{
    "uniprot_canonical_ac": "D3ZTB4-1",
    "uniprot_ac": "D3ZTB4",
    "uniprot_id": "D3ZTB4_RAT",
    "mass": {
        "chemical_mass": 107829.0,
        "monoisotopic_mass": 107829.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Vps11",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/D3ZTB4",
            "id": "D3ZTB4"
        }
    ],
    "protein_names": [
        {
            "name": "Vacuolar protein sorting-associated protein 11 homolog",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "D3ZTB4"
        }
    ],
    "function": [
        {
            "annotation": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D3ZTB4",
                    "url": "https://www.uniprot.org/uniprot/D3ZTB4#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "PIRNR007860",
                    "url": "https://www.uniprot.org/uniprot/PIRNR007860#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0060796",
            "recommended_name": {
                "id": "DOID:0060796",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0060796",
                "name": "hypomyelinating leukodystrophy 12",
                "description": "A hypomyelinating leukodystrophy characterized by autosomal recessive inheritance of severely delayed or even lack of psychomotor development that becomes apparent in the first months of life, acquired microcephaly and delayed myelination that has_material_basis_in homozygous mutation in the VPS11 gene on chromosome 11q23."
            },
            "synonyms": [
                {
                    "id": "DOID:0060796",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060796",
                    "name": "HLD12",
                    "description": ""
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "hypomyelinating leukodystrophy 12",
                    "description": "Any leukodystrophy in which the cause of the disease is a mutation in the VPS11 gene."
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "HLD12",
                    "description": ""
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "VPS11 leukodystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "VPS11-related autosomal recessive hypomyelinating leukoencephalopathy",
                    "description": ""
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "hypomyelinating leukodystrophy type 12",
                    "description": ""
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "leukodystrophy caused by mutation in VPS11",
                    "description": ""
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "leukodystrophy, hypomyelinating, 12",
                    "description": ""
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "leukodystrophy, hypomyelinating, type 12",
                    "description": ""
                },
                {
                    "id": "MONDO:0014732",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014732",
                    "name": "VPS11-related autosomal recessive hypomyelinating leukodystrophy",
                    "description": ""
                },
                {
                    "id": "MIM:616683",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/616683",
                    "name": "Leukodystrophy, hypomyelinating, 12",
                    "description": "Leukodystrophy, hypomyelinating, 12"
                }
            ],
            "evidence": [
                {
                    "id": "0060796",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060796"
                }
            ]
        },
        {
            "disease_id": "DOID:543",
            "recommended_name": {
                "id": "DOID:543",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:543",
                "name": "dystonia",
                "description": "A movement disease that is characterized by involuntary muscle contractions causing repetitive or twisting movements."
            },
            "synonyms": [
                {
                    "id": "DOID:543",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:543",
                    "name": "dystonic disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "early-onset generalized limb-onset dystonia",
                    "description": "A rare movement disorder characterized by involuntary, repetitive, sustained muscle contractions or postures involving one or more sites of the body."
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "DYT-TOR1A",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "DYT1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "EOTD",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "Oppenheim dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "Oppenheim's dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "dystonia musculorum deformans",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "dystonia-1, torsion",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "early onset primary dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "early onset torsion dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "early-onset generalised torsion dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "early-onset generalized limb-onset dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "early-onset generalized torsion dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "early-onset primary dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "early-onset torsion dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "idiopathic dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "torsion dystonia type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "DYT-TOR1A dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "Dyt1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "Early-onset Primary dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "Early-onset torsion dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "Primary torsion dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "dystonia 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "dystonia 1, torsion, Autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "dystonia 1, torsion, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "dystonia musculorum deformans 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "idiopathic dystonia DYT1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "idiopathic torsion dystonia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "torsion dystonia 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007492",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007492",
                    "name": "torsion dystonia 1, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MIM:128100",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/128100",
                    "name": "Dystonia 1, torsion, autosomal dominant",
                    "description": "Dystonia 1, torsion, autosomal dominant"
                }
            ],
            "evidence": [
                {
                    "id": "543",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:543"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D3ZTB4",
                    "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Vps11",
            "url": "https://www.uniprot.org/uniprot/D3ZTB4",
            "locus": {
                "chromosome": "8",
                "start_pos": 44684127,
                "end_pos": 44698568,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000010733",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000010733"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000010733",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010733",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd16688",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16688",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "315600",
            "url": "https://www.ncbi.nlm.nih.gov/gene/315600",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "D3ZTB4",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:D3ZTB4*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000547",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000547",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001841",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011990",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015943",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016024",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016528",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016528",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR024763",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024763",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036322",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:315600",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315600",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "ENECPAC",
            "url": "https://omabrowser.org/oma/group/ENECPAC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5491867at2759",
            "url": "http://www.orthodb.org/?query=5491867at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23323",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23323",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23323:SF24",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23323:SF24",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00637",
            "url": "http://pfam.xfam.org/family/PF00637",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF12451",
            "url": "http://pfam.xfam.org/family/PF12451",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13923",
            "url": "http://pfam.xfam.org/family/PF13923",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_006242999",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006242999",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1308038",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308038",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "D3ZTB4",
            "url": "https://www.uniprot.org/uniprot/D3ZTB4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZTB4-1",
            "url": "https://www.uniprot.org/uniprot/D3ZTB4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAYLQWRRFVFFEKELVKEPLGNDGATPGAAPTSGPTASKFLCLPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLCTRILPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGSYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIAHWFRGYLVIVSRDRKVSPKSEFTSRDSQNSDKQILNIYDLCNKFIAYSAVFEDVVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKILMHHIPEQTTQLLKGLCTDYRPSLEGRGDREFPSCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQAKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAAVLRHIENKSLMPPLLVVQTLAHNSTATLSIIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTPSLEAGLQRDLLMHSRRGT",
        "length": 941,
        "header": "tr|D3ZTB4-1|D3ZTB4_RAT Isoform 1 of Vacuolar protein sorting-associated protein 11 homolog  OS=Rattus norvegicus OX=10116 GN=Vps11 PE=3 SV=2 CANONICAL=D3ZTB4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D3ZTB4-1",
            "url": "",
            "sequence": {
                "sequence": "MAAYLQWRRFVFFEKELVKEPLGNDGATPGAAPTSGPTASKFLCLPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLCTRILPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGSYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIAHWFRGYLVIVSRDRKVSPKSEFTSRDSQNSDKQILNIYDLCNKFIAYSAVFEDVVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKILMHHIPEQTTQLLKGLCTDYRPSLEGRGDREFPSCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQAKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAAVLRHIENKSLMPPLLVVQTLAHNSTATLSIIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTPSLEAGLQRDLLMHSRRGT",
                "length": 941,
                "header": "tr|D3ZTB4-1|D3ZTB4_RAT Isoform 1 of Vacuolar protein sorting-associated protein 11 homolog  OS=Rattus norvegicus OX=10116 GN=Vps11 PE=3 SV=2 CANONICAL=D3ZTB4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 44698533,
                "end_pos": 44684455,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000065456.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000065456.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000061998.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000061998.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:315600",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315600",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q91W86-1",
            "protein_name": "Vacuolar protein sorting-associated protein 11 homolog",
            "gene_name": "Vps11",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAAYLQWRRFVFFEKELVKEPLGNDGAAPGAAPVSGSAASKFLCLPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLCTRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGNYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIVHWFRGYLVIVSRDRKVSPKSEFTSRDSQNSDKQILNIYDLCNKFIAYSAGFEDIVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKTLMHHIPEQTTQLLKGLCTDYRPSLEGRGDREALSCRASSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQAKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAAVLRHIENKSLMPPLLVVQTLAHNSTATLSIIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTPSLEAGLQRDLLMHSRRGT",
                "length": 941
            },
            "evidence": [
                {
                    "id": "45233852",
                    "url": "http://www.informatics.jax.org/homology/45233852",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9H270-1",
            "protein_name": "Vacuolar protein sorting-associated protein 11 homolog",
            "gene_name": "VPS11",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAAYLQWRRFVFFDKELVKEPLSNDGAAPGATPASGSAASKFLCLPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLCTRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGNYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIAHWFRGYLIIVSRDRKVSPKSEFTSRDSQSSDKQILNIYDLCNKFIAYSTVFEDVVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKKKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKILMHHIPEQTTQLLKGLCTDYRPSLEGRSDREAPGCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQVKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVISVCERHGEQDPSLWEQALSYFARKEEDCKEYVAAVLKHIENKNLMPPLLVVQTLAHNSTATLSVIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLRCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTSSLEAGLQRDLLMHSRRGT",
                "length": 941
            },
            "evidence": [
                {
                    "id": "45233852",
                    "url": "http://www.informatics.jax.org/homology/45233852",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 13,
                "go_terms": [
                    {
                        "name": "organelle fusion",
                        "id": "GO:0048284",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048284",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of organelle assembly",
                        "id": "GO:1902115",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902115",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular protein transport",
                        "id": "GO:0006886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "autophagy",
                        "id": "GO:0006914",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome organization",
                        "id": "GO:0007032",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome to lysosome transport",
                        "id": "GO:0008333",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of protein catabolic process",
                        "id": "GO:0045732",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosomal vesicle fusion",
                        "id": "GO:0034058",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034058",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "vacuole organization",
                        "id": "GO:0007033",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007033",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of intracellular estrogen receptor signaling pathway",
                        "id": "GO:0033147",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033147",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of early endosome to late endosome transport",
                        "id": "GO:2000643",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000643",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "vesicle docking involved in exocytosis",
                        "id": "GO:0006904",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006904",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 14,
                "go_terms": [
                    {
                        "name": "HOPS complex",
                        "id": "GO:0030897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome",
                        "id": "GO:0005768",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "early endosome",
                        "id": "GO:0005769",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "actin filament",
                        "id": "GO:0005884",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lysosome",
                        "id": "GO:0005764",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lysosomal membrane",
                        "id": "GO:0005765",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "late endosome membrane",
                        "id": "GO:0031902",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "presynaptic active zone",
                        "id": "GO:0048786",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048786",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "late endosome",
                        "id": "GO:0005770",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "clathrin-coated vesicle",
                        "id": "GO:0030136",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endocytic vesicle",
                        "id": "GO:0030139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "autophagosome",
                        "id": "GO:0005776",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "AP-3 adaptor complex",
                        "id": "GO:0030123",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030123",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "CORVET complex",
                        "id": "GO:0033263",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033263",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "protein domain specific binding",
                        "id": "GO:0019904",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein-macromolecule adaptor activity",
                        "id": "GO:0030674",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "syntaxin binding",
                        "id": "GO:0019905",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase activity",
                        "id": "GO:0061630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZTB4",
                                "url": "https://www.uniprot.org/uniprot/D3ZTB4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 435,
            "end_pos": 437,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 747,
            "end_pos": 749,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 763,
            "end_pos": 765,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 892,
            "end_pos": 894,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycans",
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
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                }
            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_predicted",
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                    "field": "total",
                    "count": 0
                },
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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            ],
            "sort_fields": []
        },
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