{ "uniprot_canonical_ac": "D3ZEB9-1", "uniprot_ac": "D3ZEB9", "uniprot_id": "D3ZEB9_RAT", "mass": { "chemical_mass": 38881.0, "monoisotopic_mass": 38881.0 }, "refseq": { "ac": "XP_006249392", "name": "N-lysine methyltransferase KMT5A isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006249392" }, "gene_names": [ { "name": "Kmt5a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3ZEB9", "id": "D3ZEB9" }, { "name": "Kmt5a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006249392", "id": "XP_006249392" }, { "name": "Pr-set7; RGD1305893; Setd8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006249392", "id": "XP_006249392" }, { "name": "Setd8", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/D3ZEB9", "id": "D3ZEB9" } ], "protein_names": [ { "name": "[histone H4]-lysine(20) N-methyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "D3ZEB9" }, { "name": "2.1.1.361", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZEB9" }, { "name": "N-lysine methyltransferase KMT5A isoform X5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006249392", "id": "XP_006249392" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "common_name": "Rat" } ], "gene": [ { "name": "Kmt5a", "url": "https://www.uniprot.org/uniprot/D3ZEB9", "locus": { "chromosome": "12", "start_pos": 32139178, "end_pos": 32162711, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000064318", "url": "https://www.ensembl.org/id/ENSRNOG00000064318" } ] } } ], "crossref": [ { "id": "ENSRNOG00000001062", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001062", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10528", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10528", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "689820", "url": "https://www.ncbi.nlm.nih.gov/gene/689820", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:689820", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:689820", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LSCDSPN", "url": "https://omabrowser.org/oma/group/LSCDSPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "11811at2759", "url": "http://www.orthodb.org/?query=11811at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46167:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46167:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00856", "url": "http://pfam.xfam.org/family/PF00856", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2299718", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2299718", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-3214841", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214841", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6804760", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804760", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1587560", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1587560", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "51736", "url": "https://www.rhea-db.org/rhea/51736", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60344", "url": "https://www.rhea-db.org/rhea/60344", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I5ZQS7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZQS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZQS7-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZQS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZY89", "url": "https://www.uniprot.org/uniprot/A0A8I5ZY89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZY89-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZY89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A5Q1", "url": "https://www.uniprot.org/uniprot/A0A8I6A5Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A5Q1-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A5Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ANW6", "url": "https://www.uniprot.org/uniprot/A0A8I6ANW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ANW6-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ANW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKG3", "url": "https://www.uniprot.org/uniprot/A0A8I6GKG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKG3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GKG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZEB9-1", "url": "https://www.uniprot.org/uniprot/D3ZEB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQGRKMCKPRAVEAAAAAVAATAPGPEMVERRGPGRPRSDGENVFAGQSKIYAYMSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH", "length": 349, "header": "tr|D3ZEB9-1|D3ZEB9_RAT Isoform 1 of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=Kmt5a PE=4 SV=3 CANONICAL=D3ZEB9-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZQS7-1", "url": "", "sequence": { "sequence": "MSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH", "length": 295, "header": "tr|A0A8I5ZQS7-1|D3ZEB9_RAT Computationally mapped isoform of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=Kmt5a PE=4 SV=1 CANONICAL=D3ZEB9-1" }, "locus": { "chromosome": "12", "start_pos": 32155330, "end_pos": 32140976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000114055.1", "url": "https://www.ensembl.org/id/ENSRNOT00000114055.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000080894.1", "url": "https://www.ensembl.org/id/ENSRNOP00000080894.1" } ] } }, { "isoform_ac": "A0A8I5ZY89-1", "url": "", "sequence": { "sequence": "MCKPRAVEAAAAAVAATAPGPEMVERRGPGRPRSDGENVFAGQSKIYAYMSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH", "length": 344, "header": "tr|A0A8I5ZY89-1|D3ZEB9_RAT Computationally mapped isoform of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=Kmt5a PE=4 SV=1 CANONICAL=D3ZEB9-1" }, "locus": { "chromosome": "12", "start_pos": 32156575, "end_pos": 32140976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000106166.1", "url": "https://www.ensembl.org/id/ENSRNOT00000106166.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000084143.1", "url": "https://www.ensembl.org/id/ENSRNOP00000084143.1" } ] } }, { "isoform_ac": "A0A8I6A5Q1-1", "url": "", "sequence": { "sequence": "MGEAGAVGRRRPFPGAPRRRWWRRQQQQQQRRRQRWWPGRGEGEGAGRAAMGLAGLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH", "length": 338, "header": "tr|A0A8I6A5Q1-1|D3ZEB9_RAT Computationally mapped isoform of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=Kmt5a PE=4 SV=1 CANONICAL=D3ZEB9-1" }, "locus": { "chromosome": "12", "start_pos": 32156981, "end_pos": 32140976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000111843.1", "url": "https://www.ensembl.org/id/ENSRNOT00000111843.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088749.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088749.1" } ] } }, { "isoform_ac": "A0A8I6ANW6-1", "url": "", "sequence": { "sequence": "PPETLSPGRILCLSFQENVFAGQSKIYAYMSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH", "length": 324, "header": "tr|A0A8I6ANW6-1|D3ZEB9_RAT Computationally mapped isoform of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=Kmt5a PE=4 SV=1 CANONICAL=D3ZEB9-1" }, "locus": { "chromosome": "12", "start_pos": 32156245, "end_pos": 32140976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000106064.1", "url": "https://www.ensembl.org/id/ENSRNOT00000106064.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095821.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095821.1" } ] } }, { "isoform_ac": "A0A8I6GKG3-1", "url": "", "sequence": { "sequence": "MGEAGAVGRRRPFPGAPRRRWWRRQQQQQQRRRQRWWPGRGEGEGAGRAAMGLAGLQENVFAGQSKIYAYMSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH", "length": 365, "header": "tr|A0A8I6GKG3-1|D3ZEB9_RAT Computationally mapped isoform of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=Kmt5a PE=4 SV=1 CANONICAL=D3ZEB9-1" }, "locus": { "chromosome": "12", "start_pos": 32156981, "end_pos": 32140976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108981.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108981.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000092997.1", "url": "https://www.ensembl.org/id/ENSRNOP00000092997.1" } ] } }, { "isoform_ac": "D3ZEB9-1", "url": "", "sequence": { "sequence": "MQGRKMCKPRAVEAAAAAVAATAPGPEMVERRGPGRPRSDGENVFAGQSKIYAYMSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH", "length": 349, "header": "tr|D3ZEB9-1|D3ZEB9_RAT Isoform 1 of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=Kmt5a PE=4 SV=3 CANONICAL=D3ZEB9-1" }, "locus": { "chromosome": "12", "start_pos": 32162523, "end_pos": 32140976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000066253.3", "url": "https://www.ensembl.org/id/ENSRNOT00000066253.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000062763.3", "url": "https://www.ensembl.org/id/ENSRNOP00000062763.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:689820", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:689820", "resource": "KEGG Pathway" }, { "id": "R-RNO-2299718", "name": "Condensation of Prophase Chromosomes", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2299718", "resource": "Reactome", "description": "Condensation of Prophase Chromosomes" }, { "id": "R-RNO-3214841", "name": "PKMTs methylate histone lysines", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214841", "resource": "Reactome", "description": "PKMTs methylate histone lysines" }, { "id": "R-RNO-6804760", "name": "Regulation of TP53 Activity through Methylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804760", "resource": "Reactome", "description": "Regulation of TP53 Activity through Methylation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q2YDW7-1", "protein_name": "N-lysine methyltransferase KMT5A", "gene_name": "Kmt5a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARGRKMCKPRAVEAAAAAVAATAPGPEMVEQRGPGRPRSDGENVFAGQSKIYAYMSPNKCSAMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNTGNVIRSAVKSDEQKSKDTRRGPLAPFPNQKSEAAEPPKTPPPSCDSTNVAVAKQALKKSLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKNELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYVQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH", "length": 349 }, "evidence": [ { "id": "45229558", "url": "http://www.informatics.jax.org/homology/45229558", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQR1-1", "protein_name": "N-lysine methyltransferase KMT5A", "gene_name": "KMT5A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH", "length": 393 }, "evidence": [ { "id": "45229558", "url": "http://www.informatics.jax.org/homology/45229558", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of double-strand break repair via homologous recombination", "id": "GO:2000042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "regulation of DNA damage response, signal transduction by p53 class mediator", "id": "GO:0043516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043516", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "peptidyl-lysine monomethylation", "id": "GO:0018026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018026", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "polytene chromosome", "id": "GO:0005700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005700", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "histone methyltransferase activity", "id": "GO:0042054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042054", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "protein-lysine N-methyltransferase activity", "id": "GO:0016279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016279", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "histone H4K20 methyltransferase activity", "id": "GO:0042799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042799", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" }, { "name": "histone H4K20 monomethyltransferase activity", "id": "GO:0140944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140944", "evidence": [ { "database": "UniProtKB", "id": "D3ZEB9", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "51736", "name": "", "equation": "L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C6Y7-1", "D3ZSK5-1", "Q7M6Z3-1", "A0A0G2JTW4-1", "A0A0G2JW37-1", "D3ZEB9-1", "M0R767-1", "D4ADE5-1", "A0A8I6AL52-1", "Q8N6R0-5", "Q9NQV7-1", "Q9BYW2-1", "P0DPD7-4", "Q9NQR1-1", "Q9NRG4-1", "Q96AZ1-1", "Q8TBK2-1", "Q8WTS6-1", "Q91YR5-3", "Q96EQ9-1", "E9Q5F9-1", "P0DPE0-1", "D3YWP0-1", "Q9CWY3-1", "Q2YDW7-1", "Q8R5A0-1", "Q8VHL1-1", "Q54J80-1", "Q9VIK9-1" ], "evidence": [ { "id": "51736", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51736" } ] }, { "id": "60344", "name": "", "equation": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C2N5-1", "P0C6Y7-1", "P0C2N6-1", "A0A0G2JTW4-1", "A0A0G2JW37-1", "D3ZEB9-1", "M0R767-1", "A0A8I6AL52-1", "Q9NVD3-1", "Q4FZB7-1", "Q9NQR1-1", "Q86Y97-1", "Q9NQX0-3", "Q9NQV7-1", "Q3U8K7-1", "P58467-1", "Q2YDW7-1", "Q6Q783-1", "Q3UZD5-1", "Q96EQ9-1", "Q9VFK6-1", "Q9W5E0-1" ], "evidence": [ { "id": "60344", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60344" } ] }, { "id": "R-RNO-2301205", "name": "SETD8 monomethylates histone H4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZEB9-1" ], "evidence": [ { "id": "R-RNO-2301205", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2301205" } ] }, { "id": "R-RNO-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-RNO-5423110" ], "enzyme_list": [ "D3ZEB9-1" ], "evidence": [ { "id": "R-RNO-5423038", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5423038" } ] }, { "id": "R-RNO-6805740", "name": "SETD8 methylates TP53", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZEB9-1" ], "evidence": [ { "id": "R-RNO-6805740", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6805740" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-5423110", "participant_name": "H4c16 [nucleoplasm]", "crossref": [ { "id": "P62804", "database": "UniProt", "url": "" }, { "id": "XP_008769992.1", "database": "RefSeq", "url": "" }, { "id": "XP_008761670.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000115294", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000107328", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000054017", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000074659", "database": "Ensembl", "url": "" }, { "id": "152995531", "database": "RGD", "url": "" }, { "id": "ENSRNOT00000105806", "database": "Ensembl", "url": "" }, { "id": "1307448", "database": "RGD", "url": "" }, { "id": "ENSRNOT00000106060", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000039602", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000064025", "database": "Ensembl", "url": "" }, { "id": "P62804", "database": "PRO", "url": "" }, { "id": "ENSRNOG00000070513", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000087795", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000063552", "database": "Ensembl", "url": "" }, { "id": "XP_578415.4", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000032224", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000087751", "database": "Ensembl", "url": "" }, { "id": "1306905", "database": "RGD", "url": "" }, { "id": "XP_008772221.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000040210", "database": "Ensembl", "url": "" }, { "id": "NP_073177.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOP00000079614", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000080829", "database": "Ensembl", "url": "" }, { "id": "NP_001258150.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000117583", "database": "Ensembl", "url": "" }, { "id": "1304905", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000091037", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000071163", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000091116", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000088408", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000093704", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000065263", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000066473", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000070706", "database": "Ensembl", "url": "" }, { "id": "NP_001116941.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000067648", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000080971", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000120238", "database": "Ensembl", "url": "" }, { "id": "620814", "database": "RGD", "url": "" }, { "id": "ENSRNOT00000080490", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000114507", "database": "Ensembl", "url": "" }, { "id": "XP_008761668.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000112120", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000091524", "database": "Ensembl", "url": "" }, { "id": "XP_003749904.3", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000112947", "database": "Ensembl", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JTW4", "gene_name": "AABR07010705.1", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A0G2JTW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTW4" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A0G2JTW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTW4" } ] } ] }, { "uniprot_ac": "A0A0G2JW37", "gene_name": "RGD1561318", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A0G2JW37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW37" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A0G2JW37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW37" } ] } ] }, { "uniprot_ac": "A0A8I6AL52", "gene_name": "ENSRNOG00000067141", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A8I6AL52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A8I6AL52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ] } ] }, { "uniprot_ac": "D3YWP0", "gene_name": "Eef1akmt3", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "D3YWP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YWP0" } ] } ] }, { "uniprot_ac": "D3ZEB9", "gene_name": "Kmt5a", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "D3ZEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "D3ZEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ] } ] }, { "uniprot_ac": "D3ZSK5", "gene_name": "Setd6", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "D3ZSK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSK5" } ] } ] }, { "uniprot_ac": "D4ADE5", "gene_name": "Setd7", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "D4ADE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADE5" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "D4ADE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADE5" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "D4ADE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADE5" } ] } ] }, { "uniprot_ac": "E9Q5F9", "gene_name": "Setd2", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "E9Q5F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q5F9" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "E9Q5F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q5F9" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "E9Q5F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q5F9" } ] } ] }, { "uniprot_ac": "M0R767", "gene_name": "AABR07033047.1", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "M0R767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R767" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "M0R767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R767" } ] } ] }, { "uniprot_ac": "P0C2N5", "gene_name": "Kmt5b", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] } ] }, { "uniprot_ac": "P0C2N6", "gene_name": "Kmt5c", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] } ] }, { "uniprot_ac": "P0C6Y7", "gene_name": "Prdm9", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] } ] }, { "uniprot_ac": "P0DPD7", "gene_name": "EEF1AKMT4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P0DPD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DPD7" } ] } ] }, { "uniprot_ac": "P0DPE0", "gene_name": "Eef1akmt4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P0DPE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DPE0" } ] } ] }, { "uniprot_ac": "P58467", "gene_name": "Setd4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] }, { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] } ] }, { "uniprot_ac": "Q2YDW7", "gene_name": "Kmt5a", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] } ] }, { "uniprot_ac": "Q3U8K7", "gene_name": "Kmt5b", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] } ] }, { "uniprot_ac": "Q3UZD5", "gene_name": "Prdm6", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q3UZD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UZD5" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q3UZD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UZD5" } ] } ] }, { "uniprot_ac": "Q4FZB7", "gene_name": "KMT5B", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q4FZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZB7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q4FZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZB7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q4FZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZB7" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "Q4FZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZB7" } ] } ] }, { "uniprot_ac": "Q54J80", "gene_name": "", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q54J80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54J80" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "Q54J80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54J80" } ] } ] }, { "uniprot_ac": "Q6Q783", "gene_name": "Kmt5c", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q6Q783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q783" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q6Q783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q783" } ] } ] }, { "uniprot_ac": "Q7M6Z3", "gene_name": "Smyd2", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q7M6Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7M6Z3" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q7M6Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7M6Z3" } ] } ] }, { "uniprot_ac": "Q86Y97", "gene_name": "KMT5C", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q86Y97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y97" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q86Y97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y97" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "Q86Y97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y97" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q86Y97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y97" } ] } ] }, { "uniprot_ac": "Q8N6R0", "gene_name": "METTL13", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q8N6R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N6R0" } ] } ] }, { "uniprot_ac": "Q8R5A0", "gene_name": "Smyd2", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q8R5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R5A0" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q8R5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R5A0" } ] } ] }, { "uniprot_ac": "Q8TBK2", "gene_name": "SETD6", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q8TBK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TBK2" } ] } ] }, { "uniprot_ac": "Q8VHL1", "gene_name": "Setd7", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q8VHL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHL1" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "Q8VHL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHL1" } ] } ] }, { "uniprot_ac": "Q8WTS6", "gene_name": "SETD7", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q8WTS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTS6" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "Q8WTS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTS6" } ] } ] }, { "uniprot_ac": "Q91YR5", "gene_name": "Mettl13", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q91YR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YR5" } ] } ] }, { "uniprot_ac": "Q96AZ1", "gene_name": "EEF1AKMT3", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q96AZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AZ1" } ] } ] }, { "uniprot_ac": "Q96EQ9", "gene_name": "Prdm9", "activity": [ { "ec_number": "2.1.1.43", "activity": "", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q96EQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96EQ9" } ] } ] }, { "uniprot_ac": "Q9BYW2", "gene_name": "SETD2", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9BYW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYW2" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "Q9BYW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYW2" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9BYW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYW2" } ] } ] }, { "uniprot_ac": "Q9CWY3", "gene_name": "Setd6", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9CWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CWY3" } ] } ] }, { "uniprot_ac": "Q9NQR1", "gene_name": "KMT5A", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9NQR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQR1" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQR1" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q9NQR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQR1" } ] } ] }, { "uniprot_ac": "Q9NQV7", "gene_name": "PRDM9", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQV7" } ] } ] }, { "uniprot_ac": "Q9NQX0", "gene_name": "PRDM6", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NQX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQX0" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q9NQX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQX0" } ] } ] }, { "uniprot_ac": "Q9NRG4", "gene_name": "SMYD2", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9NRG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NRG4" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q9NRG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NRG4" } ] } ] }, { "uniprot_ac": "Q9NVD3", "gene_name": 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