{ "uniprot_canonical_ac": "D3ZQ99-1", "uniprot_ac": "D3ZQ99", "uniprot_id": "D3ZQ99_RAT", "mass": { "chemical_mass": 130088.0, "monoisotopic_mass": 130088.0 }, "refseq": {}, "gene_names": [ { "name": "Prdm15", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3ZQ99", "id": "D3ZQ99" } ], "protein_names": [ { "name": "PR/SET domain 15", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZQ99" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "common_name": "Rat" } ], "gene": [ { "name": "Prdm15", "url": "https://www.uniprot.org/uniprot/D3ZQ99", "locus": { "chromosome": "11", "start_pos": 37165575, "end_pos": 37222207, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000001620", "url": "https://www.ensembl.org/id/ENSRNOG00000001620" } ] } } ], "crossref": [ { "id": "ENSRNOG00000001620", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001620", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19199", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19199", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ERGPWAC", "url": "https://omabrowser.org/oma/group/ERGPWAC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5400229at2759", "url": "http://www.orthodb.org/?query=5400229at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "http://pfam.xfam.org/family/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_017453588", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017453588", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1310055", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310055", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZYR1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZYR1-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZQ99-1", "url": "https://www.uniprot.org/uniprot/D3ZQ99-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEDGSEEIMFIWCEDCSQYHDSECPELGPVVMVKDSFVLSRARSSLPSNLEIRRLDDGAEGVFAVTQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLVRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKMDKPMLKQACSSVQAAGTPEPSVTVEPERAQWVCKVCSNTFLELQLLNEHLLGHLEQSKSLPAGGQQQEAASEKEPDAPRMEPPTAVESKSMQSATVTKEPKKKPRRGRKPKASKVEQPLVIIKDKEPAEHVAEIITEVPPDEPVNATPDERIMELVLGKLATPTSEASSVPKFLHHPSSTIALKRGLVLSSRHGVRRKLVRQLGEHKRIHQCGTCSKVFQNSSNLSRHVRSHGECAHGDKLFKCEECSKLFSRKESLKQHVSYKHSRNEVDGEYRYRCGSCGKTFRMESALEFHNCRTDDKTFQCEMCFRFFSTNSNLSKHKKKHGDKKFACEVCSKMFYRKDVMLDHQRRHLDGVRRVKREDLEASGESLVRYKKEPSGCPVCGKVFSCRSNMNKHLLTHGDKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSEENDDNSDESADSEPHKYSCKRCQLTFGRGKEYLKHIMEVHKEKGHGCSICHRRFALKATYHAHMVIHRENLPDPNVQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNIREYLCAECGKGMKTKHALRHHMKLHKGIKEYECKECHRKFAQKVNMLKHYKRHTGIKDFMCELCGKTFSERNTMETHKLIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLDHLPETTTIDASSIGIVQPALGLEQEELAEGKHGKAAKRSHKRKQKPEEEAGAAVPEDTTFSEYPEKEPEFTGSVGDETNSAVQSIQQVVVTLGDPNVTAPSSSVGLTNITVTPITTAAGTQFTNLQPVAVGHLTNPERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIHPQPEATNPQSVAHFINLTTLVNSITPLGNQLSEQHPLTWRAVPQTDVLQPPQAPAAPQQAVQPQVQNEQQQMYSY", "length": 1148, "header": "tr|D3ZQ99-1|D3ZQ99_RAT Isoform 1 of PR/SET domain 15 OS=Rattus norvegicus OX=10116 GN=Prdm15 PE=4 SV=3 CANONICAL=D3ZQ99-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZYR1-1", "url": "", "sequence": { "sequence": "MAEDGSEEIMFIWCEDCSQYHDSECPELGPVVMVKDSFVLSRARSSLPSNLEIRRLDDGAEGVFAVTQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLVRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKMDKPMLKQACSSVQEHLLGHLEQSKSLPAGGQQQEAASEKEPDAPRMEPPTAVESKSMQSATVTKEPKKKPRRGRKPKASKVEQPLVIIKDKEPAEHVAEIITEVPPDEPVNATPDERIMELVLGKLATPTSEASSVPKFLHHPSSTIALKRGLVLSSRHGVRRKLVRQLGEHKRIHQCGTCSKVFQNSSNLSRHVRSHGDKLFKCEECSKLFSRKESLKQHVSYKHSRNEVDGEYRYRCGSCGKTFRMESALEFHNCRTDDKTFQCEMCFRFFSTNSNLSKHKKKHGDKKFACEVCSKMFYRKDVMLDHQRRHLDGVRRVKREDLEASGESLVRYKKEPSGCPVCGKVFSCRSNMNKHLLTHGDKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSEENDDNSDESADSEPHKYSCKRCQLTFGRGKEYLKHIMEVHKEKGHGCSICHRRFALKATYHAHMVIHRENLPDPNVQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNIREYLCAECGKGMKTKHALRHHMKLHKGIKEYECKECHRKFAQKVNMLKHYKRHTGIKDFMCELCGKTFSERNTMETHKLIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLDHLPETTTIDASSIGIVQPALGLEQEELAEGKHGKAAKRSHKRKQKPEEEAGAAVPEDTTFSEYPEKEPEFTGSVGDETNSAVQSIQQVVVTLGDPNVTAPSSSVGLTNITVTPITTAAGTQFTNLQPVAVGHLTNPERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIHPQPEATNPQSVAHFINLTTLVNSITPLGNQLSEQHPLTWRAVPQTDVLQPPQAPAAPQQAVQPQVQNEQQQMYSY", "length": 1109, "header": "tr|A0A8I5ZYR1-1|A0A8I5ZYR1_RAT Computationally mapped isoform of PR/SET domain 15 OS=Rattus norvegicus OX=10116 GN=Prdm15 PE=4 SV=1 CANONICAL=D3ZQ99-1" }, "locus": { "chromosome": "11", "start_pos": 37212074, "end_pos": 37167259, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000114092.1", "url": "https://www.ensembl.org/id/ENSRNOT00000114092.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000084210.1", "url": "https://www.ensembl.org/id/ENSRNOP00000084210.1" } ] } }, { "isoform_ac": "D3ZQ99-1", "url": "", "sequence": { "sequence": "MAEDGSEEIMFIWCEDCSQYHDSECPELGPVVMVKDSFVLSRARSSLPSNLEIRRLDDGAEGVFAVTQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLVRPALEPGHQNLTAYQHGSDVYFTTSKDIPAGTELRVWYAAFYAKKMDKPMLKQACSSVQAAGTPEPSVTVEPERAQWVCKVCSNTFLELQLLNEHLLGHLEQSKSLPAGGQQQEAASEKEPDAPRMEPPTAVESKSMQSATVTKEPKKKPRRGRKPKASKVEQPLVIIKDKEPAEHVAEIITEVPPDEPVNATPDERIMELVLGKLATPTSEASSVPKFLHHPSSTIALKRGLVLSSRHGVRRKLVRQLGEHKRIHQCGTCSKVFQNSSNLSRHVRSHGECAHGDKLFKCEECSKLFSRKESLKQHVSYKHSRNEVDGEYRYRCGSCGKTFRMESALEFHNCRTDDKTFQCEMCFRFFSTNSNLSKHKKKHGDKKFACEVCSKMFYRKDVMLDHQRRHLDGVRRVKREDLEASGESLVRYKKEPSGCPVCGKVFSCRSNMNKHLLTHGDKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSEENDDNSDESADSEPHKYSCKRCQLTFGRGKEYLKHIMEVHKEKGHGCSICHRRFALKATYHAHMVIHRENLPDPNVQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNIREYLCAECGKGMKTKHALRHHMKLHKGIKEYECKECHRKFAQKVNMLKHYKRHTGIKDFMCELCGKTFSERNTMETHKLIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLDHLPETTTIDASSIGIVQPALGLEQEELAEGKHGKAAKRSHKRKQKPEEEAGAAVPEDTTFSEYPEKEPEFTGSVGDETNSAVQSIQQVVVTLGDPNVTAPSSSVGLTNITVTPITTAAGTQFTNLQPVAVGHLTNPERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIHPQPEATNPQSVAHFINLTTLVNSITPLGNQLSEQHPLTWRAVPQTDVLQPPQAPAAPQQAVQPQVQNEQQQMYSY", "length": 1148, "header": "tr|D3ZQ99-1|D3ZQ99_RAT Isoform 1 of PR/SET domain 15 OS=Rattus norvegicus OX=10116 GN=Prdm15 PE=4 SV=3 CANONICAL=D3ZQ99-1" }, "locus": { "chromosome": "11", "start_pos": 37212074, "end_pos": 37167259, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000046318.6", "url": "https://www.ensembl.org/id/ENSRNOT00000046318.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000041592.5", "url": "https://www.ensembl.org/id/ENSRNOP00000041592.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "negative regulation of MAPK cascade", "id": "GO:0043409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043409", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "regulation of stem cell division", "id": "GO:2000035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000035", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" }, { "name": "cell fate commitment", "id": "GO:0045165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045165", "evidence": [ { "database": "UniProtKB", "id": "D3ZQ99", "url": "https://www.uniprot.org/uniprot/D3ZQ99" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1011, "end_pos": 1013, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1089, "end_pos": 1091, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" }, { "start_pos": 999, "end_pos": 1001, "annotation": 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