{
    "uniprot_canonical_ac": "D4A7I8-1",
    "uniprot_ac": "D4A7I8",
    "uniprot_id": "D4A7I8_RAT",
    "mass": {
        "chemical_mass": 40080.0,
        "monoisotopic_mass": 40080.0
    },
    "refseq": {
        "ac": "NP_001102109",
        "name": "formylglycine-generating enzyme precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102109"
    },
    "gene_names": [
        {
            "name": "Sumf1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/D4A7I8",
            "id": "D4A7I8"
        },
        {
            "name": "Sumf1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102109",
            "id": "NP_001102109"
        }
    ],
    "protein_names": [
        {
            "name": "Sulfatase modifying factor 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "D4A7I8"
        },
        {
            "name": "formylglycine-generating enzyme precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102109",
            "id": "NP_001102109"
        },
        {
            "name": "formylglycine-generating enzyme",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102109",
            "id": "NP_001102109"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0050441",
            "recommended_name": {
                "id": "DOID:0050441",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050441",
                "name": "mucosulfatidosis",
                "description": "A sphingolipidosis that is characterized by leukodystrophy, ichthyosis, skeletal abnormalities and shortened life expectancy and has_material_basis_in mutation in the SUMF1 gene that results in deficiency in multiple sulfatase enzymes."
            },
            "synonyms": [
                {
                    "id": "DOID:0050441",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050441",
                    "name": "Sulfatidosis, Juvenile, Austin Type",
                    "description": ""
                },
                {
                    "id": "DOID:0050441",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050441",
                    "name": "multiple sulfatase deficiency disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "mucosulfatidosis",
                    "description": "Multiple sulfatase deficiency (MSD) is a very rare and fatal lysosomal storage disease characterized by a clinical phenotype that combines the features of different sulfatase deficiencies (whether lysosomal or not) that can have neonatal (most severe), infantile (most common) and juvenile (rare) presentations with manifestations including hypotonia, coarse facial features, mild deafness, skeletal anomalies, ichthyosis, hepatomegaly, developmental delay, progressive neurologic deterioration and hydrocephalus."
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "MSD",
                    "description": ""
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "juvenile sulfatidosis, Austin type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "mucosulfatidosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "multiple sulfatase deficiency disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "sulfatidosis, juvenile, Austin type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "juvenile sulfatidosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "multiple sulfatase deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010088",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010088",
                    "name": "sulfatidosis juvenile, Austin type",
                    "description": ""
                },
                {
                    "id": "MIM:272200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/272200",
                    "name": "Multiple sulfatase deficiency",
                    "description": "Multiple sulfatase deficiency"
                }
            ],
            "evidence": [
                {
                    "id": "0050441",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050441"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D4A7I8",
                    "url": "https://www.uniprot.org/uniprot/D4A7I8"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Sumf1",
            "url": "https://www.uniprot.org/uniprot/D4A7I8",
            "locus": {
                "chromosome": "4",
                "start_pos": 141078741,
                "end_pos": 141160708,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000006813",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000006813"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000006813",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006813",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "362409",
            "url": "https://www.ncbi.nlm.nih.gov/gene/362409",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR005532",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005532",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016187",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042095",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042095",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:362409",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362409",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "WTADLWD",
            "url": "https://omabrowser.org/oma/group/WTADLWD/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5399900at2759",
            "url": "http://www.orthodb.org/?query=5399900at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23150",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23150",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23150:SF19",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23150:SF19",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF03781",
            "url": "http://pfam.xfam.org/family/PF03781",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-1663150",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1663150",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9840310",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9840310",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001102109",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102109",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1309939",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309939",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I5ZM54",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZM54",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZM54-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZM54-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZRR9",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZRR9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5ZRR9-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5ZRR9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6ABB3",
            "url": "https://www.uniprot.org/uniprot/A0A8I6ABB3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6ABB3-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6ABB3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A7I8",
            "url": "https://www.uniprot.org/uniprot/D4A7I8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A7I8-1",
            "url": "https://www.uniprot.org/uniprot/D4A7I8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAPAGEPAPRCCTGLAQVFLLLVLACGAAGSDEAEAGEGAVSLAGSCGCGTPQRAGAHGSSAAAQRYSREANAQGLTSGPRSLALTKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTVDAFYMDAYEVSNADFEKFVNSTGYLTEAEKFGDSFVFEGMLSEPVKAQIHQAVAAAPWWLPVKGADWRHPEGPDSTILHRSNHPVLHVSWNDAVAYCAWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSAEETLNPKGPTSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAN",
        "length": 372,
        "header": "tr|D4A7I8-1|D4A7I8_RAT Isoform 1 of Sulfatase modifying factor 1  OS=Rattus norvegicus OX=10116 GN=Sumf1 PE=3 SV=1 CANONICAL=D4A7I8-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I5ZM54-1",
            "url": "",
            "sequence": {
                "sequence": "MAAPAGEPAPRCCTGLAQVFLLLVLACGAAGSDEAEAGEGAVSLAGSCGCGTPQRAGAHGSSAAAQRYSREANAQGLTSGPRSLALTKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTVDAFYMDAYEVSNADFEKFVNSTGYLTEAEKFGDSFVFEGMLSEPVKAQIHQAVAAAPWWLPVKGADWRHPEGPDSTILHRSNHPVLHVSWNDAVAYCAWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSAEETLNPRSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAN",
                "length": 353,
                "header": "tr|A0A8I5ZM54-1|D4A7I8_RAT Computationally mapped isoform of Sulfatase modifying factor 1  OS=Rattus norvegicus OX=10116 GN=Sumf1 PE=3 SV=1 CANONICAL=D4A7I8-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 141160685,
                "end_pos": 141080095,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000115716.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000115716.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000079041.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000079041.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5ZRR9-1",
            "url": "",
            "sequence": {
                "sequence": "MAAPAGEPAPRCCTGLAQVFLLLVLACGAAGSDEAEAGEGAVSLAGSCGCGTPQRAGAHGSSAAAQRYSREANAQGLTSGPRSLALTKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTVDAFYMDAYEVSNADFEKFVNSTGYLTEVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSAEETLNPKGPTSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAN",
                "length": 240,
                "header": "tr|A0A8I5ZRR9-1|A0A8I5ZRR9_RAT Computationally mapped isoform of Sulfatase modifying factor 1  OS=Rattus norvegicus OX=10116 GN=Sumf1 PE=1 SV=1 CANONICAL=D4A7I8-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 141160685,
                "end_pos": 141080095,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000106772.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000106772.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000081326.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000081326.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6ABB3-1",
            "url": "",
            "sequence": {
                "sequence": "MAAPAGEPAPRCCTGLAQVFLLLVLACGAAGSDEAEAGEGAVSLAGSCGCGTPQRAGAHGSSAAAQRYSREANAQGLTSGPRSLALTKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTVDAFYMDAYEVSNADFEKFVNSTGYLTEVAAAPWWLPVKGADWRHPEGPDSTILHRSNHPVLHVSWNDAVAYCAWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSAEETLNPKGPTSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAN",
                "length": 347,
                "header": "tr|A0A8I6ABB3-1|A0A8I6ABB3_RAT Computationally mapped isoform of Sulfatase modifying factor 1  OS=Rattus norvegicus OX=10116 GN=Sumf1 PE=1 SV=1 CANONICAL=D4A7I8-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 141160685,
                "end_pos": 141080095,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000098361.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000098361.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000089270.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000089270.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D4A7I8-1",
            "url": "",
            "sequence": {
                "sequence": "MAAPAGEPAPRCCTGLAQVFLLLVLACGAAGSDEAEAGEGAVSLAGSCGCGTPQRAGAHGSSAAAQRYSREANAQGLTSGPRSLALTKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTVDAFYMDAYEVSNADFEKFVNSTGYLTEAEKFGDSFVFEGMLSEPVKAQIHQAVAAAPWWLPVKGADWRHPEGPDSTILHRSNHPVLHVSWNDAVAYCAWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSAEETLNPKGPTSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAN",
                "length": 372,
                "header": "tr|D4A7I8-1|D4A7I8_RAT Isoform 1 of Sulfatase modifying factor 1  OS=Rattus norvegicus OX=10116 GN=Sumf1 PE=3 SV=1 CANONICAL=D4A7I8-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 141160685,
                "end_pos": 141080095,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000009008.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000009008.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000009008.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000009008.4"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:362409",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362409",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1663150",
            "name": "The activation of arylsulfatases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1663150",
            "resource": "Reactome",
            "description": "The activation of arylsulfatases"
        },
        {
            "id": "R-RNO-9840310",
            "name": "Glycosphingolipid catabolism",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9840310",
            "resource": "Reactome",
            "description": "Glycosphingolipid catabolism"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8NBK3-1",
            "protein_name": "Formylglycine-generating enzyme",
            "gene_name": "SUMF1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAAPALGLVCGRCPELGLVLLLLLLSLLCGAAGSQEAGTGAGAGSLAGSCGCGTPQRPGAHGSSAAAHRYSREANAPGPVPGERQLAHSKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTIDAFYMDAYEVSNTEFEKFVNSTGYLTEAEKFGDSFVFEGMLSEQVKTNIQQAVAAAPWWLPVKGANWRHPEGPDSTILHRPDHPVLHVSWNDAVAYCTWAGKRLPTEAEWEYSCRGGLHNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSVEETLNPKGPPSGKDRVKKGGSYMCHRSYCYRYRCAARSQNTPDSSASNLGFRCAADRLPTMD",
                "length": 374
            },
            "evidence": [
                {
                    "id": "45237202",
                    "url": "http://www.informatics.jax.org/homology/45237202",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8R0F3-1",
            "protein_name": "Formylglycine-generating enzyme",
            "gene_name": "Sumf1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAAPAREPALRCCIRLARVFLLLVLACEVAGSDEAEAREGAASLAGSCGCGTPQRAGAHGSSAAAQRYSREANAPGLTSGPRPLALTKMVPIPAGVFTMGTDDPQIRQDGEAPARRVTVDGFYMDAYEVSNADFEKFVNSTGYLTEAEKFGDSFVFEGMLSEQVKTHIHQAVAAAPWWLPVKGANWRHPEGPDSSILHRSNHPVLHVSWNDAVAYCTWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGKFPVSNTGEDGFQGTAPVDAFPPNGYGLYNIVGNVWEWTSDWWTVHHSVEETFNPKGPTSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAD",
                "length": 372
            },
            "evidence": [
                {
                    "id": "45237202",
                    "url": "http://www.informatics.jax.org/homology/45237202",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7I8",
                                "url": "https://www.uniprot.org/uniprot/D4A7I8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum lumen",
                        "id": "GO:0005788",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7I8",
                                "url": "https://www.uniprot.org/uniprot/D4A7I8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A7I8",
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