{
    "uniprot_canonical_ac": "D4A7T3-1",
    "uniprot_ac": "D4A7T3",
    "uniprot_id": "BRDT_RAT",
    "mass": {
        "chemical_mass": 106719.0,
        "monoisotopic_mass": 106719.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Brdt",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/D4A7T3",
            "id": "D4A7T3"
        }
    ],
    "protein_names": [
        {
            "name": "Bromodomain testis-specific protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "D4A7T3"
        }
    ],
    "function": [
        {
            "annotation": "Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D4A7T3",
                    "url": "https://www.uniprot.org/uniprot/D4A7T3#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q91Y44",
                    "url": "https://www.uniprot.org/uniprot/Q91Y44#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0070163",
            "recommended_name": {
                "id": "DOID:0070163",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070163",
                "name": "spermatogenic failure 21",
                "description": "A male infertility due to acephalic spermatozoa that is characterized by acephalic spermatozoa, reduced sperm number and impaired sperm motility that has_material_basis_in homozygous mutation in the BRDT gene on chromosome 1p22."
            },
            "synonyms": [
                {
                    "id": "MONDO:0054725",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0054725",
                    "name": "spermatogenic failure 21",
                    "description": ""
                },
                {
                    "id": "MONDO:0054725",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0054725",
                    "name": "spermatogenic failure 21",
                    "description": ""
                },
                {
                    "id": "MONDO:0054725",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0054725",
                    "name": "SPGF21",
                    "description": ""
                },
                {
                    "id": "MIM:617644",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/617644",
                    "name": "Spermatogenic failure 21",
                    "description": "Spermatogenic failure 21"
                }
            ],
            "evidence": [
                {
                    "id": "0070163",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070163"
                }
            ]
        },
        {
            "disease_id": "DOID:14227",
            "recommended_name": {
                "id": "DOID:14227",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:14227",
                "name": "azoospermia",
                "description": "A male infertility disease characterized by the absence of any measurable level of sperm in semen."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "14227",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:14227"
                }
            ]
        },
        {
            "disease_id": "DOID:14228",
            "recommended_name": {
                "id": "DOID:14228",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:14228",
                "name": "oligospermia",
                "description": "A male fertility issue defined as a low sperm concentration in the ejaculate."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "14228",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:14228"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D4A7T3",
                    "url": "https://www.uniprot.org/uniprot/D4A7T3"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Brdt",
            "url": "https://www.uniprot.org/uniprot/D4A7T3",
            "locus": {
                "chromosome": "14",
                "start_pos": 2387796,
                "end_pos": 2445842,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000002073",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000002073"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000002073",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002073",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd05497",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05497",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd05498",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05498",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001487",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018359",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027353",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027353",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR031354",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031354",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036427",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038336",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038336",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR043508",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043508",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR043509",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043509",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "DFKTMFL",
            "url": "https://omabrowser.org/oma/group/DFKTMFL/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR22880",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22880",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR22880:SF175",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22880:SF175",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00439",
            "url": "http://pfam.xfam.org/family/PF00439",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF17035",
            "url": "http://pfam.xfam.org/family/PF17035",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF17105",
            "url": "http://pfam.xfam.org/family/PF17105",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_D4A7T3",
            "url": "http://purl.obolibrary.org/obo/PR_D4A7T3",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1306678",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306678",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "D4A7T3",
            "url": "https://www.uniprot.org/uniprot/D4A7T3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A7T3-1",
            "url": "https://www.uniprot.org/uniprot/D4A7T3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F7F8G2",
            "url": "https://www.uniprot.org/uniprot/F7F8G2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F7F8G2-1",
            "url": "https://www.uniprot.org/uniprot/F7F8G2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSLPSRQMAIVNPPPPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPDYYTIIETPMDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEEQIVGGKERMKKDIQQKTAVSSAKEQTPSKSAENVFKRQEIPAGFPDVCLSPLNMAQEAPPTCDSQTVVQITKGVKRRADTTTPTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDSQQQHRVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGTIKGKMDKQEYKDACEFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFEMHFAKIPDEPVESMRACHLTTNSAKALSRESSSEASSGDCSSEDSEDERVQRLAKLQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAPKRKKVNRDENPKKKAKQMKQKEKAKSNQPKKKKPLLKLEEEDNAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPHAKKVVRSKEELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVAVSPRPPLPPPPPPPPELASGSRLSDSSSSSSSSGSGSSSSSSSSSGSGSSSSDSSSSDSSDSEPEISPKFTGVKQNDLPSKENTKQIQCSVPDITSAETALVQQSTGPCGAPGKPPQQMPGCQVPHHLQATESTASVQTQPLAGDCKRVLHGPPVVHASAESHTVLELQCHAPVQKDIKIKNADSWKSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQIRKHLEHSAKDPKVSQESQREFGSGFTPESSSNKVQGRSHGEEQSEQQQLPSPSETQDISKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD",
        "length": 952,
        "header": "sp|D4A7T3-1|BRDT_RAT Isoform 1 of Bromodomain testis-specific protein  OS=Rattus norvegicus OX=10116 GN=Brdt PE=1 SV=1 CANONICAL=D4A7T3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D4A7T3-1",
            "url": "",
            "sequence": {
                "sequence": "MSLPSRQMAIVNPPPPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPDYYTIIETPMDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEEQIVGGKERMKKDIQQKTAVSSAKEQTPSKSAENVFKRQEIPAGFPDVCLSPLNMAQEAPPTCDSQTVVQITKGVKRRADTTTPTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDSQQQHRVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGTIKGKMDKQEYKDACEFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFEMHFAKIPDEPVESMRACHLTTNSAKALSRESSSEASSGDCSSEDSEDERVQRLAKLQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAPKRKKVNRDENPKKKAKQMKQKEKAKSNQPKKKKPLLKLEEEDNAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPHAKKVVRSKEELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVAVSPRPPLPPPPPPPPELASGSRLSDSSSSSSSSGSGSSSSSSSSSGSGSSSSDSSSSDSSDSEPEISPKFTGVKQNDLPSKENTKQIQCSVPDITSAETALVQQSTGPCGAPGKPPQQMPGCQVPHHLQATESTASVQTQPLAGDCKRVLHGPPVVHASAESHTVLELQCHAPVQKDIKIKNADSWKSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQIRKHLEHSAKDPKVSQESQREFGSGFTPESSSNKVQGRSHGEEQSEQQQLPSPSETQDISKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD",
                "length": 952,
                "header": "sp|D4A7T3-1|BRDT_RAT Isoform 1 of Bromodomain testis-specific protein  OS=Rattus norvegicus OX=10116 GN=Brdt PE=1 SV=1 CANONICAL=D4A7T3-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "F7F8G2-1",
            "url": "",
            "sequence": {
                "sequence": "MSLPSRQMAIVNPPPPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPDYYTIIETPMDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEEQIVGGKERMKKDIQQKTAVSSAKEQTPSKSAENVFKRQEIPAGFPDVCLSPLNMAQEAPPTCDSQTVVQITKGVKRRADTTTPTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDSQQQHRVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGTIKGKMDKQEYKDACEFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFEMHFAKIPDEPVESMRACHLTTNSAKALSRESSSEASSGDCSSEDSEDERVQRLAKLQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAPKRKKVNRDENPKKKAKQMKQKEKAKSNQPKKKKPLLKLEEEDNAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPHAKKVVRSKEELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVEKLPPPPPPPPELASGSRLSDSSSSSSSSGSGSSSSSSSSSGSGSSSSDSSSSDSSDSEPEISPKFTGVKQNDLPSKENTKQIQCSVPDITSAETALVQQSTGPCGAPGKPPQQMPGCQVPHHLQATESTASVQTQPLAGDCKRVLHGPPVVHASAESHTVLELQCHAPVQKDIKIKNADSWKSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQIRKHLEHSAKDPKVSQESQREFGSGFTPESSSNKVQGRSHGEEQSEQQQLPSPSETQDISKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD",
                "length": 947,
                "header": "tr|F7F8G2-1|F7F8G2_RAT Computationally mapped isoform of Bromodomain, testis-specific  OS=Rattus norvegicus OX=10116 GN=Brdt PE=4 SV=2 CANONICAL=D4A7T3-1"
            },
            "locus": {
                "chromosome": "14",
                "start_pos": 2429831,
                "end_pos": 2388589,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000061538.4",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000061538.4"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000058256.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000058256.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 186,
            "end_pos": 186,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D4A7T3",
                    "url": "https://www.uniprot.org/uniprot/D4A7T3"
                }
            ],
            "site_lbl": "Ser186"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis.",
            "journal": "J. Biol. Chem.",
            "date": "2012",
            "authors": "Dhar S, Thota A, Rao MR",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D4A7T3",
                    "url": "https://www.uniprot.org/uniprot/D4A7T3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22215678",
                    "url": "https://glygen.org/publication/PubMed/22215678"
                }
            ]
        }
    ],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chromatin",
                        "id": "GO:0000785",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "chromatin remodeling",
                        "id": "GO:0006338",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mRNA processing",
                        "id": "GO:0006397",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "spermatogenesis",
                        "id": "GO:0007283",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of DNA-templated transcription",
                        "id": "GO:0006355",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA splicing",
                        "id": "GO:0008380",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "male meiotic nuclear division",
                        "id": "GO:0007140",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of RNA splicing",
                        "id": "GO:0043484",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "male meiosis I",
                        "id": "GO:0007141",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007141",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
                                "url": "https://www.uniprot.org/uniprot/D4A7T3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription involved in meiotic cell cycle",
                        "id": "GO:0051039",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051039",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7T3",
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