{ "uniprot_canonical_ac": "D4AA72-1", "uniprot_ac": "D4AA72", "uniprot_id": "D4AA72_RAT", "mass": { "chemical_mass": 63569.0, "monoisotopic_mass": 63569.0 }, "refseq": { "ac": "NP_001178001", "name": "protein phosphatase 1 regulatory inhibitor subunit 16B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178001" }, "gene_names": [ { "name": "Ppp1r16b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D4AA72", "id": "D4AA72" }, { "name": "Ppp1r16b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178001", "id": "NP_001178001" } ], "protein_names": [ { "name": "Protein phosphatase 1, regulatory subunit 16B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D4AA72" }, { "name": "protein phosphatase 1 regulatory inhibitor subunit 16B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178001", "id": "NP_001178001" }, { "name": "protein phosphatase 1, regulatory (inhibitor) subunit 16B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178001", "id": "NP_001178001" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "common_name": "Rat" } ], "gene": [ { "name": "Ppp1r16b", "url": "https://www.uniprot.org/uniprot/D4AA72", "locus": { "chromosome": "3", "start_pos": 147418937, "end_pos": 147324126, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000015614", "url": "https://www.ensembl.org/id/ENSRNOG00000015614" } ] } } ], "crossref": [ { "id": "ENSRNOG00000015614", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015614", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "680616", "url": "https://www.ncbi.nlm.nih.gov/gene/680616", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:680616", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:680616", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QQLKVWR", "url": "https://omabrowser.org/oma/group/QQLKVWR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5482573at2759", "url": "http://www.orthodb.org/?query=5482573at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24179:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24179:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "http://pfam.xfam.org/family/PF12796", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001178001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178001", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1589460", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1589460", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4AA72-1", "url": "https://www.uniprot.org/uniprot/D4AA72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLLHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAAGQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMPMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSAAEEQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFSTKISRGELDGPVENGLRAPVSTYQYALANGDIWKMHEIPDYSMAYGNPGMADVPPPWSGFKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSVARSGEGSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPMEEMEEKVHGCCRIS", "length": 568, "header": "tr|D4AA72-1|D4AA72_RAT Isoform 1 of Protein phosphatase 1, regulatory subunit 16B OS=Rattus norvegicus OX=10116 GN=Ppp1r16b PE=4 SV=1 CANONICAL=D4AA72-1" }, "isoforms": [ { "isoform_ac": "D4AA72-1", "url": "", "sequence": { "sequence": "MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLLHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAAGQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMPMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSAAEEQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFSTKISRGELDGPVENGLRAPVSTYQYALANGDIWKMHEIPDYSMAYGNPGMADVPPPWSGFKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSVARSGEGSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPMEEMEEKVHGCCRIS", "length": 568, "header": "tr|D4AA72-1|D4AA72_RAT Isoform 1 of Protein phosphatase 1, regulatory subunit 16B OS=Rattus norvegicus OX=10116 GN=Ppp1r16b PE=4 SV=1 CANONICAL=D4AA72-1" }, "locus": { "chromosome": "3", "start_pos": 147415396, "end_pos": 147351928, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000021133.8", "url": "https://www.ensembl.org/id/ENSRNOT00000021133.8" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000021133.4", "url": "https://www.ensembl.org/id/ENSRNOP00000021133.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:680616", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:680616", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8VHQ3-1", "protein_name": "Protein phosphatase 1 regulatory inhibitor subunit 16B", "gene_name": "Ppp1r16b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLLHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAAGQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMPMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFSTKISRGELDGPVENGLRAPVSTYQYALANGDIWKMHEMPDYSMAYGNPGVADVPPPWSGFKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSVARSGESSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPMEEMEEKVHGCCRIS", "length": 568 }, "evidence": [ { "id": "45238663", "url": "http://www.informatics.jax.org/homology/45238663", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96T49-1", "protein_name": "Protein phosphatase 1 regulatory inhibitor subunit 16B", "gene_name": "PPP1R16B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGELDMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPIEEMEEKVHGCCRIS", "length": 567 }, "evidence": [ { "id": "45238663", "url": "http://www.informatics.jax.org/homology/45238663", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "myosin phosphatase regulator activity", "id": "GO:0017020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017020", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "enzyme inhibitor activity", "id": "GO:0004857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004857", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "protein phosphatase regulator activity", "id": "GO:0019888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019888", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "establishment of endothelial barrier", "id": "GO:0061028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061028", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "positive regulation of protein dephosphorylation", "id": "GO:0035307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035307", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "negative regulation of protein dephosphorylation", "id": "GO:0035308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035308", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "negative regulation of peptidyl-serine dephosphorylation", "id": "GO:1902309", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902309", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "regulation of phosphatidylinositol 3-kinase signaling", "id": "GO:0014066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014066", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell proliferation", "id": "GO:0001938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001938", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "regulation of sprouting angiogenesis", "id": "GO:1903670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903670", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "regulation of protein dephosphorylation", "id": "GO:0035304", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035304", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "id": "GO:1903589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903589", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "D4AA72", "url": "https://www.uniprot.org/uniprot/D4AA72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 532, "end_pos": 534, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { 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