{ "uniprot_canonical_ac": "D3ZP31-1", "uniprot_ac": "D3ZP31", "uniprot_id": "D3ZP31_RAT", "mass": { "chemical_mass": 112976.0, "monoisotopic_mass": 112976.0 }, "refseq": { "ac": "NP_001165635", "name": "NLR family, pyrin domain containing 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165635" }, "gene_names": [ { "name": "Nlrp4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3ZP31", "id": "D3ZP31" }, { "name": "Nalp4; Nlrp4e; RGD1563529; RGD1564841", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165635", "id": "NP_001165635" }, { "name": "Nlrp4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165635", "id": "NP_001165635" } ], "protein_names": [ { "name": "NLR family, pyrin domain containing 4E; NACHT, leucine rich repeat and PYD containing 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165635", "id": "NP_001165635" }, { "name": "NLR family, pyrin domain containing 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165635", "id": "NP_001165635" }, { "name": "NLR family, pyrin domain containing 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZP31" } ], "function": [ { "annotation": "NLRP4 is an important mediator of cardiac remodeling in vitro and in vivo.", "evidence": [ { "database": "RefSeq", "id": "NP_001165635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165635" }, { "database": "PubMed", "id": "28486191", "url": "https://glygen.org/publication/PubMed/28486191" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZP31", "url": "https://www.uniprot.org/uniprot/D3ZP31" } ], "common_name": "Rat" } ], "gene": [ { "name": "Nlrp4", "url": "https://www.uniprot.org/uniprot/D3ZP31", "locus": { "chromosome": "1", "start_pos": 68089321, "end_pos": 68127521, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000021996", "url": "https://www.ensembl.org/id/ENSRNOG00000021996" } ] } } ], "crossref": [ { "id": "ENSRNOG00000021996", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000021996", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08320", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08320", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "499069", "url": "https://www.ncbi.nlm.nih.gov/gene/499069", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:499069", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499069", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "THPDCRV", "url": "https://omabrowser.org/oma/group/THPDCRV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45690", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45690", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45690:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45690:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02758", "url": "http://pfam.xfam.org/family/PF02758", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05729", "url": "http://pfam.xfam.org/family/PF05729", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "http://pfam.xfam.org/family/PF13516", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17776", "url": "http://pfam.xfam.org/family/PF17776", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17779", "url": "http://pfam.xfam.org/family/PF17779", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-3134975", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3134975", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-3270619", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3270619", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001165635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165635", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1563529", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563529", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "D3ZP31", "url": "https://www.uniprot.org/uniprot/D3ZP31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZP31-1", "url": "https://www.uniprot.org/uniprot/D3ZP31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASFFSDFGLMWYLEELNKKEFVKFKEFLKQEILQLRLKQISWTKVKKASREDLANLLLKHYEEKQAWDMTFKIFQKMNRKDLIERAGREIAGHSKLYQAHLKKKLTHDYARKFNIKAQDLFKQKFTQDDCDRFENLLVSKATGKKPHMVFLQGVAGIGKSLMLTKLMLAWSEGIVFQNKFSYIFYFCCQDVKQLKRASLAELISREWPNASAPTAEILSQPEKLLFIIDSLEVMECNMSERESELCDNCTEKQPVSLLLSSLLRRKMLPESSFLISATPETFEKMEDRIECTNVKIITGFNENNIKMYFRSLFQDKNRTLEAFSLVRENEQLFNVCQVPVLCWMVATCIKKEIEKGRDPVFICRRTTSLYTTHIFNLFTPQNAQYPSKKSQDQLQGLCSLAAEGMWTDTFVFSEEALRRNGILDSDIPTLLDRRILERSKESESCYIFLHPSLQEVCAAVFYLLKSHLDHPSQDVKSVEALLFTFLKKAKVQWIFLGCFLFGLLHESEQEKLEMFFGHQLSQEIKHQLYQCLETISVNEELQEQIDGMKLFYCLFEMEDEAFLMQAMNCMEQINFVAKDYSDVIVAAYCLKHCSTLKKLSFSTQNILSEEQEHSYTEKLLICWHHMCSVLISSKDIHVLQVKDTNLNETAFWVLYNHLKYPSCTLKVLVVNNVTFLCDNHLFFELIQNQRLQHLNLSLTFLSHSDVKLLCDVLNQAECNIEKLMIAACNLSPDDCKVFASVLISSKMLKHLNLSSNNLDKGISSLCKALCHPDCILKHLVLANCSLSEQCWDYLSEVVRRNKTLSHLDISSNDLKDEGLKVLCGALTLPDSGLISLSVRHCLITTSGCQDLAEVLRHNQNLRSLQVSNNKIEDAGVKLLCDAIKQPNCHLENIGLEACELTGACCKDLASAFVHCKTLWGINLLENALDHSGLVVLFEALKQQKCTLHVLGLRITDFDKETQEFLIAEEEKNPYLSILSNV", "length": 982, "header": "tr|D3ZP31-1|D3ZP31_RAT Isoform 1 of NLR family, pyrin domain containing 4 OS=Rattus norvegicus OX=10116 GN=Nlrp4 PE=3 SV=4 CANONICAL=D3ZP31-1" }, "isoforms": [ { "isoform_ac": "D3ZP31-1", "url": "", "sequence": { "sequence": "MASFFSDFGLMWYLEELNKKEFVKFKEFLKQEILQLRLKQISWTKVKKASREDLANLLLKHYEEKQAWDMTFKIFQKMNRKDLIERAGREIAGHSKLYQAHLKKKLTHDYARKFNIKAQDLFKQKFTQDDCDRFENLLVSKATGKKPHMVFLQGVAGIGKSLMLTKLMLAWSEGIVFQNKFSYIFYFCCQDVKQLKRASLAELISREWPNASAPTAEILSQPEKLLFIIDSLEVMECNMSERESELCDNCTEKQPVSLLLSSLLRRKMLPESSFLISATPETFEKMEDRIECTNVKIITGFNENNIKMYFRSLFQDKNRTLEAFSLVRENEQLFNVCQVPVLCWMVATCIKKEIEKGRDPVFICRRTTSLYTTHIFNLFTPQNAQYPSKKSQDQLQGLCSLAAEGMWTDTFVFSEEALRRNGILDSDIPTLLDRRILERSKESESCYIFLHPSLQEVCAAVFYLLKSHLDHPSQDVKSVEALLFTFLKKAKVQWIFLGCFLFGLLHESEQEKLEMFFGHQLSQEIKHQLYQCLETISVNEELQEQIDGMKLFYCLFEMEDEAFLMQAMNCMEQINFVAKDYSDVIVAAYCLKHCSTLKKLSFSTQNILSEEQEHSYTEKLLICWHHMCSVLISSKDIHVLQVKDTNLNETAFWVLYNHLKYPSCTLKVLVVNNVTFLCDNHLFFELIQNQRLQHLNLSLTFLSHSDVKLLCDVLNQAECNIEKLMIAACNLSPDDCKVFASVLISSKMLKHLNLSSNNLDKGISSLCKALCHPDCILKHLVLANCSLSEQCWDYLSEVVRRNKTLSHLDISSNDLKDEGLKVLCGALTLPDSGLISLSVRHCLITTSGCQDLAEVLRHNQNLRSLQVSNNKIEDAGVKLLCDAIKQPNCHLENIGLEACELTGACCKDLASAFVHCKTLWGINLLENALDHSGLVVLFEALKQQKCTLHVLGLRITDFDKETQEFLIAEEEKNPYLSILSNV", "length": 982, "header": "tr|D3ZP31-1|D3ZP31_RAT Isoform 1 of NLR family, pyrin domain containing 4 OS=Rattus norvegicus OX=10116 GN=Nlrp4 PE=3 SV=4 CANONICAL=D3ZP31-1" }, "locus": { "chromosome": "1", "start_pos": 68116482, "end_pos": 68089641, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000046152.6", "url": "https://www.ensembl.org/id/ENSRNOT00000046152.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000046459.6", "url": "https://www.ensembl.org/id/ENSRNOP00000046459.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "NLRP4 is an essential negative regulator of fructose-induced cardiac injury in vitro and in vivo.", "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie", "date": "2017", "authors": "Lian YG, Zhao HY, Wang SJ, Xu QL, Xia XJ", "evidence": [ { "database": "RefSeq", "id": "NP_001165635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165635" } ], "reference": [ { "type": "PubMed", "id": "28486191", "url": "https://glygen.org/publication/PubMed/28486191" } ] } ], "pathway": [ { "id": "rno:499069", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499069", "resource": "KEGG Pathway" }, { "id": "R-RNO-3134975", "name": "Regulation of innate immune responses to cytosolic DNA", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3134975", "resource": "Reactome", "description": "Regulation of innate immune responses to cytosolic DNA" }, { "id": "R-RNO-3270619", "name": "IRF3-mediated induction of type I IFN", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3270619", "resource": "Reactome", "description": "IRF3-mediated induction of type I IFN" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TKR3-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 4C", "gene_name": "Nlrp4c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASFFSDFGLMWYLEELNKKEFMKFKEFLKQEILQLRLKQISWTEVKKASREDLANLLLKHYEEKKAWDMTFKIFQKMNRKDLMERAGREIAGHSKLYQAHLKKKLTHDYARKFNIKVQDFSKQKFTQDDYDRFENFLISKVTAKKPHMVFLQGAAGIGKSLMLTKLMLAWSEGMVFQNKFSYIFYFCCQDVKKMKRASLAELISKEWPKTSAPIEDILSQPEKLLFVIDNLEVMECDMSERESELCDTCTEKQPVRILLSSLLRRKMLPKSSFLISATPETFEKMEGRVECTNVKIVTGFNESNIKMYFRSLFQDKTKTQEIFSLVKENQQLFTVCQVPVLCWMVATCLKKEIEKGRDLVSVCRRTTSLYTTHIFNLFIPQSAQYPSKESQAQLQSLCSLAAEGMWTDTFVFGEEALRRNGIMDSDIPTLLDVRILEKSKKSEKSYIFLHPSIQEVCAAIFYLLKSHMDHPSQDVKSIEALIFTFLKKVKVQWIFFGSFIFGLLHESEQKKLEAFFGHQLSQEIKRQLYQCLETISGNEELQEQVDGMKLFYCLFEMDDEAFLAQAMNCMEQINFVAKDYSDVIVAAHCLQHCSTLKKLSLSTQNVLSEGQEHSYTEKLLMCWHHMCSVLISSKDIYILQVKNTNLNETASLVLYSHLMYPSCTLKALVVNNVTFLCDNRLFFELIQNQCLQHLDLNLTFLSHGDVKLLCDVLSQEECNIEKLMVAACNLSPDDCKVFASVLISSKMLKHLNLSSNNLDKGISSLSKALCHPDCVLKNLVLVNCSLSEQCWDYLSEVLRRNKTLNHLDISSNDLKDEGLKVLCGALSLPDSVLKSLSVRYCLITTSGCQDLAEVLRKNQNLRNLQVSNNKIEDAGVKLLCDAIKHPNCHLENIGLEACALTGACCEDLASAFTHCKTLWGINLQENALDHSGLIVLFEALKQQQCTLHVLGLRITDFDKETQELLMAEEEKNPHLSILSSV", "length": 982 }, "evidence": [ { "id": "45230919", "url": "http://www.informatics.jax.org/homology/45230919", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q66X19-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 4E", "gene_name": "Nlrp4e", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASFFSDFGLMWYLEELNKKEFMKFKELLQQEILQLGLKHISWTEVKKASREDLANLLLKHYEEKKAWDMTFKIFQKMNRQDLMERAGREIAGHSKLYQVHLKKKLTHDYARKFNIKDQDSLKQKFTQDDCDHFENLLISKATGKKPHMVFLQGVAGIGKSLMLTKLMLAWSEGMVFQNKFSYIFYFCCQDVKKMKRASLAELISKEWPNASAPIEEILSQPEKLLFVIDNLEVMECDMSEWESELCDDCMEKQPVNILMSSLLRRKMLPESSFLVSATPETFEKIEDRIECTNVKMMAGFNESSIKVYFYSLFQDRNRTQEIFSLVRENEQLFSVCQVPVLCWMVATCLKKEIEKGRDPVSICRRITSLYTTYIFNLFIPHSAQYPSKKSQDQLQGLCSLAAEGMWTDTFVFAEEALRRNGIMDSDISTLLDVRILEKSKESEKSYIFLHPSIQEVCAAIFHLLKSHVDHPSQDVKSIEALIFTFLKKVKIQWIFFGSFIFGLLHESEQKKLEAFFGHQLSQEIKRQLYQCLETISGNKELQEQIDGMKLFYCLFEMDDEAFLPQVMNCMEQIKFVAKDYSDVIVAAHCLQHCSTLKKLSLSTQNILSEGQEHSYTEKLLICWHHVCSVLTSSKDIHVLQVKDTNFNERAFLVLYSHLKYPSCILKVLEVNNVTLLCDNRLLFELIQNQRLQLLNLSLTFLSHNDVKLLCDVLNQAECNIEKLMVADCNLSPDDCKVFVSVLISSKMLKHLNLSSNNLDKGISSLSKALCHPDCVLKNLVLAKCSLSEECWHYLSEVLRRNKTLTHLDISFNDLKDEGLKVLCGALTLPDSVLISLSVRYCLITTSGCQDLAEVLRNNQNLRNLQISNNKIEDAGVKLLCDAIKHPNCHLENIGLEACALTGACCEDLASSFTHCKTLLGINLQENALDHSGLVALFEAMKQQQCTVNLRGLRITDFDKETQEFLMAEKEKNPYLSI", "length": 978 }, "evidence": [ { "id": "45227217", "url": "http://www.informatics.jax.org/homology/45227217", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "D3ZP31", "url": "https://www.uniprot.org/uniprot/D3ZP31" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZP31", "url": "https://www.uniprot.org/uniprot/D3ZP31" } ], "pmid": "" }, { "name": "canonical inflammasome complex", "id": "GO:0061702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061702", "evidence": [ { "database": "UniProtKB", "id": "D3ZP31", "url": "https://www.uniprot.org/uniprot/D3ZP31" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "D3ZP31", "url": "https://www.uniprot.org/uniprot/D3ZP31" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "D3ZP31", "url": "https://www.uniprot.org/uniprot/D3ZP31" } ], "pmid": "" }, { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "D3ZP31", "url": "https://www.uniprot.org/uniprot/D3ZP31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 648, "end_pos": 650, "annotation": "n_glycosylation_sequon" }, { "start_pos": 673, "end_pos": 675, "annotation": "n_glycosylation_sequon" }, { "start_pos": 696, "end_pos": 698, "annotation": "n_glycosylation_sequon" }, { "start_pos": 730, "end_pos": 732, "annotation": "n_glycosylation_sequon" }, { "start_pos": 753, "end_pos": 755, "annotation": "n_glycosylation_sequon" }, { "start_pos": 784, "end_pos": 786, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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