{ "uniprot_canonical_ac": "D3ZVM4-1", "uniprot_ac": "D3ZVM4", "uniprot_id": "LIN41_RAT", "mass": { "chemical_mass": 92125.0, "monoisotopic_mass": 92125.0 }, "refseq": {}, "gene_names": [ { "name": "Trim71", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3ZVM4", "id": "D3ZVM4" }, { "name": "Lin41", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/D3ZVM4", "id": "D3ZVM4" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase TRIM71", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "D3ZVM4" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZVM4" }, { "name": "Protein lin-41 homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZVM4" }, { "name": "RING-type E3 ubiquitin transferase TRIM71", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZVM4" }, { "name": "Tripartite motif-containing protein 71", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZVM4" } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (By similarity). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (By similarity). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4#function" }, { "database": "UniProtKB", "id": "Q2Q1W2", "url": "https://www.uniprot.org/uniprot/Q2Q1W2#function" }, { "database": "UniProtKB", "id": "Q1PSW8", "url": "https://www.uniprot.org/uniprot/Q1PSW8#function" } ] } ], "disease": [ { "disease_id": "DOID:10908", "recommended_name": { "id": "DOID:10908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10908", "name": "hydrocephalus", "description": "A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head." }, "synonyms": [ { "id": "DOID:10908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10908", "name": "hydrocephalus, X-linked", "description": "" }, { "id": "DOID:10908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10908", "name": "hydrocephalus, nonsyndromic, autosomal recessive", "description": "" }, { "id": "MONDO:0007401", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007401", "name": "craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome", "description": "Craniosynostosis, Dandy-Walker malformation and hydrocephalus is a malformation disorder characterized by sagittal craniosynostosis, Dandy-Walker malformation, hydrocephalus, craniofacial dysmorphism (including dolichocephaly, hypertelorism, micrognathia, positional ear deformity) and variable developmental delay. The inheritance pattern appears to be autosomal dominant." }, { "id": "MONDO:0007401", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007401", "name": "Braddock-Jones-Superneau syndrome", "description": "" }, { "id": "MONDO:0007401", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007401", "name": "craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome", "description": "" }, { "id": "MONDO:0007401", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007401", "name": "Braddock Jones Superneau syndrome", "description": "" }, { "id": "MONDO:0007401", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007401", "name": "Dandy-Walker malformation with sagittal craniosynostosis and hydrocephalus", "description": "" }, { "id": "MONDO:0007401", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007401", "name": "HDCPH1", "description": "" }, { "id": "MONDO:0007401", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007401", "name": "hydrocephalus, autosomal dominant", "description": "" }, { "id": "MONDO:0007401", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007401", "name": "sagittal craniosynostosis, Dandy-Walker malformation and hydrocephalus", "description": "" }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "hydrocephalus, nonsyndromic, autosomal recessive 1", "description": "Any congenital hydrocephalus in which the cause of the disease is a mutation in the CCDC88C gene." }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "CCDC88C congenital hydrocephalus", "description": "" }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "congenital hydrocephalus caused by mutation in CCDC88C", "description": "" }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "hydrocephalus, congenital, 1", "description": "" }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "hydrocephalus, nonsyndromic, autosomal recessive 1", "description": "" }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "hydrocephalus, nonsyndromic, autosomal recessive type 1", "description": "" }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "HYC1", "description": "" }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "hydrocephaly", "description": "" }, { "id": "MONDO:0009360", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009360", "name": "ventriculomegaly", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "X-linked hydrocephalus with stenosis of the aqueduct of Sylvius", "description": "A form of L1 syndrome caused by changes in the L1CAM gene characterized by severe hydrocephalus mostly with prenatal onset, signs of intracranial hypertension, adducted thumbs, spasticity, and severe intellectual deficit. HSAS represents the severe end of the spectrum and is associated with poor prognosis." }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "Bickers-Adams syndrome", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "HSAS", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "X-linked HSAS", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "X-linked acqueductal stenosis", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "X-linked hydrocephalus", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "X-linked hydrocephalus with stenosis of aqueduct of Sylvius", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "X-linked hydrocephalus with stenosis of the aqueduct of Sylvius", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "hydrocephalus due to aqueductal stenosis, X-linked recessive", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "hydrocephalus with congenital idiopathic intestinal pseudoobstruction, X-linked recessive", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "hydrocephalus with hirschsprung disease, X-linked recessive", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "hydrocephalus with stenosis of the aqueduct of Sylvius", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "HSAS1", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "HYCX", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "XLAS", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "aqueductal stenosis, X-linked", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "hydrocephalus due to congenital stenosis of aqueduct of Sylvius", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "hydrocephalus, X-linked", "description": "" }, { "id": "MONDO:0010611", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010611", "name": "hydrocephalus, X-linked, with congenital idiopathic intestinal pseudoobstruction", "description": "" }, { "id": "MONDO:0009361", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009361", "name": "autosomal recessive hydrocephalus due to congenital stenosis of aqueduct of Sylvius", "description": "" }, { "id": "MONDO:0009361", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009361", "name": "hydrocephalus due to congenital stenosis of aqueduct of Sylvius", "description": "" }, { "id": "MONDO:0009361", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009361", "name": "aqueductal stenosis", "description": "" }, { "id": "MONDO:0014085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014085", "name": "hydrocephalus, nonsyndromic, autosomal recessive 2", "description": "Any congenital hydrocephalus in which the cause of the disease is a mutation in the MPDZ gene." }, { "id": "MONDO:0014085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014085", "name": "MPDZ congenital hydrocephalus", "description": "" }, { "id": "MONDO:0014085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014085", "name": "congenital hydrocephalus caused by mutation in MPDZ", "description": "" }, { "id": "MONDO:0014085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014085", "name": "hydrocephalus, congenital, 2, with or without brain or eye anomalies", "description": "" }, { "id": "MONDO:0014085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014085", "name": "hydrocephalus, nonsyndromic, autosomal recessive 2", "description": "" }, { "id": "MONDO:0014085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014085", "name": "hydrocephalus, nonsyndromic, autosomal recessive type 2", "description": "" }, { "id": "MONDO:0014085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014085", "name": "HYC2", "description": "" }, { "id": "MIM:236600", "resource": "MIM", "url": "https://www.omim.org/entry/236600", "name": "Hydrocephalus, congenital, 1", "description": "Hydrocephalus, congenital, 1" }, { "id": "MIM:307000", "resource": "MIM", "url": "https://www.omim.org/entry/307000", "name": "Hydrocephalus, congenital, X-linked", "description": "Hydrocephalus, congenital, X-linked" }, { "id": "MIM:615219", "resource": "MIM", "url": "https://www.omim.org/entry/615219", "name": "Hydrocephalus, congenital, 2, with or without brain or eye anomalies", "description": "Hydrocephalus, congenital, 2, with or without brain or eye anomalies" } ], "evidence": [ { "id": "10908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10908" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Trim71", "url": "https://www.uniprot.org/uniprot/D3ZVM4", "locus": { "chromosome": "8", "start_pos": 114199187, "end_pos": 114250807, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000030098", "url": "https://www.ensembl.org/id/ENSRNOG00000030098" } ] } } ], "crossref": [ { "id": "cd14954", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14954", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16589", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16589", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19796", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19796", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19812", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19812", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:301042", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301042", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QGEPRCS", "url": "https://omabrowser.org/oma/group/QGEPRCS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2901369at2759", "url": "http://www.orthodb.org/?query=2901369at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24104", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24104", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24104:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24104:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00630", "url": "http://pfam.xfam.org/family/PF00630", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00643", "url": "http://pfam.xfam.org/family/PF00643", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01436", "url": "http://pfam.xfam.org/family/PF01436", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_D3ZVM4", "url": "http://purl.obolibrary.org/obo/PR_D3ZVM4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1566388", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1566388", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZVM4-1", "url": "https://www.uniprot.org/uniprot/D3ZVM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASFPETDFQICLLCKEMCGSPAPLSSSSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRVMFTPPDQALYLALKSFGFVSSGAFAPLTKAAGDGIKRALQGKVASFTVMGYDHNGEPRLSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPVLSFGSEGDGEGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPEGLIVVVDFGNNRILIF", "length": 855, "header": "sp|D3ZVM4-1|LIN41_RAT Isoform 1 of E3 ubiquitin-protein ligase TRIM71 OS=Rattus norvegicus OX=10116 GN=Trim71 PE=3 SV=1 CANONICAL=D3ZVM4-1" }, "isoforms": [ { "isoform_ac": "D3ZVM4-1", "url": "", "sequence": { "sequence": "MASFPETDFQICLLCKEMCGSPAPLSSSSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRVMFTPPDQALYLALKSFGFVSSGAFAPLTKAAGDGIKRALQGKVASFTVMGYDHNGEPRLSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPVLSFGSEGDGEGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPEGLIVVVDFGNNRILIF", "length": 855, "header": "sp|D3ZVM4-1|LIN41_RAT Isoform 1 of E3 ubiquitin-protein ligase TRIM71 OS=Rattus norvegicus OX=10116 GN=Trim71 PE=3 SV=1 CANONICAL=D3ZVM4-1" }, "locus": { "chromosome": "8", "start_pos": 114250807, "end_pos": 114199190, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000047198", "url": "https://www.ensembl.org/id/ENSRNOT00000047198" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000044089", "url": "https://www.ensembl.org/id/ENSRNOP00000044089" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:301042", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301042", "resource": "KEGG Pathway" }, { "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q1PSW8-1", "protein_name": "E3 ubiquitin-protein ligase TRIM71", "gene_name": "Trim71", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATAEEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLMRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQALQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEDRECELLWKVEKIRQVKAKSLFLQVEKLRQSLSKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRIMFTPPDQALYLALKSIGFVSSGAFAPLTKATGDGIKRALQGKVASFTVMGYDHDGEPRHSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYIVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDGEGKLCRPWGVSVDKEGFIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIIVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNNEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGSGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPDGLIVVVDFGNNRILIF", "length": 855 }, "evidence": [ { "id": "D3ZVM4", "url": "https://omabrowser.org/oma/group/D3ZVM4/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q2Q1W2-1", "protein_name": "E3 ubiquitin-protein ligase TRIM71", "gene_name": "TRIM71", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSAPGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILVF", "length": 868 }, "evidence": [ { "id": "D3ZVM4", "url": "https://omabrowser.org/oma/group/D3ZVM4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "translation repressor activity", "id": "GO:0030371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030371", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "miRNA binding", "id": "GO:0035198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035198", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 19, "go_terms": [ { "name": "regulation of miRNA-mediated gene silencing", "id": "GO:0060964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060964", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "post-transcriptional regulation of gene expression", "id": "GO:0010608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010608", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "neural tube development", "id": "GO:0021915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021915", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "cellular response to organic substance", "id": "GO:0071310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071310", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "miRNA metabolic process", "id": "GO:0010586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010586", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "miRNA processing", "id": "GO:0035196", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035196", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "miRNA-mediated gene silencing by inhibition of translation", "id": "GO:0035278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035278", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "positive regulation of miRNA-mediated gene silencing", "id": "GO:2000637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000637", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "regulation of protein metabolic process", "id": "GO:0051246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051246", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "stem cell proliferation", "id": "GO:0072089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072089", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor signaling pathway", "id": "GO:0008543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008543", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "3'-UTR-mediated mRNA destabilization", "id": "GO:0061158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061158", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" }, { "name": "regulation of neural precursor cell proliferation", "id": "GO:2000177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000177", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 532, "end_pos": 534, "annotation": "n_glycosylation_sequon" }, { "start_pos": 811, "end_pos": 813, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Autoubiquitinated.", "evidence": [ { "database": "UniProtKB", "id": "D3ZVM4", "url": "https://www.uniprot.org/uniprot/D3ZVM4" }, { "database": "PubMed", "id": "Q1PSW8", "url": "https://glygen.org/publication/PubMed/Q1PSW8" } ] } ], "interactions": [], "reactions": [ { "id": "R-RNO-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983140" } ] }, { "id": "R-RNO-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "B2GV24-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "Q6J2U6-1", "Q99PD2-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983147" } ] }, { "id": "R-RNO-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983156" } ] }, { "id": "R-RNO-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JUC9", "gene_name": "Herc2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2JUC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JUC9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2JUC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JUC9" } ] } ] }, { "uniprot_ac": "A0A0G2K0E7", "gene_name": "Ube3b", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E7" } ] } ] }, { "uniprot_ac": "A0A0G2K612", "gene_name": "Smurf1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K612" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K612" } ] } ] }, { "uniprot_ac": "A0A0G2K6H9", "gene_name": "Rnf19b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A0G2K6H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6H9" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A0G2K6H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6H9" } ] } ] }, { "uniprot_ac": "A0A0G2K735", "gene_name": "Uba7", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A0G2K735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "A0A0G2K735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ] } ] }, { "uniprot_ac": "A0A0G2K9T1", "gene_name": "Itch", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9T1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9T1" } ] } ] }, { "uniprot_ac": "A0A0G2QC40", "gene_name": "Mkrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2QC40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC40" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A0G2QC40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC40" } ] } ] }, { "uniprot_ac": "A0A8I5YBG5", "gene_name": "Ubr2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8I5YBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5YBG5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A8I5YBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5YBG5" } ] } ] }, { "uniprot_ac": "A0A8I5ZZN6", "gene_name": "Ubr1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8I5ZZN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZN6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A8I5ZZN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZN6" } ] } ] }, { "uniprot_ac": "B1H278", "gene_name": "Trim11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "B1H278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H278" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "B1H278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H278" } ] } ] }, { "uniprot_ac": "B2GV24", "gene_name": "Ufl1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "B2GV24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV24" } ] } ] }, { "uniprot_ac": "B5DFI8", "gene_name": "Ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "B5DFI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFI8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "B5DFI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFI8" } ] } ] }, { "uniprot_ac": "D3Z8X6", "gene_name": "Dtx3l", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3Z8X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3Z8X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X6" } ] } ] }, { "uniprot_ac": "D3ZBM4", "gene_name": "Rnf182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZBM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZBM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM4" } ] } ] }, { "uniprot_ac": "D3ZBM7", "gene_name": "Hace1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM7" } ] } ] }, { "uniprot_ac": "D3ZDI6", "gene_name": "Mylip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZDI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDI6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZDI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDI6" } ] } ] }, { "uniprot_ac": "D3ZDK2", "gene_name": "Ube2d1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] } ] }, { "uniprot_ac": "D3ZFK0", "gene_name": "Rnf144b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZFK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFK0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZFK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFK0" } ] } ] }, { "uniprot_ac": "D3ZHB7", "gene_name": "Ube3c", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHB7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHB7" } ] } ] }, { "uniprot_ac": "D3ZJB8", "gene_name": "Arih2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJB8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJB8" } ] } ] }, { "uniprot_ac": "D3ZLS5", "gene_name": "Hectd1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLS5" } ] } ] }, { "uniprot_ac": "D3ZS02", "gene_name": "Cbll1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZS02" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZS02" } ] } ] }, { "uniprot_ac": "D3ZVM4", "gene_name": "Trim71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZVM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZVM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ] } ] }, { "uniprot_ac": "D3ZXK7", "gene_name": "Rnf123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZXK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXK7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZXK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXK7" } ] } ] }, { "uniprot_ac": "D3ZXM0", "gene_name": "Rnf19a", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXM0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXM0" } ] } ] }, { "uniprot_ac": "D4A1V8", "gene_name": "Dzip3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4A1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1V8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D4A1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1V8" } ] } ] }, { "uniprot_ac": "D4ABK2", "gene_name": "Rnf217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D4ABK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABK2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D4ABK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABK2" } ] } ] }, { "uniprot_ac": "D4ACF2", "gene_name": "Trim21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4ACF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACF2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D4ACF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACF2" } ] } ] }, { "uniprot_ac": "D4ADD3", "gene_name": "Hecw2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4ADD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADD3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D4ADD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADD3" } ] } ] }, { "uniprot_ac": "F1LP64", "gene_name": "Trip12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1LP64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP64" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1LP64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP64" } ] } ] }, { "uniprot_ac": "F1M3F2", "gene_name": "Smurf2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3F2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1M3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3F2" } ] } ] }, { "uniprot_ac": "F1M7B8", "gene_name": "Ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7B8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7B8" } ] } ] }, { "uniprot_ac": "F1M9Q3", "gene_name": "Ltn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9Q3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1M9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9Q3" } ] } ] }, { "uniprot_ac": "G3V930", "gene_name": "Rnf41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "G3V930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V930" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "G3V930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V930" } ] } ] }, { "uniprot_ac": "O88846", "gene_name": "Rnf4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O88846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88846" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O88846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88846" } ] } ] }, { "uniprot_ac": "P61078", "gene_name": "Ube2d3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] } ] }, { "uniprot_ac": "P62255", "gene_name": "Ube2g1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62255" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62255" } ] } ] }, { "uniprot_ac": "P62839", "gene_name": "Ube2d2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] } ] }, { "uniprot_ac": "P63149", "gene_name": "Ube2b", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63149" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63149" } ] } ] }, { "uniprot_ac": "Q2TL32", "gene_name": "Ubr4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TL32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TL32" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q2TL32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TL32" } ] } ] }, { "uniprot_ac": "Q3B7D1", "gene_name": "Ube2z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3B7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7D1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3B7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7D1" } ] } ] }, { "uniprot_ac": "Q3T1H6", "gene_name": "Ube3d", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3T1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3T1H6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3T1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3T1H6" } ] } ] }, { "uniprot_ac": "Q4V8J2", "gene_name": "Ube2l6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q4V8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8J2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q4V8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8J2" } ] } ] }, { "uniprot_ac": "Q5BK82", "gene_name": "Trim69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5BK82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK82" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5BK82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK82" } ] } ] }, { "uniprot_ac": "Q5PQN1", "gene_name": "Herc4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5PQN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQN1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5PQN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQN1" } ] } ] }, { "uniprot_ac": "Q5U203", "gene_name": "Ube2f", "activity": [ { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "Q5U203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U203" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "Q5U203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U203" } ] } ] }, { "uniprot_ac": "Q5XIQ4", "gene_name": "Mgrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XIQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIQ4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XIQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIQ4" } ] } ] }, { "uniprot_ac": "Q62921", "gene_name": "Rbck1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q62921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62921" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q62921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62921" } ] } ] }, { "uniprot_ac": "Q62940", "gene_name": "Nedd4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q62940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62940" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q62940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62940" } ] } ] }, { "uniprot_ac": "Q63364", "gene_name": "Pja2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q63364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63364" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q63364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63364" } ] } ] }, { "uniprot_ac": "Q66H79", "gene_name": "Trim32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q66H79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H79" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q66H79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H79" } ] } ] }, { "uniprot_ac": "Q68LP1", "gene_name": "Mib2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q68LP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68LP1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q68LP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68LP1" } ] } ] }, { "uniprot_ac": "Q6AYH3", "gene_name": "Rnf34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6AYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYH3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6AYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYH3" } ] } ] }, { "uniprot_ac": "Q6J2U6", "gene_name": "Rnf114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6J2U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J2U6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6J2U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J2U6" } ] } ] }, { "uniprot_ac": "Q6MFZ5", "gene_name": "Trim39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6MFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MFZ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6MFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MFZ5" } ] } ] }, { "uniprot_ac": "Q6P7A2", "gene_name": "Ube4a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6P7A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6P7A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A2" } ] } ] }, { "uniprot_ac": "Q6Y290", "gene_name": "Rnf130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6Y290", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Y290" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6Y290", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Y290" } ] } ] }, { "uniprot_ac": "Q71F54", "gene_name": "Sh3rf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q71F54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71F54" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q71F54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71F54" } ] } ] }, { "uniprot_ac": "Q810I1", "gene_name": "Trim50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q810I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q810I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I1" } ] } ] }, { "uniprot_ac": "Q8K4S7", "gene_name": "Cblb", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8K4S7", "database": "UniProtKB", "url": 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