { "id": "DOID:0110605", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110605", "name": "primary ciliary dyskinesia 7", "description": "A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with chronic respiratory infections, chronic sinusitis, recurrent bronchitis, and pneumonia beginning in infancy or early childhood and has_material_basis_in mutation in the DNAH11 gene on chromosome 7p21." }, "synonyms": [ { "id": "DOID:0110605", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110605", "name": "CILD7", "description": "" }, { "id": "DOID:0110605", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110605", "name": "primary ciliary dyskinesia 7 with or without situs inversus", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "primary ciliary dyskinesia 7", "description": "Any primary ciliary dyskinesia in which the cause of the disease is a mutation in the DNAH11 gene." }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "CILD7", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "DNAH11 primary ciliary dyskinesia", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "ciliary dyskinesia, primary, type 7", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "primary ciliary dyskinesia 7", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "primary ciliary dyskinesia 7 with or without situs inversus", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "primary ciliary dyskinesia caused by mutation in DNAH11", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "primary ciliary dyskinesia type 7", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "ciliary dyskinesia, primary, 7", "description": "" }, { "id": "MONDO:0012748", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012748", "name": "ciliary dyskinesia, primary, 7, with or without situs inversus", "description": "" }, { "id": "MIM:611884", "resource": "MIM", "url": "https://www.omim.org/entry/611884", "name": "Ciliary dyskinesia, primary, 7", "description": "Ciliary dyskinesia, primary, 7" } ], "evidence": [ { "id": "0110605", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110605" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "common_name": "Rat" } ], "gene": [ { "name": "Dnah11", "url": "https://www.uniprot.org/uniprot/E9PU24", "locus": { "chromosome": "6", "start_pos": 138839177, "end_pos": 139155536, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000005451", "url": "https://www.ensembl.org/id/ENSRNOG00000005451" } ] } } ], "crossref": [ { "id": "ENSRNOG00000005451", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005451", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "E9PU24", "url": "https://www.ebi.ac.uk/intact/interactors/id:E9PU24*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013602", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013602", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035706", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035706", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CAYLALW", "url": "https://omabrowser.org/oma/group/CAYLALW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45703", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45703", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45703:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45703:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03028", "url": "http://pfam.xfam.org/family/PF03028", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08385", "url": "http://pfam.xfam.org/family/PF08385", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08393", "url": "http://pfam.xfam.org/family/PF08393", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12774", "url": "http://pfam.xfam.org/family/PF12774", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12775", "url": "http://pfam.xfam.org/family/PF12775", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12777", "url": "http://pfam.xfam.org/family/PF12777", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12780", "url": "http://pfam.xfam.org/family/PF12780", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12781", "url": "http://pfam.xfam.org/family/PF12781", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17852", "url": "http://pfam.xfam.org/family/PF17852", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17857", "url": "http://pfam.xfam.org/family/PF17857", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18198", "url": "http://pfam.xfam.org/family/PF18198", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18199", "url": "http://pfam.xfam.org/family/PF18199", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_001061747", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001061747", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "621088", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621088", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I6GH84", "url": "https://www.uniprot.org/uniprot/A0A8I6GH84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GH84-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GH84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PU24-1", "url": "https://www.uniprot.org/uniprot/E9PU24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAQEEGTVLRLSPSEQEDEEDEEAEAARRAQRFAVDPRVRFLGGRLQQALGFPEETWGEYLESEDHRQVLGDFLESSGPASLVFSVAPGLLSASPEIPRDVKHKLVYFAKKMTGSTGESDFSQTVLFGEIPRSLFTHVTAFLDEILVPILSNKNNHESWSCFISQDVEHHTEIMKNKMHIFRGKMSRRTHLPIPTIAENIDLDQHYSVTRPQSDERRILHAIESVVIKWSHQIQEIIEKDSAQPLLSGLHPTPETELDFWTMRHDNLKCIYHQLQAPIVLKMVKILRTRQSSYLPALKGIFTTVENALLEARDVELHLRPLRKHIQGLQEADFPQTGILIAPLIHTICLIWSHSKFYNSPARVIVLLQEFCNLFIDQARAYLSPEDLLKGEIEDALEKVQVAIGVLRMFQNSFFKYRRGLTSYFTGDTEQRPWDFQSHLVFSRFNKFLDRLVKIEDMFVTILEFEKLERLEFGGSKGAVLNAQIHSMKEEFIECCNVFRQSIYDPSDCDSMEFESDYFQFKSKTLDFDRRLGTLLCEGLSNCSGLESAFKLLTIFGNFLEKPVVMEIFSPHYSTLLNMFNAELDMCKRLYDEHMKQIEHGHEILNKNMPFTSGNIKWARMLLERLQMFWSNFTSLHYLFPDSPDEAAVCQKYAEMTTLLDQFESRIYSEWRRNVDKTCEFNLNQPLVKFSPINGLLSVNFDPKLVAVLREVKYLLMLKKSNIPDSALGIFQKKNIILKHIGNLELLVQGYNKLKQTLLEVEYPLIEKELGAIDEQLRVAATWLTWQDDFWVYMEKVQVATAELERRVSQTQSNVQTIQQTMQAWAEWPLLPRRETRREAALTLDDKGDLFAKKYKLIREDGYKIHNLVEENRKLFRADPSLDSWKIYVEFIDDIVVEGFFQTILHDLDFFLRNTEKQLKPAPFFQAQMLLMPPEIVFKPPLEREAGDGFYNLVEAMLCGSFKVSAQMGRVAAHLDIPDYQNDMDNMLGLAEVRQEIMNRVADVIDKVLEFRSSLETYSYLWVDDRVEILRQFLLYGHAVPSEEIDAPAGEDILQSPTLEQFKEQIDIYEALYVQMSKFDDFRVFNSWFKIDMRPFKLSMLNVIKKWSWMFQEHLLRFVVDSLSELQGFIKQTNAGLQRQPHEGDHDGLVDIMGHLLAVRSRQRATDELFEPLKETIMLLESYGQKMPEQVYAQLEELPERWETTKKIAAVVRHEVSPLQNAEVTLLRKKCILFDEKQAEFRERFRSYAPLGFKAENPYSVLDKANQELEALEEEVVQMQNCARLFEVVLPEYKQMKQCRREVRLLKELWDIIVYVRRSIDNWTETRWRQVNMEQMDLELRRFAKEIWSLDKAVRVWDAYSGLEGTVKDMTTSLRAVAELQNPALRDRHWQQLTNAIGVRFSINDSTTLADLLAVQLHQVEEDVRDIVDKAVKELGTEKVITDVSHTWEALEFSYEVHHRTGTPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIDQVLSWQNKLNVADAVIFTWMQVQRTWSHLESIFVCSEDIRIQLVEDAQRFDEVDAEFKELMFKTAKIKNVLEATCRPHLYEKLKDFQHRLSLCEKALAEYLETKRVTFSRFYFISSADLLDLLSKGAQPKQVTRHLVKLFDSISDLQFEDNPEVSTCKAVGMFSKEKEYVSFQAGCECIGHVESWLLQLEQTMKETVRLAIAEAIAAYEEKPRELWIFDFPAQVALTGSQIWWTTDVGIAFSRLEEGYETALKDFHKKQISQLNTLITLLLGELSPGDRQKVMTICTIDVHARDVVAKLISQKVVSPRAFTWLSQLRHEWEESRKHCIVNICDAHFQYCYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYRSIGNIYKGLVQTGAWGCFDEFNRIAVEVLSVVAVQVKMIHDAIRSRRRRFVFLGETIPLKPSVGIFITLNPGYAGRTELPENLKALFRPCAMVAPDTELICEIMLVAEGFVDARSLARKFISLYTLCDELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMRALRDFNMPKIVTDDVPVFLGLVSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVRHSIFVVGNAGTGKSKILRTLNRTYVNMKQKPVWNDLNPKAVTTDELFGFIHHATREWKDGLLSSILREQANLTHDGPTWIVLDGDIDPLWIESLNTVMDDNKVLTLASNERVALTPSMRLLFETHHLQTATPATVSRAGILYVNPQDLGWNPYVASWIDRRRHQSEKANLTILFDKYIPVCLEKLRTSFKAITSVPESSLVQTICTLLECLLTPENIPSDSPKETYEVYFVFACVWTFGGTLLRDQLSDYQADFSRWWHKEMKAVKFPSQGTIFDYYLDHKTKKFLPWTDKVPQFTMDADAPLKTVLVHTPETTRLRYFTELLLNKGKPLMLVGNAGVGKTVFLSDTLASISEDYIVSRVPFNYYTTSADLQRILEKPLEKKAGRNYGPRGNKKLVYFIDDLNMPEVDLYGTVQPHALLRQHIDYGHWYDRHKVMLKEIRNCQYVACMNPMAGSFTVDPRLKRHFTVLAFNFPSLDTLTTIYGQIFSFYLQQQAFCPSVLRTGPSLIQATIAFHQTMAENFVPTAIKFHYNFNLRDLSNIFQGILFASPECLKCPEDLARLWLHETSRVYGDRLVDANDSDLFQRKMLEAAHKYFKGADANTLQQQPLVYCHFASGREDPCYEPVKDWEGLKAVLTEMMGNYNELHSEMHLVLFEDAMQHVCRISRILRTPQGHALLVGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGTQDLRVDLANLYVRTGAKNMPTVFLLTDAHVLDESFLVLINDLLASGDIPGLFSDEDTDKIISGIRNEVRGLGITDSRENCWAFFLARVRLQLKMVFCFSPVGHTLRVRARKFPALVNCTAIDWFHAWPQEALVSVSRRFIEEIEGIEPQHKDSISLFMAYVHTSVKEVSAWYYQNERRYNYTTPRSFLEQISLFKSLLKKKRGEVQRKKEHLGNGIQKLQTTASQVGNLKARLASQEAELQLRNQDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQRECEADLLKAEPALVAATAALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAARIFMGKVDDFLQALINYDKEHIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQTNLDLAAATEKLEAVRRKLVDLDHNLRRLTASFEKATAEKVRCQEEVNQTNKTIDLANRLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAAFVSYIGSFTRQYRQELVDCKWIPFLQQKVSIPIAEGLDMIATLTDDATIATWNNQGLPSDRMSTENATILTHCKRWPLMIDPQQQGIKWIKNKYGPDLKVTHLGQKGFLNAIEMALAFGDVILIENLKETVDPVLGPLLGRNTIKKGKYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVSVERPDLERLKLVLTKHQNDFKIELRHLEEDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVIEARENERKINETRECYRPVAARASLMYFVISDLRKINPVYQFSLKAFKTLFHRAIEQADKVEDTQERICALMESVTYATFLHASQALFEKDKLTFLSQMAFQILLRRNEIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVKAVALMEEFRGLDRDVEGSAKQWRKWVESECPEKEKLPQEWKKKSLIQKLIILRAVRPDRMTYALRNFVEEKLGTKYVERTRLDLGKAFGESSPGTPVFFILSPGVDALKDLEVLGKRLGFTIDSGKFHNVSLGQGQELVAEMALEKAAIGGHWVFLQNVHLVAKWLGTLEKLLEKFSQGSHRDYRVFLSAEAAPSQHEPVIPQGLLENSIKITNEPPTGMLANLHAALYNFDQDTLEMCSKDQEFKSILFSLCYFHGCVAGRLRFGPQGWSRSYPFSPGDLTICTNILYNHLEANPHVPWEDLRYLFGEIIYGGHITDAWDRKLCRVYLEEFMNPSLIEDELMLAPGFAAPPYSDYSGYHQYIEDMLPPESPALYGLHPNAEIELLTVTSNMLFRTLLEMQPRNAVSNEEQGQSTEDKVKNILDDILERLPEEFNMAEIMQKNPNRSPYILVCFQECERMNVLLREIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWLSGLFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKKTKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTSTMPVIFAKAIPADRQEVKHAYECPVYKTKARGLTYVWTFRLRSKDRIAKWVLAGVALLLEA", "length": 4487, "header": "tr|E9PU24-1|E9PU24_RAT Isoform 1 of Dynein, axonemal, heavy chain 11 OS=Rattus norvegicus OX=10116 GN=Dnah11 PE=3 SV=4 CANONICAL=E9PU24-1" }, "isoforms": [ { "isoform_ac": "A0A8I6GH84-1", "url": "", "sequence": { "sequence": "MAAQEEGTVLRLSPSEQEDEEDEEAEAARRAQRFAVDPRVRFLGGRLQQALGFPEETWGEYLESEDHRQVLGDFLESSGPASLVFSVAPGLLSASPEIPRDVKHKLVYFAKKMTGSTGESDFSQTVLFGEIPRSLFTHVTAFLDEILVPILSNKNNHESWSCFISQDVEHHTEIMKNKMHIFRGKMSRRTHLPIPTIAENIDLDQHYSVTRPQSDERRILHAIESVVIKWSHQIQEIIEKDSAQPLLSGLHPTPETELDFWTMRHDNLKCIYHQLQAPIVLKMVKILRTRQSSYLPALKGIFTTVENALLEARDVELHLRPLRKHIQGLQEADFPQTGILIAPLIHTICLIWSHSKFYNSPARVIVLLQEFCNLFIDQARAYLSPEDLLKGEIEDALEKVQVAIGVLRMFQNSFFKYRRGLTSYFTGDTEQRPWDFQSHLVFSRFNKFLDRLVKIEDMFVTILEFEKLERLEFGGSKGAVLNAQIHSMKEEFIECCNVFRQSIYDPSDCDSMEFESDYFQFKSKTLDFDRRLGTLLCEGLSNCSGLESAFKLLTIFGNFLEKPVVMEIFSPHYSTLLNMFNAELDMCKRLYDEHMKQIEHGHEILNKNMPFTSGNIKWARMLLERLQMFWSNFTSLHYLFPDSPDEAAVCQKYAEMTTLLDQFESRIYSEWRRNVDKTCEFNLNQPLVKFSPINGLLSVNFDPKLVAVLREVKYLLMLKKSNIPDSALGIFQKKNIILKHIGNLELLVQGYNKLKQTLLEVEYPLIEKELGAIDEQLRVAATWLTWQDDFWVYMEKVQVATAELERRVSQTQSNVQTIQQTMQAWAEWPLLPRRETRREAALTLDDKGDLFAKKYKLIREDGYKIHNLVEENRKLFRADPSLDSWKIYVEFIDDIVVEGFFQTILHDLDFFLRNTEKQLKPAPFFQAQMLLMPPEIVFKPPLEREAGDGFYNLVEAMLCGSFKVSAQMGRVAAHLDIPDYQNDMDNMLGLAEVRQEIMNRVADVIDKVLEFRSSLETYSYLWVDDRVEILRQFLLYGHAVPSEEIDAPAGEDILQSPTLEQFKEQIDIYEALYVQMSKFDDFRVFNSWFKIDMRPFKLSMLNVIKKWSWMFQEHLLRFVVDSLSELQGFIKQTNAGLQRQPHEGDHDGLVDIMGHLLAVRSRQRATDELFEPLKETIMLLESYGQKMPEQVYAQLEELPERWETTKKIAAVVRHEVSPLQNAEVTLLRKKCILFDEKQAEFRERFRSYAPLGFKAENPYSVLDKANQELEALEEEVVQMQNCARLFEVVLPEYKQMKQCRREVRLLKELWDIIVYVRRSIDNWTETRWRQVNMEQMDLELRRFAKEIWSLDKAVRVWDAYSGLEGTVKDMTTSLRAVAELQNPALRDRHWQQLTNAIGVRFSINDSTTLADLLAVQLHQVEEDVRDIVDKAVKELGTEKVITDVSHTWEALEFSYEVHHRTGTPLLKSDEQLFETLEHNQSFLLGLGTSWLATEPLGSAYSHAGILQVQLQTLLQSKYVEYFIDQVLSWQNKLNVADAVIFTWMQVQRTWSHLESIFVCSEDIRIQLVEDAQRFDEVDAEFKELMFKTAKIKNVLEATCRPHLYEKLKDFQHRLSLCEKALAEYLETKRVTFSRFYFISSADLLDLLSKGAQPKQVTRHLVKLFDSISDLQFEDNPEVSTCKAVGMFSKEKEYVSFQAGCECIGHVESWLLQLEQTMKETVRLAIAEAIAAYEEKPRELWIFDFPAQVALTGSQIWWTTDVGIAFSRLEEGYETALKDFHKKQISQLNTLITLLLGELSPGDRQKVMTICTIDVHARDVVAKLISQKVVSPRAFTWLSQLRHEWEESRKHCIVNICDAHFQYCYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYRSIGNIYKGLVQTGAWGCFDEFNRIAVEVLSVVAVQVKMIHDAIRSRRRRFVFLGETIPLKPSVGIFITLNPGYAGRTELPENLKALFRPCAMVAPDTELICEIMLVAEGFVDARSLARKFISLYTLCDELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMRALRDFNMPKIVTDDVPVFLGLVSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVRHSIFVVGNAGTGKSKILRTLNRTYVNMKQKPVWNDLNPKAVTTDELFGFIHHATREWKDGLLSSILREQANLTHDGPTWIVLDGDIDPLWIESLNTVMDDNKVLTLASNERVALTPSMRLLFETHHLQTATPATVSRAGILYVNPQDLGWNPYVASWIDRRRHQSEKANLTILFDKYIPVCLEKLRTSFKAITSVPESSLVQTICTLLECLLTPENIPSDSPKETYEVYFVFACVWTFGGTLLRDQLSDYQADFSRWWHKEMKAVKFPSQGTIFDYYLDHKTKKFLPWTDKVPQFTMDADAPLKTVLVHTPETTRLRYFTELLLNKGKPLMLVGNAGVGKTVFLSDTLASISEDYIVSRVPFNYYTTSADLQRILEKPLEKKAGRNYGPRGNKKLVYFIDDLNMPEVDLYGTVQPHALLRQHIDYGHWYDRHKVMLKEIRNCQYVACMNPMAGSFTVDPRLKRHFTVLAFNFPSLDTLTTIYGQIFSFYLQQQAFCPSVLRTGPSLIQATIAFHQTMAENFVPTAIKFHYNFNLRDLSNIFQGILFASPECLKCPEDLARLWLHETSRVYGDRLVDANDSDLFQRKMLEAAHKYFKGADANTLQQQPLVYCHFASGREDPCYEPVKDWEGLKAVLTEMMGNYNELHSEMHLVLFEDAMQHVCRISRILRTPQGHALLVGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGTQDLRVDLANLYVRTGAKNMPTVFLLTDAHVLDESFLVLINDLLASGDIPGLFSDEDTDKIISGIRNEVRGLGITDSRENCWAFFLARVRLQLKMVFCFSPVGHTLRVRARKFPALVNCTAIDWFHAWPQEALVSVSRRFIEEIEGIEPQHKDSISLFMAYVHTSVKEVSAWYYQNERRYNYTTPRSFLEQISLFKSLLKKKRGEVQRKKEHLGNGIQKLQTTASQVGNLKARLASQEAELQLRNQDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQRECEADLLKAEPALVAATAALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAARIFMGKVDDFLQALINYDKEHIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQTNLDLAAATEKLEAVRRKLVDLDHNLRRLTASFEKATAEKVRCQEEVNQTNKTIDLANRLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAAFVSYIGSFTRQYRQELVDCKWIPFLQQKVSIPIAEGLDMIATLTDDATIATWNNQGLPSDRMSTENATILTHCKRWPLMIDPQQQGIKWIKNKYGPDLKVTHLGQKGFLNAIEMALAFGDVILIENLKETVDPVLGPLLGRNTIKKGKYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVSVERPDLERLKLVLTKHQNDFKIELRHLEEDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVIEARENERKINETRECYRPVAARASLMYFVISDLRKINPVYQFSLKAFKTLFHRAIEQADKVEDTQERICALMESVTYATFLHASQALFEKDKLTFLSQMAFQILLRRNEIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVKAVALMEEFRGLDRDVEGSAKQWRKWVESECPEKEKLPQEWKKKSLIQKLIILRAVRPDRMTYALRNFVEEKLGTKYVERTRLDLGKAFGESSPGTPVFFILSPGVDALKDLEVLGKRLGFTIDSGKFHNVSLGQGQELVAEMALEKAAIGGHWVFLQNVHLVAKWLGTLEKLLEKFSQGSHRDYRVFLSAEAAPSQHEPVIPQGLLENSIKITNEPPTGMLANLHAALYNFDQDTLEMCSKDQEFKSILFSLCYFHGCVAGRLRFGPQGWSRSYPFSPGDLTICTNILYNHLEANPHVPWEDLRYLFGEIIYGGHITDAWDRKLCRVYLEEFMNPSLIEDELMLAPGFAAPPYSDYSGYHQYIEDMLPPESPALYGLHPNAEIELLTVTSNMLFRTLLEMQPRNAVSNEEQGQSTEDKVKNILDDILERLPEEFNMAEIMQKNPNRSPYILVCFQECERMNVLLREIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWLSGLFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKKTKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTSTMPVIFAKAIPADRQEVKHAYECPVYKTKARGLTYVWTFRLRSKDRIAKWVLAGVALLLEA", "length": 4514, "header": "tr|A0A8I6GH84-1|A0A8I6GH84_RAT Computationally mapped isoform of Dynein, axonemal, heavy chain 11 OS=Rattus norvegicus OX=10116 GN=Dnah11 PE=3 SV=1 CANONICAL=E9PU24-1" }, "locus": { "chromosome": "6", "start_pos": 139155406, "end_pos": 138839560, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000102541.1", "url": "https://www.ensembl.org/id/ENSRNOT00000102541.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000089399.1", "url": "https://www.ensembl.org/id/ENSRNOP00000089399.1" } ] } }, { "isoform_ac": "E9PU24-1", "url": "", "sequence": { "sequence": "MAAQEEGTVLRLSPSEQEDEEDEEAEAARRAQRFAVDPRVRFLGGRLQQALGFPEETWGEYLESEDHRQVLGDFLESSGPASLVFSVAPGLLSASPEIPRDVKHKLVYFAKKMTGSTGESDFSQTVLFGEIPRSLFTHVTAFLDEILVPILSNKNNHESWSCFISQDVEHHTEIMKNKMHIFRGKMSRRTHLPIPTIAENIDLDQHYSVTRPQSDERRILHAIESVVIKWSHQIQEIIEKDSAQPLLSGLHPTPETELDFWTMRHDNLKCIYHQLQAPIVLKMVKILRTRQSSYLPALKGIFTTVENALLEARDVELHLRPLRKHIQGLQEADFPQTGILIAPLIHTICLIWSHSKFYNSPARVIVLLQEFCNLFIDQARAYLSPEDLLKGEIEDALEKVQVAIGVLRMFQNSFFKYRRGLTSYFTGDTEQRPWDFQSHLVFSRFNKFLDRLVKIEDMFVTILEFEKLERLEFGGSKGAVLNAQIHSMKEEFIECCNVFRQSIYDPSDCDSMEFESDYFQFKSKTLDFDRRLGTLLCEGLSNCSGLESAFKLLTIFGNFLEKPVVMEIFSPHYSTLLNMFNAELDMCKRLYDEHMKQIEHGHEILNKNMPFTSGNIKWARMLLERLQMFWSNFTSLHYLFPDSPDEAAVCQKYAEMTTLLDQFESRIYSEWRRNVDKTCEFNLNQPLVKFSPINGLLSVNFDPKLVAVLREVKYLLMLKKSNIPDSALGIFQKKNIILKHIGNLELLVQGYNKLKQTLLEVEYPLIEKELGAIDEQLRVAATWLTWQDDFWVYMEKVQVATAELERRVSQTQSNVQTIQQTMQAWAEWPLLPRRETRREAALTLDDKGDLFAKKYKLIREDGYKIHNLVEENRKLFRADPSLDSWKIYVEFIDDIVVEGFFQTILHDLDFFLRNTEKQLKPAPFFQAQMLLMPPEIVFKPPLEREAGDGFYNLVEAMLCGSFKVSAQMGRVAAHLDIPDYQNDMDNMLGLAEVRQEIMNRVADVIDKVLEFRSSLETYSYLWVDDRVEILRQFLLYGHAVPSEEIDAPAGEDILQSPTLEQFKEQIDIYEALYVQMSKFDDFRVFNSWFKIDMRPFKLSMLNVIKKWSWMFQEHLLRFVVDSLSELQGFIKQTNAGLQRQPHEGDHDGLVDIMGHLLAVRSRQRATDELFEPLKETIMLLESYGQKMPEQVYAQLEELPERWETTKKIAAVVRHEVSPLQNAEVTLLRKKCILFDEKQAEFRERFRSYAPLGFKAENPYSVLDKANQELEALEEEVVQMQNCARLFEVVLPEYKQMKQCRREVRLLKELWDIIVYVRRSIDNWTETRWRQVNMEQMDLELRRFAKEIWSLDKAVRVWDAYSGLEGTVKDMTTSLRAVAELQNPALRDRHWQQLTNAIGVRFSINDSTTLADLLAVQLHQVEEDVRDIVDKAVKELGTEKVITDVSHTWEALEFSYEVHHRTGTPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIDQVLSWQNKLNVADAVIFTWMQVQRTWSHLESIFVCSEDIRIQLVEDAQRFDEVDAEFKELMFKTAKIKNVLEATCRPHLYEKLKDFQHRLSLCEKALAEYLETKRVTFSRFYFISSADLLDLLSKGAQPKQVTRHLVKLFDSISDLQFEDNPEVSTCKAVGMFSKEKEYVSFQAGCECIGHVESWLLQLEQTMKETVRLAIAEAIAAYEEKPRELWIFDFPAQVALTGSQIWWTTDVGIAFSRLEEGYETALKDFHKKQISQLNTLITLLLGELSPGDRQKVMTICTIDVHARDVVAKLISQKVVSPRAFTWLSQLRHEWEESRKHCIVNICDAHFQYCYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYRSIGNIYKGLVQTGAWGCFDEFNRIAVEVLSVVAVQVKMIHDAIRSRRRRFVFLGETIPLKPSVGIFITLNPGYAGRTELPENLKALFRPCAMVAPDTELICEIMLVAEGFVDARSLARKFISLYTLCDELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMRALRDFNMPKIVTDDVPVFLGLVSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVRHSIFVVGNAGTGKSKILRTLNRTYVNMKQKPVWNDLNPKAVTTDELFGFIHHATREWKDGLLSSILREQANLTHDGPTWIVLDGDIDPLWIESLNTVMDDNKVLTLASNERVALTPSMRLLFETHHLQTATPATVSRAGILYVNPQDLGWNPYVASWIDRRRHQSEKANLTILFDKYIPVCLEKLRTSFKAITSVPESSLVQTICTLLECLLTPENIPSDSPKETYEVYFVFACVWTFGGTLLRDQLSDYQADFSRWWHKEMKAVKFPSQGTIFDYYLDHKTKKFLPWTDKVPQFTMDADAPLKTVLVHTPETTRLRYFTELLLNKGKPLMLVGNAGVGKTVFLSDTLASISEDYIVSRVPFNYYTTSADLQRILEKPLEKKAGRNYGPRGNKKLVYFIDDLNMPEVDLYGTVQPHALLRQHIDYGHWYDRHKVMLKEIRNCQYVACMNPMAGSFTVDPRLKRHFTVLAFNFPSLDTLTTIYGQIFSFYLQQQAFCPSVLRTGPSLIQATIAFHQTMAENFVPTAIKFHYNFNLRDLSNIFQGILFASPECLKCPEDLARLWLHETSRVYGDRLVDANDSDLFQRKMLEAAHKYFKGADANTLQQQPLVYCHFASGREDPCYEPVKDWEGLKAVLTEMMGNYNELHSEMHLVLFEDAMQHVCRISRILRTPQGHALLVGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGTQDLRVDLANLYVRTGAKNMPTVFLLTDAHVLDESFLVLINDLLASGDIPGLFSDEDTDKIISGIRNEVRGLGITDSRENCWAFFLARVRLQLKMVFCFSPVGHTLRVRARKFPALVNCTAIDWFHAWPQEALVSVSRRFIEEIEGIEPQHKDSISLFMAYVHTSVKEVSAWYYQNERRYNYTTPRSFLEQISLFKSLLKKKRGEVQRKKEHLGNGIQKLQTTASQVGNLKARLASQEAELQLRNQDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQRECEADLLKAEPALVAATAALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAARIFMGKVDDFLQALINYDKEHIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQTNLDLAAATEKLEAVRRKLVDLDHNLRRLTASFEKATAEKVRCQEEVNQTNKTIDLANRLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAAFVSYIGSFTRQYRQELVDCKWIPFLQQKVSIPIAEGLDMIATLTDDATIATWNNQGLPSDRMSTENATILTHCKRWPLMIDPQQQGIKWIKNKYGPDLKVTHLGQKGFLNAIEMALAFGDVILIENLKETVDPVLGPLLGRNTIKKGKYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVSVERPDLERLKLVLTKHQNDFKIELRHLEEDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVIEARENERKINETRECYRPVAARASLMYFVISDLRKINPVYQFSLKAFKTLFHRAIEQADKVEDTQERICALMESVTYATFLHASQALFEKDKLTFLSQMAFQILLRRNEIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVKAVALMEEFRGLDRDVEGSAKQWRKWVESECPEKEKLPQEWKKKSLIQKLIILRAVRPDRMTYALRNFVEEKLGTKYVERTRLDLGKAFGESSPGTPVFFILSPGVDALKDLEVLGKRLGFTIDSGKFHNVSLGQGQELVAEMALEKAAIGGHWVFLQNVHLVAKWLGTLEKLLEKFSQGSHRDYRVFLSAEAAPSQHEPVIPQGLLENSIKITNEPPTGMLANLHAALYNFDQDTLEMCSKDQEFKSILFSLCYFHGCVAGRLRFGPQGWSRSYPFSPGDLTICTNILYNHLEANPHVPWEDLRYLFGEIIYGGHITDAWDRKLCRVYLEEFMNPSLIEDELMLAPGFAAPPYSDYSGYHQYIEDMLPPESPALYGLHPNAEIELLTVTSNMLFRTLLEMQPRNAVSNEEQGQSTEDKVKNILDDILERLPEEFNMAEIMQKNPNRSPYILVCFQECERMNVLLREIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWLSGLFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKKTKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTSTMPVIFAKAIPADRQEVKHAYECPVYKTKARGLTYVWTFRLRSKDRIAKWVLAGVALLLEA", "length": 4487, "header": "tr|E9PU24-1|E9PU24_RAT Isoform 1 of Dynein, axonemal, heavy chain 11 OS=Rattus norvegicus OX=10116 GN=Dnah11 PE=3 SV=4 CANONICAL=E9PU24-1" }, "locus": { "chromosome": "6", "start_pos": 139155406, "end_pos": 138839560, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000007233.7", "url": "https://www.ensembl.org/id/ENSRNOT00000007233.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000007233.7", "url": "https://www.ensembl.org/id/ENSRNOP00000007233.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "epithelial cilium movement involved in extracellular fluid movement", "id": "GO:0003351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003351", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "learning or memory", "id": "GO:0007611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007611", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "determination of left/right symmetry", "id": "GO:0007368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "regulation of cilium beat frequency", "id": "GO:0003356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003356", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "determination of left/right asymmetry in nervous system", "id": "GO:0035545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035545", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "cardiac septum morphogenesis", "id": "GO:0060411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060411", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "epithelial cilium movement involved in determination of left/right asymmetry", "id": "GO:0060287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060287", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "protein localization to motile cilium", "id": "GO:0120229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120229", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "minus-end-directed microtubule motor activity", "id": "GO:0008569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008569", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "dynein light intermediate chain binding", "id": "GO:0051959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051959", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "dynein intermediate chain binding", "id": "GO:0045505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045505", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" } ], "pmid": "" }, { "name": "dynein complex", "id": "GO:0030286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030286", "evidence": [ { "database": "UniProtKB", "id": "E9PU24", "url": "https://www.uniprot.org/uniprot/E9PU24" 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