{
    "uniprot_canonical_ac": "D4A531-1",
    "uniprot_ac": "D4A531",
    "uniprot_id": "D4A531_RAT",
    "mass": {
        "chemical_mass": 14523.0,
        "monoisotopic_mass": 14523.0
    },
    "refseq": {
        "ac": "NP_001099714",
        "name": "DNA-directed RNA polymerase II subunit RPB9",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099714"
    },
    "gene_names": [
        {
            "name": "Polr2i",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/D4A531",
            "id": "D4A531"
        },
        {
            "name": "Polr2i",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099714",
            "id": "NP_001099714"
        }
    ],
    "protein_names": [
        {
            "name": "DNA-directed RNA polymerase subunit",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "D4A531"
        },
        {
            "name": "DNA-directed RNA polymerase II subunit RPB9",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099714",
            "id": "NP_001099714"
        },
        {
            "name": "polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa; polymerase (RNA) II subunit I",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099714",
            "id": "NP_001099714"
        }
    ],
    "function": [
        {
            "annotation": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D4A531",
                    "url": "https://www.uniprot.org/uniprot/D4A531#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "PIRNR005586",
                    "url": "https://www.uniprot.org/uniprot/PIRNR005586#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D4A531",
                    "url": "https://www.uniprot.org/uniprot/D4A531"
                }
            ],
            "common_name": "Rat"
        }
    ],
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            "name": "Polr2i",
            "url": "https://www.uniprot.org/uniprot/D4A531",
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                "end_pos": 85483515,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000020799",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000020799"
                    }
                ]
            }
        }
    ],
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        {
            "id": "ENSRNOG00000020799",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020799",
            "database": "Bgee",
            "categories": [
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        },
        {
            "id": "cd10508",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10508",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "292778",
            "url": "https://www.ncbi.nlm.nih.gov/gene/292778",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001222",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001222",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001529",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001529",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR012164",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012164",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019761",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019761",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR034012",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR034012",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:292778",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:292778",
            "database": "KEGG Pathway",
            "categories": [
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        },
        {
            "id": "DTSMVLF",
            "url": "https://omabrowser.org/oma/group/DTSMVLF/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "19808at2759",
            "url": "http://www.orthodb.org/?query=19808at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11239",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11239",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11239:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11239:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01096",
            "url": "http://pfam.xfam.org/family/PF01096",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02150",
            "url": "http://pfam.xfam.org/family/PF02150",
            "database": "Pfam",
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                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-112382",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112382",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-113418",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-113418",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5578749",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5578749",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-674695",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-6781823",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6781823",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-6782135",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782135",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-6782210",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782210",
            "database": "Reactome",
            "categories": [
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            ]
        },
        {
            "id": "R-RNO-6796648",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6796648",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-6803529",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6803529",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-6807505",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-72086",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72086",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-72163",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72163",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-72165",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72165",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-72203",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72203",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-73776",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73776",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-73779",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73779",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-75953",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75953",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-75955",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75955",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-76042",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-76042",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-77075",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77075",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-9018519",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9018519",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001099714",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099714",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1309395",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309395",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "D4A531",
            "url": "https://www.uniprot.org/uniprot/D4A531",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A531-1",
            "url": "https://www.uniprot.org/uniprot/D4A531-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0RCG9",
            "url": "https://www.uniprot.org/uniprot/M0RCG9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0RCG9-1",
            "url": "https://www.uniprot.org/uniprot/M0RCG9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE",
        "length": 125,
        "header": "tr|D4A531-1|D4A531_RAT Isoform 1 of DNA-directed RNA polymerase subunit  OS=Rattus norvegicus OX=10116 GN=Polr2i PE=3 SV=1 CANONICAL=D4A531-1"
    },
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        {
            "isoform_ac": "D4A531-1",
            "url": "",
            "sequence": {
                "sequence": "MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE",
                "length": 125,
                "header": "tr|D4A531-1|D4A531_RAT Isoform 1 of DNA-directed RNA polymerase subunit  OS=Rattus norvegicus OX=10116 GN=Polr2i PE=3 SV=1 CANONICAL=D4A531-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 85484906,
                "end_pos": 85483893,
                "strand": "-",
                "evidence": [
                    {
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                        "id": "ENSRNOT00000028222.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000028222.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000028222.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000028222.5"
                    }
                ]
            }
        },
        {
            "isoform_ac": "M0RCG9-1",
            "url": "",
            "sequence": {
                "sequence": "MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYAVSAGSPLASEFAPSLRAPCWLPTLSPLDYPSTHPLSHLVHPLLGSPYPPVQSCCGSDLFVILSSRHALPSAVPELRLPAGSRQQLHLRQQNHARSGRADPDHRRRVPGPYVAPDRGPPVPEVWPQGGSVLPVTQCPS",
                "length": 175,
                "header": "tr|M0RCG9-1|M0RCG9_RAT Computationally mapped isoform of RNA polymerase II subunit I  OS=Rattus norvegicus OX=10116 GN=Polr2i PE=4 SV=1 CANONICAL=D4A531-1"
            },
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                "chromosome": "1",
                "start_pos": 85484663,
                "end_pos": 85483893,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000073107.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000073107.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000067287.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000067287.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:292778",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:292778",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-112382",
            "name": "Formation of RNA Pol II elongation complex",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112382",
            "resource": "Reactome",
            "description": "Formation of RNA Pol II elongation complex"
        },
        {
            "id": "R-RNO-113418",
            "name": "Formation of the Early Elongation Complex",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-113418",
            "resource": "Reactome",
            "description": "Formation of the Early Elongation Complex"
        },
        {
            "id": "R-RNO-5578749",
            "name": "Transcriptional regulation by small RNAs",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5578749",
            "resource": "Reactome",
            "description": "Transcriptional regulation by small RNAs"
        },
        {
            "id": "R-RNO-674695",
            "name": "RNA Polymerase II Pre-transcription Events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695",
            "resource": "Reactome",
            "description": "RNA Polymerase II Pre-transcription Events"
        },
        {
            "id": "R-RNO-6781823",
            "name": "Formation of TC-NER Pre-Incision Complex",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6781823",
            "resource": "Reactome",
            "description": "Formation of TC-NER Pre-Incision Complex"
        },
        {
            "id": "R-RNO-6782135",
            "name": "Dual incision in TC-NER",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782135",
            "resource": "Reactome",
            "description": "Dual incision in TC-NER"
        },
        {
            "id": "R-RNO-6782210",
            "name": "Gap-filling DNA repair synthesis and ligation in TC-NER",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782210",
            "resource": "Reactome",
            "description": "Gap-filling DNA repair synthesis and ligation in TC-NER"
        },
        {
            "id": "R-RNO-6796648",
            "name": "TP53 Regulates Transcription of DNA Repair Genes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6796648",
            "resource": "Reactome",
            "description": "TP53 Regulates Transcription of DNA Repair Genes"
        },
        {
            "id": "R-RNO-6803529",
            "name": "FGFR2 alternative splicing",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6803529",
            "resource": "Reactome",
            "description": "FGFR2 alternative splicing"
        },
        {
            "id": "R-RNO-6807505",
            "name": "RNA polymerase II transcribes snRNA genes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505",
            "resource": "Reactome",
            "description": "RNA polymerase II transcribes snRNA genes"
        },
        {
            "id": "R-RNO-72086",
            "name": "mRNA Capping",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72086",
            "resource": "Reactome",
            "description": "mRNA Capping"
        },
        {
            "id": "R-RNO-72163",
            "name": "mRNA Splicing - Major Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72163",
            "resource": "Reactome",
            "description": "mRNA Splicing - Major Pathway"
        },
        {
            "id": "R-RNO-72165",
            "name": "mRNA Splicing - Minor Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72165",
            "resource": "Reactome",
            "description": "mRNA Splicing - Minor Pathway"
        },
        {
            "id": "R-RNO-72203",
            "name": "Processing of Capped Intron-Containing Pre-mRNA",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72203",
            "resource": "Reactome",
            "description": "Processing of Capped Intron-Containing Pre-mRNA"
        },
        {
            "id": "R-RNO-73776",
            "name": "RNA Polymerase II Promoter Escape",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73776",
            "resource": "Reactome",
            "description": "RNA Polymerase II Promoter Escape"
        },
        {
            "id": "R-RNO-73779",
            "name": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73779",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
        },
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            "id": "R-RNO-75953",
            "name": "RNA Polymerase II Transcription Initiation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75953",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Initiation"
        },
        {
            "id": "R-RNO-75955",
            "name": "RNA Polymerase II Transcription Elongation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75955",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Elongation"
        },
        {
            "id": "R-RNO-76042",
            "name": "RNA Polymerase II Transcription Initiation And Promoter Clearance",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-76042",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance"
        },
        {
            "id": "R-RNO-77075",
            "name": "RNA Pol II CTD phosphorylation and interaction with CE",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77075",
            "resource": "Reactome",
            "description": "RNA Pol II CTD phosphorylation and interaction with CE"
        },
        {
            "id": "R-RNO-9018519",
            "name": "Estrogen-dependent gene expression",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9018519",
            "resource": "Reactome",
            "description": "Estrogen-dependent gene expression"
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    ],
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            "uniprot_canonical_ac": "P36954-1",
            "protein_name": "DNA-directed RNA polymerase II subunit RPB9",
            "gene_name": "POLR2I",
            "tax_id": 9606,
            "organism": "Homo sapiens",
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                "sequence": "MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE",
                "length": 125
            },
            "evidence": [
                {
                    "id": "45228810",
                    "url": "http://www.informatics.jax.org/homology/45228810",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P60898-1",
            "protein_name": "DNA-directed RNA polymerase II subunit RPB9",
            "gene_name": "Polr2i",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE",
                "length": 125
            },
            "evidence": [
                {
                    "id": "45228810",
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