{ "uniprot_canonical_ac": "D3ZEF4-1", "uniprot_ac": "D3ZEF4", "uniprot_id": "CUL7_RAT", "mass": { "chemical_mass": 192660.0, "monoisotopic_mass": 192660.0 }, "refseq": {}, "gene_names": [ { "name": "Cul7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3ZEF4", "id": "D3ZEF4" } ], "protein_names": [ { "name": "Cullin-7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "D3ZEF4" }, { "name": "CUL-7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZEF4" } ], "function": [ { "annotation": "Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1. Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development. Does not promote polyubiquitination and proteasomal degradation of p53/TP53. While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4#function" }, { "database": "PubMed", "id": "21572988", "url": "https://glygen.org/publication/PubMed/21572988" } ] } ], "disease": [ { "disease_id": "DOID:0060241", "recommended_name": { "id": "DOID:0060241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060241", "name": "3-M syndrome", "description": "A syndrome characterized by dwarfism, facial dysmorphia and skeletal abnormalities." }, "synonyms": [ { "id": "DOID:0060241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060241", "name": "Le Merrer syndrome", "description": "" }, { "id": "DOID:0060241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060241", "name": "Miller-McKusick-Malvaux syndrome", "description": "" }, { "id": "DOID:0060241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060241", "name": "Yakut short stature syndrome", "description": "" }, { "id": "DOID:0060241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060241", "name": "dolichospondylic dysplasia", "description": "" }, { "id": "DOID:0060241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060241", "name": "gloomy face syndrome", "description": "" }, { "id": "DOID:0060241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060241", "name": "three M syndrome", "description": "" }, { "id": "MONDO:0013039", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013039", "name": "3M syndrome 2", "description": "Any 3-M syndrome in which the cause of the disease is a mutation in the OBSL1 gene." }, { "id": "MONDO:0013039", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013039", "name": "3-M syndrome 2", "description": "" }, { "id": "MONDO:0013039", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013039", "name": "3-M syndrome caused by mutation in OBSL1", "description": "" }, { "id": "MONDO:0013039", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013039", "name": "3M syndrome 2", "description": "" }, { "id": "MONDO:0013039", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013039", "name": "OBSL1 3-M syndrome", "description": "" }, { "id": "MONDO:0013039", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013039", "name": "three M syndrome 2", "description": "" }, { "id": "MONDO:0013039", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013039", "name": "three M syndrome type 2", "description": "" }, { "id": "MONDO:0013039", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013039", "name": "3M2", "description": "" }, { "id": "MONDO:0013627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013627", "name": "3M syndrome 3", "description": "Any 3-M syndrome in which the cause of the disease is a mutation in the CCDC8 gene." }, { "id": "MONDO:0013627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013627", "name": "3-M syndrome 3", "description": "" }, { "id": "MONDO:0013627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013627", "name": "3-M syndrome caused by mutation in CCDC8", "description": "" }, { "id": "MONDO:0013627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013627", "name": "3M syndrome 3", "description": "" }, { "id": "MONDO:0013627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013627", "name": "CCDC8 3-M syndrome", "description": "" }, { "id": "MONDO:0013627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013627", "name": "three M syndrome 3", "description": "" }, { "id": "MONDO:0013627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013627", "name": "three M syndrome type 3", "description": "" }, { "id": "MONDO:0013627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013627", "name": "3M3", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "3M syndrome 1", "description": "Any 3-M syndrome in which the cause of the disease is a mutation in the CUL7 gene." }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "3-M syndrome 1", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "3-M syndrome caused by mutation in CUL7", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "3-M syndrome caused by mutation in Cul7", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "CUL7 3-M syndrome", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "Cul7 3-M syndrome", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "three M syndrome 1", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "three M syndrome type 1", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "3M syndrome", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "3M1", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "Dolichospondylic dysplasia", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "Le Merrer syndrome", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "Yakut short stature syndrome", "description": "" }, { "id": "MONDO:0010117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010117", "name": "gloomy face syndrome", "description": "" }, { "id": "MIM:612921", "resource": "MIM", "url": "https://www.omim.org/entry/612921", "name": "3M syndrome 2", "description": "3M syndrome 2" }, { "id": "MIM:614205", "resource": "MIM", "url": "https://www.omim.org/entry/614205", "name": "3M syndrome 3", "description": "3M syndrome 3" }, { "id": "MIM:273750", "resource": "MIM", "url": "https://www.omim.org/entry/273750", "name": "3M syndrome 1", "description": "3M syndrome 1" } ], "evidence": [ { "id": "0060241", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060241" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Cul7", "url": "https://www.uniprot.org/uniprot/D3ZEF4", "locus": { "chromosome": "9", "start_pos": 14319108, "end_pos": 14332741, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000017857", "url": "https://www.ensembl.org/id/ENSRNOG00000017857" } ] } } ], "crossref": [ { "id": "ENSRNOG00000017857", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017857", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSRNOG00000054698", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054698", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "680835", "url": "https://www.ncbi.nlm.nih.gov/gene/680835", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "D3ZEF4", "url": "https://www.ebi.ac.uk/intact/interactors/id:D3ZEF4*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:680835", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:680835", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RCWPVAS", "url": "https://omabrowser.org/oma/group/RCWPVAS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4161627at2759", "url": "http://www.orthodb.org/?query=4161627at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22771", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22771", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22771:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22771:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00888", "url": "http://pfam.xfam.org/family/PF00888", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03256", "url": "http://pfam.xfam.org/family/PF03256", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11515", "url": "http://pfam.xfam.org/family/PF11515", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_D3ZEF4", "url": "http://purl.obolibrary.org/obo/PR_D3ZEF4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1587048", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1587048", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K959", "url": "https://www.uniprot.org/uniprot/A0A0G2K959", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K959-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K959-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0H2UHP4", "url": "https://www.uniprot.org/uniprot/A0A0H2UHP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0H2UHP4-1", "url": "https://www.uniprot.org/uniprot/A0A0H2UHP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZEF4-1", "url": "https://www.uniprot.org/uniprot/D3ZEF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGELRYREFRVPLGPGLHAYPDELIRQRVGHNGHPEYQIRWLILRRGDDGDSSQVDCKAEHILLWMTDDEIYANCHKMLGEDGQVIRPSQESAEAGALDKSVLGEMETDVKSLIQRALRQLEECVGAVPPAPLLHTVHVLSAYASIEPLTGVFKDRRVLDLVMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLTEHPMSFEGVQLPQVPGRLLFSLVKRYLCVTFLLDRLNGNAEDQDAQNNFIPEELNAGRGRVELEFSMAMGTLISELVQAMRWDWASSRSESSSPIFQPPPTEFFRPRAQRFRRSRRFRPRTAFASVNTYALYVRDTLRPGMRVRMLEDFEEISAGDEGQFRQSNDGMPPVQVLWDSTGHTYWVHWHMLEILGFEEDIEDVVDIDDQGAMVHGGLGVAPPFQHWKPIAQLFAEPYVVPEEEDREEREHLTQAEWWELFFFIKKLNAEERQHVVELLQEFLEGEHVLDFEILPELTVPVELAQDLMLSLPQQLDDSALRDLFNCYVYRKYGPEVLVGKRNRPFVLDDQLNLFRIETDSEAQDPPSQSASPALRQLVEGLGPSGKLLVDLERALSSEAPQENEVKPCLLQLQEEPQPFLTLMRSLDTPASNKALHLTALRILMQLVNFPEALLLPWHEAMDACMTCLRSPNTDREVLQELIFFLHRLTSTSRDYAVILNQLGARDAISKVLEKHRGKLELAQELRDMVFKCEKHAHLYRKLTTNILGGCIQMVLGQIEDHRRTHRPIQIPFFDVFLRYLCQGSSAEVKKNKYWEKVEVSSNPHRASRLTDRNAKTYWESNGTAGSHFITVHMRPGVLIRQLTLLVAGEDSSYMPAWVVVCGGDSISSVNTELNAVNVMPHASRVILLENLTRFWPIVQIRIKRCQQGGINTRIRGLEVLGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDIAEDRRSLLHLSSRLNGALRQEQNFADRFLPDEEAALALSKTCWEALVSPLVQNITSPDEDSTSSLGWLLNQYLECREAAYNPQSRAAAFSSRVRHLTHLLVHVEPCEAAPPVVAISQSKGRNRSHDWSSLTTRGLPSSIMRNLTRCWRSVVEEQVNKFLTSSWKDDDFVPRYCERYYILQKSSSELFGPRAAFLLAMRNGCADALLRLPFLRAAHVSEQFARHIDQRIQGSRMGGARGMEMLAQLQRCLESVLILSPLEIATTFEHYYQHYMADRLLSVGSSWLEGAVLEQIGPCFPGRLPQQMLQTLNISEELQRRFHVYQLQQLDQELLKLEDTEKKIQVAHEDSGKEHKSKKEDAAGETAAVAMADEEEEEGKKEEGEEEEGEGEEELEEEEERYYEGTMPEVCVLVLSPRFWPVASVCHMLNPTTCLPSYLRGTINHYSNFYSKSQSHSGLEKESPRQLQWTWQGRAEVQFGDQILHVSTVQMWLLLHLNHLKAVSVESLQALSELPPEVLNKAIGPLTSSRGPLDLQEQKNIPGGVLKIRDDSEEPRPRRGNVWLIPPQTYLKAEDEEGRNLEKRRNLLNCLVVRILKAHGDEGLHIDQLVHLVLEAWEKGPCPPRGLVSSLGRGAACRSSDVLSCILHLLGKGTLRRHDDRPQMLFYAVPITVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTGTQTFSTFR", "length": 1692, "header": "sp|D3ZEF4-1|CUL7_RAT Isoform 1 of Cullin-7 OS=Rattus norvegicus OX=10116 GN=Cul7 PE=1 SV=1 CANONICAL=D3ZEF4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K959-1", "url": "", "sequence": { "sequence": "MVGELRYREFRVPLGPGLHAYPDELIRQRVGHNGHPEYQIRWLILRRGDDGDSSQVDCKAEHILLWMTDDEIYANCHKMLGEDGQVIRPSQESAEAGALDKSVLGEMETDVKSLIQRALRQLEECVGAVPPAPLLHTVHVLSAYASIEPLTGVFKDRRVLDLVMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLTEHPMSFEGVQLPQVPGRLLFSLVKRYLCVTFLLDRLNGNAEDQDAQNNFIPEELNAGRGRVELEFSMAMGTLISELVQAMRWDWASSRSESSSPIFQPPPTEFFRPRAQRFRRSRRFRPRTAFASVNTYALYVRDTLRPGMRVRMLEDFEEISAGDEGQFRQSNDGMPPVQVLWDSTGHTYWVHWHMLEILGFEEDIEDVVDIDDQGAMVHGGLGVAPPFQHWKPIAQLFAEPYVVPEEEDREEREHLTQAEWWELFFFIKKLNAEERQHVVELLQEFLEGEHVLDFEILPELTVPVELAQDLMLSLPQQLDDSALRDLFNCYVYRKYGPEVLVGKRNRPFVLDDQLNLFRIETDSEDEAGAEAQDPPSQSASPALRQLVEGLGPSGKLLVDLERALSSEAPQENEVKPCLLQLQEEPQPFLTLMRSLDTPASNKALHLTALRILMQLVNFPEALLLPWHEAMDACMTCLRSPNTDREVLQELIFFLHRLTSTSRDYAVILNQLGARDAISKVLEKHRGKLELAQELRDMVFKCEKHAHLYRKLTTNILGGCIQMVLGQIEDHRRTHRPIQIPFFDVFLRYLCQGSSAEVKKNKYWEKVEVSSNPHRASRLTDRNAKTYWESNGTAGSHFITVHMRPGVLIRQLTLLVAGEDSSYMPAWVVVCGGDSISSVNTELNAVNVMPHASRVILLENLTRFWPIVQIRIKRCQQGGINTRIRGLEVLGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDIAEDRRSLLHLSSRLNGALRQEQNFADRFLPDEEAALALSKTCWEALVSPLVQNITSPDEDSTSSLGWLLNQYLECREAAYNPQSRAAAFSSRVRHLTHLLVHVEPCEAAPPVVAISQSKGRNRSHDWSSLTTRGLPSSIMRNLTRCWRSVVEEQVNKFLTSSWKDDDFVPRYCERYYILQKSSSELFGPRAAFLLAMRNGCADALLRLPFLRAAHVSEQFARHIDQRIQGSRMGGARGMEMLAQLQRCLESVLILSPLEIATTFEHYYQQAGRLAVLGVGSSWLEGAVLEQIGPCFPGRLPQQMLQTLNISEELQRRFHVYQLQQLDQELLKLEDTEKKIQVAHEDSGKEHKSKKEDAAGETAAVAMADEEEEEGKKEEGEEEEGEGEEELEEEEERYYEGTMPEVCVLVLSPRFWPVASVCHMLNPTTCLPSYLRGTINHYSNFYSKSQSHSGLEKESPRQLQWTWQGRAEVQFGDQILHVSTVQMWLLLHLNHLKAVSVESLQALSELPPEVLNKAIGPLTSSRGPLDLQEQKNIPGGVLKIRDDSEEPRPRRGNVWLIPPQTYLKAEDEEGRNLEKRRNLLNCLVVRILKAHGDEGLHIDQLVHLVLEAWEKGPCPPRGLVSSLGRGAACRSSDVLSCILHLLGKGTLRRHDDRPQMLFYAVPITVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTGTQTFSTFR", "length": 1698, "header": "tr|A0A0G2K959-1|A0A0G2K959_RAT Computationally mapped isoform of Cullin 7 OS=Rattus norvegicus OX=10116 GN=Cul7 PE=3 SV=2 CANONICAL=D3ZEF4-1" }, "locus": { "chromosome": "9", "start_pos": 14331927, "end_pos": 14319181, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000091215.2", "url": "https://www.ensembl.org/id/ENSRNOT00000091215.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074869.2", "url": "https://www.ensembl.org/id/ENSRNOP00000074869.2" } ] } }, { "isoform_ac": "A0A0H2UHP4-1", "url": "", "sequence": { "sequence": "MVGELRYREFRVPLGPGLHAYPDELIRQRVGHNGHPEYQIRWLILRRGDDGDSSQVDCKAEHILLWMTDDEIYANCHKMLGEDGQVIRPSQESAEAGALDKSVLGEMETDVKSLIQRALRQLEECVGAVPPAPLLHTVHVLSAYASIEPLTGVFKDRRVLDLVMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLTEHPMSFEGVQLPQVPGRLLFSLVKRYLCVTFLLDRLNGNAEDQDAQNNFIPEELNAGRGRVELEFSMAMGTLISELVQAMRWDWASSRSESSSPIFQPPPTEFFRPRAQRFRRSRRFRPRTAFASVNTYALYVRDTLRPGMRVRMLEDFEEISAGDEGQFRQSNDGMPPVQVLWDSTGHTYWVHWHMLEILGFEEDIEDVVDIDDQGAMVHGGLGVAPPFQHWKPIAQLFAEPYVVPEEEDREEREHLTQAEWWELFFFIKKLNAEERQHVVELLQEFLEGEHVLDFEILPELTVPVELAQDLMLSLPQQLDDSALRDLFNCYVYRKYGPEVLVGKRNRPFVLDDQLNLFRIETDSEDEAGAEAQDPPSQSASPALRQLVEGLGPSGKLLVDLERALSSEAPQENEVKPCLLQLQEEPQPFLTLMRSLDTPASNKALHLTALRILMQLVNFPEALLLPWHEAMDACMTCLRSPNTDREVLQELIFFLHRLTSTSRDYAVILNQLGARDAISKVLEKHRGKLELAQELRDMVFKCEKHAHLYRKLTTNILGGCIQMVLGQIEDHRRTHRPIQIPFFDVFLRYLCQGSSAEVKKNKYWEKVEVSSNPHRASRLTDRNAKTYWESNGTAGSHFITVHMRPGVLIRQLTLLVAGEDSSYMPAWVVVCGGDSISSVNTELNAVNVMPHASRVILLENLTRFWPIVQIRIKRCQQGGINTRIRGLEVLGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDIAEDRRSLLHLSSRLNGALRQEQNFADRFLPDEEAALALSKTCWEALVSPLVQNITSPDEDSTSSLGWLLNQYLECREAAYNPQSRAAAFSSRVRHLTHLLVHVEPCEAAPPVVAISQSKGRNRSHDWSSLTTRGLPSSIMRNLTRCWRSVVEEQVNKFLTSSWKDDDFVPRYCERYYILQKSSSELFGPRAAFLLAMRNGCADALLRLPFLRAAHVSEQFARHIDQRIQGSRMGGARGMEMLAQLQRCLESVLILSPLEIATTFEHYYQHYMADRLLSVGSSWLEGAVLEQIGPCFPGRLPQQMLQTLNISEELQRRFHVYQLQQLDQELLKLEDTEKKIQVAHEDSGKEHKSKKEDAAGETAAVAMADEEEEEGKKEEGEEEEGEGEEELEEEEERYYEGTMPEVCVLVLSPRFWPVASVCHMLNPTTCLPSYLRGTINHYSNFYSKSQSHSGLEKESPRQLQWTWQGRAEVQFGDQILHVSTVQMWLLLHLNHLKAVSVESLQALSELPPEVLNKAIGPLTSSRGPLDLQEQKNIPGGVLKIRDDSEEPRPRRGNVWLIPPQTYLKAEDEEGRNLEKRRNLLNCLVVRILKAHGDEGLHIDQLVHLVLEAWEKGPCPPRGLVSSLGRGAACRSSDVLSCILHLLGKGTLRRHDDRPQMLFYAVPITVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTGTQTFSTFR", "length": 1698, "header": "tr|A0A0H2UHP4-1|A0A0H2UHP4_RAT Computationally mapped isoform of Cullin 7 OS=Rattus norvegicus OX=10116 GN=Cul7 PE=1 SV=1 CANONICAL=D3ZEF4-1" }, "locus": { "chromosome": "9", "start_pos": 14331927, "end_pos": 14319181, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000024266.7", "url": "https://www.ensembl.org/id/ENSRNOT00000024266.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000024266.4", "url": "https://www.ensembl.org/id/ENSRNOP00000024266.4" } ] } }, { "isoform_ac": "D3ZEF4-1", "url": "", "sequence": { "sequence": "MVGELRYREFRVPLGPGLHAYPDELIRQRVGHNGHPEYQIRWLILRRGDDGDSSQVDCKAEHILLWMTDDEIYANCHKMLGEDGQVIRPSQESAEAGALDKSVLGEMETDVKSLIQRALRQLEECVGAVPPAPLLHTVHVLSAYASIEPLTGVFKDRRVLDLVMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLTEHPMSFEGVQLPQVPGRLLFSLVKRYLCVTFLLDRLNGNAEDQDAQNNFIPEELNAGRGRVELEFSMAMGTLISELVQAMRWDWASSRSESSSPIFQPPPTEFFRPRAQRFRRSRRFRPRTAFASVNTYALYVRDTLRPGMRVRMLEDFEEISAGDEGQFRQSNDGMPPVQVLWDSTGHTYWVHWHMLEILGFEEDIEDVVDIDDQGAMVHGGLGVAPPFQHWKPIAQLFAEPYVVPEEEDREEREHLTQAEWWELFFFIKKLNAEERQHVVELLQEFLEGEHVLDFEILPELTVPVELAQDLMLSLPQQLDDSALRDLFNCYVYRKYGPEVLVGKRNRPFVLDDQLNLFRIETDSEAQDPPSQSASPALRQLVEGLGPSGKLLVDLERALSSEAPQENEVKPCLLQLQEEPQPFLTLMRSLDTPASNKALHLTALRILMQLVNFPEALLLPWHEAMDACMTCLRSPNTDREVLQELIFFLHRLTSTSRDYAVILNQLGARDAISKVLEKHRGKLELAQELRDMVFKCEKHAHLYRKLTTNILGGCIQMVLGQIEDHRRTHRPIQIPFFDVFLRYLCQGSSAEVKKNKYWEKVEVSSNPHRASRLTDRNAKTYWESNGTAGSHFITVHMRPGVLIRQLTLLVAGEDSSYMPAWVVVCGGDSISSVNTELNAVNVMPHASRVILLENLTRFWPIVQIRIKRCQQGGINTRIRGLEVLGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDIAEDRRSLLHLSSRLNGALRQEQNFADRFLPDEEAALALSKTCWEALVSPLVQNITSPDEDSTSSLGWLLNQYLECREAAYNPQSRAAAFSSRVRHLTHLLVHVEPCEAAPPVVAISQSKGRNRSHDWSSLTTRGLPSSIMRNLTRCWRSVVEEQVNKFLTSSWKDDDFVPRYCERYYILQKSSSELFGPRAAFLLAMRNGCADALLRLPFLRAAHVSEQFARHIDQRIQGSRMGGARGMEMLAQLQRCLESVLILSPLEIATTFEHYYQHYMADRLLSVGSSWLEGAVLEQIGPCFPGRLPQQMLQTLNISEELQRRFHVYQLQQLDQELLKLEDTEKKIQVAHEDSGKEHKSKKEDAAGETAAVAMADEEEEEGKKEEGEEEEGEGEEELEEEEERYYEGTMPEVCVLVLSPRFWPVASVCHMLNPTTCLPSYLRGTINHYSNFYSKSQSHSGLEKESPRQLQWTWQGRAEVQFGDQILHVSTVQMWLLLHLNHLKAVSVESLQALSELPPEVLNKAIGPLTSSRGPLDLQEQKNIPGGVLKIRDDSEEPRPRRGNVWLIPPQTYLKAEDEEGRNLEKRRNLLNCLVVRILKAHGDEGLHIDQLVHLVLEAWEKGPCPPRGLVSSLGRGAACRSSDVLSCILHLLGKGTLRRHDDRPQMLFYAVPITVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTGTQTFSTFR", "length": 1692, "header": "sp|D3ZEF4-1|CUL7_RAT Isoform 1 of Cullin-7 OS=Rattus norvegicus OX=10116 GN=Cul7 PE=1 SV=1 CANONICAL=D3ZEF4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.", "journal": "PLoS Biol.", "date": "2011", "authors": "Litterman N, Ikeuchi Y, Gallardo G, O'Connell BC, Sowa ME, Gygi SP, Harper JW, Bonni A", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "reference": [ { "type": "PubMed", "id": "21572988", "url": "https://glygen.org/publication/PubMed/21572988" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A0H2UHP4", "url": "https://www.uniprot.org/uniprot/A0A0H2UHP4" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:680835", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:680835", "resource": "KEGG Pathway" }, { "id": "R-RNO-8951664", "name": "Neddylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14999-1", "protein_name": "Cullin-7", "gene_name": "CUL7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDCKAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQRALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAMGTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPRSEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRTYWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPEDEDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIELAQDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQAKDSEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQLQRQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSPNTDREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFKCEKHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDSSYMPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGIDTRIRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQEQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSSIMRNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENEDLYYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNLEKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTDVLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQIRSRGVPYASCTATQSFSTFR", "length": 1698 }, "evidence": [ { "id": "45240934", "url": "http://www.informatics.jax.org/homology/45240934", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VE73-1", "protein_name": "Cullin-7", "gene_name": "Cul7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGELRYREFRVPLGPGLHAYPDELIRQRVGHNGHPEYQIRWLILRRGDDGDRDSTVDCKAEHILLWMSDDEIYANCHKMLGENGQVIAPSRESTEAGALDKSVLGEMETDVKSLIQRALRQLEECVGTVPPAPLLHTVHVLSAYASIEPLTGIFKDRRVVNLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLTEHPMSFEGVQLPQVPGRLLFSLVKRYLHVTFLLDRLNGDAGDQGAQNNFIPEELNVGRGRLELEFSMAMGTLISELVQAMRWDGASSRPESSSSSTFQPRPAQFRPYTQRFRRSRRFRPRASFASFNTYALYVRDTLRPGMRVRMLENYEEIAAGDEGQFRQSNDGVPPAQVLWDSTGHTYWVHWHMLEILGFEEDIEDVIDIEELQELGANGALSIVPPSQRWKPITQLFAEPYVVPEEEDREESENLTQAEWWELLFFIRQLSEAERLHIVDLLQDHLEEERVLDYDMLPELTVPVDLAQDLLLSLPQQLEDSALRDLFSCSVYRKYGPEVLVGHLSYPFVPGAQPNLFGANEESEAKDPPLQSASPALQRLVESLGPEGEVLVELEQALGSEAPQETEVKSCLLQLQEQPQPFLALMRSLDTSASNKTLHLTVLRILMQLVNFPEALLLPWHEAMDACVTCLRSPNTDREVLQELIFFLHRLTTTSRDYAVILNQLGARDAISKVLEKHRGKLELAQELRDMVSKCEKHAHLYRKLTTNILGGCIQMVLGQIEDHRRTHRPIQIPFFDVFLRYLCQGSSEEMKKNRYWEKVEVSSNPQRASRLTDRNPKTYWESSGRAGSHFITLHMRPGVIIRQLTLLVAGEDSSYMPAWVVVCGGNSIKSVNKELNTVNVMPSASRVTLLENLTRFWPIIQIRIKRCQQGGINTRIRGLEVLGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDIAEDRRSLLHLSSRLNGALRHEQNFAERFLPDMEAAQALSKTCWEALVSPLVQNITSPDEDSTSSLGWLLDQYLGCREAAYNPQSRAAAFSSRVRRLTHLLVHVEPREAAPPVVAIPRSKGRNRIHDWSYLITRGLPSSIMKNLTRCWRSVVEEQMNKFLTASWKDDDFVPRYCERYYVLQKSSSELFGPRAAFLLAMRNGCADAVLRLPFLRAAHVSEQFARHIDQRIQGSRMGGARGMEMLAQLQRCLESVLIFSPLEIATTFEHYYQHYMADRLLSVGSSWLEGAVLEQIGPCFPSRLPQQMLQSLNVSEELQRQFHVYQLQQLDQELLKLEDTEKKIQVAHEDSGREDKSKKEEAIGEAAAVAMAEEEDQGKKEEGEEEGEGEDEEEERYYKGTMPEVCVLVVTPRFWPVASVCQMLNPATCLPAYLRGTINHYTNFYSKSQSRSSLEKEPQRRLQWTWQGRAEVQFGGQILHVSTVQMWLLLHLNNQKEVSVESLQAISELPPDVLHRAIGPLTSSRGPLDLQEQKNVPGGVLKIRDDSEEPRPRRGNVWLIPPQTYLQAEAEEGRNMEKRRNLLNCLVVRILKAHGDEGLHVDRLVYLVLEAWEKGPCPARGLVSSLGRGATCRSSDVLSCILHLLVKGTLRRHDDRPQVLYYAVPVTVMEPHMESLNPGSAGPNPPLTFHTLQIRSRGVPYASCTDNHTFSTFR", "length": 1689 }, "evidence": [ { "id": "45240934", "url": "http://www.informatics.jax.org/homology/45240934", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Cul7-RING ubiquitin ligase complex", "id": "GO:0031467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031467", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "3M complex", "id": "GO:1990393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990393", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "vasculogenesis", "id": "GO:0001570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001570", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "placenta development", "id": "GO:0001890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001890", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "positive regulation of dendrite morphogenesis", "id": "GO:0050775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050775", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "epithelial to mesenchymal transition", "id": "GO:0001837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001837", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "regulation of mitotic nuclear division", "id": "GO:0007088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007088", "evidence": [ { "database": "UniProtKB", "id": "D3ZEF4", "url": "https://www.uniprot.org/uniprot/D3ZEF4" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": 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