{
    "uniprot_canonical_ac": "D4AC19-1",
    "uniprot_ac": "D4AC19",
    "uniprot_id": "D4AC19_RAT",
    "mass": {
        "chemical_mass": 26188.0,
        "monoisotopic_mass": 26188.0
    },
    "refseq": {
        "ac": "NP_001100510",
        "name": "homeobox protein DLX-4",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100510"
    },
    "gene_names": [
        {
            "name": "Dlx4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/D4AC19",
            "id": "D4AC19"
        },
        {
            "name": "Dlx4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100510",
            "id": "NP_001100510"
        }
    ],
    "protein_names": [
        {
            "name": "Distal-less homeobox 4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "D4AC19"
        },
        {
            "name": "Homeodomain transcription factor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "D4AC19"
        },
        {
            "name": "homeobox protein DLX-4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100510",
            "id": "NP_001100510"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0080408",
            "recommended_name": {
                "id": "DOID:0080408",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080408",
                "name": "orofacial cleft 15",
                "description": "An orofacial cleft that has_material_basis_in mutation in the DLX4 gene on chromosome 17q21."
            },
            "synonyms": [
                {
                    "id": "MONDO:0014772",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014772",
                    "name": "orofacial cleft 15",
                    "description": "Any cleft lip/palate in which the cause of the disease is a mutation in the DLX4 gene."
                },
                {
                    "id": "MONDO:0014772",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014772",
                    "name": "DLX4 cleft lip/palate",
                    "description": ""
                },
                {
                    "id": "MONDO:0014772",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014772",
                    "name": "OFC15",
                    "description": ""
                },
                {
                    "id": "MONDO:0014772",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014772",
                    "name": "cleft lip/palate caused by mutation in DLX4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014772",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014772",
                    "name": "orofacial cleft 15",
                    "description": ""
                },
                {
                    "id": "MONDO:0014772",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014772",
                    "name": "orofacial cleft type 15",
                    "description": ""
                },
                {
                    "id": "MIM:616788",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/616788",
                    "name": "Non-syndromic orofacial cleft 15",
                    "description": "Non-syndromic orofacial cleft 15"
                }
            ],
            "evidence": [
                {
                    "id": "0080408",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080408"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D4AC19",
                    "url": "https://www.uniprot.org/uniprot/D4AC19"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Dlx4",
            "url": "https://www.uniprot.org/uniprot/D4AC19",
            "locus": {
                "chromosome": "10",
                "start_pos": 80085465,
                "end_pos": 80090456,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000004399",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000004399"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000004399",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004399",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00086",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "303469",
            "url": "https://www.ncbi.nlm.nih.gov/gene/303469",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000047",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000047",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001356",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017970",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR020479",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:303469",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303469",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "GNNFGAW",
            "url": "https://omabrowser.org/oma/group/GNNFGAW/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2969529at2759",
            "url": "http://www.orthodb.org/?query=2969529at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24327",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24327",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24327:SF21",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24327:SF21",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00046",
            "url": "http://pfam.xfam.org/family/PF00046",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001100510",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100510",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1308744",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308744",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "D4AC19",
            "url": "https://www.uniprot.org/uniprot/D4AC19",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4AC19-1",
            "url": "https://www.uniprot.org/uniprot/D4AC19-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTSLPCPLPGLGPSNVVFPDLAPASSVVAAYQLGLSPGTAASPDLSFSQTYGHLLSYSYPGPATPGDSYLSSQQQSAAPSRPFHQPTEHPQELEAESEKLALSLEPSQPSLTRKLRKPRTIYSSLQLQHLNQRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKKLLKQSSGELEEDFSGRPPSLSPHSLTLPSIWDLPKAGTLPTSGYDNSFGTWYQHHSPDVLALPQRM",
        "length": 238,
        "header": "tr|D4AC19-1|D4AC19_RAT Isoform 1 of Distal-less homeobox 4  OS=Rattus norvegicus OX=10116 GN=Dlx4 PE=2 SV=1 CANONICAL=D4AC19-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D4AC19-1",
            "url": "",
            "sequence": {
                "sequence": "MTSLPCPLPGLGPSNVVFPDLAPASSVVAAYQLGLSPGTAASPDLSFSQTYGHLLSYSYPGPATPGDSYLSSQQQSAAPSRPFHQPTEHPQELEAESEKLALSLEPSQPSLTRKLRKPRTIYSSLQLQHLNQRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKKLLKQSSGELEEDFSGRPPSLSPHSLTLPSIWDLPKAGTLPTSGYDNSFGTWYQHHSPDVLALPQRM",
                "length": 238,
                "header": "tr|D4AC19-1|D4AC19_RAT Isoform 1 of Distal-less homeobox 4  OS=Rattus norvegicus OX=10116 GN=Dlx4 PE=2 SV=1 CANONICAL=D4AC19-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 80090434,
                "end_pos": 80085955,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000005807.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000005807.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000005807.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000005807.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:303469",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303469",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P70436-1",
            "protein_name": "Homeobox protein DLX-4",
            "gene_name": "Dlx4",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MTSLPCPLPDRGASNVVFPDLAPALSVVAAYPLGLSPGTAASPDLSYSQSYGHPRSYSHPGPATPGDSYLPRQQQLVAPSQPFHRPAEHPQELEAESEKLALSLVPSQQQSLTRKLRKPRTIYSSLQLQHLNQRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKKLLKQSSGEPEEDFSGRPPSLSPHSPALPFIWGLPKADTLPSSGYDNSHFGAWYQHRSPDVLALPQMM",
                "length": 240
            },
            "evidence": [
                {
                    "id": "45224443",
                    "url": "http://www.informatics.jax.org/homology/45224443",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q92988-1",
            "protein_name": "Homeobox protein DLX-4",
            "gene_name": "DLX4",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MTSLPCPLPGRDASKAVFPDLAPVPSVAAAYPLGLSPTTAASPNLSYSRPYGHLLSYPYTEPANPGDSYLSCQQPAALSQPLCGPAEHPQELEADSEKPRLSPEPSERRPQAPAKKLRKPRTIYSSLQLQHLNQRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKKLLKQNSGGQEGDFPGRTFSVSPCSPPLPSLWDLPKAGTLPTSGYGNSFGAWYQHHSSDVLASPQMM",
                "length": 240
            },
            "evidence": [
                {
                    "id": "45224443",
                    "url": "http://www.informatics.jax.org/homology/45224443",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "negative regulation of transcription by RNA polymerase II",
                        "id": "GO:0000122",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4AC19",
                                "url": "https://www.uniprot.org/uniprot/D4AC19"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell differentiation",
                        "id": "GO:0030154",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4AC19",
                                "url": "https://www.uniprot.org/uniprot/D4AC19"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4AC19",
                                "url": "https://www.uniprot.org/uniprot/D4AC19"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific",
                        "id": "GO:0001227",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4AC19",
                                "url": "https://www.uniprot.org/uniprot/D4AC19"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
                        "id": "GO:0000978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4AC19",
                                "url": "https://www.uniprot.org/uniprot/D4AC19"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4AC19",
                                "url": "https://www.uniprot.org/uniprot/D4AC19"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific DNA binding",
                        "id": "GO:0043565",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4AC19",
                                "url": "https://www.uniprot.org/uniprot/D4AC19"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific double-stranded DNA binding",
                        "id": "GO:1990837",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4AC19",
                                "url": "https://www.uniprot.org/uniprot/D4AC19"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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}
