{
    "uniprot_canonical_ac": "D3ZGP2-1",
    "uniprot_ac": "D3ZGP2",
    "uniprot_id": "D3ZGP2_RAT",
    "mass": {
        "chemical_mass": 48519.0,
        "monoisotopic_mass": 48519.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Edar",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/D3ZGP2",
            "id": "D3ZGP2"
        }
    ],
    "protein_names": [
        {
            "name": "Ectodysplasin-A receptor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "D3ZGP2"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0111663",
            "recommended_name": {
                "id": "DOID:0111663",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111663",
                "name": "ectodermal dysplasia 10A",
                "description": "A hypohidrotic ectodermal dysplasia that has_material_basis_in heterozygous mutation in the EDAR gene on chromosome 2q13."
            },
            "synonyms": [
                {
                    "id": "DOID:0111663",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111663",
                    "name": "ECTD10A",
                    "description": ""
                },
                {
                    "id": "DOID:0111663",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111663",
                    "name": "ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007509",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007509",
                    "name": "ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007509",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007509",
                    "name": "ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007509",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007509",
                    "name": "ECTD10A",
                    "description": ""
                },
                {
                    "id": "MONDO:0007509",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007509",
                    "name": "ectodermal dysplasia hypohidrotic autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007509",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007509",
                    "name": "ectodermal dysplasia, hypohidrotic, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007509",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007509",
                    "name": "hypohidrotic ectodermal dysplasia autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MIM:129490",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/129490",
                    "name": "Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant",
                    "description": "Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant"
                }
            ],
            "evidence": [
                {
                    "id": "0111663",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111663"
                }
            ]
        },
        {
            "disease_id": "DOID:0111665",
            "recommended_name": {
                "id": "DOID:0111665",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111665",
                "name": "ectodermal dysplasia 10B",
                "description": "A hypohidrotic ectodermal dysplasia that has_material_basis_in homozygous or compound heterozygous mutation in the EDAR gene on chromosome 2q13."
            },
            "synonyms": [
                {
                    "id": "DOID:0111665",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111665",
                    "name": "ECTD10B",
                    "description": ""
                },
                {
                    "id": "DOID:0111665",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111665",
                    "name": "ectodermal dysplasia 10B, hypohidrotic/hair/nail type, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0009147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009147",
                    "name": "ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0009147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009147",
                    "name": "ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0009147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009147",
                    "name": "ECTD10B",
                    "description": ""
                },
                {
                    "id": "MONDO:0009147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009147",
                    "name": "ectodermal dysplasia, anhidrotic",
                    "description": ""
                },
                {
                    "id": "MONDO:0009147",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009147",
                    "name": "ectodermal dysplasia, hypohidrotic",
                    "description": ""
                },
                {
                    "id": "MIM:224900",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/224900",
                    "name": "Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive",
                    "description": "Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive"
                }
            ],
            "evidence": [
                {
                    "id": "0111665",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111665"
                }
            ]
        },
        {
            "disease_id": "DOID:14793",
            "recommended_name": {
                "id": "DOID:14793",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:14793",
                "name": "hypohidrotic ectodermal dysplasia",
                "description": "An ectodermal dysplasia that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth)."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "14793",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:14793"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "D3ZGP2",
                    "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Edar",
            "url": "https://www.uniprot.org/uniprot/D3ZGP2",
            "locus": {
                "chromosome": "20",
                "start_pos": 26587839,
                "end_pos": 26666494,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000028598",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000028598"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000028598",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000028598",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd13421",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13421",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011029",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR034052",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR034052",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047526",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047526",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:365581",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365581",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "CGENEYH",
            "url": "https://omabrowser.org/oma/group/CGENEYH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5405444at2759",
            "url": "http://www.orthodb.org/?query=5405444at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12120",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12120",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12120:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12120:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5669034",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5669034",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1561714",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1561714",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "D3ZGP2",
            "url": "https://www.uniprot.org/uniprot/D3ZGP2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZGP2-1",
            "url": "https://www.uniprot.org/uniprot/D3ZGP2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "length": 449,
        "header": "tr|D3ZGP2-1|D3ZGP2_RAT Isoform 1 of Ectodysplasin-A receptor  OS=Rattus norvegicus OX=10116 GN=Edar PE=4 SV=2 CANONICAL=D3ZGP2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D3ZGP2-1",
            "url": "",
            "sequence": {
                "sequence": "MAHVGDCKWMSWLPVLVVSLMCSAKAEDSNCGENEYHNQTTGLCQQCPPCRPGEEPYMSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGVSAHSSSTSGGSTLSPFQHAHKELSSQGHLATALIIAMSTIFIMAIAIVLIIMFYIMKTKPSAPAACCSSPPGKSAEAPANTHEEKKEAPDSVVTFPENGEFQKLTATPTKTPKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSVASNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASPPPAAS",
                "length": 449,
                "header": "tr|D3ZGP2-1|D3ZGP2_RAT Isoform 1 of Ectodysplasin-A receptor  OS=Rattus norvegicus OX=10116 GN=Edar PE=4 SV=2 CANONICAL=D3ZGP2-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 26618283,
                "end_pos": 26589901,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000030348.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000030348.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000029258.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000029258.5"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:365581",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365581",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-5669034",
            "name": "TNFs bind their physiological receptors",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5669034",
            "resource": "Reactome",
            "description": "TNFs bind their physiological receptors"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "transmembrane signaling receptor activity",
                        "id": "GO:0004888",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "signaling receptor activity",
                        "id": "GO:0038023",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apical part of cell",
                        "id": "GO:0045177",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 8,
                "go_terms": [
                    {
                        "name": "positive regulation of gene expression",
                        "id": "GO:0010628",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of JNK cascade",
                        "id": "GO:0046330",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of NIK/NF-kappaB signaling",
                        "id": "GO:1901224",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of I-kappaB kinase/NF-kappaB signaling",
                        "id": "GO:0043123",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "hair follicle development",
                        "id": "GO:0001942",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001942",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "odontogenesis of dentin-containing tooth",
                        "id": "GO:0042475",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042475",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "pigmentation",
                        "id": "GO:0043473",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043473",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "salivary gland cavitation",
                        "id": "GO:0060662",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060662",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "D3ZGP2",
                                "url": "https://www.uniprot.org/uniprot/D3ZGP2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
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            "start_pos": 318,
            "end_pos": 320,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 38,
            "end_pos": 40,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [],
    "section_stats": [
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        {
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