{
    "uniprot_canonical_ac": "D4A265-1",
    "uniprot_ac": "D4A265",
    "uniprot_id": "D4A265_RAT",
    "mass": {
        "chemical_mass": 15060.0,
        "monoisotopic_mass": 15060.0
    },
    "refseq": {
        "ac": "NP_001099927",
        "name": "helix-loop-helix protein 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099927"
    },
    "gene_names": [
        {
            "name": "Nhlh2",
            "resource": "UniProtKB",
            "type": "recommended",
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            "id": "D4A265"
        },
        {
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            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099927",
            "id": "NP_001099927"
        }
    ],
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        {
            "name": "Nescient helix loop helix 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "D4A265"
        },
        {
            "name": "helix-loop-helix protein 2",
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            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099927",
            "id": "NP_001099927"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0090070",
            "recommended_name": {
                "id": "DOID:0090070",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0090070",
                "name": "hypogonadotropic hypogonadism",
                "description": "A hypogonadism characterized by a impaired signalling by gonadotrpin relasing hormone."
            },
            "synonyms": [
                {
                    "id": "DOID:0090070",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0090070",
                    "name": "hypogonadotropism",
                    "description": ""
                },
                {
                    "id": "DOID:0090070",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0090070",
                    "name": "congenital idiopathic hypogonadotropic hypogonadism",
                    "description": ""
                },
                {
                    "id": "DOID:0090070",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0090070",
                    "name": "isolated congenital gonadotropin deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0007844",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007844",
                    "name": "hypogonadotropic hypogonadism 2 with or without anosmia",
                    "description": "Any hypogonadotropic hypogonadism in which the cause of the disease is a mutation in the FGFR1 gene."
                },
                {
                    "id": "MONDO:0007844",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007844",
                    "name": "FGFR1 hypogonadotropic hypogonadism",
                    "description": ""
                },
                {
                    "id": "MONDO:0007844",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007844",
                    "name": "hypogonadotropic hypogonadism 2 with or without anosmia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007844",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007844",
                    "name": "hypogonadotropic hypogonadism caused by mutation in FGFR1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007844",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007844",
                    "name": "HH2",
                    "description": ""
                },
                {
                    "id": "MONDO:0007844",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007844",
                    "name": "KAL2",
                    "description": ""
                },
                {
                    "id": "MONDO:0007844",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007844",
                    "name": "Kallmann syndrome 2",
                    "description": ""
                },
                {
                    "id": "MIM:147950",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/147950",
                    "name": "Hypogonadotropic hypogonadism 2 with or without anosmia",
                    "description": "Hypogonadotropic hypogonadism 2 with or without anosmia"
                }
            ],
            "evidence": [
                {
                    "id": "0090070",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090070"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
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                    "url": "https://www.uniprot.org/uniprot/D4A265"
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            "common_name": "Rat"
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                "evidence": [
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                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000054375",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000054375"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000054375",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054375",
            "database": "Bgee",
            "categories": [
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            ]
        },
        {
            "id": "cd19702",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19702",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "295327",
            "url": "https://www.ncbi.nlm.nih.gov/gene/295327",
            "database": "GeneID",
            "categories": [
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            ]
        },
        {
            "id": "IPR011598",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036638",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR040238",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR040238",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:295327",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:295327",
            "database": "KEGG Pathway",
            "categories": [
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            ]
        },
        {
            "id": "CASDPEP",
            "url": "https://omabrowser.org/oma/group/CASDPEP/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5403650at2759",
            "url": "http://www.orthodb.org/?query=5403650at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13864",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13864",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13864:SF19",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13864:SF19",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00010",
            "url": "http://pfam.xfam.org/family/PF00010",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
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            "id": "NP_001099927",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099927",
            "database": "RefSeq",
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            ]
        },
        {
            "id": "1308294",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308294",
            "database": "RGD",
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            ]
        },
        {
            "id": "D4A265",
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            "database": "UniProtKB",
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        },
        {
            "id": "D4A265-1",
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            "database": "UniProtKB",
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        }
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        "sequence": "MMLSPDQAADSDHPSSTHSDPESLGGVDTKVLGSVSDLEPVEEVDGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV",
        "length": 135,
        "header": "tr|D4A265-1|D4A265_RAT Isoform 1 of Nescient helix loop helix 2  OS=Rattus norvegicus OX=10116 GN=Nhlh2 PE=4 SV=1 CANONICAL=D4A265-1"
    },
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            "isoform_ac": "D4A265-1",
            "url": "",
            "sequence": {
                "sequence": "MMLSPDQAADSDHPSSTHSDPESLGGVDTKVLGSVSDLEPVEEVDGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV",
                "length": 135,
                "header": "tr|D4A265-1|D4A265_RAT Isoform 1 of Nescient helix loop helix 2  OS=Rattus norvegicus OX=10116 GN=Nhlh2 PE=4 SV=1 CANONICAL=D4A265-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 189447192,
                "end_pos": 189446788,
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                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000101630.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000101630.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000097496.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000097496.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:295327",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:295327",
            "resource": "KEGG Pathway"
        }
    ],
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        {
            "uniprot_canonical_ac": "Q02577-1",
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                "sequence": "MMLSPDQAADSDHPSSAHSDPESLGGTDTKVLGSVSDLEPVEEAEGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV",
                "length": 135
            },
            "evidence": [
                {
                    "id": "45232291",
                    "url": "http://www.informatics.jax.org/homology/45232291",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q64221-1",
            "protein_name": "Helix-loop-helix protein 2",
            "gene_name": "Nhlh2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MMLSPDQAADSDHPSSTHSDPESLGGADTKVLGSVSDLEPVEEADGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV",
                "length": 135
            },
            "evidence": [
                {
                    "id": "45232291",
                    "url": "http://www.informatics.jax.org/homology/45232291",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
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        "categories": [
            {
                "name": "Biological Process",
                "total": 9,
                "go_terms": [
                    {
                        "name": "male mating behavior",
                        "id": "GO:0060179",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060179",
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                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apoptotic process",
                        "id": "GO:0006915",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "male gonad development",
                        "id": "GO:0008584",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008584",
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                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "peripheral nervous system development",
                        "id": "GO:0007422",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007422",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell migration in hindbrain",
                        "id": "GO:0021535",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021535",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ovulation cycle",
                        "id": "GO:0042698",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042698",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "hypothalamus gonadotrophin-releasing hormone neuron development",
                        "id": "GO:0021888",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021888",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 7,
                "go_terms": [
                    {
                        "name": "protein dimerization activity",
                        "id": "GO:0046983",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
                        "id": "GO:0000978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific",
                        "id": "GO:0001228",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II-specific DNA-binding transcription factor binding",
                        "id": "GO:0061629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific double-stranded DNA binding",
                        "id": "GO:1990837",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "chromatin",
                        "id": "GO:0000785",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D4A265",
                                "url": "https://www.uniprot.org/uniprot/D4A265"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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            "table_stats": [
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                {
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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        {
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        {
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