{ "uniprot_canonical_ac": "D3ZY16-1", "uniprot_ac": "D3ZY16", "uniprot_id": "D3ZY16_RAT", "mass": { "chemical_mass": 65965.0, "monoisotopic_mass": 65965.0 }, "refseq": {}, "gene_names": [ { "name": "Trim65", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3ZY16", "id": "D3ZY16" } ], "protein_names": [ { "name": "Tripartite motif-containing 65", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZY16" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "common_name": "Rat" } ], "gene": [ { "name": "Trim65", "url": "https://www.uniprot.org/uniprot/D3ZY16", "locus": { "chromosome": "10", "start_pos": 101357937, "end_pos": 101364971, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000024145", "url": "https://www.ensembl.org/id/ENSRNOG00000024145" } ] } } ], "crossref": [ { "id": "ENSRNOG00000024145", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000024145", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12896", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12896", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RVERAHW", "url": "https://omabrowser.org/oma/group/RVERAHW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR25465", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25465", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR25465:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25465:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "http://pfam.xfam.org/family/PF00622", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13445", "url": "http://pfam.xfam.org/family/PF13445", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1559497", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1559497", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZY16-1", "url": "https://www.uniprot.org/uniprot/D3ZY16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSCPGRPEGAAPQLPVRQKPDKGDLDPCQGTFRGTRAQRSRCPCALPSSWTVLRPSVASVPLRGLRTQDLASAMAVQLLEEDLVTCPICLGRYCDPVTLPCGHTFCGNCIQDSWRCCEKICPECRQPFPEGAKLSRNVKLSTLLQGLPAAIQRLESGTSQSARCPRHGRPLEFFCLTEGLCVCSACTVHDCSHHERALLDVERRVREDRLRARVMVTRQQATQAETQLEELQQQSSQIESSARTLASVVSRRFSSLLQVLEKQQASTLSDIEGAKKRALDQVLHERQRLTDHLKALSQYDQSVQDLLGQGDDFIFFQGLQQLSEPIGSLGPPTPPQWDEEEQLNSVNQLLSPLCELLLEEKTLPTAADKAASAGPMEALGPLAPVPSAMCPLRKKLWQNYRNLTFDPETANRYLLLSHKAQQVTHHFQAQSPARSGSFELWQVQCTQSFQTGQHYWEVRASDHSITLGVTYPELPRRKLGTHTDNIGRGPYSWGLCIQEDSIQAWHNGRAQRLSRAGVSGGLLGVDLNLTSGCLTFYSLEPHTQPLHTFYAVFSRPLFPVFWLLEGRTLSLCHQPEAELPPRPQEEAIAPS", "length": 592, "header": "tr|D3ZY16-1|D3ZY16_RAT Isoform 1 of Tripartite motif-containing 65 OS=Rattus norvegicus OX=10116 GN=Trim65 PE=4 SV=2 CANONICAL=D3ZY16-1" }, "isoforms": [ { "isoform_ac": "D3ZY16-1", "url": "", "sequence": { "sequence": "MWSCPGRPEGAAPQLPVRQKPDKGDLDPCQGTFRGTRAQRSRCPCALPSSWTVLRPSVASVPLRGLRTQDLASAMAVQLLEEDLVTCPICLGRYCDPVTLPCGHTFCGNCIQDSWRCCEKICPECRQPFPEGAKLSRNVKLSTLLQGLPAAIQRLESGTSQSARCPRHGRPLEFFCLTEGLCVCSACTVHDCSHHERALLDVERRVREDRLRARVMVTRQQATQAETQLEELQQQSSQIESSARTLASVVSRRFSSLLQVLEKQQASTLSDIEGAKKRALDQVLHERQRLTDHLKALSQYDQSVQDLLGQGDDFIFFQGLQQLSEPIGSLGPPTPPQWDEEEQLNSVNQLLSPLCELLLEEKTLPTAADKAASAGPMEALGPLAPVPSAMCPLRKKLWQNYRNLTFDPETANRYLLLSHKAQQVTHHFQAQSPARSGSFELWQVQCTQSFQTGQHYWEVRASDHSITLGVTYPELPRRKLGTHTDNIGRGPYSWGLCIQEDSIQAWHNGRAQRLSRAGVSGGLLGVDLNLTSGCLTFYSLEPHTQPLHTFYAVFSRPLFPVFWLLEGRTLSLCHQPEAELPPRPQEEAIAPS", "length": 592, "header": "tr|D3ZY16-1|D3ZY16_RAT Isoform 1 of Tripartite motif-containing 65 OS=Rattus norvegicus OX=10116 GN=Trim65 PE=4 SV=2 CANONICAL=D3ZY16-1" }, "locus": { "chromosome": "10", "start_pos": 101364163, "end_pos": 101358934, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000046026.6", "url": "https://www.ensembl.org/id/ENSRNOT00000046026.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000047932.4", "url": "https://www.ensembl.org/id/ENSRNOP00000047932.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "positive regulation of interferon-alpha production", "id": "GO:0032727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "positive regulation of protein phosphorylation", "id": "GO:0001934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "type I interferon-mediated signaling pathway", "id": "GO:0060337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060337", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "positive regulation of protein oligomerization", "id": "GO:0032461", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032461", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "protein K63-linked ubiquitination", "id": "GO:0070534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070534", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "D3ZY16", "url": "https://www.uniprot.org/uniprot/D3ZY16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }