{
    "uniprot_canonical_ac": "D3ZPB8-1",
    "uniprot_ac": "D3ZPB8",
    "uniprot_id": "D3ZPB8_RAT",
    "mass": {
        "chemical_mass": 31555.0,
        "monoisotopic_mass": 31555.0
    },
    "refseq": {
        "ac": "NP_001101434",
        "name": "transmembrane protein 53",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101434"
    },
    "gene_names": [
        {
            "name": "Tmem53",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/D3ZPB8",
            "id": "D3ZPB8"
        },
        {
            "name": "RGD1307066",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101434",
            "id": "NP_001101434"
        },
        {
            "name": "Tmem53",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101434",
            "id": "NP_001101434"
        }
    ],
    "protein_names": [
        {
            "name": "Transmembrane protein 53",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "D3ZPB8"
        },
        {
            "name": "transmembrane protein 53 isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238727",
            "id": "XP_006238727"
        },
        {
            "name": "transmembrane protein 53",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101434",
            "id": "NP_001101434"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0112340",
            "recommended_name": {
                "id": "DOID:0112340",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112340",
                "name": "craniotubular dysplasia Ikegawa type",
                "description": "A craniodiaphyseal dysplasia characterized by childhood-onset short stature in association with macrocephaly, dolichocephaly, or prominent forehead that has_material_basis_in homozygous or compound heterozygous mutation in the TMEM53 gene on chromosome 1p34.1."
            },
            "synonyms": [
                {
                    "id": "DOID:0112340",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112340",
                    "name": "CTDI",
                    "description": ""
                },
                {
                    "id": "MONDO:0859226",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0859226",
                    "name": "craniotubular dysplasia, Ikegawa type",
                    "description": ""
                },
                {
                    "id": "MIM:619727",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/619727",
                    "name": "Craniotubular dysplasia, Ikegawa type",
                    "description": "Craniotubular dysplasia, Ikegawa type"
                }
            ],
            "evidence": [
                {
                    "id": "0112340",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112340"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D3ZPB8",
                    "url": "https://www.uniprot.org/uniprot/D3ZPB8"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Tmem53",
            "url": "https://www.uniprot.org/uniprot/D3ZPB8",
            "locus": {
                "chromosome": "5",
                "start_pos": 130737692,
                "end_pos": 130721659,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000019186",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000019186"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000019186",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019186",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "313529",
            "url": "https://www.ncbi.nlm.nih.gov/gene/313529",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR008547",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008547",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029058",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:313529",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313529",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "SPHVKHY",
            "url": "https://omabrowser.org/oma/group/SPHVKHY/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "10602at2759",
            "url": "http://www.orthodb.org/?query=10602at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12265",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12265",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12265:SF30",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12265:SF30",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05705",
            "url": "http://pfam.xfam.org/family/PF05705",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001101434",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101434",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1307066",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307066",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K1Q4",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1Q4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K1Q4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K1Q4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5YBB7",
            "url": "https://www.uniprot.org/uniprot/A0A8I5YBB7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I5YBB7-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5YBB7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6G340",
            "url": "https://www.uniprot.org/uniprot/A0A8I6G340",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6G340-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6G340-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZPB8",
            "url": "https://www.uniprot.org/uniprot/D3ZPB8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZPB8-1",
            "url": "https://www.uniprot.org/uniprot/D3ZPB8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MASAELDYSIEIPDQPCWSQKNSQGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVVAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSDLIGALRALATILERRPAVLRLLLLAAFALVVVLFHFLFAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEERLAHQVSVRGVDFVTSAHVSHLRDYPTYYTSLCVDFMHNCVQC",
        "length": 276,
        "header": "tr|D3ZPB8-1|D3ZPB8_RAT Isoform 1 of Transmembrane protein 53  OS=Rattus norvegicus OX=10116 GN=Tmem53 PE=3 SV=1 CANONICAL=D3ZPB8-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K1Q4-1",
            "url": "",
            "sequence": {
                "sequence": "MGPDGKNSQGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVVAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSDLIGALRALATILERRPAVLRLLLLAAFALVVVLFHFLFAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEERLAHQVSVRGVDFVTSAHVSHLRDYPTYYTSLCVDFMHNCVQC",
                "length": 261,
                "header": "tr|A0A0G2K1Q4-1|A0A0G2K1Q4_RAT Computationally mapped isoform of Transmembrane protein 53  OS=Rattus norvegicus OX=10116 GN=Tmem53 PE=3 SV=2 CANONICAL=D3ZPB8-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 130737301,
                "end_pos": 130722857,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000087764.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000087764.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000071938.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000071938.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5YBB7-1",
            "url": "",
            "sequence": {
                "sequence": "VEEWLESGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVVAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSDLIGALRALATILERRPAVLRLLLLAAFALVVVLFHFLFAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEERLAHQVSVRGVDFVTSAHVSHLRDYPTYYTSLCVDFMHNCVQC",
                "length": 259,
                "header": "tr|A0A8I5YBB7-1|A0A8I5YBB7_RAT Computationally mapped isoform of Transmembrane protein 53  OS=Rattus norvegicus OX=10116 GN=Tmem53 PE=1 SV=1 CANONICAL=D3ZPB8-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 130737301,
                "end_pos": 130733073,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000102293.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000102293.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000076469.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000076469.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6G340-1",
            "url": "",
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                "sequence": "MEELEKNSQGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVVAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSDLIGALRALATILERRPAVLRLLLLAAFALVVVLFHFLFAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEERLAHQVSVRGVDFVTSAHVSHLRDYPTYYTSLCVDFMHNCVQC",
                "length": 261,
                "header": "tr|A0A8I6G340-1|A0A8I6G340_RAT Computationally mapped isoform of Transmembrane protein 53  OS=Rattus norvegicus OX=10116 GN=Tmem53 PE=1 SV=1 CANONICAL=D3ZPB8-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 130737301,
                "end_pos": 130727683,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000094823.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000094823.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000079317.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000079317.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3ZPB8-1",
            "url": "",
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                "sequence": "MASAELDYSIEIPDQPCWSQKNSQGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVVAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSDLIGALRALATILERRPAVLRLLLLAAFALVVVLFHFLFAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEERLAHQVSVRGVDFVTSAHVSHLRDYPTYYTSLCVDFMHNCVQC",
                "length": 276,
                "header": "tr|D3ZPB8-1|D3ZPB8_RAT Isoform 1 of Transmembrane protein 53  OS=Rattus norvegicus OX=10116 GN=Tmem53 PE=3 SV=1 CANONICAL=D3ZPB8-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 130737301,
                "end_pos": 130722223,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000025990.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000025990.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000025990.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000025990.4"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:313529",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313529",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6P2H8-1",
            "protein_name": "Transmembrane protein 53",
            "gene_name": "TMEM53",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MASAELDYTIEIPDQPCWSQKNSPSPGGKEAETRQPVVILLGWGGCKDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVLAQKLLELLFDYEIEKEPLLFHVFSNGGVMLYRYVLELLQTRRFCRLRVVGTIFDSAPGDSNLVGALRALAAILERRAAMLRLLLLVAFALVVVLFHVLLAPITALFHTHFYDRLQDAGSRWPELYLYSRADEVVLARDIERMVEARLARRVLARSVDFVSSAHVSHLRDYPTYYTSLCVDFMRNCVRC",
                "length": 277
            },
            "evidence": [
                {
                    "id": "45232908",
                    "url": "http://www.informatics.jax.org/homology/45232908",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9D0Z3-1",
            "protein_name": "Transmembrane protein 53",
            "gene_name": "Tmem53",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MASAELDYSIEIPDQPCWSQKNRQGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVIAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSNLIGALRALATILERRPAVLRLLLLAAFALVVILFHFLLAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEARLAHQVMVRGVDFVSSAHVSHLRDYPTYYTSLCVDFMHNCVQC",
                "length": 276
            },
            "evidence": [
                {
                    "id": "45232908",
                    "url": "http://www.informatics.jax.org/homology/45232908",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nuclear membrane",
                        "id": "GO:0031965",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZPB8",
                                "url": "https://www.uniprot.org/uniprot/D3ZPB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear outer membrane",
                        "id": "GO:0005640",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005640",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZPB8",
                                "url": "https://www.uniprot.org/uniprot/D3ZPB8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "regulation of nucleocytoplasmic transport",
                        "id": "GO:0046822",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046822",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZPB8",
                                "url": "https://www.uniprot.org/uniprot/D3ZPB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of BMP signaling pathway",
                        "id": "GO:0030514",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZPB8",
                                "url": "https://www.uniprot.org/uniprot/D3ZPB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of osteoblast differentiation",
                        "id": "GO:0045668",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045668",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZPB8",
                                "url": "https://www.uniprot.org/uniprot/D3ZPB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of ossification",
                        "id": "GO:0030279",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030279",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZPB8",
                                "url": "https://www.uniprot.org/uniprot/D3ZPB8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
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                    "field": "total",
                    "count": 0
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                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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            "sort_fields": []
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        {
            "table_id": "glycosylation_reported",
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                {
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                {
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        {
            "table_id": "glycosylation_reported_with_glycan",
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